Associations of serotonergic genes with poststroke emotional incontinence

Kim, Jae‐,Min,Stewart, Robert,Kang, Hee‐,Ju,Bae, Kyung‐,Yeol,Kim, Sung‐,Wan,Shin, Il‐,Seon,Kim, Joon‐,Tae,Park, Man‐,Seok,Cho, Ki‐,Hyun,Yoon, Jin‐ John Wiley Sons, Ltd 2012 INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY Vol.27 No.8

<P><B>Objectives</B></P><P>Poststroke emotional incontinence (PSEI) has been associated with serotonergic dysfunction. Polymorphisms of serotonin transporter (5‐HTT) and serotonin 2a receptor (5‐HTR2a) genes may regulate serotonergic signaling at brain synapses, and this study was to investigate associations with PSEI in an East Asian population.</P><P><B>Methods</B></P><P>In 276 stroke cases, PSEI was diagnosed by Kim's criteria. Covariates included age, gender, education, history of depression or stroke, current depression, and stroke severity and location. Genotypes were ascertained for 5‐HTT gene‐linked promoter region (5‐HTTLPR), serotonin transporter intron 2 variable number tandem repeat, 5‐HTR2a 1438A/G, and 5‐HTR2a 102 T/C. Associations with PSEI were estimated by using logistic regression models, and gene–gene interactions were investigated by using the generalized multifactor dimensionality reduction method.</P><P><B>Results</B></P><P>PSEI was present in 37 (13.4%) patients. The 5‐HTT gene‐linked promoter region <I>s</I>/<I>s</I> genotype was independently associated with PSEI. No associations with STin2 VNTR and 5‐HTR2a genes were found, and no significant gene–gene interactions were identified.</P><P><B>Conclusions</B></P><P>Stroke patients with 5‐HTTLPR <I>s</I> allele had higher susceptibility to PSEI, which underlines the potential role of serotonergic pathways in its etiology. Copyright © 2011 John Wiley & Sons, Ltd.</P>

초등학생에서 인두배양과 항-OF 항체 보유율

정현주,김선주,김윤정,맹국영,정현주,김선주,김윤정,맹국영 대한임상병리학회 1998 대한임상병리학회지 Vol.18 No.3

S-542 Indomethacin aggravates the renal injury by inhibition of adenosine-medited renal protection in AKI

( Hyejung Kim ),( Sun-hee Kim ),( Mi Seon Kang ),( Park Seok Ju ),( Min Sung An ),( Ki Beom Bae ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Background: Ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury with high morbidity and mortality due to limited therapy. AKI emerges in various clinical settings and is complex with outcome linking oxidative stress, inflammation, and cell death. Therefore protection of AKI is still an unsolved problem. Indomethacin is generally known that it inhibits the production of prostaglandins through the inhibition both cyclooxygenase (COX) 1 and 2. Prostaglandins have a wide variety of effect such as regulation of vasodilation, inflammation, regeneration, pain, fever. Therefore effect of indomethacin in AKI is different according to injury model. We investigated whether indomethacin which inhibits the production of prostaglandins aggravate the renal injury in AKI mouse model. Methods: Male C57/BL6 mice (8-10 weeks old, weight 20~25 g) were used. Acute kidney injury is induced by bilateral kidneys pedicle clamping which were subjected to 20 min or 30 min at both kidneys. Mice were treated with indomethacin at before and after injury. Blood and kidney samples were collected at 24 hr after IRI. The expression level of creatinine, N-gal & Kim-1 were detected in serum. And the expression level of PGE2, cAMP and adenosine were detected in kidney. Kidney Injury score were measured by HE staining and TUNEL. Results: In bilateral AKI model, Serum NGAL level and creatinine level were significantly highest in indomethacin treated group compared to non-treated group (NGAL, p<0.05; creatinine, p<0.01). Indomethacin treated group showed significantly more necrosis and apoptosis compared to non-treated group. Furthermore, Indomethacine inhibited the production of prostaglandins, cAMP and adenosine. Conclusions: Indomethacin inhibits adenosine-mediated renal protection by inhibition of prostaglandin production in AKI. Therefore Indomethacin worsened renal injury by inhibition of prostaglandin production in AKI. * This research was supported by a grant of the Korea Health Technology R&D Project through the KHIDI, funded by the Ministry of Health & Welfare, Republic of Korea (grant number :H15C2212)

CIS 고려인 디아스포라 소설 연구

장사선(Jang Sa Seon),김현주(Kim Hyeon Ju) 한국현대소설학회 2004 현대소설연구 Vol.- No.21

This study aims to examine the general trend of novels written by Soviet-Korean in C I S. Soviet-Koreans in this Central Asian area have moved from the Far Eastern area of Russia by the enforcement of the Stalinian policy of deportation in 1937. The authors have written a number of novels describing the life of diaspora experienced by Korean residents. To be more specific, the main focus of these novels is centered onto the issues such as the adaptation to the socialist system, the discord or accord with the different nation, the self-identity, and so on. The representative authors and their works are as follow: Seil Kim`s HongBeomDo and Jun Kim`s A happening of one hundred and fifty thousand won that depict the heros of anti-Japanese fight, Gicheol Kim`s When red stars were seen and a group works, The melody of Syrdarya that praise the socialism, sunflower and ``자말러, you are my life that treat the agony of identity as Koreans in a foreign country, and several works of Anatoli Kim and Lee-Jin that reflect the times of the various open door, On the whole, each novel expresses successfully the scenes of life with a different ideology and in the unfamiliar environment and embodies such troubles adequately into the form of literature. However, there also exist some problems of the plain development of plot. the dichotomic way of thinking, the excessive exposure of the theme, and so forth. After the collapse of the Soviet Union around 1990. a rapid conversion of direction toward modernism has occurred. With the opening of the exchange gate between Korea and CIS, there have been many changes in the content and publication of the works. More extensive research is needed.

UR 보조금 협정과 정보통신진흥기금의 개편방향

김동주,최선규 高麗大學校 産業開發硏究所 1995 産業開發硏究 Vol.4 No.-

서울 국민학생 인두에서 베타용혈성 연쇄구균 분리 : Compared with the Results of Children in Kangwon and Chungnam Province 강원도, 충남 국민학생의 분리율과 비교

김선주 대한감염학회 1994 감염 Vol.26 No.2

목적 : 서울 아동의 인두에서 BHS와 S. pyogenes 보균을 구하고, 이미 보고한 바 있는 강원도와 충남 아동의 결과와 비교하고자 했다. 방법 : 상기도 감염 증상이나 징후가 없는 590명의 아동에 대한 인두배양을 시행하고, bacitracin 디스크와 라텍스 응집법으로 동정하였다. 결과 : 대상 아동 중 103명 (17.5%)에서 BHS가 분리되었고, 76명(12.9%)에서 S. pyogenes가 분리되었다. 18명은 G군, 4명은 C군, 2명 B군이었으며, 나머지 3명은 비 A,B,C,G 군을 가지고 있었다. 결론 : 본 연구 결과와 강원도 및 충남 아동의 인두 배양결과를 종합해보면, 우리나라 국민학교 아동의 겨울철 BHS 보균율은 약 15%, S. pyogenes 보균율은 약 10%라고 볼 수 있다. Background : The carrier rates of beta-hemolytic streptococci (BHS) and Streptococcus pyogenes of the children in Seoul were investigated epidemiologically and compared with those of Kangwon and Chungnam Province previously reported. Methods : Throat cultures were taken from the healthy 590 elementary school children who had no symptoms or signs of upper respiratory tract infection, and the beta-hemolytic colonies were identified with bacitracin disk and latex agglutination test. Results : Of those children, 103 (17.5%) yielded BHS and 76(12.9%) did S.pyogenes. Eighteen strains (6.0%) of BHS were identified as group G, 4 ones (1.3%) as gorup C, 2 ones (0.8%) as group B,andtheotherthree(1.0%)wereclassified as non-group A,B,C,G. Conclusion : Including the results of Kangwon and Chungnam Province, BHS from the throats of healthy elementary school children in winter were similarly isolate from about 15% and S. pyogenes from about 10% respectively regardless of geographical differences.

진주지역에서 연쇄구균감염후 사구체신염의 재유행 : 최근 10년간의 임상적 고찰 Clinical Review of Recent 10 Years

김선주,김윤정 대한감염학회 1998 감염 Vol.30 No.6

목적 : 최근 구미에서 류마티스열이 재유행하고 A군 연쇄구균의 침습성 감염이 증가하고 있다. A군 연쇄구균 감염의 비화농성 후유증의 하나인 PSAGN이 재유행하는지 살펴보기 위해 진주지역에서 PSAGN의 발생 빈도를 조사하였다. 방법 : 1988년 1월부터 1998년 8월까지 경상대학교병원에 입원한 환자 중 PSAGN으로 진단받은 90명의 의무기록을 후향적으로 조사하여 PSAGN의 연도별 발생율과 환자들의 임상적 특성 및 검사 결과를 살펴보았다. 결과 : PSAGN의 발생빈도는 1993년까지 점차 감소하여 1993년에는 0.09%이었다가 1994년부터 다시 증가하였는데, 특히 1996년에는 1.83%로 유의하게 증가하였다(P<0.01). 월별로 보면 10월부터 1월까지 주로발생하여 전체 발생율의 64.4%를 차지하였다. 증상은 부종 78.9%, 육안적 혈뇨 65.6%, 핍뇨 22.2%, 발열이 16.7%에서 있었고, 내원당시 혹은 입원 중에 고혈압이 나타난 예는 28.9%이었다. ASO 증가가 92.0% (80/87)에서 있었고, C3와 CH50의 감소는 각각 94.4% (85/90)와 93.2% (41/44)에서 나타났다. 결론 : PSAGN의 발생은 1993년까지 감소하였지만 1994년 이후 다시 증가하는 추세임을 알 수 있었다. PSAGN의 재유행이 한 지역에 국한된 현상인지 전국적인 현상인지에 대한 신속한 조사가 필요하다. PSAGN의 원인균을 규명하기 위해 A군 연쇄구균에 대한 혈청학적 연구 등 역학적 조사가 필요하며, 비화농성 후유증을 예방하기 위해 A군 연쇄구균 인두염에 대한 적절합한 항생제 치료가 요구된다. Background : Rheumatic fever (RF) or streptococcal invasive disease have surged in developed countries recently. Incidence of poststreptococcal acute glomerulonephritis (PSAGN), a sequelae of group A streptococci (GAS) infection was investigated to evaluate the resurgence of PSAGN in Chinju. Methods : Medical records of 90 patients with PSAGN from January 1988 to August 1998 were reviewed retrospectively. Annual incidence, clinical characteristics, and laboratory findings were analyzed. Results : Annual incidence of PSAGN decreased until 1993, to as low as 0.09%, but started to increase in 1994 and became significantly high (1.83%) in 1996 (p<0.01). Most (64.6%) of PSAGN cases occurred from October to January. Major symptoms were edema (78.9%), gross hematuria (65.6%), oliguria (22.2%), and fever (16.7%). Hypertension was observed in 28.9% during admission. Increase of ASO were observed in 92.0% (80/87), decrease of C3 and CH50 in 94.4% (85/90) and 93.2% (41/44), respectively. Conclusion : Annual incidence of PSAGN decreased until 1993, but increased from 1994. Whether this resurgence of PSAGN is merely regional or part of a national epidemic should be investigated.

셋트 제품의 컨테이너 적재 알고리즘 개발에 관한 연구

김홍배,노재정,강주선 慶星大學校 1998 論文集 Vol.19 No.1

This study is focused on the methodology for the determination of the loading pattern for set products which can be charactertized by the fact that various kinds of parts should be provided together in order to function as one product such as home appliances or military supplies. This study is composed of the development of the mathematical model and its solution algorithm. The model tries to maximize the utilization rate of the loading space under the condition that the same number of the components of each set product should be loaded. This study can give the loading pattern and present the quantity information on the sub-set products to the user. The result of this study is compared with George & Robinson's algorithm under the same condition that this study is performed.

지역사회 획득 폐렴의 원인으로서 Chlamydia pneumoniae의 중요성에 관한 연구

김의종,김성민,오명돈,김선주,최강원 대한감염학회 1995 감염 Vol.27 No.1

연구 배경 : Chlamydia pneumoniae(TWAR)는 급성 호흡기 감염증을 일으키는 병원체로, 혈청역학적 연구 결과에 의하면 세계적으로 성인의 20-50%가 C. pneumoniae 대한 IgG 항체를 가지고 있다. 우리나라의 경우, 건강한 성인의 약 50%가 항체 양성임을 고려하면 C. pneumoniae는 우리나라에서도 호흡기 감염증의 흔한 원인중 하나일 것으로 생각된다. 대상 및 방법 : 건강인 108명과 1993년 2월부터 5월 말까지 신병 훈련소에 입대한 군인 중 폐렴으로 인해 후송병원에 입원한 환자를 대상으로 하였다. C. pneumoniae에 대한 IgG 및 IgM 항체는 microimmunofluorescent 법을 이용하여 측정하였다. 항체검사에 사용한 elementary body 항원은 Washington research Foundation으로부터 분양을 받았다. 현증 감염은 항체 역가가 4배 이상 상승하거나, IgG항체 역가 ≥512, 또는 IgM항체 역가>16으로 정의하였다. 성적 : 건강인 108명 중 IgM 항체 양성자는 한 명도 없었으나, IgG >16인 사람은 67명 (62%) 이었다. 폐렴에 걸린 신병 79명의 증상은 기침, 객담이 100%, 발열 87%,수포음 78%, 흉부 X-선상 침윤이 87%였고, 증상 발현 후 입원까지의 기간은 1주일이내가 27%, 8-13일 27%, 14-20일 27%, 21일 이상 20% 였다. 이들 폐렴 환자들 중 C. pneumoniae에 대한 lgG 항체 역가가 4배 이상 상승한 환자는 11명, lgG 항체 역가 ≥512인 환자가 4명 (3명은 항체 역가가 4배 이상 상승)으로, 전체 대상환자 중 15%(12/79)가 급성 간염증의 소견을 보였다. 결론 : C. pneumoniae 감염은 비교적 흔히 발생하며, 지역 사회 획득 폐렴의 중요한 원인 중 하나로 생각된다. Background : Chlamydia pneumoniae strain TWAR cause acute infections of the respiratory tract. Previous study showed that prevalence of TWAR antibody in adults from different areas of the world ranged from 25% to 50%. In Korea, positive rate of poly- IgG antibodies against TWAR was reported to be about 50% among healthy adults. These suggest that infections caused by TWAR may be quite prevalent in Korea. We tried to determine whether TWAR is an important pathogen of community-acquired pneumonia. Methods : We studied 108 healthy persons and 79 military recruits with pncumonia who were evacuated from the training camp to the military hospital from February to April 1993. IgG and IgM antibodies to TWAR were measured using the microimmunofluorescence method. Elementary body antigen from TWAR was provided by the Washington Research Foundation. Serologic evidence of current infection was defined as a four-fold rise in antibody titer. In addition, a titer of 16 or greater in the IgM fraction and of 512 or greater in the IgG fraction were considered presumptive evidence of current or recent infection. Results : Of the 108 healthy subjects, none had IgM TWAR antibody, while 67 (62%) had IgG antibody at a titer of 16 or greater. Of the 79 military recruits with pneumonia, cough and sputum developed in 100%, fever in 87%, and crackles in 78% Chest X-ray infiltration was noticed in 87%. Duration of symptoms before admission was less than 7days in 27%, 8-13 days in 27%, 14-20 days in 27%, 21 days or longer in 20%. Of the military recruits with pneumonia, 15% (12/79) showed evidence of acute TWAR infection: 11 showed a four-fold antibody titer rise, and 1 had IgG antibody titer greater than 512. Conclusion : These results suggest that TWAR infections are quite prevalent and TWAR may be one of the important pathogens of community-acquired pneumonia in Korea.

치과 구내 X-선 촬영기의 사용연한에 따른 해상능에 관한 연구

김선주 전남대학교 치과대학 1990 전남치대논문집 Vol.2 No.1

The purpose of this study was to assess the resolution and focal spot size of dental X-ray machines. Fifty dental X-ray machines were selected for measuring resolution and focal spot size of them. These machines were used in general dental clinics. The time of installation of the X-ray machine varies from 1 year to 10 years. The resolution of these machines was measured with the test pattern. The focal spot size of thses machines was measured with the star test pattern. The following results were obtained : 1. The resolution of dental intraoral X-ray machines was not significantly changed within ten years. 2. The focal spot size of dental intraoral X-ray machines was not significantly increased within ten years. The statistical analysis between the mean focal spot size and nominal focal spot size was significant at the 0.05 level about the more than 3 years used machines.