固本祛瘀1號方의 抗癌活性에 關한 硏究(Ⅰ)

徐寅源,金聖勳,최봉균,金東熙 대전대학교 한의학연구소 2000 혜화의학회지 Vol.9 No.1

To evaluate the antitumor activity and antimetastatic effects of Gobongeerlhobang(GGIB), studies were done experimentally. The results were obtained as follows: 1.GGIB extracts exhibited a siginficant cytotoxicity against HT1080, A549, SK-MEL-2 and SK-OV-3 cell lines. 2.The T/C% was 120.7% in GGIB treated group in S-180 bearing ICR mice. 3.GGIB extracts exhibited inefficient adhesive effect of A549,B16-BL6 cell to complex extracellular matrix. 4.GGIB extracts showed a significant inhibition of lung metastasis of B16-BL6 cells in C57BL/6. 5.In CAM assays, angiogenesis was insignificantly inhibited in GGIB treated group than control group. These results suggested that GGIB extracts might be usefully applied for prevention and treatment of cancer.

쌍봉천창형 유리온실(Twin Vent Glasshouse,TVG)신모형 개발

서범석,정종훈,정순주,서상용 全南大學校 農業科學技術硏究所 1993 農業科學技術硏究 Vol.28 No.-

네모나프라이드의 유효성 및 추체외로 부작용 : Haloperidol 및 Risperidone과의 자연관찰적 개방형 비교연구 A Naturalistic Open Comparative Study with Haloperidol and Risperidone

서영수,김용관,신동환,공보금,이정구,박정환,윤성환,정치영,이상경,김영훈 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2

Objectives : This open prospective study was performed in order to evaluate the efficacy and extrapyramidal adverse effects of nemonapride in the schizophrenic patients, and was compared wit one of typical antipshchotics. haloperidol and one of atypical antipsychotics, risperidone. Methods : Thirty male and female schizophrenic patients(DSM-Ⅳ) were treated for 12 weeks with haloperidol(n=10), risperidone(n=10) and nemonapride(n=10). The overall efficacy was assessed at baseline, 1st week, 2nd week, 4th week, 8th week, and 12th week by the Positive and Negative Syndrome Scale for Schizophrenia(PANSS). Also the overall safety was assessed in the same time period by the Extrapyramidal Symptom Rating Scale(ESRS). Results : There were no significant differences in PANSS scores(total, positive, negative, and general psycho­pathology subscale) among haloperidol, risperidone, and nemonapride groups, Treatment responders, defined as at least 20% reduction of baseline total PANSS score, were achieved by 8 patients(80%) in haloperidol group, 10 patients(100%) in risperidone group, and 8 patients(80%) in nemonapride group. And there were no significant differences in ESRS total scores among haloperidol, risperidone, and nemonapride group. Inter-group comparison among haloperidol, risperidone and nemonapride group, as assessed by the ESRS, revealed no significant differences in the shifts to the maximum score, 9.4(±9.4), 6.2(±8.4), and 11.3(±8.1) respectively, and also revealed no significant differences in the mean time reaching the maximum score, 4.5(±4.5) week, 7.8(±4.8) week, and 4.6(±4.4) week, respectivily. Conclusion : There wee no significant differences in the efficacy and extrapyramidal adverse effects among haloperidal, rispecridone and nemonapride groups. These results suggest that nemonapride was as efficacious and safe in he treatment of schizophrenia, as well known and widely used antipsychotics, haloperidol and risperidone.

마그네트론 스퍼터용 20kW급 플라즈마 전원장치 개발

서광덕,김상훈 강원대학교 산업기술연구소 2007 産業技術硏究 Vol.27 No.A

This paper describes a power supply aimed at the production of plasma and its control method for a magnetron sputter in thin film coating process of PVD(Physical Vapor Deposition). Plasma load changes its impedance characteristic easily according to operating conditions and frequently produces electric arc. So, in this paper, a plasma power supply with improved output control performance in the transient state for the plasma load is presented. Also, it includes a strategy that can detect arc rapidly and reduce arc energy effectively into a load. The validity of the proposed power supply through experimentation on 20kW system was proved.

한약개발에 관한 연구(第Ⅱ報) : 왕자귀나무 Albizzia coreana Nakai의 활성성분 및 행동약리학적 연구(2) Studies on the behavioral pharmacology and the activated constituents of Albizzia coreana Nakai(2)

徐成勳,陸昌洙,姜三植 慶熙大學校 1987 論文集 Vol.16 No.-

Albizzia coreana belonging to Leguminosae was firstly collected from southern area of Korea in 1930 by Dr. Nakal. A deciduous tree(higher:3∼5m). Leaves bipinnate, leablet(20∼45㎜), entire, 6-10 pairs. Flowers in axillary long-peduncled heads, pale yellowish. pods thin(width:2㎝. length 7∼12㎝), Seeds(Width:4-5㎜, length 7㎜) The stem bark(Albizia coreana) are used medicinally(folk medicine). Prescreibed as sedative in insonmia, in a state of deep depression and nervosity. Dose 6∼12gm.(powdered) The chemical components of the methanol extracts of Leaves, stem bark and root barks of Albizzia coreana Nakai. From the stem bark of Albizzia coreana, sapogenin, 3β, 21 β-dihydroxyolean-12-en-28-vic acid methylester, 3β-hydroxyolean-12-en-28-oic acid and acacic acid lactone were isolated and characterized by chemical and spectral analysis. β-sitosterol, cholesterol and octadecanoic acid were isolated from the stem bark and leaves. Flavone and flavonol glycosides, quercetin-3-L-rhammoside, quercetin-3-0-glucoside and quercetin-3-0-galactoside were isolated from the Albizzia leaves and identified by spectral data.

액-액 평형에서 첨가제의 영향에 관한 연구

서진기,정상훈,박동원 동아대학교 공과대학부설 생산기술연구소 1996 生産技術硏究所硏究論文集 Vol.1 No.2

The experimental binodal curves and tie lines were determined for solvent-5% KF salt solution-1 propanol systems at 25℃, and those tie line data were used to test thermodynamic consistency. From experimental data of tie line, the parameter estimated using NRTL and the caculated values fo tie line were predicted. The effect of KF salt on liquid-liquid equilibria was also studied.

산화 분위기에서의 다종 폐기물 성분의 열적 감량 연구

서용칠,이성준,김대환,윤성훈 연세대학교 보건과학연구소 1997 보건과학논집 Vol.7 No.-

상품 속성의 특성과 자료수집 방법이 컨조인트 모형의 효과에 미치는 영향에 관한 비교연구

서상윤;이훈영;남양호 경희대학교 산업관계연구소 2009 産硏論叢 Vol.34 No.-

컨조인트 분석에 사용되는 다양한 속성들은 이들 속성들이 갖는 특성에 따라 컨조인트 분석결과에 영향을 미칠 수 있다. 컨조인트 분석에 활용되는 개별 속성들은 색상이나 브랜드처럼 크기와 방향이 없는 이산적인 경우와 가격 혹은 무게 등과 같이 단조적인 크기와 방향을 갖는 벡터속성인 경우가 있다. 또한 이들 속성간 관계가 상품의 원산지와 색상처럼 상호 독립적인 경우가 있으며, 상품의 용량과 가격처럼 연관되어 있는 경우도 있다. 본 연구에서는 이렇게 상품 속성의 특성이 컨조인트 모형의 예측정확도에 어떠한 영향을 미치는 가를 비교연구 하였다. 연구결과, 상품의 속성들이 이산적인 속성들로 구성되어 있고 속성간에 서로 독립적인 경우, 속성이 단조적인 크기와 방향의 벡터속성과 서로 연관된 속성을 갖는 모형보다 예측정확도가 더 높게 나타났다. 또한, 트레이드 오프법과 전체프로필법을 이용한 두 자료수집 방법 간 예측정확도 비교에 있어서 상품의 속성들이 서로 독립적인 경우에는 트레이드 오프법을 이용한 자료 수집방법이 전체프로필법을 이용한 자료수집방법 보다 예측정확도 측면에서 더 효과적인 것으로 나타났고, 속성들이 서로 연관되어 있는 경우에는 두 방법간에 유의한 차이가 없는 것으로 나타났다. The performance of conjoint model tends to depend on the characteristics of product attributes as well as the strength of correlation among attributes. If attributes used in the analysis are highly related with each other, the thult of conjoint analysis might not be so reliable neither effective in measuring the utility. The association among the attribute levels within an attribute also negatively influences on the performance of conjoint model. The purpose of this research is to investigate into how the effectiveness of conjoint model varies depending on the relation among attributes as well as on the monotonic variies depenattribute levels within an attribute. This paper also examines which data collecting method is more angropriiee depending on the different association among attributes and attribute levels' characteristics within an attribute. This research finds that both the dependency among attributes and the monotonic variies depenattribute levels influence the accuracyepenebute. ed conjoint model. The model develonto with independent product attributes outperforms that with sibuwhat related product attributes. The better model is ebute. ed whennattribute levels are non-monotonic relirelated ds independent. Also when attributes are independent, the model mas onic vardata collected uthe m vart as well method outperforms that develonto using the data collected by the full profile method.

퇴행성 슬관절염 환자의 증상 중증도 지표와 DITI의 상관성 연구

서병관,류성룡,강중원,안경애,이재동,최도영,김건식,이두익,이윤호,이상훈 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : To investigate the applicability of thermography as severity measurement in the patients with osteoarthritis (OA) of the knee. Methods : Data were obtained from 80 patiens with OA of the knee. They were asked to answer two disease-specific questionnaire (Western Ontario and McMaster Universities (WOMAC) OA index, Lequesne's Functional Index (LFI)), one generic instrument (Korean Health Assessment Questionnaire (KHAQ)), VAS in order to assess the severity of disease, quality of life, degree of pain and taken thermography in standardized environment. Results : The thermal difference between ipsilateral side and contralaterla side of lateral aspect of knee was correlated with that of medial aspect of knee, and the thermal difference of anterior thigh was correlated with that of lateral, medial aspect of knee and patella region. Age, duration of disease, duration of morning stiffness, sex, crepitus, and painful side of knee were not correlated with the thermal differences of each region. LFI, WOMAC, WOMAC pain subscale, WOMAC stiffness subscale, WOMAC physical function, KHAQ,, VAS were not correlated with the thermal differences of each region. Conclusion : Further study on the thermography on OA of the knee in population with appropriate severity grade and the standardization of analysis of thermographic data were recommended.

퇴행성 슬관절염에 대한 제통단의 안정성과 효능 임상연구

서병관,류성룡,강중원,안경애,이상훈,최도영,김건식,이두익,이윤호,이재동 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : In order to investigate the efficacy and safety of the newly developed herbal medicine Jetongdan, a placebo-controlled randomized clinical trial of patients with osteoarthriotis of the knee was undertaken. Methods : Data were obtained from 80 patients with OA of the knee. After the enrollment, they were asked to answer a disease-specific questionnaire (Western Ontario and McMaster Universities (WOMAC) OA index) and analyzed with the erythrocyte sedimentation rate (ESR) in order to evaluate the efficacy of Jetongdan, and analyzed for aspartate transaminase (AST) level, alanine transminase (ALT) level, blood urea mitrogen (BUN) level, and creatinine (Cr) level in order to evaluate the safety of Jetongdan. Results : The liver function and renal function did not deteriorate after treatment with Jetongdan. Composite WOMAC score and physical function subscale was improved, but pain subscale, stiffness subscale, and ESR were not improved by Jetongdan. This was possibly because the baseline characteristics of the two groups were not homogenized after randomization. Conclusions : Jetongdan could be a promising treatment option for osteoarthritis of the knee. Further study in a larger population with appropriate severity grades is recommended.