Monocyte Chemoattractant Protein-1[MCP1] -2518 유전자 다형성과 주요 우울장애

배치운,이지현,신윤경,김태석,김정진,이창욱,이수정,전태연,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Object : This study was designed to examine the association between monocyte chemoattractant protein-l (MCPl) -2518poly morphism and major depressive disorder (MDD). Methods : Ninety patients with MDD and 114 healthy controls participated in this study. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method. Results : Genotype and allele distributions in patients with MDD were significantly different from those of the controls, In particular, subjects with the allele A were found to have an increased risk of MDD. Conclusion : The present study suggests that the MCPl -2518 polymorphism may have a potential role for susceptibility to MDD in the Korean population and thus calls for consecutive studies in order to pile up the data with larger different ethnic background.

양극성 장애와 Monocyte Chemoattractant Protein-1 유전자 다형성

배치운,김태석,장우영,김정진,이창욱,이수정,전태연,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : Several studies suggested that cytokines could be involved in the pathogenesis of mood disorders, while data for bipolar disorder is relatively deficient (BD). BD, Knowned to have a inherited tendency, has been considered to be related with T-helper cell system. This study was designed to investigate the association between polymorphism of monocyte chemoattractant protein-1 (MCP1) gene at promoter-2518 and BD. Methods : Patients with BD (n=92) in accordance with DSM-FV criteria and control subjects (n=114) participated in this study. DNA was extracted from whole blood and the MCP-1 gene promoter region was amplified by polymerase chain reaction-based method. Results : Genotype and allele distributions in patients with BD were not different from those of control subjects (p=0.587 ; p=0.384). Genotype and allele distributions in accordance to presence or absence of suicide attempt (p=0.423), family history (p=0.733) and psychotic feature (p=0.436) were not different between the two groups. Conclusion : Present study suggests that the MCP1 promoter -2518 polymorphism may not affect the susceptibility and clinical diversity of the development of BD.

Hinman 증후군(비신경인성 신경인성 방광) 1예

이경욱,채정호,이승주,김세웅,박원명,전태연,김광수 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.3

Objectives : The Hinman Syndrome is a condition representing urinary voiding dysfunction in a neurologically intact child. This syndrome probably is an acquired behavioral and psychosocial disorders. We present a case presenting voiding dysfuntion with no neurologic etiology. Case : The departmcnt of urology consulted the department of psychiatry for a psychiatric evaluation of a 14-year-o1d girl with a history of recurrent urinary tract infections, enuresis, and urinary dribbling since early childhood. She visited the emergency room bccausc of severe abdominal pain and hematuria. She was admitted to the department of urology. Neurological tests showed no abnormality, but a retrograde cystogram showed free vesicoureteral reflux to the level of the dilated intrarenal collecting systems. Marked blunting and dilatation of the caliccs suggested longstanding urinary flow obstruction. She had a history of scparation anxiety disorder and was very competetive, perfectionistic, and nervous. She also had very poor relationships with her friends and had difficults in managing them. Afer admission, she had stent operation and cystostomy. Antidepressant and anxiolytic medications with supportive psychotherapy were administered to treat anxiety, tension and depression. Gradually, her depressive symptoms and voiding difficulties improved. Conclusions : Psychological factors such as a perfectionistic and obsessive personality, a history of severe separation anxiety, stressors from poor interpersonal relationships and Ihe failure of an entrance examination seem to have contributes to the development and exacerbation of the urinary dysfunction. Pharmacotherapy and supportive psycho-therapy may be efective in treating associated psychiatric problems of these patients with hinman syndrome.

정신분열병 환자에서 얼굴 영상의 작동기억 장애 : 기능자기공명영상연구

이창욱,김태석,주라형,박주미,박여진,김종진,전신수,배치운,김정진,이수정,이철,백인호 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : Impaired processing of facial information is one of the broad ranges of cognitive deficits seen in patients with Schi-zophrenia. We aimed to elucidate the differences in brain activities involved in the process of facial working memory between schizophrenic patients and healthy comparison subjects. Methods : Twelve patients with schizophrenia were recruited along with twelve demographically matched healthy volunteers as a comparison group. Functional magnetic resonance imaging (fMRI) was used to assess cortical activities during the Perfor-mance of a 2-back working memory paradigm using images of neutral faces as mnemonic content. Rcsults : The patient group performed the tasks with reduced accuracy. Group analysis revealed that the left fusiform gyrus, the right superior frontal gyrus, the bilateral middle frontal gyri/insula, the left middle temporal gyrus, the precuneus, the quadrangular lobules and the vermis of cerebellum showed decreased cortical activities in the patient group. On the other hand, an increased level of activation in the lateral prefrontal cortex and the pahetal lobule was observed from the patient group, all in the right hemisphere. Conulusion : A decreased level of activity in the left fusiform gyrus among the patient group implicates inefficient processing of facial information. An increased level of activation in prefrontal and parietal neural networks from the patient group confirms earlier findings on the impaired working memory of patients with schizophrenia.

소결체 Scrap으로부터 Co 회수

이종대,이종욱,박노국,박영효,이태진 영남대학교 공업기술연구소 2001 工業技術硏究所論文集 Vol.29 No.1

The recovery of Cobalt(Co) and Tungsten Carbide(WC) from refractory scrap using electrolysis in an acid solution is studied. The method of electrochemical decomposition is a simple and economical process. The most important factor in the process of electrochemical decomposition is the component and concentration of electrolyte. The results show that the decomposition yield in sulfuric acid is better than other acid. This method is applicable for industrial process, because the decomposition yield is increased as scrap weight.

무선 애드 혹 기반 액티브네트워크상에서 QoS지원에 관한 연구

李基源,裵振勝,丁燦赫,金玄郁,李光培,姜景仁,朴京培,文泰洙,郭承郁,河載承 明知大學校 産業技術硏究所 2003 産業技術硏究所論文集 Vol.22 No.-

Abstract - In this thesis, we propose a QoS supporting method on wireless ad hoc-based active network for improving reliability. On the loss of route path, the existing DSR routing protocol has several problems with wireless network communication because of decease of data reception rate and increase of network load. The proposed method improves reliability of data transfer by using functions of active network. That is, by using functions of active nodes and active packets, the proposed method supports QoS with reservation transfer method that saves data packets on transfer at intermediate nodes with lost path and then re-transmit the packets after route reconfiguration.

알긴산나트륨 및 첨가제를 함유한 서방성 매트릭스 정제

이범진,이태섭,신성이,허보욱,유승구 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.3

The matrix tablet containing sodium alginate and CaHPO₄ can release drugs in a controlled fashion from hydrogel with gelling and swelling due to their interaction as water penetrates the matrices of the tablet. The purpose of this study was to evaluate release characteristics of the matrix tablet varying the amount of sodium alginate, CaHPO₄ and other excipients such as chitosan, hydroxypropyl methylcellulose (HPMC) and Eudragit^ⓡ RS100 in the simulated gastric and intestinal fluid. The practically soluble ibuprofen was used as a model drug. The release profiles of matrix tablet in the gastric fluid as a function of sodium alginate/CaHPO₄ ratio was not pronounced because of low solubility of drug and stability of alginate matrices. However, release rate of drug from the matrix tablet in the intestinal fluid was largely changed when sodium alginate/CaHPO₄ ratio was increased, suggesting that the ratio of sodium alginate/CaHPO₄ was an important factor to control the gelling and swelling of the matrix tablet. The incorporation of other excipients into the matrix tablet also influenced the release rate of drug. The chitosan and HPMC decreased the release rate of drug. No release of drug was occurred when Eudragit^ⓡ RS100 was added into the tablet. The retarded release of matrix tablet when excipients were added resulted from the hindrance of swelling and gelling of the matrix tablet containing sodium alginate and CaHPO₄. The hardness and bulk density of the matrix tablet was not correlated with release rate of drug in the study. From these findings, the ratio of sodium alginate and CaHPO₄ in the matrix tablet in addition to incorporation of excipients could be very important to control the release rate of drug in dosage form design.

복압성요실금(Stress urinary incontinence)과 절박성요실금(Urge incontinence)환자에서 TVT 수술 결과의 비교

이경구,이준호,권용욱,정태융,심희영,이상익 관동대학교 의과대학 의과학연구소 2005 關東醫大學術誌 Vol.9 No.1

Tension-free vaginal tape(TVT) has been widely used in the management of stress urinary incontinence(SUI), and has been applied to urge incontinence (UI). We evaluated and compared the outcomes between SUI and UI for patients who had undergone TVT. Patients were categorized into SUI(33 patients) and UI(26 patients). Before treatment, we asked about LUTSs using female bladder questionnaire. And we asked about sexual function. After treatment, the same questionnaires were repeated. During the postperative period, the objective and subjective success rate were evaluated. For operation outcome results, in SUI group there were 29 cases of cure (87.9%)and 2 of improvement(6.1%), and in UI group there were 20 cases of cure(76.9%)and 3 of improvement(11.5%) (p>0.05). The operation satisfaction rate of patients was 90.9% in SUI group and 84.6% in UI group(p>0.05). Improvement of sexual satisfaction occurred in 6(20.0%) of SUI group, and 3 (18.8%) of UI group, respectively(p>0.05). The objective success rate, satisfaction rate and sexual satisfaction of SUI patients did not significantly differ from the women with UI. Also, these results shows that TVT procedure improves some LUTSs in both groups. We consider the TVT procedure to be an effective treatment not for stress urinary incontinence but also urge incontinenece.

석유 화학 공장 폐수처리를 위한 고정생물막공법의 Pilot Plant 적용

이종현,남해욱,김미화,박태주 부산대학교 환경문제연구소 1998 環境硏究報 Vol.16 No.-

The pilot plant of biological fixed-film process(BFFP) was developed to treat the petrochemical wastewater with high organic loading rate, where a stationary biofilm was attached to net-type media(SARAN 1000D) under diffused aeration. The specific surface area of SARAN 1000D was 400 ㎡/㎥ approxirnately. The organic removal ability was tested in the pilot-scale three biological fixed-film reactors. The pilot scale reactor demonstrated more than 95% effciency in removing chemical oxygen demand(COD) at B reactor with 20% Packing ratio. The reactor also showed stable performance at the organic loading rates of 1.27~3.12 ㎏ COD/㎥/day. The effluent COD and SS concentrations of the pilot scale reactors were more unstable than those of the lab scale reactors. Based on the experimental results, the BFFP could be suitable for pre-treatment petrochemical wastewater with relatively high organic loading rate.

팽이 톱밥 人工栽培時 培地微生物相의 經時的인 密度變化

배태웅,文炳周,辛元敎,宋模烈,李鉉旭,曺東進 東亞大學校生命資源科學大學附設 農業資原硏究所 1996 農業生命資援硏究 Vol.5 No.1

팽이 재배에 있어 가장 큰 문제 중의 하나는 雜菌에 대한 汚染, 특히 細菌에 의한 피해가 극심하므로 作業段階와 栽培過程 전반에 걸쳐 培地徵生物相의 經時的인 密度變化에 따른 雜菌의 培地內 流入時期를 조사하여 汚染菌의 發生消長을 알아보기 위해 現地農家에서 시험해 본 결과 接種후 培養室에서 菌絲培養을 시작한 5일후부터 細菌이 檢出되기 시작하여 菌긁기전까지 약 25일간 0.5∼3.1×10⁴cfu/g의 密度를 보였으나 經時的인 密度增加는 없었고, 菌絲培養이 끝난 뒤 菌긁기직후부터 細菌의 密度는 118.3×10⁴cfu/g으로 급격히 높아졌으며 子實體生育 기간동안에 시간이 경과함에 따라 密度가 현저하게 증가되는 경향을 나타냈다. 이는 培養室 안으로 흐르는 空氣를 통하여 甁內로 細菌이 流入되고 또한 菌긁기 직후 培地表面에 灌注하는 물과 加濕機에서 噴霧되는 물粒子가 細菌의 密度增加에 절대적으로 영향을 미치는 것으로 판단되므로 이때가 細菌性褐斑病菌에 感染되기 가장 용이한 시기로 생각된다. 眞菌은 菌긁기후 子實體生育 기간동안 1.17∼7.87×10⁴/g의 密度로서 菌絲培養 기간동안의 密度보다 다소 높게 檢出되었으나 대체로 經時的인 密度增加는 보이지 않았으며, 放線菌은 거의 검출되지 않거나 菌絲培養 후 5일째부터 다소 검출되기 시작했으나 밀도가 매우 낮았고 經時的으로도 증가되지 않았다. One of the most serious problem on the Enoki mushroom cultivation is the infection by pathogenicitic microorganisns, especially bacterial diseases causing serious economical losses in the mushroom production. It was carried out to find the tendency of the development of mushroom diseases by temporal changes and variation of the densities of media microflora through the cultivation periods and working stages in a mushroom farm. According to the results, several bacteria were detected from the fifth day after the inoculation and incubation of mycelium in the incubation room, and the density of bacterium was 0.5∼3.1×10⁴cfu/g media for 25 days before the inoculum-removing, although there was no increment of the density. Since the inoculum-removing after the spawn run, the density of bacterium was rapidly increased as 118.3×10⁴cfu/g media, and was significantly increased by time during the growth period of fruitbodies. It was hypothesized that it is the most suitable period for the pathogen infection because the bacterium might be introduced by the air in the incubation-room, and the increment of bacterium density might be affected by moisture supplied through watering or humidifier in the growing room after the inoculum-removing. Fungi were detected as the density as 1.17∼7.87×10⁴/g media and the density was slightly higher than that during the incubation period of hyphae, although there was no significant increment. Generally, the density of Actinomycetes was disregardfully low, or Actinomycetes were hardly ever found, although there was found some 5 days after incubation hyphae in few cases.