말라리아 환자 32예의 임상적 고찰

정용희,백일현,김태형,김영식,이우인,서환조 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

목적 : 삼일열 말라리아는 국내에서 1986년 이후에는 박멸된 것으로 알려졌으나 1993년 이후 증가하는 양상을 보이고 있다. 이에 말라리아의 임상적 고찰을 통하여 이 질환을 이해함에 있다. 방법 : 1991년 1월부터 1999년 10월까지 반복적 고열과 오한을 주소로 본 병원에 내원하여 말초혈액 도말검사에 의해 말라리아 감염으로 확진된 32예의 환자에 대해서 후향적으로 조사하였다. 결과 : 1991년부터 1999년 10월까지 총 32명의 환자의 연도별 발생빈도는 각각 1991년에 1명, 1996년에 1명, 1997년에 3명, 1998년에 13명, 1999년에 14명이었다. 월별발생빈도는 7월과 8월에 집중적으로 발생하였다.(46.9%) 환자의 거주지는 경기 연천과 파주에 주로 분포되었다(53.1%). 성별발생분포는 32예의 환자중에 여자가 5명, 남자가 27명으로 남자가 더 많았다. 발병연령은 22세에서 87세까지 분포되었고 20-30대에 많이 발생하였으며 20대가 가장 많았다. 군인 및 제대자가 17명(59.4%)에 해당하였으며, 제대자의 평균 제대후의 기간은 10개월 정도였다. 가장 흔한 임상증상은 발열 및 오한이었다.(100%) 비장종대 및 간장종대는 각각 26명(81.3%), 3명(9.4%)에서 관찰되었다. 검사실 소견은 평균적으로 WBC 5.317/㎕, 혈색소 12.5±7.1g/㎗, 혈소판 78,906.3±68391.4㎕, GOT/GPT 43.7±26.7/49.6±57.3 IU/ℓ, Total bilirubin 1.6±0.9㎎/㎗를 보였다. 말초혈액 도말검사상 모두 P. vivax였다. 치료는 hydroxychloroquine과 primaquine의 치료에 잘 반응하였다. 결론 : 말라리아는 7월과 8월에 한국에서 호발하는 중요한 급성 열성 질환으로 조기 진단 및 치료에 보다 관심을 기울여야 할 것이다. Background : In Korea malaria has been rare, but since reemergence of indigenous vivax malaria in 1993, the number of cases of malaria have recently increased. We analyzed the cases of malaria who were treated in Kyung-Hee University College of Medicine with regard to define the clinical characteristics of malaria. Methods : We retrospectively analyzed of 32 cases of malaria admitted to Kyung-Hee University Hospital between 1991 and 1999. Malaria was diagnosed by peripheral blood smear. Results : Among a total of 32 cases, the number of yearly incidence of 1991, 1996. 1997, 1998 and 1999 were 1,1,3,13,14 respectively. It demonstrated the high incidence especially between July and August. The most patients (53.1%) resided in Yeonchon and Pajoo. Among them, 5 cases were female and 27 cases were male. The age distribution ranged from 22 to 76 year old. The high incidence of age was between 20's and 30's. Military solidiers and ex-soldiers are 17 cases(59.4 %). The most frequent symptom was fever and chills (100%). Splenomegaly and hepatomegaly were also observed in 81.3 %(26 of 32) and 9.4 %(3 of 32) respectively. The laboratory findings were WBC 5.317/㎕. Hb 12.5±2.1 g/dl. platelet 78,906±68,391.4/㎕. GOT/GPT 43.7±26.7/49.6±57.3 IU/L. LD 678.3±50.1 IU/L. total bilirubin 1.6±0.9mg/dl- The all cases were treated suscessfully with hydroxychloroquine and primaquine. There were no central nervous system complications and pulmonary edema. Conclusion : Malaria is one of the important acute febrile illness with the high incidence between July and August.

Discordance in Spirometric Interpretations Based on Korean and Non-Korean Reference Equations

Nami Kim,Mi-Hee Park,Se-yeong Kim,Chunhui Suh,Sangyoon Lee,Kun-Hyung Kim,Chae-Kwan Lee,Dae-Hwan Kim,Jong-Tae Lee 대한직업환경의학회 2013 대한직업환경의학회지 Vol.25 No.-

Objectives: Korean regression models for spirometric reference values are different from those of other ethnic groups. The purpose of this study was to evaluate discordance in spirometric interpretations based on using Korean reference equations versus non-Korean reference equations. Methods: Spirometry was performed on 825 Korean male workers from April 2009 to November 2011. The spirometric patterns and disease severity were evaluated using two Korean equations (Choi’s and Lee’s) and three equations for Caucasians (NHANES III, Morris’s, and Knudson’s), and the results of Choi’s equation were compared with the non-Korean equations. The spirometric patterns were defined as normal, restrictive, and mild and moderate obstructive. Results: The mean differences in the FEV1% and FVC% between the two Korean equations were 2.0 ± 1.3% and 3.5 ± 2.2%, respectively. Morris’s equation had the greatest difference in the FEV1% from Choi’s equation: 32.9 ± 8.5%. Knudson’s equation had the greatest difference in the FVC% from Choi’s equation: 10.5 ± 6.5%. Conclusions: The two Korean equations shared similar characteristics of spirometric interpretation. The spirometric interpretations of Choi’s equation were significantly different from those of Morris’s equation and Knudson’s equation.

치수 절단술 약제의 치수 섬유모세포에 대한 세포독성 연구

이영희,이긍호 大韓小兒齒科學會 2000 大韓小兒齒科學會誌 Vol.27 No.1

유치의 치수 절단술에 이용되는 약제들 (formaldehyde, formocresol, paraformaldehyde, ferric sulfate)이 농도 변화에 따라 치수 섬유모세포의 활성, 단백질 기질의 합성 및 무기질 침착에 미치는 영향을 규명하고자, 각각 0.01, 0.05, 0.10, 0.25, 0.50, 1.00㎕/㎖의 농도로 사람의 치수 섬유모세포에 24시간 적용시킨 후 세포활성검사와 함께, 조직의 재생과정 중 유기질이 되는 단백질의 합성능과 무기질 침착에 관여하는 알칼리성 인산효소의 활성에 미치는 영향을 완충액만을 투여한 대조군과 비교 평가한 결과 다음과 같은 결론을 얻었다. 치수 절단술 약제를 첨가한 후 24시간 배양하였을 때, formaldehyde, formocresol, paraformaldehyde 등의 경우 약제 농도가 증가함에 따라 대조군에 비하여 치수 섬유모세포의 세포활성이 크게 저하되었으며, ferric sulfate를 이용한 경우에는 세포활성이 유지되거나 약간 촉진되었다. formaldehyde, formocresol, paraformaldehyde 사이의 세포활성간에는 유의성 있는 차이가 보여지지 않았다. 치수 절단술 약제 첨가 후 배양액내의 총단백질양에는 큰 변화가 없었으나, paraformaldehyde에 의해 총단백질양이 약간 감소하였다. 약제 첨가 후 세포내의 단백질양을 측정하였을 때 ferric sulfate의 경우, 약제의 농도가 증가하였을 때도 지속적으로 단백질 합성이 저해됨을 알 수 있었다. formaldehyde, formocresol, paraformaldehyde, ferric sulfate는 치수 섬유모세포의 알칼리성 인산효소 활성을 약간 저해하였다. The effect of concentration as factor in cytotoxicity, protein synthesis and alkaline phosphatase activity was compared for pulpotomy medicaments (formaldehyde, formocresol. paraformaldehyde, ferric sulfate). Human pulp fibroblasts were exposed to a range of concentrations(0.01, 0.05,0.10, 0.25,0.50, 1.00㎕/㎖) of each agents, for period of 24hrs. The cell activities were evaluated by MTT assay, protein assay and alkaline phosphatase activity examination. The results as follows: 1. After 24hrs culture, pulp fibroblasts adding formaldehyde, formocresol and paraformaldehyde were suppressed cell activities with concentration increasing, but, no depression of cell activities by sulfate. No significant difference was in formaldehyde, formocresol and paraformaledhyde. 2. Protein synthesis by pulpotomy agents were not significant difference in pulp fibreblasts but protein synthesis were a little decreased by paraformaldehyde. 3. Alkaline phosphatase activity was a little decreased by pulpotomy medicaments.

유아 비만과 관련된 유아특성과 어머니의 식생활관리 및 양육행동

이송숙,김영희 충북대학교 교육 ·생활연구소 생활과학연구센터 2003 생활과학연구논총 Vol.7 No.1

The purpose of this research was to investigate the personal characteristics and environmental factors related to children's obesity. Subjects of this study were composed of 3∼5-year-old children of 7 kindergartens located in Cheongju and Cheongwon. The weight types of children had been classified into normal, over-weight, and obesity groups under WLI value. Data were analyzed by SPSSWIN with the method of frequency, percentage, t-test, F-test and Duncan post-hoc test. The results of this study were as follows: 1. Weight types of children were related to children's eating behaviors such as surfeit(overeating), gluttony, light eating and eating speed. That is to say, overweight and obesity group children ate more and they were more gluttonous than normal weight group of children. Normal weight group ate little compared with overweight and obesity group. Children of obesity group ate faster than children of normal and overweight group. 2. Children's eating behaviors were associated with their psychological characteristics such as sociality and activity. Children of obesity group were lack of sociality and activity compared with normal weight and overweight group. 3. Mother's control of children's eating habits was found to be related to the recognition of children figure and advice of reducing weight. Mothers considered normal weight children as thin and overweight and also evaluated obesity as normal or fat. Also they frequently urged overweight or obesity group to reduce weight. 4. There were statistically significant differences in mothers' parenting behavior according to the weight types. Normal weight children got more mothers' support parenting behavior than did overweight and obesity children. This research suggest that obesity group of children is not much different from children of overweight group.

초등학교 5. 6 학년의 비만도에 따른 스트레스·자아존중감 조사 연구

이은주,김옥란,신영희 김천과학대학 2003 김천과학대학 논문집 Vol.29 No.-

This paper is a descriptive study that inquires about stress and self-esteem of obese children to lend assistance about understanding emotional care as weight management of children. The data collection was given by the structured questionnaire during five days, from 5th to 10th on march in 2003 at one primary school located in K-city. The subjects were 286 children in 11-12 year old children. The instruments used for this study were an Obesity-Stress Scale(Cho Yang Rae, 1997) and a self-esteem questionnaire including Self-Perception Profile(Harter, 1982). Data were analyzed with frequency, percentages, x²-test, ANOVA, Pearson correlation using the SPSS program. The results were as follows; 1. A stress of obese children was the highest among three group, which was significant of statistical data. On the other hand, self-esteem do be shown the same as the above but was not significant statistically. 2. A relation between stress and self-esteem of obese children was shown to be in inverse proportion ratio so that the higher stress was the lower self-esteem. 3. To research the differences of the stress followed by the general characteristics of children, there are meaningful differences in sex, character, factor of stress, shape of father's body and shape of mother's body. 4. To research the differences of the self-esteem followed by the general character of children, there are meaningful differences in sex, character, shape of mother's body and socioeconomic status.

성찰적 실천의 관점에 비추어 본 수업설계자의 전문성 개발방안 탐색 : Focused Reflection in Action and on Action

이승희,유영만 한국교육정보방송학회 2002 교육정보미디어연구 Vol.8 No.2

수업설계는 역동적이고 복잡하면서도 고도의 전문성이 요구되는 지적 활동이다. 그러나 수업설계자의 전문성을 개발하는 전통적 방식은 기술적 합리성과 도구적 관심에 바탕을 두고 수업설계에 대한 개념적 지식과 스킬을 습득하는데 많은 비중을 두어왔다. 이러한 방식으로는 수업설계자가 수업설계 능력을 향상시키는 것이 쉽지 않다. 나아가 실천적 지침을 주지 못하는 수업설계 매뉴얼과 이를 기반으로 개발된 교육 프로그램은 현장의 교육요구를 해결하거나 수행문제 개선에 크게 기여하기 어렵다. 본 연구는 수업설계자의 핵심역량 중의 하나인 수업설계자의 능력을 향상시키는 기존의 방안에 한계가 있음을 지적하고, 성찰적 실천의 관점에서 기존의 문제점을 해결하는 방안을 모색해 보고자 하였다. 이를 위해 (1)실천적 지식구성, (2)상황구속성, (3)협력적 학습이라는 수업설계 활동의 본질과 수업설계에 대한 선행연구들을 토대로, 수업설계자의 전문성 개발의 원칙(실제성, 대화, 협력 및 다의적 의미구성)을 도출하였다. 또한, 성찰적 실천의 관점에 비추어 본 수업설계자의 전문성 개발 방안으로 학습 사이클 - (비)형상화된 문제상황 탐색, 문제상황 가시화, 문제해결을 위한 활동표현, 성찰적 실행 및 순환 반복적 개선-을 적용할 것을 제안하였다. Instructional designing activities can be said as the highly complicated but dynamic profession. The traditional ways of developing competencies for instructional designers have rooted from assumption of technical rationality and technical interest in which all the related process, knowledge and skills needed for designing instructional programs have been acquired followed by prescribed and systematic methods. Those assumptions have the tendency to lead a variety of learning programs in the real fields, therefore, have come to unfruitful training for activity, not training for impact. What matters most for instructional designers lies on the reflective thinking or reflective practice with which instructional designers or field practitioners can diversely understand problem situations and explore possible solutions to meet fields learning needs. The model of instructional systems designing activities for educating instructional designers should be come to an approach in the same manner. Instructional designing activities themselves should be redefined as knowledge constructing process, situation-specific activity as well as collaborative inquiry experiences with partner groups involved in a particular project. This paper suggests an alternative professional development for instructional designers in terms of reflective practice perspectives, and drew out some implications of five major learning principles and a feasible circular instructional designing process(exploring ill-structured problematic situation, visualizing problems, expressing problem solving activities, implementing keen observation and finally recursive revising).

KF114와 KB108 원료가공업의 연기증 Nicotine 및 Tar 함량의 변화

이철희,임흥빈,신주식,석영선 충북대학교 연초연구소 2004 煙草硏究 Vol.19 No.-

궐련담배 연기 중 Tar와 Nicotine 함량은 대부분의 국가에서 담배 포갑지에 표시하도록 규정하고 있으며 우리나라에서도 2003년부터 시행하고 있다. 그리하여 궐련담배 제품의 설정목표에 따라 엽배합의 방안을 강구하고자 우리나라에서 생산하고 있는 황색종과 버어리종의 주 품종인 KF114와 KB108의 원료 가공엽을 김천원료공장과 남원료공장에서 착엽위치 및 등급별로 채취하여 연기 중 Nicotine, Tar 및 CO 함량을 조사하였으며, 그 결과를 요약하면 다음과 같다. 1. 원료엽 중 니코틴 함량은 황색종 KF114에 비하여 버어리종 KB108이 높고, 본엽과 상엽에서는 등급이 낮을수록 함량이 높고, 중엽과 하엽에서는 등급이 낮을수록 함량이 낮았다. 2. 황색종 KF114는 궐련담배 1개비 당 중량이 본엽, 중엽, 상엽, 하엽 순으로 무거웠고, 엽위별 등급간에는 등급이 높을수록 무거웠다. 연소시간과 흡연회수는 본엽, 상엽, 중엽, 하엽 순으로 길고 많았다. 3. 버어리종 KB108은 궐련담배 1개비 당 중량이 상엽, 본엽, 중엽, 하엽 순으로 무거웠고, 엽위별 등급간에는 등급이 높을수록 무거웠다. 연소시간은 상엽, 본엽, 중엽, 하엽 순으로 길었으며, 중엽과 하엽에서는 등급이 높을수록 본엽과 상엽에서는 등급이 낮을수록 길었다.4. 황색종 KF114 원료 가공엽의 연기 중 니코틴과 타르 함량은 본엽에서는 등급이 낮을수록 높고, 중엽과 하엽에서는 등급이 높을수록 높은 값을 나타냈다. CO 함량은 본엽, 중엽, 상엽, 하엽순으로 많았고, 등급간 차이는 니코틴과 타르 함량에 대한 등급간 차이보다 적었다. 5. 버어리종 KB108 원료 가공엽의 연기 중 니코틴과 타르 함량은 상엽과 본엽에서는 등급이 낮을수록 높고, 중엽과 하엽에서는 등급이 높을수록 높은 값을 나타냈다. CO의 함량은 상엽, 본엽, 중엽, 하엽 순으로 높았고, 엽위 별 등급간에 차이가 없었다. 6. 잎담배 종류 및 가공엽의 등급에 따라 nicotine/tar 및 Co/tar 비율에 차이가 있는 것을 알 수 있으며, 엽위가 낮을수록 비율도 감소하였다. 7. 버어리종 KB108는 흡연회수, 니코틴, 타르및 CO가 각각 정의 상관관계가 인정되었으나, 황색종 KF114에서는 CO와 니코틴, CO와 타르 간에는 상관관계가 없었다. In most countries, nicotine and tar contents of cigarette smoke should be represented on the cigarette pack by law. It has been carrying out in Korea from 2003. In order to control those contents, It was tested the contents of tar, nicotine, carbon monoxide (CO) of smoke components and puff number for blending two major varieties produced in Korea, KF114, a flue-cured, and KB108, a burley. The processed leaf tobacco were taken from Kim-cheon and Ock-cheon leaf tobacco processing factory. The results were summarized as followed ; 1. Nicotine contents of processed leaf tobacco were higher in KB108, a burley, than in KF114, a flue-cured. Nicotine contents of leaf and tips were higher in low-grade leaves than in high-grade leaves, but those of cutters and lugs were lower in low-grade leaves than in high-grade leaves. 2. The weight per cigarette of KF114 was heavier in the order of leaf, cutters, tips and lugs, and was heavier in high-grade leaves than in low-grade leaves. Combustion time was longer and puff number was more in the order of leaf, tips, cutters and lugs. 3. The weight per cigarette of KB108 was heavier in the order of tips, leaf, cutters and lugs, and was heavier in high-grade leaves than in low-grade leaves. Combustion time was longer in the order of tips, leaf, cutters and lugs. The time of cutters and lugs was longer in high-grade leaves than in low-grade leaves, but those of leaf and tips was longer in low-grade leaves than in high-grade leaves. 4. Nicotine and tar contents of the smoke from the processed leaf tobacco of KF114 were higher in low-grade leaf than in high-grade leaf and cutters and lugs were higher in high-grade than in low-grade. CO contents were higher in the order of leaf, cutters, tips and lugs. The difference of CO contents between different grades was lower than that of nicotine and tar contents. 5. In nicotine and tar contents of the smoke from the processed leaf tobacco of KB108, leaf and tips were higher in low-grade than in high-grade and cutters and lugs were higher in high-grade than in low-grade. CO contents were higher in the order of tips, leaf, cutters and lugs. There was no significant difference of CO contents between different grades of the stalk position. 6. Nicotine/Tar and CO/Tar ratios showed significant difference according to tobacco variety and grade of processed leaf tobacco. The ratios were reduced in lower stalk position. 7. There were positive correlations between puff number, nicotine, tar and CO contents in KB108, but there were no correlations between CO and nicotine, or CO and tar in KF114.

새로운 디지탈 다중 서명 방식에 대한 고찰

이임영,박희운 순천향대학교 부설 산업기술연구소 1998 순천향 산업기술연구소논문집 Vol.3 No.3

In this paper, We propose more efficient Digital multisignature method for data integrity and user authentication. A sequential and a simultaneous digital multisignature schemes based on discrete logarithm problem scheme are proposed, and their efficiency is discussed. The proposed multisignature schemes overcome the communication complexity problem that arises in the Ohta and Okamoto scheme, and the sequential multisignature scheme enables any intermediate signer to verify the previous multisignature.

경주 남리사지에 사용된 석재의 암석학적 특성과 원산지 해석

이찬희,정연삼,정민호,이명성,김영택 공주대학교 문화재보존과학연구소 2004 문화재과학기술 Vol.3 No.1

이 연구는 경주 남리사지에 이용된 석재를 대상으로 암석의 성인적 분류, 광물 및 지구화학적 특성을 검토하여 석재의 기원지 추정과 고고지질학적 의미를 해석한 것이다. 남리사지에서 출토된 암석은 5종의 화강암질암 (알카리 화강암, 흑운모 화강암, 미문상 화강암, 등립질 화강암, 홍장석 화강암), 세립질 퇴적암 (셰일, 미사암), 호온펠스, 옹회암질암, 염기성 맥암 등이 있다. 이 중에서 서탑에 이용된 암석은 유백색의 중립질 알카리 화강암과 담홍색의 흑운모 화강암이 주류를 이룬다. 각 석재들의 대자율 값은 흑운모 화강암이 4.94~7.59 (평균 6.47)로서 제일 높았으며 미문상 화강암이 0.86~1.54 (평균 1.13)로 제일 낮았다. 알카리 화강암은 3.51, 홍장석 화강암이 5.88, 등립질 화강암이 4.89로서 분화경로와 산출상태에 따라 조금씩 다른 값을 보였다. 이 화강암류는 화학조성으로 볼 때, 거의 동일한 마그마 기원의 칼크-알카리 계열 화강암 영역에 해당된다. 이 석재의 화학적 풍화지수와 풍화 잠재지수는 각각 49.87~61.64와 4.12~8.46 범위로서, 현재 암석이 화학적 풍화작용이 왕성하게 발생하는 정도는 아니나 풍화잠재력은 매우 높은 것으로 나타났다. 이 화강암질암의 암석학적 및 지구화학적 특징으로 볼 때, 이들의 성인적 유형은 남산 일대에 분포하는 화강암과 동일하다. 따라서 남리사지의 석조문화재 건축에 사용된 석재는 현지에서 재료를 구하고 현장에서 제작한 자급자족형 석재와 수계의 상류지역에서 도입된 외래형 석재가 공준하고 있는 것으로 해석된다. 자급형 석재가 현지의 원료를 이용한 것은 확실하나 어느 지역에서 채석하여 어디서 가공을 하였는지는 불분명하다. Rock properties around the Namri temple site was studied source area and archaeogeological interpretations based on petrology, mineralogy and geochemistry. Excavated rocks from the area composed of granitic rocks (alkali granite, biotite granite, micrographic granite, eqigranular granite, pink feldspar granite), fine grained sedimentary rocks (shale and siltstone), hornfels, tuffaceous and basic dyke rocks. Almost rock materials of the west pagoda made of white medium grained alkali granite and biotite granite. As the magnetic susceptibility (MS), biotite granite ranges from 4.94 to 7.59 (mean 6.47), and micrographic granite is lowest value of 0.86 to 1.54 (mean 1.13). The mean MS values revealed that alkali granite = 3.51, pink feldspar granite = 5.88, eqigranular granite = 4.89, which are little variatins because of differentiation process and field occurrences. In the geochemical data, the granitic rocks represent a comagmatic calc-alkali series granite. The values of WPI and CIA for rock properties from the Namri temple site range from 49.87 to 61.64 and 4.12 to 8.46, respectively, which values don't going active weathering right now, but weathering potential represents very high. On the basis of petrology and geochemistry of the rock properties from the Namri temple site, the genetic types are the similar as those of the Namsan granite. Therefore, the using rocks of the Namri temple site suggested that domestic type rock properties getting material in the actual place and making in situ, and foreign type rock properties getting from the upstream area are coexisted. Domestic types are sure of making the actual place material, but unclear where is a quarry and working.

접합부 해석모델에 따른 철골조 연성모멘트골조의 비선형 응답

이정희,김연동,이용택 大田産業大學校 2000 한밭대학교 논문집 Vol.17 No.1

The purpose of this study is to evaluate the overstrength inherent in ductile moment resisting frames with two different joint models. The overstrength is obtained by nonlinear static pushover analysis using two analytical models. Only one panel element used in this study can reflect the panel zone deformation explicitly. For this purpose, moment resisting frames are designed using two different seismic design provisions. According to the results of this study, the range of overstrength radio is from 2.8 to 5.6. Also this study shows that explicit modeling of panel zone is more important for the buildings designed in compliance to Korean design provision since Korean provision does not have the requirement of strong column-weak beam.