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동시공학 설계 개념을 이용한 자동차 현가 장치의 최적 설계
김정욱,전용범,이종원 중앙대학교 미래신기술연구소 2002 미래신기술연구소 논문집 Vol.11 No.2
동시동학 설계 방법은 보다 짧은 개발기간과 저렴한 생산비용으로 보다 우수한 품질을 갖는 제품의 개발을 위해 적용될 수 있다. 본 논문에서는 이러한 동시공학 설계개념을 이용하여 자동차 현가 장치의 최적 설계에 대한 연구를 수행하였다. 본 논문에서 제안한 동시공학 설계 개념을 이용한 자동차 현가 장치의 최적 설계 과정은 전처리 설계 단계, 해석 단계, 후처리 단계로 구성된다. 또한 본 논문에서는 현재 독립식 현가 장치 중에서도 전륜 현가 장치로 널리 쓰이고 있는 맥퍼슨 스트럿 현가 장치에 대해 기구학적 민감도 해석과 함계 이를 통한 최적 설계를 수행함으로써 최초 현가장치를 설계 시, 레이아웃(layout) 결정에 유용하게 적용될 수 있는 새로운 접근법을 제시한다. Concurrent engineering design methods can be applied to meet the demand for the quality product with lower production cost and time. In this paper, the optimal design of the automotive suspension system using concurrent engineering design concept is studied. The optimal design process of the automotive suspension system is composed of a pre-processing design stage, and analysis stage and a post-processing stage. In this paper, optimal design with kinematic sensitivity analysis for a McPherson strut suspension system which is widely used for a from wheel suspension is proposed and new approach method which can be applied usefully to determine the layout of suspension system is proposed when a engineer designs the suspension system at the first stage.
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자폐장애 환자에서 FMR-1 유전 삼염기 반복의 분자생물학적 분석
곽호순,정철호,전효진,장은진,김희철,김정범,박영남 대한소아청소년정신의학회 2000 소아청소년정신의학 Vol.11 No.1
연구목적 : 자폐장애의 원인을 유전학적으로 규명하려는 연구가 시도되고 있으며, 그 중 fragile-X 증후군과의 연관성에 대한 연구가 활발히 진행되고 있다. fragile-X 염색체(Xq27.3)는 세포유전학적 방법으로 증명할 수 있으나 검사에 많은 제약과 단점이 있으므로, 본 연구에서는 보다 신뢰성이 높은 분자 생물학적 방법으로 FMR-1 유전자내 CGG 삼염기 반복부위를 분석하여 자폐장애와 fragile-X 증후군의 연관성을 규명하고자 하였다. 방법 : 자폐장애 환아(99명)와 정상대조군(8명)을 대상으로 FMR-1 유전자의 CGG 반복배열 부위를 sense와 antisense primer를 이용하여 PCR법으로 분석하엿으며, 동시에 세포유전학적 검사도 시행하였다. PCR 분석에서 CGG 반복수가 50 이상인 경우에 대해서는 StB12.3 혹은 Pfxa3 probe를 이용한 Sourthern blot hybridization으로 확인하였다. 결과 : FMR-1 유전자의 CGG 반복배열에 대한 PCR 분석 결과 CGG 삼염기의 반복배열의 수는 자폐장애 환자군과 정상대조군 사이에 통계적으로 유의한 차이가 없었다(p=0.207). 자폐장애 환자에서 CGG 반복수가 50회 이상인 조기변이(premutation) 환자가 2명 있었으나 Sourthern blot hybridization 결과 완전변이(full mutation)로 판정할 수 있는 경우는 없었다. 세포유전학적 검사에서 환자군 모두에서 정상 핵형을 나타내었으며 fragile-X 염색체는 확인되지 않았다. 결론 : 이상의 결과에서 자페장애 환자가 FMR-1 유전자의 CGG 삼염기 반복부위 이상, 즉 fragile-X 염색체 이상을 동반하지 않았음을 증명할 수 있었다. 이는 fragile-X 증후군을 자�장애의 직접적인 원인이라고 보기에는 어려움이 있음을 시사한다. Objectives : There has been a rapid expansion of studies aimed at elucidating the genetic basis of autistic disorder, especially it's relationship to fragile-X syndrome. The detection of fragile X chromosome(Xq27.3) by cytogenetic analysis has revealed many difficulties in testing. Therefore, to explore the relationship between autistic disorder and fragile X syndrome, this study administered molecular biologic methods which examined an unstable CGG repeat within the fragile X mental retardation-1(FMR-1) gene. Methods : Ninety nine autistic children and eight normal control children were tested. The number of CGG repeats within FMR-1 gene was measured after amplification by PCR, and cytogenetic analysis was also carried out to detect fragile site Xq27.3. Sourthern blot hybridization, using StB12.3 and/or Pfxa3 probe, was done for the patients showing expansion of more than 50 CGG repeats(premutation). Results : All but two autistic patients had no expansion in CGG repeats by PCR and there was no significant statistical difference in number of CGG repeat in comparison with normal control. Two autistic patients, considered as premutation by PCR analysis, had no full mutation or premutation by Southern blot hybridization. All autistic children tested did not have any abnormal karyotype or fragile site Xq27.3. Conclusions : These results suggest that autistic patients may not have abnormality in FMR-1 gene or abnormal expansion in CGG repeat. In conclusion, fragile X syndrome may not be antecedent of autistic disorder. KEY WORDS : Autistic disorder·FMR-1 gene trinucleotide repeats·Molecular biologic analysis.
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Dynamic-Range Widening in a CMOS Image Sensor Through Exposure Control Over a Dual-Photodiode Pixel
Jung-Bum Chun,Hunjoon Jung,Chong-Min Kyung IEEE 2009 IEEE transactions on electron devices Vol.56 No.12
<P>In this paper, we propose a technique for automatic-exposure control and synthesis for a wide-dynamic-range sensor based on dual-exposure method. Using the proposed technique, a sensor can adaptively adjust its exposure to widely varying illumination conditions and consequently accomplish an infinite dynamic range in theory. An artificial test bench consisting of a virtual illumination source and its imaging system is introduced to verify the performance of the proposed technique. Simulations show how a wider dynamic range can be achieved by the proposed technique. It is also shown that a VGA-resolution CMOS image sensor developed based on the proposed technique can support up to a 119-dB dynamic range.</P>
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정재범(Jae-bum Jung),편성범(Sung-bom Pyun),손효정(Hyo-jung Sohn),지성우(Sung-woo Gee),조성호(Sung-ho Cho),남기춘(Ki-chun Nam) 한국정보기술학회 2008 한국정보기술학회논문지 Vol.6 No.4
Anomia, word finding difficulty, is one of the most common feature in aphasia. Previous studies support that the process of picture naming consists of three stages, in the order of the object recognition, semantic, and phonological output stages. Anomic patients have many symptoms and it means that anomia can be sub-divided into several symptom groups. Our anomia assessment battery consists of several parts; (1) picture naming set, (2) picture-word matching task, (3) lexical decision task for mental lexicon damage, (4) naming task for phonological lexicon damage, and (5) semantic decision task. Pictures and words were selected on the basis of usage frequency, semantic category, and word length. We administered this anomia evaluation battery to many anomic aphasics and we subdivided patients into several groups. We hope that our anomia evaluation set is useful and helpful for evaluation anomic aphasics.
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정희원,심기범,정천기 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.12
A retrospective analysis was performed to evaluate the prognostic factors affecting the length of survival of 86 adults(age>15 years) with newly diagnosed biopsy-proven supratentorial anaplastic astrocytomas and glioblasmas treated at the Seoul National University Hospital and Korea Cancer Center Hospital between June, 1980 and June, 1990. Of the 86 patients, 44 patients (51%) had anaplastic astrocytoma, and 42 patients(49%) had glioblastoma multiforme. The mean age was 40 years, and mean initial Karnofsky performance score(KPS) was 70. The duration of follow up ranged from 3 months to 85 months. Survival curves were generated using the Kaplan-Meier curves. Median survival times were compared using the log-rank test. Additionally, for a study of the prognostic importance of multiple factors acting simultaneously, the proportional hazards regression model of Cox was used in which survival times were modeled as a function of the important independent variables identified in the univariate analysis. Categories included biopsy, partial resection, and gross total resection. Seventeen patient(20%) who underwent a gross total resection of their tumors had median survival time and 6-, 12-, 24- month survival rates of approximately 33 months, 94%, 80% and 57% respectively, when compared to 13 months, 74%, 53%, 34% for fifty patients(60%) who had partial resection. Multivariate analysis demonstrated that the age(p=0.010), the initial KPSP(p<0.001), the histology(p<0.001) and the extent of resection (p=0.016) were significant and independent variables influencing survival. These results suggest that gross total resection of supratentorial anapalstic astrocytomas and glioblastomas is directly associated with longer survival when compared to partial resection or biopsy.
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부신피질종양에서 신호전달체계에 연관된 Oncogenes발현에 관한 연구 : Gs alpha, Gi alpha, CREB 단백의 변이에 대하여
정은경,이현숙,신동환,박형천,허갑범,이현철,임승길,이은직,김경래,정우희,윤영대 대한내분비학회 1994 Endocrinology and metabolism Vol.9 No.4
Functioning adrenal cortical tumors are originated form a distinct zone(zonna glomerulosa, zonna fasciculata or zonna reticularis) or the transitonal zone of adrenal gland. Each zone of the gland is regulated by their specific hormons or cytokines, and their signal transduction systems are different. The oncogenes of many endocrine tumors were mutated proteins involved in signal transduction, however gip is the only reported oncogene in adrenal cortical tumors. Therefore we decided to reevaluate whether gsp might be detected as an oncogene in several different functioning adrenal tumors, and we also tested whether CREB protein is a tentative oncogene or not. In our study, gsp was not detected in 13 patients, however gip was not also detected unexpectedly. There were no mutations in the phosporylation site of CREB("P" box) in adrenal cushing syndrome. We concluded that gip was not a oncogene detected frequently in adrenal cortical tumor, and CREB protein was not considered as a tentative oncogen, because there might be no amplification of the signals due to its extreme distal component of PKA or PKC system(J Kor Soc Endocrinol 9: 350-357, 1994).
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Jung, Youn-Sang,Chun, Ho-Young,Yoon, Min-Ho,Park, Bum-Joon Neoplasia Press 2014 Neoplasia Vol.16 No.12
<P>Since loss of VHL is frequently detected early phase genetic event in human renal cell carcinoma, pVHL is assumed to be indispensable for suppression of tumor initiation step. However, induction of HIF-1α, target of pVHL E3 ligase, is more adequate to angiogenesis step after tumor mass formation. Concerning this, it has been reported that pVHL is involved in centrosome location during metaphase and regulates ER-α signaling. Here, we provide the evidences that pVHL-mediated ER-α suppression is critical for microtubule organizing center (MTOC) maintaining and elevated ER-α promotes MTOC amplification through disruption of BRCA1-Rad51 interaction. In fact, numerous MTOC in VHL- or BRCA1-deficient cells are reduced by Fulvestrant, inhibitor of ER-α expression as well as antagonist. In addition, we reveal that activation of ER signaling can increase γ-tubulin, core factor of TuRC and render the resistance to Taxol. Thus, Fulvestrant but not Tamoxifen, antagonist against ER-α, can restore the Taxol sensitivity in VHL- or BRCA1-deficient cells. Our results suggest that pVHL-mediated ER-α suppression is important for regulation of MTOC as well as drug resistance.</P>
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