경피적 승모판막 성형술 전후 측정방법에 따른 승모판구 면적

성인환,이종구,박종훈 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

To assess mitral valve area(MVA) before and after percutaneous mitral ballon valvuloplasty (PMV), MVA was calculated by 2-D and Doppler (pressure half time) echocardiography before and 1 day after PMV. Also the catheterization derived MVA was calculated by modified Gorlin's fomula before and immediately after PMV. Among a total of 63 patients performed successful PMV, 29 patients were female and 24 patients were male. The age of the patients were between 21 and 68 years with the mean age of 42±12 years. On the EKG 34 patients showed a sinus rhythm 29 patients showed an atrial fibrillation. PMV was performed using Inoue balloon in 31 patients and double balloon in 32 patients with mitral stenosis. After PMV MVA by Gorlins formula, 2-D and Doppler echocardiography was increased from 0.84±0.22㎠ to 1.86±0.47, 1.86±0.31 and 1.76±0.34㎠, respectively (p<0.01). Before PMV MVA determined by the Gorlin's formula correlated closely with MVA by 2D and Doppler echocardiography (r=0.66 and r=0.69 respectively). However, after PMV MVA determined by the Gorlin's formula did not correlate well with MVA by 2-D and Dopper echocardiography (r=0.32 and r=0.41) However, after PMV MVA determined by the Gorlin's formula did not correlate well with MVA by 2-D and Doppler echocardiography (r=0.32 and r=0.41 respectively). Then Correlation between the 2-D planimeteral MVA and doppler derived MVA was good (r=0.82) After PMV the discrepancy of correlation may be bue to lack of simultaneous meusurements of MVA by echocardiogrphy and catheterization. Immediately after PMV the dramatic hemodynamic changes by have a disturbing effect of MVA measurement by Gorlin's formula. In conclusion, 2-D and Doppler echocardiography was non-invasive and effective method for assessment of MVA before and after PMV.

The Epidemiological and Clinical Characteristics of Patients Admitted for Coronary Angiography to Evaluate Ischemic Heart Disease

( Jong Seon Park ),( Hyun Ju Lee ),( Young Jo Kim ),( In Whan Seong ),( Jae Hwan Lee ),( Chong Jin Kim ),( Jin Man Cho ),( Myeong Chan Cho ),( Jang Whan Bae ),( Myung Ho Jeong ),( Young Keun Ahn ),( K 대한내과학회 2007 The Korean Journal of Internal Medicine Vol.22 No.2

Background: Most of the known risk factors associated with ischemic heart disease are based on studies from Western countries; there is only limited information on Korean populations. This study was designed to analyze age related differences in epidemiologic and clinical characteristics in patients who were admitted for coronary angiography for the evaluation of ischemic heart disease. Methods: As part of the multicenter KCAR (Korean Coronary Artery disease Registry) Study, the clinical data of 6,549 patients, who were evaluated at the cardiac catheterization laboratory by coronary angiography, at seven university hospitals in Korea from March 1999 to December 2005, were registered into the KCAR database and analyzed. All patients were divided into three groups according to age: age ≤40, age 41-70 and age ≥71. All demographic and coronary angiographic features were analyzed for the different groups. Results: The demographic data showed that compared to the older patients young patients ≤40 had a higher prevalence of males and smokers, but a lower prevalence of hypertension, diabetes and prior history of stroke and myocardial infarction. For the lipid profiles, the younger patients had much higher levels of total cholesterol, triglycerides and LDL-cholesterol than the older groups; however, there was no difference in the HDL-cholesterol levels among the three age groups. The most common component of the metabolic syndrome was obesity (79%) in the younger patients and hypertension (92%) in the older patients. The most common reason for presentation was ST-segment elevated myocardial infarction in the younger patients and unstable angina in the older patients. Conclusions: Ischemic heart disease in younger adults ≤40 had different demographic characteristics and clinical presentation than older patients.

대기오염지역에 자라고 있는 덩굴유의 중금속함량

김종갑 ( Jong Kab Kim ),윤석락 ( Seoc Lak Yun ),이정환 ( Jung Whan Lee ),박은희 ( Eun Hee Park ),이총규 ( Chong Kyu Lee ),진영란 ( Young Ran Jin ) 한국농림기상학회 2005 학술발표논문집 Vol.2005 No.2

Vibrio vulnificus 감염증으로 확진된 92예의 임상적 고찰

유종선,문범,지미선,최성규,백강우,김기태,박창환,윤종만 대한감염학회 1995 감염 Vol.27 No.4

목적: V. vulnificus 감염증은 전남지방에서 매년 발생하고 있고 지속적인 계몽과 집중적인 치료에도 불구하고 아직도 높은 치사율을 나타내고 있어 1983년부터 1994년까지의 전남지방의 V. vulnificus 감염증의 임상상과 역학적인 특성을 분석 검토해보았다. 방법:1983년부터 1994년 9월 까지 전남대학병원에 내원한 환자중 균 배양검사로 V. vulnificus 감염증으로 확진된 92예를 대상으로 세균학적 검사소견, 역학적 특성, 임상소견을 분석 검토하였다. 혈액배양은 BACTEC blood culture system(Bekton Dickinson)을 이용하였고, 피부병변 조직배양은 혈액한천배지, MacConkey agar, Thioglycolate broth에 접종 배양한 후 배양된 세균을 ATB 32GN(biome-rieux. France)과 API 20E(biomerieux. France)로 동정하였다. 항생제 감수성은 Kirby-Bauer 디스크(BBL Sensi disc)확산법으로 검사하였다. 결과: 1) V. vulnificus는 혈액배양에서 20예(22%), 조직배양에서 43예(47%), 혈액과 조직에서 27예(29%), 혈액과 복수에서 1예(1%), 혈액과 뇌척수액에서 1예(1%)가 배양되었다. 원판 확산법에 의한 균 감수성검사에서는 tetracycline, chloramphenicol, ampicillin, gentamicin, piperacillin, cefoperazone, cefotaxime, ciprofloxacin등은 100%의 감수성을 나타냈고 amikacin, kanamycin, carbenicillin등은 약 85%, cephalothin은 77%의 감수성을 나타냈으며 colistin은 전 균주에서 내성을 나타냈다. 2) 연도별 발생빈도는 85년에 21예로 가장 많았고, 94년 12예, 89년 10예, 87년 9예, 91년 8예, 93년 8예의 순이었다. 월별로는 5월에서 10월 사이에 발생하였으며 특히 7월에서 9월 사이에 78예(85%)로 집중적으로 발생하였다. 지역별로는 해안지방과 인접 내륙지방에 주로 발생하는 경향을 보였다. 3) 간질환이나 중등도 이상의 음주력이 있는 40-50대의 남자에서 어패류를 생식 또는 불충분하게 조리하여 섭취했을때 많이 발생하였다. 환자 발생시기의 남서해안 근해 평균수온은 16.3℃-28.7℃였으며 특히 22.0℃-23.9℃시기의 발생이 전체의 54%를 차지하였고 해수온도가 상승함에 따라 발생빈도가 증가하는 경향을 보였다(r=0.43 p=0.006). 4) 대부분이 원발성 패혈증 증세를 보였고 하지의 부종과 수포등 피부병변만 나타나고 패혈증 증세가 없었던 창상감염증 1예와 뇌막염 증세를 동반한 패혈증이 1예 관찰되었다. 임상증상으로는 주로 피부병변(96%), 사지통(56%), 저혈압(52%), 발열(47%), 오한(43%), 설사(33%), 복통(26%), 구토(25%)등이 나타났고, 심한 경우에는 핍뇨(9%), 호흡곤란(7%), 혈변(2%)도 나타났다. 피부병변으로는 수포(56%), 부종(52%), 홍반(51%), 괴사(18%), 자반(11%), 구진(7%), 농포(2%), 등이 관찰되었고 주로 하지(73%)에 많이 발생하였다. 5) 사망률은 전체적으로는 57.6%이였고, 점차 감소화 하는 추세를 보였다. 사망군과 생존군간에는 생명징후, 잠복기에 따른 차이는 없었으나 백혈구수와 혈소판수가 감소할수록, AST가 높을수록 사망률이 높았다 결론:V. vulnificus 감염증은 일단 패혈증이 발생하면 병의 진행이 빠르고 감수성 있는 항생제로 집중적인 치료를 해주어도 사망률이 높기때문에 발병후 치료보다 예방이 훨씬 중요하리라 사료된다. Background:V. vulnificus infection is a highly fatal disease prevailing in Chonnam area. To increase understanding of V. vulnificus infection, we investigated clinical and epidemiological characteristics of V. vulnificus infection in Chonnam area. Methods:We retrospectively reviewed the clinical recores of 92 cases with V. vulnificus infection which admitted to Chonnam University Hospital from 1983 to 1994 and bacteriologically were confirmed. Results: 1) V. vulnificus was isolated from blood in 22%, tissue in 47%, blood and tissue in 29%, blood and peritoneal fluid in 1%, and blood and cerebrospinal fluid in 1% of the cases. All the isolates were susceptible to tetracycline, chloramphenicol, ampicillin, gentamicin, piperacillin, cefoperazone and cefotaxime. About eighty-five pervent of the isolates were susceptible to amikacin, kanamycin and carbenicillin and seventy-seven percent to cephalothin. All the isolates were resistant to colistin. 2) The yearly distribution was 21 cases in 1985, followed by 12 in 1994, 10 in 1989, 9 in 1987 in decreasing. The monthly distribution was each 27 cases in July and August, followed by 24 in September, 8 in June, 5 in October, 1 in May. The majority of cases occurred in coastal areas and nearly inlands of Chonnam province. 3) All of V. vulnificus infections occurred in association with ingestion of raw seafoods. The age and sex distribution ranged from the thirties to the eighties and occurred mainly in adult males in the fifties(48%) and the forties(24%). Of ninety-two cases, 73 cases had underlying liver diseases and 67 cases were heavy alcohol consumers. 4) Almost all cases showed primary septicemia except one which had wound infection without septicemia. One case showed septicemia with meningeal symptoms. Clinical manifestations included skin lesion(96%), pain in the extremities or myalgia (56%), hypotension(52%), fever(47%), chills(43%), diarrhea(33%), abdominal pain(26%), oliguria(9%), dyspnea(7%) and melena(2%). Skin lesions included vesicles or bullae(56%), edema(52%), erythema(51%), necrosis(18%), purpura(11%), macules(7%) and pustules(2%). Most of the skin lesions developed in the lower extremities. 5) The average sea water temperature ranged from 16.3℃ to 28.7℃ which was provided by National Fisheries Research & Developement Agency from 1983 to 1994, when V. vulnificus infection occurred. As sea water temperature rose, the incidence of V. vulnificus infection tended to be increased(r=0.43 p=0.006) 6) The overall case fatality rate was 57.6%. There were no significant differences between survivors and non-survivors in vital signs, incubation period, arrival time, and liver function test except aspartate aminotransferase. However, leukocyte and platelet counts were significanty lower in non-survivors (p<0.05). Conclusion:In spite of the susceptible antibiotics therapy and intensive care, V. vulnificus infection was highly fatal. Therefore, we stress that prevention is more important rather than treatment of the disease.

비 낭종성 양성 갑상선 결절의 Tetracycline 경화 요법

김종순,김옥,김종호,김윤자,이병두,문병천,김광회,문재환 대한내분비학회 1991 Endocrinology and metabolism Vol.6 No.1

Percutaneous tetracycline injection (PTI) is a sclerosing method for the treatment of the pure thyroid cyst. PTI of 23 cases of benign thyroid nodules (solid echopattern-six, mixed echopattern-nine, cystic echopattern-six, resected nodules-two cases) were done with 23-G needle under the guidance of ultrasonography. After then, we followed up ultrasonographical size and volume of nodules, thyroid function test, cytology, histopathological examination and complications of treatment. The results were as follows: 1) with 0.5-2ml tetracycline injection, the mean volume of thyroid nodules were reduced after PTI at 6 months.In the solid nodules, (4.70 1.20 4.44 2.67)(ml)(p$gt;0.05) In the mixed nodules, (13.59 7.85 4.34 6.73)(ml)(p$lt;0.05) In the cystic nodules, (20.33 21.66 6.79 8.32)(ml)(p$lt;0.05) 2) The echogenicity was decreased of unchanged in the most solid and mixed nodules but increased in the cystic nodules. 3) There were no significant changes at 6 months follow-up of TFT after PTI in all cases as compared with the base line studies. 4) Aspiration cytologic finding shows the decreased number of thyroid follicular cells, the increased number of macrophages, a few foam cells and the cytoplasm containing the pale brown foreign body. (Tetracycline phagocytosis).Histopathologic finding shows the destruction and sclerotic changes of the cystic degenerated follicles with infiltration of the lymphocytes and macrophages. 5) The complication such as burning sensation, pain and tenderness developed in the two cases but disappeared within several days. In conclusion, sclerotherapy using tetracycline is a safe and effective adjunctive treatment of the benign mixed of cystic thyroid nodules and Percutaneous Alcohol Injection (PAI) is recommendable for solid nodules. (J Kor Soc Endocrinol 6:58 67, 1991)

하드웨어 설계언어 HHDL과 컴파일러 구성에 관한 연구

이석환(Seuk-whan Lee),김호룡(Ho-Royng Kim),김기현(Ki-Hyun Kim),정정화(Jong-wha Chong) 대한전자공학회 1990 대한전자공학회 학술대회 Vol.1990 No.11

데이타 플로우 커버리지를 이용한 테스트 데이타 생성의 자동화에 관한 연구

이경환(Kyung Whan Lee),김정종(Chong Jong Kim),이종은(Jong Eun Lee) 한국정보과학회 1988 정보과학회논문지 Vol.15 No.1

본 논문은 데이터 플로우 기법을 이용하여 프로그램을 구조적으로 분석하여, 데이터 플로우에 의한 정보들로써 allue 커버리지를 적용하고 프로그램의 패스생성을 위한 단계 및 알고리즘을 제시한다. 생성된 테스트 패스는 프로그램 개발자가 객관적으로 프로그램을 테스트할 수 있는 환경을 제공하기 위해, 각 패스들에 대한 기호처리(symbolic evaluation)를 하여 테스트 데이터를 생성하는 방법에 관하여 연구하고 구현하였다. This paper analyzes a program with data flow technique structurally and proposes the algorithm that generates paths of the program that satisfies all-use coverage using data flow information. In order to build the testing environment objectively, we study and implement the method that automatically generates test data by symbolic evaluation for each generated path.

종격동 종양 47 치험례 : Report of 47 cases

이영,김종인,양기민,노준량,손광현,김종환,서경필,이영균 최신의학사 1971 最新醫學 Vol.14 No.10

Fourty-seven cases of mediastinal tumors originating in the mediastinum or metastasized from other organs were reviewed and classified on the basis of histopathological types and specific anatomical location in this department, during 13 years and six months period from Jan. 1959 to Jun. 1971. In thirty-seven cases, diagnosis was confirmed by histological findings. Range of age was 3 to 63 years and sex ratio was 1.4:1 male to female. In this series, metastatic mediastinal carcinomas of unknown pimary site were most frequent and thymoma ranked second in frequency, comprising 24.3% and 16. 2% of the total cases. The operative mortality was 3.1 There were histologically 11 different kinds of mediastinal tumors in this series.

Anti-inflammatory activity of bark of Dioscorea batatas DECNE through the inhibition of iNOS and COX-2 expressions in RAW264.7 cells via NF-κB and ERK1/2 inactivation

( Mei Hua Jin ),( Seok Jong Suh ),( Ju Hye Yang ),( Yue Lu ),( Su Jeong Kim ),( Soon Youl Kwon ),( Tae Hyung Jo ),( Jin Wan Kim ),( Young In Park ),( Ghe Whan Ahn ),( Chong Kil Lee ),( Cheorl Ho Kim ) 영남대학교 약품개발연구소 2011 영남대학교 약품개발연구소 연구업적집 Vol.21 No.-

Bentall씨 수술후 발생한 상행대동맥 가성동맥류 치험 1례

홍종면,안혁,김종환,Hong, Jong-Myun,Ahn, Hyuk,Kim, Chong-Whan 대한흉부심장혈관외과학회 1991 Journal of Chest Surgery (J Chest Surg) Vol.24 No.9

A 31 year-old male patient underwent surgical treatment of the pseudoaneurysm of the ascending aorta complicating after the Bentall operation, He had undergone the replacement of the ascending aorta using the composite valved graft with direct coronary reimplantation under the diagnosis of the annuloaortic ectasia of ascending aorta associated with Marfan syndrome. Eleven months after the operation, he started to feel dyspnea and anterior chest pain, and was diagnosed as pseudoaneurysm around the ascending aortic graft. The second operation consisted of the dacron patch closure of the defect of the aortic graft which was the hole for previous coronary reimplantation, and the anastomosis between the coronary orifice and the aortic graft with the intermediate graft of a 10mm woven dacron tube, and suture closure of the fistula opening from the aneurysm. His postoperative course was uneventful and discharged without complication. He is doing well 10 months postoperatively.