대전 지역에서 급성 A형 간염의 유전자형에 따른 임상 특성 고찰

이영우 ( Young Woo Lee ),양현웅 ( Hyeon Woong Yang ),이진아 ( Jin A Lee ),윤기호 ( Ki Ho Yun ),양성은 ( Seong Eun Yang ),이민지 ( Min Ji Lee ),박세영 ( Se Young Park ),김새희 ( Sae Hee Kim ),이향이 ( Hyang Ie Lee ),이윤정 ( Yun Ju 대한내과학회 2011 대한내과학회지 Vol.80 No.5

Background/Aims: Acute viral hepatitis A is a major health problem in Korea and the influx of genotype IIIA is thought to be one reason. We examined the differences in the clinical characteristics and laboratory findings of genotypes IA and IIIA in Daejeon. Methods: From November 2009 to June 2010, 81 patients positive for IgM anti-HAV were enrolled prospectively. The hepatitis A was genotyped using real-time polymerase chain reaction. The clinical characteristics and laboratory results were compared on the Results: The mean patient age was 32.6±7.4 years. The mean hospitalization was 7.7±2.4 days. The patient occupation varied. Clinically, vomiting and diarrhea were relatively more prevalent in genotype IIIA than in IA. Abdominal pain and skin spots were relatively more prevalent in genotype IA than in IIIA. The hemoglobin, peak aspartate aminotransferase (AST) level, and C-reactive protein were statistically higher in genotype IIIA than in IA. The distributions of the peak AST, alanine aminotransferase (ALT) and total bilirubin values tended to be perched in genotype IIIA than in IA. The international normalized ratio (INR) tended to be slightly prolonged in genotype IIIA than in IA. Conclusions: Recently, genotype IIIA of acute viral hepatitis A has become prevalent in Daejeon. Hepatitis A genotype IIIA probably causes worse laboratory abnormalities than genotype IA.

다변량 일반화가능도 이론을 활용한 창의적 사고력 검사 (TTCT- 도형 A형) 독창성 평가 최적화 조건 탐색

이진아(LEE JIN A),한기순(Han ki Soon) 한국창의력교육학회 2017 창의력교육연구 Vol.17 No.2

본 연구에서는 TTCT 도형 A검사를 활용한 독창성 요소 측정 시 문항유형별(활동 1, 2, 3) 적절 문항수와 상대가중치 산출 조건을 탐색함으로써 독창성 평가 최적화를 위한 대안을 제시하는데 목적이 있다. 이를 위하여 수도권 지역 초등학생 61명을 대상으로 TTCT도형 A검사를 실시하여 정규형 버전과 간편형 버전으로 각각 채점을 하였다. 주요 결과를 요약하면 다음과 같다. 첫째, 각 채점 방법에서 문항유형별로 피험자 점수에 영향을 주는 요인들의 상대적 영향력 분석 결과 공통적으로 피험자와 문항의 상호작용에 의한 오차분산이 매우 큰 것으로 나타났으며, 피험자 오차 분산보다 문항 오차 분산은 상대적으로 높게 나타났다. 둘째, 각 채점 기준에서 합성 점수 산출 시 간편형 채점기준에서는 일반화가능도 계수에서 적합신뢰도에 못미친 반면 정규형 채점기준에서는 .8이상의 신뢰로운 결과값이 나타났다. 간편형 채점기준은 최적 문항 유형별 상대 가중치 조건이 산출되지 못하였으며, 정규형 채점기준은 현행 상대가중치인 .18 : .82에서 오차분산이 높은 활동 2에 가중치를 더한 .2 : .8의 조건에서도 적합 신뢰도로 나타났다. 마지막으로 각 각의 채점 방법에서 유형별 문항 수와 상대가중치 조합 조절을 통해 재분석해 본 결과 간편형 채점기준의 경우는 문항 수 및 상대가중치 조합을 변화시켜도 신뢰도 계수값을 만족하지 못했으며, 정규형 채점기준의 경우는 활동 3의 문항수를 최대 10개까지 줄여도 적합 신뢰도값을 보였다. 이때 문항유형별 최적 상대가중치는 활동 2와 활동 3이 각각 .2 : .8이었다. 즉, 연구 결과 정규형 채점기준에서만 신뢰성과 효율성을 만족하는 최적의 측정 조건 구성이 도출되었다. 더불어 검사실시의 시간적 어려움으로 활동 2만을 활용하여 독창성을 측정한다면 필히 신뢰도를 확보할 대안 마련 및 검증이 선행되어야 한다는 시사점을 얻을 수 있었다. This research is to find the right number of questions per category and an ideal set of conditions for computing relative significance value, thus providing an alternative as a better originality assessment tool. 61 elementary school children took the TTCT figural A and were each reviewed by both regular scoring version and steamlined version. Here is the summary of meaningful outcome. First, in each scoring method, relative influences of factors affecting the subjects’ score were analyzed and it was shown that each testing method had in common a high error variance from interaction between the subjects and items. Also, subject error variance was shown relatively higher than items error variance. Second, when computing the total score, steamed version was short of reliability on generalizability coefficient whereas regular version showed a reliable result above .8. Steamlined version was inadequate to produce ideal condition for relative significance and regular version has shown adequate reliability under current relative significance value, .18 : .82, as well as under .2 : .8, a weighted value on activity 2, which showed high error variance. Lastly, each scoring method was reanalyzed under different combinations of question per category and relative significance. Steamlined version didn’t satisfy the reliability coefficient value under any combinations and regular version showed acceptable reliability value when number of questions in activity 3 was reduced by up to 10. At that point, optimal relative significance on activity 2 and 3 were .2 : .8. In summary, optimal test condition that satisfies both reliability and efficiency was produced only in regular scoring version. Also, when performing the test with only activity 2, perhaps due to lack of time, results of the research underscored the need to find solution to secure reliability.

소아의 임상 검체 및 건강한 소아의 비인두에서 분리된 폐구균의 혈청형 및 페니실린 감수성

이진아,김남희,김동호,박기원,김윤경,김경효,박진영,최은화,이환종,Lee, Jin-A,Kim, Nam-Hee,Kim, Dong-Ho,Park, Ki-Won,Kim, Yun-Kyung,Kim, Kyoung-Hyo,Park, Jin-Young,Choi, Eun-Hwa,Lee, Hoan-Jong 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.9

목 적 : 폐구균은 건강한 소아의 비인두에서 분리될 수 있는 정상 균총이지만, 다양한 종류의 침습성 감염과 국소 감염을 일으킨다. 최근에 영아 및 어린 소아에서도 침습성 감염에 대한 예방 효과가 우수한 7가의 단백 결합 백신이 개발되었다. 백신의 적절한 사용을 위해서는 백신을 사용하고자 하는 지역에서 분리되는 폐구균의 혈청형에 대한 분석이 필요하다. 방 법 : 2000년 3월부터 2002년 2월까지 2년간 서울대학교 어린이병원, 이화여자대학교 동대문병원, 성균관대학교 강북삼성병원에 내원한 15세 미만의 환아의 임상 검체에서 분리된 폐구균 127 균주와 1997년 11월부터 1998년 10월까지 1-5세 사이의 건강한 소아의 인후 도찰 검체에서 분리된 폐구균 72균주를 대상으로 Quellung reaction을 이용하여 혈청형을 결정하였으며, oxacillin 디스크 확산법을 이용하여 penicillin에 대한 감수성을 검사하였다. 결 과 : 임상 검체에서 폐구균이 분리된 소아의 연령은 2세 미만이 43%, 2-5세가 35%, 5-15세가 21%였다. 균혈증, 뇌수막염, 복막염 등의 침습성 감염은 전체 감염의 24%를 차지하였으며 이러한 경우 폐구균의 페니실린 내성률은 90%였다. 2세 미만의 경우는 전체 폐구균 감염의 22%가 침습적 감염이었고 호흡기계 검체 및 중이염은 각각 46%, 26%를 차지하였다. 폐구균의 혈청형 분포는 19F(24%), 19A(17%), 23F(15%), 6A(11%), 6B(7%), 9V (6%)의 순이었으며, 페니실린 내성빈도는 94%였다. 임상 검체에서 분리된 폐구균 중 56%(교차반응 혈청형 포함시 84%), 침습성 감염과 중이염의 경우 각각 57%(80%), 48%(88%)가 7가 백신에 포함되었다. 건강한 소아의 인후두 도찰 검사의 폐구균 혈청형은 19F(31%), 14(21%), 11A(13%), 23F(11%), 18C(6%), 19A(4%)의 순으로 이 6가지 혈청형이 전체의 86%를 차지하였고 페니실린 내성률은 86%였으며 7가 백신에 71%(78%)가 포함되었다. 임상 검체 및 건강한 소아에서 분리된 폐구균 중 페니실린 내성균의 60%(90%)가 7가 백신에 포함되었다. 결 론 : 우리나라 소아의 임상 검체 및 건강한 소아의 비인두에서 분리되는 폐구균의 혈청형은 6A, 6B, 14, 19A, 19F, 23F 등이 대부분을 차지하였으며, 분리된 균주의 56-84%가 7가 단백 결합 백신에 포함되었다. Purpose : Pneumoccocus is one of the most important causes of invasive infection through the childhood period and the prevelance of antibiotics resistance of pneumococcus is increasing worldwide. A 7-valent conjugate vaccine has been developed. It is important to know the prevalence of each serotype of pneumococci in the countries where the vaccine is used to estimate the coverage rate by the vaccine. Methods : One hundred and twenty seven strains of clinical isolates and 72 strains from healthy carriers recovered from Korean children during the period from 1997 to 2002 were subjected to determination of serotype by Quellung reaction and penicillin susceptibility with oxacillin disc diffusion test. Results : Forty-three per cent of clinical isolates were obtained from children under two years of age. Thirty strains(24%) were isolated from normally sterile body fluids. The frequent serotypes were 19F, 19A, 23F, 6A, 6B and 9V. Fifty-six per cent of the clinical isolates were represented in the current 7-valent protein conjugate pneumococccal vaccine, and 84% when the cross-reactive serotypes were included. Frequent serotypes of strains isolated from one to five year-old healthy children were 19F, 14, 11A, 23F, 18C, and 19A. Seventy-one per cent of the carrier strains were included in the 7-valent vaccine. Ninety-three per cent of the clinical isolates and 86% of carrier strains were not susceptible to penicilline. Conclusion : Fifty-six to 84% of pneumococci recovered from Korean children are covered by the current 7-valent protein conjugate pneumococcal vaccine and the prevalence of penicillin resistance was very high.

목과(木瓜)추출물이 급성 간손상 흰쥐에 미치는 효과

이진아,신미래,이지혜,노성수,Lee, Jin A,Shin, Mi-Rae,Lee, Ji Hye,Roh, Seong-Soo 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.1

Objective: This study was conducted to investigate the effect of Chaenomelis Fructus (CF) water extract on thioacetamide (TAA)-treated rats. Methods: Rats were divided into five groups: one normal group (n=8) and four with TAA-induced hepatic injury. These treatment groups were administered distilled water (n=8); silymarin 100 mg/kg (n=8); CF 100 mg/kg (n=8); and CF 200 mg/kg (n=8). In the TAA groups, the acute liver injury was induced via IP injection (200 mg/kg), and the silymarin and CF extract were then orally administered for three days. Subsequently, serum levels of GOT, GPT, and ammonia were confirmed as well as protein expressions using liver tissue. Results: In the liver injury-induced rats, CF administration reduced tissue damage and serum levels of GOT, GPT, and ammonia. In addition, CF increased the anti-oxidant proteins Nrf2, Keap1, HO-1, and catalase and significantly regulated matrix metalloproteinases (MMP-2 and MMP-9) and their tissue inhibitors (TIMP-1 and TIMP-2). Conclusions: In this animal model of liver injury induced by TAA, CF extract is determined to have a hepatoprotective effect by increasing anti-oxidant proteins that relieve damage and by regulating the expression of matrix metalloproteinases.

연료전지용(燃料電池用) 막전극접합체(膜電極接合體)의 막분리(膜分離) 및 염산(鹽酸)에 의한 백금(白金)과 루테늄의 침출(浸出)에 관(關)한 연구(硏究)

이진아,강홍윤,유호진,Lee, Jin-A,Kang, Hong-Yoon,Ryu, Ho-Jin 한국자원리싸이클링학회 2012 資源 리싸이클링 Vol.21 No.3

본 논문에서는 연료전지 막전극접합체에서 막분리 및 염산침출법을 이용하여 백금과 루테늄을 침출하는 연구를 하였다. 증류수, 10 vol.% 부탄올 용액, 15 vol.% 양이온 계면활성제(Koremul-LN-7)를 이용하여 연료전지 막전극접합체의 전해질막과 확산층을 침지법으로 촉매입자의 분산 없이 분리하였다. 그리고 질산 또는 과산화수소를 산화제로 하고 사용하는 염산에 의해 분리된 가스확산층의 촉매에 함유된 백금과 루테늄 금속을 침출하는 연구를 하였다. 과산화수소를 산화제로 사용하였을 때 백금과 루테늄의 침출율이 더 높았으며 최적 조건은 $90^{\circ}C$에서 염산 농도 8 M, 과산화수소 첨가량 5 M, 침출시간 6시간이었다. 이 조건에서 백금의 침출률은 98%, 루테늄의 침출율은 71.5%였다. In this paper, we carried out separation of membrane and leaching of Pt and Ru using hydrochloric acid from MEA(membrane-electrode assembly) of fuel cell. In this method, these were separated from MEA of fuel cell using the distilled water, 10 vol.% butanol solution and 15 vol.% cationic surfactant(Koremul-LN-7) by dipping method without the dispersion of catalyst particles. And the leaching of Pt and Ru containing in the separated carbon paper catalysts has been studied by hydrochloric acid using $HNO_3$ or $H_2O_2$ as a oxidant. The leaching ratio of Pt and Ru were higher when $H_2O_2$ was used as a oxidant and the optimum conditions were obtained in 8M HCl, the amount of $H_2O_2$ 5M and 6 hours of leaching time at $90^{\circ}C$. In this condition, extraction of Pt and Ru were 98% and 71.5%, respectively.

Acetobacter orientalis MAK88 균주를 이용한 양파 식초의 발효 최적화

이진아 ( Jin-a Lee ),이설희 ( Sulhee Lee ),박영서 ( Young-seo Park ) 한국산업식품공학회 2017 산업 식품공학 Vol.21 No.4

Acetic acid bacteria strains were isolated from a variety of fermented foods and fallen fruits. Among them, the strain MAK88, whose acetic acid fermentation ability, acid-tolerance, and alcohol-tolerance were high, was selected and identified as Acetobacter orientalis. A seed culture of A. orientalis MAK88 was inoculated into onion juice, and the optimum conditions of acetic acid fermentation was investigated. The optimum initial concentration of ethanol in onion juice was 5% (v/v) and in that condition, acidity was 4.31% at 144 h of fermentation. The optimum initial concentration of acetic acid was 1% and the final acidity was 5.32%. The optimum fermentation temperature was determined to be 28℃. The most appropriate preparation method of onion juice was to heat the onion at 121℃ for 15 min and produce juice with pressure followed by filtering, and then sterilization at 121℃ for 15 min. Prepared onion juice was used for fermentation without dilution.

가미보허탕(加味補虛湯)으로 치료한 산후우울증 1예에 대한 임상보고

이진아,반혜란,조성희,Lee, Jin-A,Ban, Hye-Ran,Cho, Seong-Hee 대한한의학방제학회 2005 大韓韓醫學方劑學會誌 Vol.13 No.1

As woman receive many stress during pregnancy and delivery, they happen to contract to psychopathy like a postpartum depression. Postpartum depression is a serious problem if they are not treated early enough the unhappy seriousness can be resulted. A 32-yeared-old female patient with postpartum depression was taken to Dongshin University oriental medical hospital on April, 28, 2003. We diagnosed this patient as postpartum depression, which originated from and efficiency of vital energy and blood. We treated this postpartum depression patient with herb medicine(Cami-Boheo-tang),acupuncture, moxibustion, and psychical therapy. After the oriental medical treatments, the patient was improved in all complains of the postpartum disease. After this, further study and approach will be needed about the disease of the postpartum depression.

애엽(艾葉) 추출물이 알코올성 위염에 미치는 효과

이진아,서정복,김진영,신미래,박해진,노성수,Lee, Jin A,Seo, Jeong Bok,Kim, Jin Young,Shin, Mi-Rae,Park, Hae-Jin,Roh, Seong-Soo 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.4

Objective: Alcohol is known to cause inflammation in the stomach by decreasing the protective substances of the gastric mucosa and increasing oxidative stress. The purpose of this study was to investigate the anti-inflammatory effect of Artemisiae Argyi Folium extract (AF) on alcohol-induced gastritis. Methods: The total polyphenol and flavonoid contents of AF were confirmed through an in vitro experiment. Radical scavenging activities were confirmed using DPPH and ABTS assays. In vivo experiments were conducted on mice divided into 5 groups (n=8): a normal group (Nor), an alcohol-induced gastritis group (Con), an alcohol-induced gastritis group administered 10 mg/kg sucralfate (SC), an alcohol-induced gastritis group administered 100 mg/kg AF (AFL), and an alcohol-induced gastritis group administered 200 mg/kg AF(AFH). The serum levels of reactive oxygen species (ROS) were determined, and protein expressions were confirmed in gastric tissues. Results: In alcohol-induced gastritis, AF alleviated damage to the gastric mucosa caused by alcohol. AF also decreased the serum ROS levels. Western blots showed that AF decreased the expression of NADPH oxidase and decreased the expression of the NF-κB pathway associated with inflammation. AF also decreased the expression of adhesion molecules and chemokine proteins, and increased the expression of anti-inflammatory proteins. Conclusions: AF not only reduced oxidative stress in alcohol-induced gastritis, but it also relieved gastric mucosal inflammation by regulating the expression of the NF-κB pathway.

면역 기능이 정상인 소아에서 발생한 b형 Haemophilus influenzae에 의한 협부 봉와직염(Buccal Cellulitis) 1례

이진아,김동호,구자욱,이환종,Lee, Jin A,Kim, Dong Ho,Koo, Ja Wook,Lee, Hoan Jong 대한소아감염학회 2001 Pediatric Infection and Vaccine Vol.8 No.2

어린 소아에서 상기도 감염의 증상이 선행한 후 수 시간 내에 급격히 진행하며 고열을 동반하는 적보라빛의 협부 및 경부 부종이 있는 경우, 반드시 H. influenzae에 의한 감염을 고려하여야 하며, 균혈증 및 무증상적 수막염이 동반될 가능성이 크므로 혈액배양검사 및 뇌척수액 천자를 반드시 시행하여야 한다. 예방접종 시행 전 서구의 경우, 봉와직염이 Hib에 의한 침습성 질환 중 수막염, 후두염 등에 이어 5번째를 차지하며, 전체적으로 2~15%를 차지할 정도로 그 빈도가 높은 것으로 알려져 있으나 우리나라에서는 매우 드물게 발견된다. 저자들은 면역기능에 이상이 없었던 18개월 여아에서 상기도 감염의 증상 및 고열이 선행한지 수 시간 후 급격히 진행하는 적보라빛의 협부 봉와직염으로, Hib에 의한 균혈증이 동반되었고, 2주간 3세대 cephalosporin의 투여로 호전되었던 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Buccal cellulitis which presents with high fever and a swelling of the cheek with violaceous hue in young children is most often caused by H. influenzae. Bacteremia is common in buccal cellulitis caused by H. influenzae, and a culture of cerebrospinal fluid should be obtained because meningitis may be present despite the lack of meningeal irritation signs. Although buccal cellulitis is considered to be one of the important manifestations of H. influenzae infection, only two cases have been reported in Korea yet. We experienced a case of buccal cellulitis with H. influenzae bacteremia in an immunocompetent girl of 18-month-old. She was presented with high fever followed by rapidly progressive swelling and tenderness of both cheeks with violaceous hue in four hours. The blood culture revealed H. influenzae type b. There was no concurrent otitis media, sinusitis, or meningitis and no portal of entry was identified. Fever subsided two days after starting intravenous cefotaxime. Intravenous cefotaxime was subsequently changed to oral cefixime, and antibiotics were administered for a total of two weeks. We report this case with a review of related literature.

자궁절제술 후유증을 동반한 갱년기증후군 환자 치험 1례

이진아,반혜란,양승정,박경미,조성희,Lee Jin-A,Ban Hye-Ran,Yang Seung-Joung,Park Kyung-Mi,Cho Seong-Hee 대한한의학방제학회 2004 大韓韓醫學方劑學會誌 Vol.12 No.1

Clinical study on one case of climacteric syndrome induced hysterectomy climacteric syndrome is symptoms of physical, mental, physiological in menopausal period. Importance of treatment of climacteric symptoms was on the rise recently. I have treated one patient who has mental depression, anxiety, impatience, impotence, palpitations, facial flushing, abdominal pain in the menopausal period in Dongshin University Oriental Hospital. I took acupunture, moxibustion, cupping, and also I made herbal medicine-gamiguibitang(加味歸脾湯). As a result, I got a good effect through above methods. So I came to write this case report.