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난소절제후 Estrogen을 투여한 흰쥐 대동맥에서 Protein Kinase C-α와 Fas 발현의 변화
이왕수,이상엽,안지현,송영빈,김학진,이광재,유재격,김상욱,김태호,김치정,류왕성 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.3
Estrogen is believed to decrease coronary artery disease. Protein kinase C-α(PKCα)appear to be important in signal conduction pathways. Estrogen treatment increases catalytic activity of PKCα,and activation of PKCαcan modulate estrogen receptor levels and responsiveness. And it was reported that activation of PKC can protect cells from apoptosis induced by Fas ligation. But the beneficial effect of estrogen on PKCαwas not clearly demonstrated. The objective of this study was to evaluate the role of PKCαafter ovariectomy and estrogen therapy in rat aorta. The results were summarized as below: 1. The significant pathological changes were not observed in the rat aorta irrelevant to ovariectomy and estrogen therapy. 2. The expression of Fas was decreased in the aorta of estrogen-treated rats than that of ovariectomized rats without estrogen therapy. 3. Increased expression of PKCαwas more marked in the aprta of estrogen-treated rats than that of ovariectomized rat without estrogen therapy. In conclusion,PKCαmay be important in signal conduation pathway on the effect of estrogen. Activation of PKCαby estrogen reduced Fas expression, suggesting that PKCαactivation may play a role in protection against atherasclerosis. Further studies are needed to elucidate the role of PKCαafter estrogen therapy.
β-Lactam 유도체의 N(1)-C(4) 위치에 한 개의 탄소를 도입한 입체 선택적 고리확장에 관한 연구
하진렬,오선주,김지아,신동수,안철진 昌原大學校 基礎科學硏究所 2003 基礎科學硏究所論文集 Vol.15 No.-
The base induced ring opening of β -1actam derivatives with LDA gave γ-lactam derivatives stereoselectively. The γ -1actam derivatives were formed stereoselectively depending on β-3 substituent of B-lactam derivatives.
락탐화합물의 고리 확장 연구 : 입체 선택성과 Mechanism에 관한 연구 Study of Stereoselectivity and Mechanism
하진렬,최경민,김지아,원태진,신동수,이민주,안철진 昌原大學校 基礎科學硏究所 2002 基礎科學硏究所論文集 Vol.14 No.-
The ring expansion chemistry is one of the most important methods to prepare five-and six-membered heterocylic compounds. We have studied about γ-lactam ring expansion with stereoselectivity from β-lactam derivative. To do this chemistry, proton of N-benzyl group in β-lactam derivatives is eliminated by LDA and make carbanion.This anion make unstable 4-membered lactam intermediate, and then the ring is opened by homo clevage or hetero cleavage for releasing ring strain, followed by recyclization to one carbon to make γ-lactam ring with stereoselectivity in β-, γ- positions.
Kim, Ji Yeun,Kwon, Jung Hyun,Ahn, So Hyun,Lee, Sang Il,Han, Young Shin,Choi, Young Ok,Lee, Soo Young,Ahn, Kang Mo,Ji, Geun Eog Blackwell Publishing Ltd 2010 Pediatric allergy and immunology Vol.21 No.2
<P>Kim JY, Kwon JH, Ahn SH, Lee SI, Han YS, Choi YO, Lee SY, Ahn KM, Ji GE. Effect of probiotic mix (<I>Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus</I>) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial.Pediatr Allergy Immunol 2010: 21: e386–e393.© 2009 John Wiley & Sons A/S</P><P>Controversy exists regarding the preventive effect of probiotics on the development of eczema or atopic dermatitis. We investigated whether supplementation of probiotics prevents the development of eczema in infants at high risk. In a randomized, double-blind, placebo-controlled trial, 112 pregnant women with a family history of allergic diseases received a once-daily supplement, either a mixture of <I>Bifidobacterium bifidum</I> BGN4, <I>B. lactis</I> AD011, and <I>Lactobacillus acidophilus</I> AD031, or placebo, starting at 4–8 wks before delivery and continuing until 6 months after delivery. Infants were exclusively breast-fed during the first 3 months, and were subsequently fed with breastmilk or cow’s milk formula from 4 to 6 months of age. Clinical symptoms of the infants were monitored until 1 yr of age, when the total and specific IgE against common food allergens were measured. A total of 68 infants completed the study. The prevalence of eczema at 1 yr in the probiotic group was significantly lower than in the placebo group (18.2% vs. 40.0%, p = 0.048). The cumulative incidence of eczema during the first 12 months was reduced significantly in probiotic group (36.4% vs. 62.9%, p = 0.029); however, there was no difference in serum total IgE level or the sensitization against food allergens between the two groups. Prenatal and postnatal supplementation with a mixture of <I>B. bifidum</I> BGN4, <I>B. lactis</I> AD011, and <I>L. acidophilus</I> AD031 is an effective approach in preventing the development of eczema in infants at high risk of allergy during the first year of life.</P>
Ahn, Ji Young,Kim, Whi Dong,Kim, Jae Hyun,Kim, Ji Hoon,Lee, Jae Keun,Kim, Jong Man,Kim, Soo H. Hindawi Limited 2011 Journal of nanomaterials Vol.2011 No.-
<P>We demonstrate a simple and viable method for controlling the energy release rate and pressurization rate of nanoenergetic materials by controlling the relative elemental compositions of oxidizers. First, bimetallic oxide nanoparticles (NPs) with a homogeneous distribution of two different oxidizer components (CuO and Fe2O3) were generated by a conventional spray pyrolysis method. Next, the Al NPs employed as a fuel were mixed with CuO-Fe2O3bimetallic oxide NPs by an ultrasonication process in ethanol solution. Finally, after the removal of ethanol by a drying process, the NPs were converted into energetic materials (EMs). The effects of the mass fraction of CuO in the CuO-Fe2O3bimetallic oxide NPs on the explosive reactivity of the resulting EMs were examined by using a differential scanning calorimeter and pressure cell tester (PCT) systems. The results clearly indicate that the energy release rate and pressurization rate of EMs increased linearly as the mass fraction of CuO in the CuO-Fe2O3bimetallic oxide NPs increased. This suggests that the precise control of the stoichiometric proportions of the strong oxidizer (CuO) and mild oxidizer (Fe2O3) components in the bimetallic oxide NPs is a key factor in tuning the explosive reactivity of EMs.</P>
Ahn, Ji Young,Kim, Ji Hoon,Kim, Jong Man,Lee, Deug Woo,Park, Jong Kweon,Kim, Soo Hyung American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.10
<P>We demonstrated that the size and morphology of an oxidizer have strong effects on the propulsion forces of nano-Al-based propellants. Enhanced propulsion forces could be obtained through the creation and addition of various oxidizer nanoparticles and nanowires in nano-Al-based propellants.</P>
Ahn, Ji Young,Kim, Ji Hoon,Moon, Kook Joo,Park, So Dam,Kim, Soo Hyung RSC Pub 2013 Nanoscale Vol.5 No.15
<P>The existence of numerous interfacial boundaries among TiO2 nanoparticles (NPs) accumulated in the photoelectrode layer of dye-sensitized solar cells (DSSCs) hinders the effective transport of photogenerated electrons to an electrode. Therefore, as a replacement for TiO2 NPs, one-dimensional TiO2 nanowires (NWs) can be suggested to provide pathways for fast electron transport by significantly reducing the number of interfacial boundaries. In order to provide direct evidence for the better performance of such longer TiO2 NWs than shorter TiO2 NWs, we examine the effect of the controlled aspect ratio of the TiO2 NWs randomly accumulated in the photoelectrode layer on the photovoltaic performance of DSSCs. It is clearly found that longer TiO2 NWs significantly improve the electron transport by reducing the TiO2/dye/electrolyte interfacial contact resistance. Furthermore, the embedment of multi-walled carbon nanotubes (MWCNTs) as an effective charge transfer medium in longer TiO2 NWs is proposed in this study to promote more synergistic effects, which lead to significant improvements in the photovoltaic properties of DSSCs.</P>