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골수 유래 기질 줄기세포의 탐식작용 매개성 케모카인 수용체 발현 연구
정영신,변향민,신지영,김정목,정형민,오유경 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.4
To design gene delivery systems which can deliver higher amounts of genes into stem cells, we studied the expression of receptors involved in the receptor-mediated endocytosis of bone marrow stromal stem cells. Bone marrow was isolated from ICR mice, and bone marrow stromal stem cells were isolated based on their plastic adherence property. Several cultrure conditions were screened for effective and continuous culture of marrow stromal stem cells. MesenCult medium was finally used to cultivate marrow stromal stem cells in vitro. As candidate receptors, various chemokine receptors were studied. Both bone marrow cells and marrow-derived stromal stem cells showed expression of CC chemokine receptors (CCR) and CXC chemokine receptors (CXCR). Marrow stromal stem cells showed higher expression of CCR5 and CXCR4 chemokine receptors as compared to other types of chemokine receptors. Moreover, though the expression chemokine receptors generally decreased in most chemokine receptors with the cultivation of marrow stromal stem cells, CCR5 and CXCR4 chemokine receptors retained the higher lever of receptor expressions over prolonged periods. These results suggest that the ligands exhibiting specific binding to CCR5 or CXCR4 might be used to modify gene delivery systems for increased level of receptor-mediated gene delivery into stromal stem cells.
열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구
배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2
Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.
피질하 혈관성 치매 환자에서 협착성 뇌혈관 병변의 의의 : 자기공명 혈관조영술과 양전자방출단층촬영을 이용한 연구 MR Angiography and ^(18)FDG-PET Study
유경호,이병철,마효일,김윤중,정지향,나덕렬,강연욱 대한치매학회 2004 Dementia and Neurocognitive Disorders Vol.3 No.1
Background and Objective:Subcortical vascular dementia (SVD) incorporates small vessel disease as the primary vascular etiology, represents in MRI by lacunar infarct and deep white matter lesions. In clinical practice, a number of SVD patients present with various vascular risk factors for large artery disease (LAD) i.e., old age, hypertension, and diabetes. However the current diagnostic criteria for SVD did not include angiographic findings as a key feature. Therefore we tried to find out the frequency of large artery disease in SVD and to elucidate whether the presence of LAD affects clinico-radiological manifestations of SVD. Methods:Thirty three patients fulfilling 'Research criteria for SVD' by Erkinjuntti from 17 study centers were recruited. Of these 33 patients, 21 who underwent comprehensive neuropsychological test battery, MRI ^(18)FDG-PET, and MR angiography were classified into two subgroups according to the patterns of MRI abnormality:white matter dominant (WM) type (n=5) and multiple lacunar (LC) type (n=16). Clinical and neuropsychological profile and ^(18)FDG-PET findings of 21 SVD patients with and without LAD were compared. Results: Twelve (57%) of 21 SVD patients had mild stenotic lesions in intracranial large arteries:4 in middle cerebral artery, 8 in posterior cerebral artery, and 4 in vertebrobasilarj artery. There were no differences in vascular risk factors, characteristics of cognitive dysfunctions, and ^(18)FDG-PET findings between SVD with and without LAD. Conclusions:Our results showed that the presence of mild degree of large artery stenosis did not affect the clinical., neuropsychological profile and cerebral metabolism in PET. Therefore, the current 'Research criteria for SVaD' by Erkinjuntti could be used to diagnose SVD as a homogenous clinical group regardless of angiographic abnormalities.
Jeong, Jee-Hyang,Park, Kee-Duk,Choi, Kyoung-Gyu 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.1
Background:Neurodegenerative process in AD is characterized by progressive neuronal and synaptic loss with gliosis and formation of senile plaque and neurofibriollary tangles. Relationship between severity of NFTs and SPs has still intriguing aspect. Methods:Hierarchial rank order of NFT and SPs was done instead of absolute morphometric quantitation to find out severity of each pathologic changed in regions of frontal, temporal, hippocampus, amygdala, entorrhinal cortex, piriform cortex, basal nucleus of Meynert(BNM), substantia nigra and locus coeruleus. Also age and brain weight were analyzed to find out relationship to each region. Results:Weight of brain showed significant correlation with neuronal loss in frontal, temporal and BNM but it did not show any correlation with the neuronal loss in LC., SN and amygdala. In amygdala NFT were high in cortical and cortical transitional nuclei. SPs were heavily accumulated in basomedial,, cortical and cortical transitional nuclei. In hippocampus, entorrhinal cortex, H1 and subiculum of the hippocampus were the most consistent and severely affected regions. BNM did not show any correlation with laterobasal nucleus of amygdala which projects to BNM. SN, LC as well as BNM were interrelated in the severity of these changes. Nevertheless, these changes were not correlated with the brain weight. Conclusion:Different regional vulnerability even in a single area is demonstrated in an hierarchial order. But it is still a perpetuating question how these regional vulnerability occurs.
이향선 ( Hyang Sun Lee ),지용관 ( Yong Gwan Jee ),송신한 ( Sin Han Song ),성세용 ( Se Yong Sung ),이지호 ( Ji Ho Lee ),양재원 ( Jae Won Yang ),한병근 ( Byoung Geun Han ),정순희 ( Soon Hee Jung ),박정하 ( Jeong Ha Park ),강태영 ( T 대한류마티스학회 2011 대한류마티스학회지 Vol.18 No.3
Rhabdomyolysis is caused by injury to skeletal muscle and it involves leakage of intracellular contents into the plasma. Rhabdomyolysis is an extremely rare manifestation of dermatomyositis. Dermatomyositis is a rare idiopathic inflammatory myopathy that is characterized by chronic inflammation of skeletal muscles and skin, resulting in muscle weakness. A 20 year old Korean male soldier presented with acute muscle pain, weakness and skin rashes over the face, neck and anterior chest. He received military training with carrying a radio set one week previouslyago. The patient was treated for rhabdomyolysis. However, the patient`s symptoms did not improve. Muscle biopsy results suggested the diagnosis of rhabdomyolysis. Nevertheless, the features of skin and muscle inflammation raised the possibility of dermatomyositis. High dose steroid treatment was started, and then the symptoms and signs of muscle inflammation were improved. Rhabdomyolysis as the presenting sign of dermatomyositis has not been reported in Korea. Thus, we report on this case with a literature review.
상용 영양수액 투여 시 적정 비단백열량 질소 비율에 따른 수액 투여량 결정을 위한 도구의 개발
홍정 ( Jeong Hong ),이영주 ( Young Joo Lee ),송미경 ( Mee Kyung Song ),은명온 ( Myoung On Eun ),김미향 ( Mee Hyang Kim ),이연희 ( Youn Hee Lee ),안연희 ( Youn Hee Ahn ),김지양 ( Jee Yang Kim ) 한국정맥경장영양학회 2009 한국정맥경장영양학회지 Vol.2 No.1
Purpose: The purpose of this study was to make a numeric table for easy adjustment of the amount of 5% dextrose solution or 10% fat emulsion solution when added to a 2- or 3-chamber nutrient stock solution. Methods: Nutrient stock solutions were designated as group A or B according to the non-protein calorie-to-nitrogen ratio(NCR). The NCR of groups A and B was approximately 100 : 1 and 150 : 1, respectively. The weight (g) of protein which is to be administered to the patient was arranged in increasing order from 30~100 g in increments of 2 g. An imaginary NCR was arranged from 110 : 1 to 150 : 1.The difference between the imaginary NCR and the NCR of the nutrient stock solution (A) was multiplied by the grams of protein, which is the equivalent amount of additionally administrable calories. Each calorie value was divided by 3.4 or 1.1 to obtain a volume of 5% dextrose solution or 10% fat emulsion, and arranged in increasing order. All calculations were made with a Microsoft Excel program. Results: The numeric table was made for 2- and 3-chamber solutions in group A. The numeric table for the 2-chamber solution was set for determination of the volume and infusion rate of a 10% fat emulsion. The numeric table for the 3-chamber solution was for determination of the volume of a 5% dextrose solution. Conclusion: This numeric table can be easily used in adjusting the amount of 5% dextrose solution and 10% fat emulsion at the bedside. (KJPEN 2009;2(1):19-23)
Choi, Chulhee,Jeong, Jee-Hyang,Jang, Joong Sik,Choi, Kyungsun,Lee, Jungsul,Kwon, Jongbum,Choi, Kyoung-Gyu,Lee, Jong-Seo,Kang, Sang Won 대한신경과학회 2008 Journal of Clinical Neurology Vol.4 No.2
<P><B>Background and purpose</B></P><P>The availability and promise of effective treatments for neurodegenerative disorders are increasing the importance of early diagnosis. Having molecular and biochemical markers of Alzheimer's disease (AD) would complement clinical approaches, and further the goals of early and accurate diagnosis. Combining multiple biomarkers in evaluations significantly increases the sensitivity and specificity of the biochemical tests.</P><P><B>Methods</B></P><P>In this study, we used color-coded bead-based Luminex technology to test the potential of using chemokines and cytokines as biochemical markers of AD. We measured the levels of 22 chemokines and cytokines in the serum and cerebrospinal fluid (CSF) of 32 <I>de novo</I> patients (13 controls, 11 AD, and 8 Parkinson's disease [PD]).</P><P><B>Results</B></P><P>MCP-1 was the only cytokine detectable in CSF, and its levels did not differ between control and disease groups. However, the serum concentration of eotaxin was significantly higher in AD patients than in the control group.</P><P><B>Conclusions</B></P><P>The analysis of multiple inflammatory mediators revealed marginal differences in their CSF and serum concentrations for the differential diagnosis of AD and PD. These results provide evidence that immunological responses are not major contributors to the pathogenesis of AD and PD.</P>