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랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구
김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.
한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고
최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1
The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.
Yun Kyeong Seon,Moon Bong-Goon,Park Miae,Kim Seong-Ju,Shin Yunmi,Cho Sun Mi,Noh Jai Sung,Lim Ki-Young,Chung Young-Ki,Son Sang Joon,Roh Hyun Woong,Hong Chang Hyung 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.5
Objective Early detection and proper management of mental illness can help to prevent severe deterioration. However, with limited financial and human resources of community mental health services, it is not practical to carry out all conventional screening tools simultaneously. In this study, we aimed to develop and validate a brief but comprehensive screening questionnaire for four common mental illnesses of the elderly. Methods The brief screening for four mental illnesses of elderly (BS4MI-elderly) is a 14-item binary response questionnaire that covers dementia, depressive disorder, sleep disorder, and hwa-byung. To test validity, we compared conventional scale scores for three groups of participants classified using the BS4MI-elderly. The sensitivity, specificity, predictive value of positive test, likelihood ratio of positive test and internal consistency of the BS4MI-elderly were assessed. Finally, a correlation analysis between the BS4MI-elderly and general mental health scales was conducted. Results A total of 254 participants aged over 65 years were recruited. The BS4MI-elderly showed moderate to high sensitivity for the test that distinguishes the normal group from the risk and disorder groups (dementia: 0.61, depressive disorder: 0.88, sleep disorder: 0.85, hwa-byung: 0.94) and high specificity for the test that distinguishes the disorder group from the normal and risk groups (dementia: 0.91, depressive disorder: 0.93, hwa-byung: 0.84, sleep disorder: 0.84). The BS4MI-elderly also exhibited good internal consistency and significant correlations with general mental health scales. Conclusion The BS4MI-elderly, a brief but comprehensive screening tool, could be a useful instrument for screening the elderly in community mental health services.
Hyung Mi Lim,Joonho Yun,Mikyung Hyun,Yeomyoung Yoon,Dong Jin Lee,Sang Ok Jeong,Seung-Ho Lee,Chin Myung Whang 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.4
Magnesium hydroxide as a halogen-free flame retardant attracts increasing attention due to environmental regulations and its unique physical properties such as non-toxicity and smoke suppressant ability during combustion. Low-density polyethylene/ethylene vinyl acetate(LDPE/EVA) blends are one of the polyolefins of which the flame retardance is enhanced by compositions containing magnesium hydroxide. Natural magnesium hydroxide flame retardant is available from the mineral brucite by the adjusting size distribution and surface treatment. A synthetic magnesium hydroxide is usually prepared by precipitation and hydrothermal treatment from magnesium salts or hydrolysis of MgO mineral(periclase). Natural and synthetic magnesium hydroxide have been prepared and mixed with LDPE/EVA by melt compounding. The dependence of the particle size and purity of the magnesium hydroxide and various additives for the synergistic effect on the flame retardance of LDPE/EVA has been studied through combustion tests of the polymer composites. The combustion behavior has been tested by limited oxygen index tests and the vertical burning tests of UL-94. Magnesium hydroxide as a halogen-free flame retardant attracts increasing attention due to environmental regulations and its unique physical properties such as non-toxicity and smoke suppressant ability during combustion. Low-density polyethylene/ethylene vinyl acetate(LDPE/EVA) blends are one of the polyolefins of which the flame retardance is enhanced by compositions containing magnesium hydroxide. Natural magnesium hydroxide flame retardant is available from the mineral brucite by the adjusting size distribution and surface treatment. A synthetic magnesium hydroxide is usually prepared by precipitation and hydrothermal treatment from magnesium salts or hydrolysis of MgO mineral(periclase). Natural and synthetic magnesium hydroxide have been prepared and mixed with LDPE/EVA by melt compounding. The dependence of the particle size and purity of the magnesium hydroxide and various additives for the synergistic effect on the flame retardance of LDPE/EVA has been studied through combustion tests of the polymer composites. The combustion behavior has been tested by limited oxygen index tests and the vertical burning tests of UL-94.
Lim, Hyun-Chang,Nam, Ok Hyung,Kim, Mi-joo,El-Fiqi, Ahmed,Yun, Hyung-Mun,Lee, Yoo-Mi,Jin, Guang-Zhen,Lee, Hae-Hyoung,Kim, Hae-Won,Kim, Eun-Cheol DOVE MEDICAL PRESS 2016 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.11 No.-
<P>Therapeutically relevant design of scaffolds is of special importance in the repair and regeneration of tissues including dentin and pulp. Here we exploit nanofiber matrices that incorporate bioactive glass nanoparticles (BGNs) and deliver the odontogenic drug dexamethasone (DEX) to stimulate the odontogenic differentiation of human dental pulp cells (HDPCs). DEX molecules were first loaded onto the BGN, and then the DEX-BGN complex was incorporated within the biopolymer nanofiber matrix through electrospinning. The release of DEX continued over a month, showing a slow releasing profile. HDPCs cultured on the DEX-releasing BGN matrices were viable, proliferating well up to 14 days. The odontogenic differentiation, as assessed by alkaline phosphatase activity, mRNA expression of genes, and mineralization, was significantly stimulated on the matrices incorporating BGN and further on those releasing DEX. The DEX-releasing BGN matrices highly upregulated the expression of the integrin subsets α1, α5, and β3 as well as integrin downstream signaling molecules, including focal adhesion kinase (FAK), Paxillin, and RhoA, and activated bone morphogenetic protein mRNA and phosphorylation of Smad1/5/8. Furthermore, the DEX-releasing BGN-matrices stimulated Akt and mammalian target of rapamycin (mTOR), which was proven by the inhibition study. Collectively, the designed therapeutic nanofiber matrices that incorporate BGN and deliver DEX were demonstrated to promote odontogenesis of HDPCs, and the integrins, bone morphogenetic protein, and mTOR signaling pathways are proposed to be the possible molecular mechanisms. While further in vivo studies are still needed, the DEX-releasing bioactive scaffolds are considered as a potential therapeutic nanomatrix for regenerative endodontics and tissue engineering.</P>
임진형(Lim Jin-Hyung),김경미(Kim Kyung-mi),진미선(Jin Mi-sun) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.1
본 연구의 목적은 유아교사가 경험한 실외놀이의 의미와 어려움을 분석하여, 유아교육기관에서의 바람직한 실외놀이 운영을 위한 기초자료를 제시하는 것이다. 이를 위하여 유아교사 8명을 대상으로 유아교육기관 실외놀이의 의미, 실외놀이 운영의 어려움을 심층면담을 통해 살펴보았다. 연구결과, 첫째, 유아교사들은 신체발달을 도모하는 실외놀이, 소통으로서의 실외놀이, 에너지 발산으로서의 실외놀이, 자연과 함께하는 실외놀이의 의미를 인식하고 있었다. 이를 통해 유아들의 대 · 소 근육을 발달시키고 사회성 발달의 기회를 가질 수 있으며, 에너지의 발산과 자연과의 교감을 할 수 있다는 점에 의미를 두고 있었다. 둘째, 유아교사들은 여러 자료와 방법을 통해 유아들에게 의미있는 실외놀이 활동을 제공하고자 하였으나 계획과 일치하지 않는 실외놀이의 운영, 시간의 부족, 놀이지도 자질의 부족의 어려움을 제시하였다. 본 연구는 실외놀이의 운영에대한 유아교사의 경험을 분석함으로써 실외놀이에 대한 의미를 되새겨보고, 실외놀이를 효율적으로 운영해 보도록 하는데 의미를 시사한다. The objective of this study is to analyze teachers" experience in the operation of outdoor play in an early childhood educational institute. For this purpose, the experience obtained in planning/operating the outdoor play in early childhood educational institutes, as well as the difficulties experienced in their operational process, were examined. The data was collected through interviews with eight early childhood teachers. In the results of the study, first, the teachers" perception of outdoor play was analyzed. The teachers considered outdoor play as meaningful in that the children could develop gross/fine-motor skills, have the chance to develop their sociality, relieve their stress, and also commune with nature through outdoor play. Second, regarding the plan/operation of the outdoor play activities, even though they aimed to provide the children with meaningful outdoor play activities through various materials and methods, most of the teachers could not put their original plans into practice, because of the numerous variables in the actual site. The teachers" difficulties included insufficient time, spatial limitations, and insufficient qualifications for play instruction.