황구침법(黃丘鍼法)을 이용한 고혈압 환자의 혈압강하 효과에 대한 증례보고

한창현 ( Chang Hyun Han ),황치원 ( Chi Won Hwang ),신미숙 ( Min Suk Shin ),신선화 ( Seon Hwa Shin ),최선미 ( Sun Mi Choi ) 대한경락경혈학회 2006 Korean Journal of Acupuncture Vol.23 No.3

Objectives: The aim of the study was to investigate the antihypertensive effect of Hwang-gu Acupuncture in hypertensive patients. Methods: We measured the blood pressure of the patients who were admitted in the Oriental Medical Clinic of Brother from 25th November 2005 to 27th March 2006. We included the patients only in case of the systolic blood pressure was over 140mmHg or diastolic blood pressure was over 90mmHg, Twenty two patients were treated by Hwang-gu Acupuncture. In order to evaluate the effect of the Hwang-gu Acupuncture, the blood pressure was measured before and after Acupuncture procedure total 4 times, 10times. Results: There were a significant decrease in the systolic blood pressure and significant decrease in the diastolic blood pressure by Hwang-gu Acupuncture 4 times. The effect of Hwang-gu Acupuncture by measurement time on blood pressure were follows: In a systolic blood pressure was gradually deceased significantly from 1st to 4th but diastolic blood pressure was significantly decreased after 2nd and 4th only. Conclusions: These results suggest that Hwang-gu Acupuncture is effective in decreasing the systolic and diastolic blood pressure.

Ex Vivo Live Full-Thickness Porcine Skin Model as a Versatile In Vitro Testing Method for Skin Barrier Research

( Jee-hyun Hwang ),( Haengdueng Jeong ),( Nahyun Lee ),( Sumin Hur ),( Nakyum Lee ),( Jeong Jun Han ),( Hye Won Jang ),( Wang Keun Choi ),( Ki Taek Nam ),( Kyung-min Lim ) 한국피부장벽학회 2021 한국피부장벽학회지 Vol.23 No.2

Since the European Union (EU) announced their animal testing ban in 2013, all animal experiments related to cosmetics have been prohibited. Here, we investigated whether an ex vivo live porcine skin model can be employed to study the safety and skin barrier-improving effects of hydroxyacids widely used in cosmetics for keratolytic peels. Glycolic acid (1-10%), salicylic acid (0.2-2%), and lactobionic acid (1.2-12%) were used as representative substances for α-hydroxyacid (AHA), β-hydroxyacid (BHA), and polyhydroxyacid (PHA), respectively. When hydroxyacids were applied at high concentrations on the porcine skin every other day for 6 days, tissue viability was reduced to 50-80%, suggesting that the toxicity of cosmetic ingredients can be evaluated with this model. Based on tissue viability, the treatment scheme was changed to a single exposure for 20 min. The protective effects of a single exposure of hydroxyacids on skin barrier function were evaluated by examining rhodamine permeability and epidermal structural components of barrier function using immunohistochemistry (IHC) and immunofluorescence (IF) staining. Lactobionic acid (PHAs) improved skin barrier function most compared to other AHAs and BHAs. Most importantly, trans-epidermal water loss (TEWL), an important functional marker of skin barrier function, could be measured with this model, which confirmed the significant skin barrier-protective effects of PHAs. Collectively, we demonstrated that the ex vivo live full-thickness porcine skin model can be an excellent alternative to animal experiments for skin studies on the safety and efficacy of cosmetic ingredients. Funding: This study was funded by the Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (Grant no. HP20C0061).

개체동결 굴(Crassostrea gigas)을 이용한 레토르트파우치 굴국의 제조 및 품질특성

황영숙 ( Young-sook Hwang ),조준현 ( Jun-hyun Cho ),황석민 ( Seok-min Hwang ),김상현 ( Sang-hyun Kim ),김병균 ( Byeong-gyun Kim ),오광수 ( Kwang-soo Oh ) 한국수산과학회(구 한국수산학회) 2016 한국수산과학회지 Vol.49 No.6

To develop a value-added product from individually quick-frozen oysters Crassostrea gigas (IQFO), we prepared a retort pouched oyster soup (RPOS) from IQFOs and characterized its processing conditions and quality metrics. We found that the most appropriate manufacturing process for the RPOS consisted of half-thawing and washing raw IQF oysters, blanching, adding them to the retort pouch along with other ingredients (base soup stock, IQF oyster extract, radish, bean sprouts, garlic, and red pepper), sealing, retort sterilization (120°, F0-value 10 min.), cooling, and packaging inspection. The moisture, crude protein, pH and salinity of the RPOS were 91.0%, 2.8%, 6.20 and 0.9%, respectively. The total amino acid content of the RPOS was 2,163.8 mg/100 g, and the main amino acids were glutamic acid, aspartic acid, leucine, proline, lysine and arginine. The primary inorganic ions were Na, K, S and Zn. In taste compounds, total free amino acid content was 313.4 mg/100 g, and the main free amino acids were glutamic acid, taurine, proline, hydroxyproline, aspartic acid, glycine, alanine, valine, lysine and arginine. This RPOS has good storage stability and organoleptic qualities compared with commercial retort pouched shellfish soup, and is suitable for commercialization as a value-added instant seafood soup.

이동형 스크러버를 이용한 암모니아 및 톨루엔의 제거 효율

김재영 ( Jae-young Kim ),김장윤 ( Jang-yoon Kim ),이연희 ( Yeon Hee Lee ),김민선 ( Min Sun Kim ),김민수 ( Min-su Kim ),김현지 ( Hyun Ji Kim ),류태인 ( Tae In Ryu ),정재형 ( Jae Hyeong Jeong ),황승율 ( Seung-ryul Hwang ),김균 ( Ky 한국환경농학회 2018 한국환경농학회지 Vol.37 No.1

본 연구는 국내에서 다량 취급되고 있는 암모니아 및 톨루엔을 흄 상태로 노출시킨 후 흡수/흡착방법을 달리한 이동형 스크러버를 이용해 각 유해화학물질의 제거효율을 비교 분석하였다. 이동형 스크러버는 기 개발된 장치를 개선하여 와류세정에 의한 흡수, 유입풍속 조절의 장점을 살리고, 활성탄 및 카본필터를 통한 기체상 유해화학물질의 흡착방법 도입을 통해 단점을 보완하였다. 개선된 장치는 기초성능평가를 통해 적정 제어풍속이 검증되었고, 5% 암모니아수 용액을 흄 상태로 노출시켜 후드 흡입부, 송풍기 배출부 및 세정기가 정상 작동함을 확인하였다. 흡수/흡착방법에 따른 암모니아 제거효율은 90분 경과 후 C≥PCA>SWA 순으로 가장 우수한 SWA 군의 노출 농도별 제거 효율은 시간이 경과할수록 노출 농도와 무관하게 배출 농도는 증가되었고, 세정액의 pH는 산성에서 염기성으로 변화되었다. 또한, 시간 경과에 따른 노출 농도 별 세정액의 pH 변화와 배출구 농도 변화 사이에 0.9429~0.9491 수준의 정의 상관관계를 나타내었다. 흡착방법에 따른 톨루엔의 제거 효율은 초기 10분 경과 후 배출구농도에서 C>CMA≥GCA 순을 나타내다 90분 경과까지 일정한 농도로 유지되었다. 가장 우수한 GCA 군의 노출 농도 별 제거 효율은 초기 10분 경과 시 노출 농도에 비례하여 배출 농도가 높은 경향이었다. 이와 같은 결과를 통해 개선된 이동형 스크러버는 중화반응에 의해 산성 또는 염기성 유해화학물질의 제거뿐 아니라, 활성탄 등의 흡착기능 개선을 통해 VOCs 제거에도 효과적이었다. 하지만, 실제 현장에서 활용이 가능하도록 세정액 pH를 지속적으로 유지하여 연속적으로 흡수 제거할 수 있는 방법과 노출되는 화학물질 농도와 흡착제의 관계에서 파괴점, 포화점, 흡착속도 등의 물리적인 요소가 추가적인 연구를 통해 도출되어야 할 것이다. BACKGROUND: The mobile vortex wet scrubber was developed to remove the harmful chemicals from accidental releases. However, there was a disadvantage that it was limitedly used for volatile organic compounds (VOCs) such as toluene according to the physicochemical properties. This study compared the removal efficiencies of an improved mobile scrubber on toluene and ammonia by applying diverse adsorption and absorption methods. METHODS AND RESULTS: The removal efficiencies on harmful chemicals were examined using various adsorption and absorption methods of water vortex process (C), phosphoric acid-impregnated activated carbon adsorption (PCA), pH-controlled water (pH 2.5) vortex process absorption with sulfuric acid (SWA) after ammonia exposure, granular activated carbon adsorption (GCA), and activated carbon mat adsorption (CMA) after toluene exposure. As a result, the best removal efficiency was shown in the SWA for ammonia and GCA for toluene. Also, the SWA and GCA methods were compared with different concentration levels. In the case of ammonia exposure (5, 10 and 25%), there was no difference by concentration levels, and the concentration in the outlet gradually increased, with pH change from acid to base. In the case of toluene exposure (50, 75 and 100%), the outlet concentration was higher relative to the exposure concentration in the initial 10 min, but the outlet concentration was remained steady after 10 min. CONCLUSION: The newly improved mobile scrubber was also effective in removing VOCs through adsorption techniques (activated carbon, activated carbon fiber, carbon mat filter etc.), as well as removing acid-base harmful chemicals by neutralization reaction.

평양 남정리 53호분 출토 토제칠기의 보존 및 제작기법 연구 : 토제칠이배, 토제칠반, 토제칠안

황현성,임수경,김희진,이태진,고민정,윤은영 국립중앙박물관 2013 고고학지 Vol.19 No.-

본고는 일제 강점기 조사 미등록 유물 정리사업의 일환으로 수행한 평양 남정리 53호분 출토 토제칠이배, 토제칠반, 토제칠안에 관한 연구이다. 남정리 출토 유물은 소지가 목심이 아닌 토제라는 것과 칠이배와 칠반을 얹은 칠안이 함께 출토되었다는 점에서 주목할 만하다. 토제칠이배 및 칠반 그리고 칠안의 보존처리를 통해 이들의 형태와 문양 등에 대해 알 수 있었다. 또한 칠기에 사용된 붉은색 안료의 성분을 분석하여 안료의 주성분이 진사(HgS)였음을 확인하였다. 이번 연구에서 기존에 잘 알려지지 않았던 한반도 내 위치한 낙랑의 토제칠기에 관해 살펴볼 수 있었으며 이러한 제작방법이 한나라 고유의 문화인지 아니면 재지세력이 한나라의 영향을 받아 현지화한 문화의 산물인지에 대해 생각해 볼 수 있는 기회라 생각된다. This research paper examines the lacquered pottery cup, plate and table unearthed from Tomb No. 53 at Namjeong-ri in Pyongyang, which were under conservation treatment as a part of the Project of Unregistered Artefacts Uncovered in the Japanese Colonial Era. It is very rare to have a lacquered pottery cup and plate, lying on a lacquered pottery table, as a set of grave goods. In particular, they are not wooden but pottery items. Through conservation treatment for lacquered pottery cup, plate and table, it was possible to find out their shapes and decoration patterns. The resulting analysis of the red pigment used indicates that cinnabar (HgS) is the main element. This research is significant because it examines lacquered pottery wares produced in Lelang, which has rarely been conducted. Further research will need to prove whether their production techniques were in the unique Chinese Han style or were produced by indigenous craftsmen who adopted the Chinese Han technique.

임신중 발견된 원발성 폐고혈압증 1예

황인후,최재웅,문찬희,황의경,민현조,송창섭 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.8

마쇄처리 고추의 냉동저장중 이화학적 성분의 변화

설민숙,황성연,이현자,박소희,김종군 한국식생활문화학회 2004 韓國食生活文化學會誌 Vol.19 No.2

To investigate physico-chemical changes of mashed red repper and red pepper powder during frozen storage, we analyzed the quality of samples after mashing, mashing and blanching, mashing and addition of vitamin C, mashing and addition of NaCl. The most important quality factor of red pepper is red color. α value of red pepper powder of Pochungchun was 31.51. These results showed that those processing methods were effective to preserve red color. Capsanthiin contents of mashed red pepper treated with vitamii C were decreased 1.8% after 180 days of frozen storage. Thii decrease was the Least, showing that addition of vitamin C helped retaining capsanthiin contents. Capsaicin and dihydrocapsaicin contents in Pochungchun powder were decreased 11.9 and 18.3% during frozen storage respectively. These results showed that capsaicin was more stable than dhycrocapsaicin during frozen storage. Generally capsaicin and dhycrocapsaicinin the Pochungchun red pepper frozen-stored after mashing were less decreased than red pepper powder, and addition of vitamin C to the mashed red pepper was the most effective to retain capsaicin and dihydrocapsaicin than others. The content of vitamin C in the red pepper frozen-stored after mashing and blanching was 12.0 mg/100g, compared with 44.0mg/100g in the sample stored after only mashing. This suggested that blanching process destroyed vitamin C in the mashed red pepper. Addition of salt in the mashed red pepper showed the same inclination. But, addition of vitamin C to the mashed red pepper was decreased 32.9%, compared with 69.0% in the mashed red repper during frozen storage. Theser results indicated that addition of vitamin C could retain vitamin C in the mashed red repper.

선천성 완전방실차단이 동반된 신생아 루프스 1예

정재현,이은지,이은주,황진원,송영진,최병진,김일환,김종윤,허민영,김동욱 인제대학교 2009 仁濟醫學 Vol.30 No.-

Neonatal lupus is a rare syndrome occurring In neonates with tranplacentally acquired maternal autoantibodies, In particular anti-SSA/Ro-SSB/Ra antibodies. Manifestations include congenital heart block, cutaneous lesions, thrombocytopenia, neutropenia, pulmonary or neurological disease and hepatitis. The non-cardiac manifestations resolve by 6 months of age, congenital heart block is irreversible. We experienced a case of neonatal lupus with congenital complete heart block in a newborn of asyptomatic mother with anti-SSA/Ro-SSB/Ra antibodies.

냉동마쇄고추를 첨가한 깍두기의 저장기간에 따른 이화학적 성분 변화 및 관능적 특성

설민숙,황성연,박소희,이현자,김종군 한국조리과학회 2004 한국식품조리과학회지 Vol.20 No.5

The purpose of this study was to examine the physico-chemical and sensory characteristics of Kakdugi made with mashed red pepper. With regard to the pH of the Kakdugi. those of the juice from Kakdugi with red pepper powder and of the liquid with mashed red pepper were the highest and lowest immediately after preparation. respectively, but thereafter both slightly decreased, but were similar after the fifth week. Generally. the total acidity of Kakdugi liquid was the higher than that of Kakdtegi juice. With regard to the L value, that of the Kakdugi juice was higher than that of Kakdugi liquid and that of Kakdugi with mashed red pepper washigher than that of Kakdugiuitlr red pepper powder. From the third week, the values of all samples generally decreased. The 'a' value of the Kakdugi liquid with mashed red pepper during fermentation was highest During early fermentation, the juice of Kukdugi with red pepper powder showed a higher value than that of Kakdugi with mashed red pepper, but conversely, from the second week that of Kakdugr with mashed red pepper was higher than that of Kakdugi with red pepper powder. The 'L' value of the juice from Kakdugi with red pepper powder was highest until the second week, but trout the third week that of Kalotugi with trashed red pepper was highest. With respect to the organic acids contents, those of citric, quinic and malic acids decreased, but those of lactic and acetic acids increased during tcrrnentatton progression. In addition, the citric, lacticand malic acids contents of the Kakdugi with mashed red pepper werethe highest, whereas that of quinic acid of the Kakdugi with red pepper powder was the highest. From the forth week, the acetic acid content of the Kakdugi with mashed red pepper was further increased. As a result of the sensory test. Kakdugi with mashed red pepper showed significantly higher values with regard to redness and fresh flavor, hut in overall acceptability in the QDA, appearance and taste in the acceptance test. 'Therefore, our results indicate that mashed red pepper particularly increased the 'a' value and organic acid contents of Kakdugi compared to those of red pepper powder, leading to an increased overall acceptability.

ABAQUS를 이용한 휨벽체의 비선형 유한요소 해석기법

한민기,박완신,한병찬,황선경,최창식,윤현도 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

The finite element method(FEM) models were developed for the reinforced concrete flexural walls and analysed under constant axial and monotonic lateral load using ABAQUS. The major objective of the present study is to determine if the ABAQUS finite element program can be used to accurately model the post-cracked mode of failure in plastic regions of walls, and, if so, to develop practical failure criteria in the plastic range of the material response. The research comprises constitutive models to represent behavior of the materials that compose a wall on the basis of experimental data, development of techniques that are appropriate for analysis of reinforced concrete structures, verification, and calibration of the global model for reinforced concrete walls of increasing complexity. The proposed FEA technique is verified by Lefas's benchmark data. Results from the analyses of these FEM models offers significant insight into the flexural behavior of benchmark data.