조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

플라즈마 표지소자의 제작

이상윤,라병욱,박동수,황인헌,이덕동,신영남,박성배,이동욱,박용석,박형근,손상호,권태근,채경락,정경득 慶北大學校 自然科學大學 1986 自然科學論文集 Vol.4 No.-

An Ac-type Plasma Display Panel (PDP) operating with Ne-Ar(0.1%) Penning mixture gas is fabicated. The characterics of the panel with electrodes covered with thin and thick dielectric layers are studied. The brightness of the Neon-orange light emitted by the panel measured as function of applied voltage and frequency. As an application, a graphic display system equipped with PDP showing still and moving pictures is made.

스쿠버다이빙을 통한 스포츠관광 활성화 연구

조동진,이강욱,박현서,박상규 朝鮮大學校 스포츠科學硏究所 2006 스포츠科學硏究 Vol.17 No.-

본 연구는 스쿠버관광의 현황을 파악하고 현안과제 및 개선방안을 통한 스포츠관광 활성화에 목적을 두고자 한다. 이를 위해 문헌조사와 포커스그룹인터뷰를 통해 전문가적인 방안을 제시하였다. 인터뷰 대상은 전국에서 활동중인 스쿠버강사를 대상으로 지역적 안배를 고려하였고 평균 나이41세, 강사경력 11년의 활동경력을 가진 전문가들이였으며 제주도에서 인터뷰가 실시되었다. 본 연구의 결과, 첫째, 관련업계 종사자들이 현안 문제를 해결하기 위해서는 적극적인 노력이 요구되며 둘째, 다양한 교육과 이벤트를 통한 수익창출과 장비 국산화를 통한 저가의 장비개발이 필요하며 셋째, 투자를 통한 시설의 확충으로 편리성을 제공하여야 하며 다양한 홍보를 통해 스쿠버의 안전성과 교육적 효과에 대해 대중에게 알려야 하는 것으로 분석되었다. The purpose of this study is to understand the situation of scuba tourism and revitalize sports tourism by examining pending tasks and methods for revitalization. In order to achieve this, literature review and focus group interview were used to present professional methods. An interview was conducted with practicing scuba instructors nationwide in Jeju-do in consideration of local arrangement. Subjects' mean age was 41, and mean career was 11 years. The following results were obtained. First, related-industry practitioners should make active efforts to solve pending problems. Second, it is needed to create profit through various education and events, and develop inexpensive equipment through the localization of equipment. Finally, it is needed to provide convenience with the expansion and improvement of facilities through investment, and introduce the safety and educational effect of scuba to the public using a variety of PR activity.

한국인의 치과의원 내원요인 조사 연구

류영욱,배현숙,성진효,김동기 조선대학교 구강생물학연구소 2003 Oral Biology Research (Oral Biol Res) Vol.27 No.1

According to the increase of the number of dental clinics and the level of the patient's recognition about oral health care, the need for effective clinical management to provide proper oral health care service to the patients has arisen. Many patients has selected the dental clinics based on self estimation or other recommendation. Therefore the main reasons for selecting the dental clinic by the patients needed to analyze, So we conducted the survey which prepared questionnaire were provided to 700 subjects and collected data related to the factors for patients to select the dental clinics. The results were as follows : 1. In the view of access, the place easy of access and parking capacity was important to the degree of 43.0% and 30.8%, respectively. 2. In relation to the dentist, the quality of treatment and the trust was important to the degree of 80.7% and 71.3%, respectively. 3. Modern clinical facility was occupied 65.5% in the basic environment factors. 4. In the basic factors, kindness and cleanliness was 76.6% and 76.7%, respectively, and it showed that these factors were more important than the number of the clinicians and comfort of the waiting room. 5. In relation to the satisfaction of treatment, cheaper treatment cost, decreased waiting tine, the variety of treatment tine and various payment method were important to the degree of 51.8%, 48.4%, 42.8% and 39% in order.

Iron Nitrilitriacetate(FeNTA)의 신 조직 손상에 관한 연구

천현욱,김회영,김동영,최종원 慶星大學校 環境問題硏究所 1994 環境硏報 Vol.4 No.1

Nitrilotriacetic acid(NTA) is a synthetic amino polycarboxylic acid chelating agent. It has a high affinity for aluminium and rare earth and alkali earth metals. NTA has been used various countries as a substitute for polyphosphates in houshold detergents to reduce or reverse eutrophication. Renal lipid peroxide concentration of mouse on kidney treated with FeNTA was significantly increased in comparison with that of the normal. Blood urea nitrogen(BUN) level and urinary γ-glutamyltransferase(γ-GT) activity of mice given FeNTA significantly increased in comparison with that of control. But urinary lactate dehydrogenase(LDH) activity was not affected any other conditions. Renal protein bound-SH and glutathione concentration of male mice given FeNTA significantly decreased in comparison with that of control mice. These result suggest that nephrotoxicity of FeNTA caused proximals tubule necrosis on kidney of male mice.

구개측 매복된 상악 견치의 교정적 치험례

감동훈,김정욱,한세현 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.1

An impacted tooth is defined pathologically as a tooth that remains under the mucosa of inside bone without eruption of the crown after a specific period of eruption. Clinically, the term includes those teeth, even before eruption period, that are not expected to erupt due to shape, position and alignment of tooth and lack of space. Canine is prome to impaction more than other teeth because it has the longest time to develop and a complex route from the place of formation to the site of eruption. The impaction incidence of maxillary canine is repoted 0.92~3.3%(Ferguson, 1990). In 1995 Orton reported that the incidence was 0.92~2.2% and palatal impaction was more frequent than labial impaction(85%:15%). In 1969 Johnston presented it was more common to woman than to man(3:1). The etiology includes systemic disease such as endocrine disorder, cleidocranial dysostosis, irradiation, Crouzon syndrome, ricketts, facial hemihypertrophy and hereditary and local problems such as ectopic position of the tooth, distance of tooth from its place of eruption, malformation of the tooth, presence of supernumerary teeth, trauma of tooth germ, infection of tooth germ, displacement of tooth germ or tooth by a neoplasm, ankylosis, overretention of deciduous predecessor, lack of space for the tooth in th dental arch and mucosal barrier due to gingival fibrosis. The maxillary canine is especially important as ti has the longest root, provides guidance for lateral movement of the mandible and masticatory function and assumes an important role esthetically as it is located at mouth angle. If left untreated, it may cause migration and external, internal resorption of adjacent teeth, loss of arch length, formation of dentigerous cyst or tumors, infection and referred pain as well as malposition of the tooth. Therefore, periodic examination of the development and eruption of the maxillary canine is especially important in a growing child. This case study presents the results of treatment of palatally impacted maxillary canine utilizing surgical exposure and orthodontic tooth movement on patients visiting SUNDH dept. of pediatric dentistry.

대학생의 성별 스포츠에 대한 가치관과 태도 비교 연구

신영균,주동욱 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.3

The purpose of this study is to investigate an attitude and Value to nave cognizance of Sport on sex by University Students, concretely, the purpose of this study is to analyze and clarify the effects of the experience, Style, Proper degree of sports participation. For the study 323 sports and 333non-sports participation were selected(totaled 656 university students 342, college students 314). statistical analysis techniques for this study included multiple classification analysis, analysis of convenance, multiple regression analysis. Based on findings of these analysis the results of the study are as follow: First, there were differences on 0.1% an attitude and Value to have cognizance of Sport by sex. Second, University Style of according to an attitude and Value to have cognizance of Sport on differences 5%. Third, there were differences on 0.l% an attitude and Value to have cognizance of Sport by the grades. Fourth, there were differences on 0.1% an attitude and Value to have cognizance of Sport by regression. Fifth, there were differences on 0.1% an attitude and Value to have cognizance of Sport by reduction on marks of the arts and physical fitness. Sixth, an attitude and Value to have cognizance of Sport by total University Students were social intercourse and a cultural level in the higher.

광섬유 방사선 센서와 EBT 필름을 이용한 심부선량 백분율 측정 및 비교

조동현,장경원,유욱재,신상훈,이봉수,문주현,박병기 제주대학교 방사선응용과학연구소 2008 방사선응용과학연구소논문집 Vol.22 No.-

In this study, fiber-optic sensor is fabricated to measure PDD of CLINAC. As a scintillating light generated by a high energy X-ray from the medical LINAC is measured using photo diode amp system, It is expected that a high-resolution, real-time fiber-optic dosimeter for medical LINAC can be developed.

도시거주자의 혈중 카드뮴 농도와 간 및 신장 기능과의 상관성 평가

김호현,임영욱,임종한,양지연,신동천 한국환경독성학회 2003 환경독성보건학회지 Vol.18 No.1

The possibility that liver and kidney function is adversely affected by current levels of environmental exposure to cadmium (Cd) as investigated in adult men and women in the general population in Seoul. From February to August in 2001, blood and morning spot urine samples were collected from 136 not occupationally exposed group (age range 20~75 years) at 4 survey sites throughout Seoul. Liver and kidney function parameters in serum and urine were examined by conventional methods. The questionnaire included factors, i.e. sex, age, smoking, alcohol, diet habit etc. The geometric mean values for Cd in blood (Cd-B) were 1.43 μg/l. It seemed prudent to conclude that liver and kidney function as not disturbed by the current environmental exposure to Cd in study.