HPLC/ELSD에 의한 Diterpenoid Alkaloids의 분석

임미애,이주선,백승경,최혜영,박유신,이한선,육창수,오세욱 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

국소성 분절성 사구체 경화증의 완전 관해 후 발병한 IgA 신병증 1예

임현민,김현정,박민석,주혜원,최원,김상현,박원도 인제대학교 2006 仁濟醫學 Vol.27 No.-

We report a rare case of primary glomerular disease with IgA nephropathy in a 43-year old man. 7-years ago, he was diagnosed with minimal change nephrotic syndrome. After treatment with steroid for 1-year, azotemia and proteinuria were improved. But, nephrotic range proteinuria was relapsed within 1 week after cessation of steroid. Renal biopsy revealed focal segmental glomerulosclerosis, and achived a complete remission with the use of steroids and cyclophosphamide. Then, he was followed up with normal renal function for 4-years. On admission, the patient showed generalized edema and marked proteinuria. In 3rd renal biopsy, mesangial proliferative glomerulonephritis with diffuse global sclerosis was observed. Electron microscopy showed electron-dense deposit on the mesangium with slight mesangial proliferation, and immunofluoroscence microscopy showed granular deposits of IgA and IgM. These features were consistent with IgA nephropathy, different from results of previous biopsies. The pathogenesis of IgA nephropathy occurred with primary FSGS is not clear, as well as treatment. Now, proteinuria is improving, steroid and cyclophosphamide are probably useful for the disease.

이소골 전위 및 골절에서의 고해상 CT 소견

임수미,최혜영,팽미혜,변성완,김미성 梨花女子大學校 醫科大學 醫科學硏究所 2003 EMJ (Ewha medical journal) Vol.26 No.1

목적 : 측두골 외상으로 인한 이소골 전위나 골절의 고해상 CT 소견을 알아보고자 하였다. 대상 및 방법 : 1998년 1월부터 2002년 6월까지 측두골 외상 환자 중 고해상 CT에서 이소골 전위나 골절이 있었던 11명의 환자를 대상으로 하였다. 8명의 환자에서는 필름을, 3명의 환자에서는 PACS를 이용한 고해상 CT를 후향적으로 분석하였고 이소골 전위 및 골절의 분류, 측두골 골절의 분류, 그 외 주위조직의 동반된 이상소견을 알아보았다. 결과 : 11명의 이소골 이상이 있었던 환자 중 침추골 관절 분리가 10예로 가장 많았고 침등골 관절 분리가 4예 있었으며 추골 골절, 침골 골절, 침골의 장각과 두상돌기 전위, 침골돌기가 보이지 않았던 경우가 각각 1예씩 있었다. 측두골 골절은 8예에서 있었으며 종위골절이 7예, 황위골절 1예였고 그 외에도 경동맥관 골절, 경동맥해면루, 접형골과 후두골의 골절이 동반되었다. 필름을 이용한 고해상 CT에서 보다 PACS를 이용한 CT에서 확대 및 창폭(window width) 변화가 가능하여 이소골 평가에 이용하였다. 결론 : 측두골 외상으로 인한 이소골의 전위가 골절은 고해상 CT상 횡단 및 관상면의 정확한 해부학적 지식이 필요하였으며 침추골 관절 분리가 가장 흔하고 측두골의 종위골절이 많이 동반되며 특히 PACS를 이용한 고해상 CT가 이소골 평가에 유용하였다. Purpose : To evaluate the CT findings of ossicular disruption and fracture utilizing high resolution computed tomography(HRCT) of the temporal bone. Materials and Methods : The authors retrospectively reviewed the HRCT scans of 11 patients with ossicular injuries between January 1998 and June 2002 using films in 8 patients, PACS in 3 patients. The type of ossicular injuries, temporal bone fracture, and associated adjacent injuries were evaluated. Results : Among the 11 patients of ossicular injuries, there were 10 cases of incudomalleal disruption, 4 cases of incudostapedial disruption, and 1 case of fracture of malleus, fracture of incus, disruption of long and lenticular process of incus, nonvisualization of processes of incus. The temporal bone fractures were longitudinal in 7 cases, transverse in I case. Other injuries were fracture of the carotid canal, caroticocavemous fistula, fracture of sphenoid and occipital bones. Conclusion : Incudomalleal disruption was the most frequent tupe of ossicular injuries and associated temporal bone fracture was longitudinal type. HRCT using PACS was useful in evaluation of ossicular injuries than films.

변위된 미맹출 상악 견치의 교정 치험례 : CASE REPORT

임혜정,최남기,김선미,양규호 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.3

상악 견치는 가장 긴 치근을 가지며 저작기능과 함께 하악의 측방운동을 유도하고 심미적으로도 치열궁의 구각부위에 위치하여 교합관계의 조화와 대칭을 유지하는 등의 중요한 기능을 수행한다. 상악 견치는 발육기간이 가장 길며 형성되어 맹출하기까지 복잡한 경로를 갖기 때문에 다른 치아보다 매복의 빈도가 높다. 이러한 매복치를 치료하기 위해 임상의는 관찰을 하거나 외과적 노출과 교정적 견인, 자가치아이식, 발치 등 다양한 치료방법을 고려할 수 있다. 외과적 노출과 교정치료는 견치를 교합선상에 배치할 수 있기 때문에 가장 이상적인 접근으로 생각할 수 있다. 본 증례 보고는 구개측으로 매복된 상악 견치를 외과적 노출과 교정적 치아이동을 통해 기능적, 심미적으로 양호한 결과를 얻었다. The maxillary canine is especially important as it has the longest root, provides guidance for lateral movement of the mandible and masticatory function and is a key in esthetics due to its position. Maxillary canine has the longest time to develop and a complex route from the place of formation to the site of eruption, and so it is prone to impaction more than other teeth. The clinician should consider the various treatment options : (a) No treatment and observation, (b) surgical exposure and orthodontic traction (c) autotransplantation (d) extraction. Surgical exposure of the canine and orthodontic treatment to bring the tooth into the line of occlusion is considered the most desirable approach. This case presents the results of treatment for impacted maxillary canine by surgical exposure and orthodontic tooth movement.

상악 전치부에 발생한 여러 유형의 치아 외상 : CASE REPORT

임혜정,최남기,양규호,김선미 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.1

외상으로 인해 완전 탈구와 함입성 및 정출성 탈구가 병합되어 나타나는 경우는 드물다. 2003년 7월에 10세 2개월의 여아가 상악우측 측절치의 완전탈구와 상악우측 중절치의 함입성 탈구, 상악 좌측 중절치의 정출성 탈구로 전남대학교병원 소아치과에 내원하였다. 내원 당일 외상치아를 외과적으로 재위치시켰으며 레진 강선 고정을 시행하였다. 외상 2주 후 완전탈구된 상악우측 측절치는 근관치료를 시행하였다. 외상 3개월 후 방사선사진 상에 상악 좌우측 중절치의 치근 외흡수가 관찰되었으며 수산화칼슘을 이용한 근관치료를 시행한 후 치근 외흡수가 정지되었다. 1년 4개월 동안의 관찰기간 동안 병적인 변화없이 양호한 결과를 보였으며 추후 장기적인 추적관찰이 필요하리라 사료된다. It is rare that the complete avulsion, intrusive luxation, and extrusive luxation occurred by trauma at the same time. In July, 2003, 10-year and 2 month-old-girl was referred to Department of Pediatric dentistry, Chonnam National University Hospital due to complete avulsion of upper right lateral incisor, intrusive luxation of upper right cental incisor and extrusive luxation of upper left central incisor. Traumatized teeth were surgically repositioned and fixated with resin-wire splint at the same day. Endodontic treatment of avulsed tooth was performed 2 weeks after trauma. A radiograph was taken 3 months after trauma, which demonstrated root resorption of both upper central incisors. External root resorption was arrested by the root canal therapy with calcium hydroxide. It showed good results for 1 year and 4 month but further follow-up is needed to check root resorption and ankylosis.

고본 Ethanol 추출물의 투여가 streptozotocin 유발 당뇨 흰쥐의 혈당 및 글리코겐 함량에 미치는 영향

임숙자,한혜경,최성숙 덕성여자대학교 자연과학연구소 2007 자연과학 논문집 Vol.13 No.-

This study was designed to examine the effects of ethanol (EtOH) extract of Angelicae tenuissimae on glucose and glycogen levels in streptozotocin (STZ) induced diabetic rats. Sprague-Dawley rats were induced diabetes mellitus by STZ injection (45 mg/kg) into the tail vein and were divided into 4 groups: normal, STZ-control, two experimental diabetic groups. EtOH extract of Angelicae tenuissimae were administered orally into the diabetic rats for 14 days. The diet intake and body weight were monitored and plasma levels of glucose, aminotransferase activity and glycogen level in liver and muscle were analyzed. Oral administration of 2.0g/kg b.w. on the EtOH extracts for 14 days resulted in a significant reduction in plasma levels of glucose, activities of ALT and AST. The glycogen levels in liver and muscle of EtOH-2 group were significantly higher than that of STZ-control group. The results show that EtOH extract of Angelicae tenuissimae could be effective to control the STZ-induced diabetic rats.

영도지역 남녀 중ㆍ고교 학생들의 성지식에 관한 연구

강혜숙,남은우,박성빈,최재임 고신대학교 영도발전연구소 2000 영도연구 Vol.2 No.-

The purpose of this study was to grasp the sex knowledge in middle and high school students in Youngdo-Gu, Busan, and to provide some basic data for the needs and the direction of sex education for the teenagers. The survey was conducted by using questionnaires in two middle schools and two high schools in Youngdo-Gu. The questionnaires were took back after record by the respondents. The survey was conducted at September 15∼17, 2000 and a total of 791 were completed. The respondents were 200 (25.3%) males and 199 (25.2%) females in middle schools and 196 (24.8%) males and 196 (24.8%) females in high schools. For the statistical analysis, χ2-test, t-test and one-way ANOVA were used by using SPSS/PC+ WIN 8.0 program. The conclusions based on the results obtained from this study are as follows: 1) An attitude of the sexual matters showed that boys, students and non-christians were more progressive than girls, parents and christians, respectively (p<0.01). 2) The sexual agonies of students were in order of having a date 36.2%, sexual drive 11.1%, sexual intercourse 8.8%, masturbation 8.6% and sexual abuse 6.7%. 3) The points for sexual knowledges appeared 40.6 points out of 100 points from boys and 42.3 points from girls in middle schools, and 57.3 points from boys and 66.1 points from girls in high schools. Therefore, the girls had much knowledges on sexuality than those of the boys. There were a significant differences of knowledge on sexuality between boys and girls (p<0.001). Over 60% of both boys and girls had not enough knowledges on sexually transmitted diseases (STDs). 4) Satisfaction of sex education was common or unsatisfied as over 90% of respondents. The reasons were a textbook-like general information (50%) and nothing practically to help (29%). 5) The students wanted sex education for the practice in future life such as male and female relationship with etiquette(23%); and pregnancy and delivery (17%) in middle school students, and contraceptive and abortion (34%) and preventive STDs (18%). There was not enough to understand whole adolescent in Youngdo area because the study subjects were only public middle and hight school students in Youngdo-Gu, Busan. Conclusively, it is necessary to educate to give right information of sexuality to the adolescents in Youngdo, and to have systematically sex education from the kindergartens to the high schools by long range sex educational program. Also, a proper program for integrated sex education is necessary to build healthful sexual consciousness and worth in cooperation with sex educators, universities and health centers.

Whole-genome resequencing analysis of 20 Micro-pigs

Da‑Hye Son,Nam‑Hyun Hwang,Won‑Hyong Chung,Ha‑Seung Seong,Hyungbum Lim,Eun‑Seok Cho,Jung‑Woo Choi,Kyung‑Soo Kang,Yong‑Min Kim 한국유전학회 2020 Genes & Genomics Vol.42 No.3

Background Miniature pigs have been increasingly used as mammalian model animals for biomedical research because of their similarity to human beings in terms of their metabolic features and proportional organ sizes. However, despite their importance, there is a severe lack of genome-wide studies on miniature pigs. Objective In this study, we performed whole-genome sequencing analysis of 20 Micro-pigs obtained from Medi Kinetics to elucidate their genomic characteristics. Results Approximately 595 gigabase pairs (Gb) of sequence reads were generated to be mapped to the swine reference genome assembly (Sus scrofa 10.2); on average, the sequence reads covered 99.15% of the reference genome at an average of 9.6-fold coverage. We detected a total of 19,518,548 SNPs, of which 8.7% were found to be novel. With further annotation of all of the SNPs, we retrieved 144,507 nonsynonymous SNPs (nsSNPs); of these, 5968 were found in all 20 individuals used in this study. SIFT prediction for these SNPs identified that 812 nsSNPs in 402 genes were deleterious. Among these 402 genes, we identified some genes that could potentially affect traits of interest in Micro-pigs, such as RHEB and FRAS1. Furthermore, we performed runs of homozygosity analysis to locate potential selection signatures in the genome, detecting several loci that might be involved in phenotypic characteristics in Micro-pigs, such as MSTN, GDF5, and GDF11. Conclusion In this study, we identified numerous nsSNPs that could be used as candidate genetic markers with involvement in traits of interest. Furthermore, we detected putative selection footprints that might be associated with recent selection applied to miniature pigs.

초등교사의 열정에 대한 인식: 의미연결망 분석의 활용

임효진 ( Hyo Jin¸ Lim ),최은혜 ( Eun Hye¸ Choi ),박호익 ( Ho Ik¸ Park ),이지현 ( Ji Hyun¸ Lee ) 한국초등교육학회 2021 초등교육연구 Vol.34 No.3

본 연구에서는 초등교사가 가지고 있는 열정에 대한 인식구조를 파악하기 위해 현직 초등교사 131명을 대상으로 설문조사를 실시하였다, 연구에서는 열정, 열정의 장단점, 교사열정에 대한 인식구조를 알아보기 위해 의미연결망 분석을 활용하여 근접 중심성, 연결중심성, 매개중심성, 아이겐벡터 중심성을 위주로 살펴보았다. 연구결과 첫째, 열정에서는 ‘힘’,‘강렬’과 같은 높은 강도나 에너지를 나타내는 단어들이 중요한 역할을 하였으며 커뮤니티 분석 결과 열정의 행동, 정서, 동기 특성에 대한 주제가 분류되었다. 둘째, 열정의 장점에서는 ‘삶’,‘원동력’,‘에너지’등이, 열정의 단점에서는 ‘타인’,‘피로’,‘살피지 못함’등이 중요한 역할을 하는 것으로 보아 기존 이론에 나타난 열정의 특성을 설명하고 있었다. 셋째, 교사열정에서는 ‘학생’,‘수업’과 같은 교수활동의 실천을 나타내는 단어들이 중요한 역할을 하였으며 커뮤니티 분석 결과 교육활동 전반, 학생과 수업, 전문성 개발에 대한 주제가 분류되었다. The purpose of this study was to explore the meaning of passion perceived by elementary school teachers. In order to understand the structure of perception of passion, we surveyed 131 in-service elementary school teachers. Responses to passion, the positive and negative role of passion, and teacher passion were analyzed using a semantic network analysis. We focused on closeness centrality, degree centrality, betweenness centrality and eigenvector centrality. Results showed that first, in passion, words indicating high strength and energy such as‘power’and‘intensity’played an important role in the structure of perception. Themes on behavioral, emotional, and motivational characteristics of passion were classified as sub-factors of passion as a result of community analysis. Secondly,‘life’,‘motivation’, and‘energy’appeared in key-word analysis in the positive role of passion while‘others’,‘fatigue’, and‘not caring for’appeared in the negative role of passion, reflecting the theory on the dualistic model of harmonious and obsessive passion. Third, in teacher passion, words indicating teaching activities and their practices such as‘student’and‘instruction’played an important role in the structure of perception. Themes related to educational activities in general, students and instruction, and professional development were classified as sub-factors of teacher passion.

폐 내 병변으로 인한 소아 급성 호흡부전의 원인 질환과 예후

이혜영,박지숙,최희라,서지현,김점수,임재영,최명범,박찬후,우향옥,윤희상 대한소아과학회 2004 小兒科 Vol.47 No.5