심방중격결손증 환아에서의 삼첨판류역류에 관한 관찰

한혜경,손재일,윤용수,홍창의 대한순환기학회 1988 Korean Circulation Journal Vol.18 No.3

혈우병 A형 환자에서 재조합 혈액응고인자 Ⅷ (그린진주^TM)의 내약성 및 약동학적 특성에 관한 연구

한혜경,신광희,백상훈,정재용,임경수,조주연,윤서현,신상구,장인진,유경상 대한임상약리학회 2011 Translational and Clinical Pharmacology Vol.19 No.2

Background: GreenGene^TM (Green Cross Corp.) is a recombinant clotting factor Ⅷ which is used for hemophilia A. This study aimed to investigate the pharmacokinetics and safety profiles of 25 IU/kg and 50 IU/kg of GreenGene^TM in Korean hemophilia A patients. Methods: A dose-block randomized, single-blind, active drug-controlled, single and multiple dose, parallel-group study was conducted with 16 hemophilia A patients (25 IU/kg: 50 IU/kg = 8:8). They received GreenGene^TM or GreenMono^TM(active control) intravenously on day 1 and every other day from day 4 to 10. FⅧ:C (Factor Ⅷ procoagulant activity) was measured to determine the pharmacokinetics (PK) at baseline and up to 48 hours for single and multiple administration. PK parameters were determined using noncompartmental methods. Results: The maximum concentration (C_max) and the area under the concentration-time curve (AUC_0-48) of the GreenGene^TM 25 IU/kg (mean ± SD) were 59.00 ± 19.26 % and 774.40 ± 380.13 %·h respectively, while those of 50 IU/kg were 131.50 ± 39.81 % and 1462.44 ± 397.09 %·h after single administration. The C_max and AUC_0-48 in steady state of the GreenGene^TM 25 IU/kg were 68.17 ± 22.75 % and 863.30 ± 334.40 %·h, while those of 50 IU/kg were 147.17 ± 18.47 % and 1820.08 ± 704.42 %·h. No serious adverse event was observed. Conclusion: The GreenGene^TM to hemophilia A patients appeared to be well tolerated within range of 25-50 IU/kg. The PK parameters of factor Ⅷ showed dose-independent manner with 25 IU/kg and 50 IU/kg dose ranges.

조기퇴직자의 우울감과 영향요인 연구

한혜경 한국가족사회복지학회 2003 한국가족복지학 Vol.- No.11

본 연구의 목적은 조기퇴직자를 대상으로 우울감에 대한 조사를 통해 조기퇴직자의 우울수준이 어느 정도인지를 파악하고, 조기퇴직자의 개인적, 가족적, 사회적 차원의 변인들과 우울 정도 간의 상관관계를 살펴보며, 우울감의 영향요인을 분석하는 것이다. 이를 위해 본 연구에서는 서울시에 거주하는 50대의 조기퇴직자 92명을 대상으로 서베이조사를 실시하였다. 분석 결과 조사대상자의 약 60%가 우울감을 느끼고 있고, 평균적으로 가벼운 기분장애 정도를 넘어 중간 정도의 우울감을 가지며, 약 27.2%는 심한 우울감을 가지는 것으로 나타남으로써 조기퇴직자의 우울 수준이 매우 심각하다는 것을 보여주었다. 관련 변인에 따른 우울 정도의 차이를 분석한 결과에 의하면, 개인적 차원의 변수 중 일상생활 만족도와 자존감, 가족적 차원의 변수 중 배우자와의 의사소통 빈도와 대화만족도, 환경적 차원의 변수 중 경제적 어려움, 사회적 지지에 대한 인식정도, 일하고 싶은 정도, 무료함의 정도, 그리고 교육프로그램 참여여부, 퇴직준비 여부 등의 변수가 유의한 관련을 가지는 것으로 나타났다. 한편 우울 영향요인을 파악하기 위한 회귀분석 결과에 의하면, 조기퇴직자의 우울 정도를 예측케 하는 가장 중요한 요인으로 검증된 것은 일(취업)하고 싶은 정도였으며, 다음으로 중요한 요인은 배우자와의 대화만족도, 무료함의 정도로서 일과 가족이 조기퇴직자의 심리적인 안정에 미치는 영향을 다시 한 번 확인케 했다. 본 연구에서는 위의 연구결과를 토대로 하여 거시적, 미시적 차원의 함의를 제시하였다. The purpose of this study was to examine the degree of depression of early retirees and analyze the effects of psycho-social factors on the depression. The study categorizes determinants of depression in early retirees into individual, family, and social environment level. The respondents of survey research are 92 retirees residing in Seoul. The result shows serious level of depression among the subjects, the average retirees were suffered from moderate depression, and 27.2% of them are clinically diagnosed as severe depression. The range of reactions to early retirement is quite varied and is presumably affected by a wide variety of variables. This study examined variables to determine which particular combination could best predict the current level of depression. Five variables are found to be related to the depression, that is, anxiety for work, satisfaction of communication with the spouse, tedious hours, unstability of economy, and daily life satisfaction. The most powerful predictor of psychological distress is the variable of anxiety for work. We should make an effort to make changes in those intervenable variables such as work, tedious hours, unstability of economy. Finally, implications for alternatives to support early retirees from this study were provided.

명대 의화본 소설에 나타난 상인들의 풍모와 이국정취: <轉運漢巧遇洞庭紅, 波斯胡指破龜龍殼>을 중심으로

한혜경 한국중국소설학회 2008 中國小說論叢 Vol.27 No.-

<轉運漢巧遇洞庭紅, 波斯胡指破鼉龍殼〉載于《初刻拍案驚奇》卷首, 是一篇反映明代海外貿易的擬話本小說. 篇中主人公文若虚在国内经商屡屡失败,陷入破产境地,于是想到海外冒险. 他偶然搭上商船出海,临行时带了国内只值一钱银子的洞庭红,到海外却意外卖了八百多两银子, 归途中又意外在荒岛上拣了个掩藏24个夜明珠的大乌龟壳,于是摇身變成了一个大富商,在闽中沿海“重立家园”. 有些人批評這篇小說的宿命論思想太濃厚. 但如果深入閱讀和探討, 可以尋找出新的內涵.. 基於此, 本篇論文首先探討古代中國人對商人和商業活動的看法如何, 進行分析作品內容如海外貿易商人的風貌和交易狀況、海外風物和異國情趣等等. 這篇小說一反過去對商人和商品交換經濟鄙視、輕蔑的寫法, 寫出了商人們眞誠、善良、友好的品格, 肯定了互通有無、平等競爭、互利互惠的商品貿易往來. 这个故事,反映了晚明海运开禁以后,市民百姓对于海外贸易的兴趣,還肯定了商人们投机冒险、逐利生财的心理. 主人公文若虛成功的秘訣也値得思考. 他儘管經商飽嚐了波折和失敗的苦果, 但絶不放棄對未來的希望. 以樂觀的冒險精神來抓住發財的好機會. 不料在外国竟然賺了八百两银子, 有人勸他再做投資. 但他却採取節制而保守的態度. 因他深信過慾往往招來不可挽回的結果, 這種小富卽安的心理來表現他當時的立場是最爲恰當不過的. 此外, 對外國風物和異國情趣的描寫也十分浪漫而幻想, 頗耐人尋味. 明代許多描寫商業活動和海外貿易的許多小說中, 這是屬于上乘之作. 在<轉運漢巧遇洞庭紅, 波斯胡指破鼉龍殼〉以前的小說中, 描寫海外故事的也不少, 但一般都是荒誕無稽之談, 和實際情況沒有什麽牽連. 這篇小說却用廣範的篇幅來描寫了商人及其貿易活動本身, 這就是前所未有的大突破.

녹차, 청차 및 홍차 투여에 의한 당뇨쥐의 혈당과 콜레스테롤 함량 변화

한혜경,최성숙,정하숙 한국차학회 2010 한국차학회지 Vol.16 No.2

This study was designed to examine the effects of ethanol extract of green tea (non-fermented tea, GT), chung tea (10% fermented tea, CT) and black tea (fermented tea, BT) on blood profiles in normal and diabetic rats. Rats were divided into normal [normal-control (NC), GT (N-GT), CT (N-CT), and BT (N-BT)] and diabetic groups [diabetic-control (DC), diabetic-GT(D-GT), diabetic-CT (D-CT), and diabetic-BT (D-BT)]. Diabetic groups (DC, D-GT, D-CT, and D-BT) were induced to have diabetes mellitus by streptozotocin (STZ) injection (45 mg/kg body weight) into the tail vein. Normal groups (NC, N-GT, N-CT, and N-BT) were injected with citrate buffer alone. No significant changes in plasma glucose were shown in normal rats regardless of administration of GT, CT, and BT. Significant decreases in plasma glucose were shown in the diabetic groups, D-GT, D-CT, and D-BT. Plasma cholesterol levels were significantly lower in the D-GT and D-BT groups compared to the DC group. D-CT and D-BT demonstrated decreased ALT activity. In conclusion, Camellia sinensis L. might be effective for the treatment of diabetes by reducing blood glucose, cholesterol, and ALT levels in STZ-induced diabetic male rats.

도서정가제와 인터넷서점 : 오프라인과 온라인의 성공적 제휴,단 하나의 생존전략

한혜경 한국출판연구소 2000 출판 연구 Vol.12 No.1

텔레비전 휴먼 다큐멘터리가 재현하는 의사-환자의 권력관계

한혜경,김주미 한국방송학회 2011 한국방송학회 학술대회 논문집 Vol.2011 No.11

심정적 존재로서의 인간 이해 : 하나님의 사랑의 체험을 중심으로

한혜경 통일사상학회 2020 통일사상연구 Vol.19 No.-

이 논문은 통일사상의 심정적 존재로서의 인간 이해가 가지는 의미를 하나님의 사랑의 체험의 관점에서 설명하고자 했다. 그것은 심정적 존재인 인간이 추구하고 지향하여야 할 하나님의 사랑에 대한 체험이 이루어지는 인간론의 차원들을 분석하 여 설명하고자 한 것이다. 이를 위해서 먼저 인간의 심정과 사랑의 근본이며 주체인 하나님의 심정과 사랑'의 특징 및 그 구조를 정리하여 제시하고자 했다. 이를 통해서 그러한 속성을 닮은 존재로서 하나님의 사랑을 체험할 수 있는 인간 본연의 모습을 사랑의 본성인, 사랑의 욕망인, 사랑의 생활인으로 개념화하여 설명하고자 했다. 사 랑의 본성인은 심정에 의한 사랑을 체험함으로써 인격을 완성하는 본성을 지닌 인 간이다. 사랑의 욕망인은 심정에 의한 사랑의 자극을 통해서 지정의의 욕망을 발휘 하는 인간이다. 사랑의 생활인은 심정에 의한 지정의의 욕구를 통해서 지적활동, 정 적활동, 의적활동을 생활화하는 인간이다. This thesis attempted to explain the human being as a being of Shimjung based on Unification Thought in terms of the experience of God's love. It is intended to analyze and explain the dimensions of the human being that has been accomplished through the experiences of God's love which human beings, who are beings of Shimjung, should seek and pursue. To this end, I first tried to present the characteristics and structure of the Shimjung and love of God, which is the fundamental root of the Shimjung and love of human beings. Through this, this paper explained and conceptualized the nature of human beings who can experience the love of God, as beings that resemble those attributes, as a person who has the nature of love, desires of love, and live a life of love. The person in the nature of love is a person who has the nature of completing a person by experiencing love through the Shimjung. The person who desires love is a person who demonstrates the desire of intelligence, emotion, will through the stimulation of love by the Shimjung. The person who lives a life of love is a person who makes a way of life of intellectual, emotional, and willing activities through the desire of intelligence, emotion, will by the Shimjung.

王ㆍ張ㆍ姚 三家評點을 통해 본 『紅樓夢』의 寓意體系

한혜경 한국중국소설학회 1997 中國小說論叢 Vol.6 No.-

강화지역 남녀 장수노인의 사회적, 신체적 건강상태조사

한혜경,김명화,이성동,최성숙 대한지역사회영양학회 2005 대한지역사회영양학회지 Vol.10 No.1

This study was to performed to assess social factors and physical health status. The subjects of the study were 103 elderly people of age over 85 years living in Ganghwa-gun area. The method of this research was based on the interviewsurvey with questionnaire. Chi-square test was the main data analysis method. The subject group was composed of 36 males and 67 females, the average age being 91.0 ± 3.2 years old for the males and 91.1 ± 3.4 years old for the females. The aged average height and weight were 161.0 ± 7.9 cm and 54.6 ± 7.8 kg in males, 141.0 ± 8.2 cm and 42.2 ± 7.9 kg in females which were lower than the Korean average standard but the mean BMIs of both male and female showed normal range. Their level of education was lower and they tended to be religious. The aged population might be economically poor. Their level of living standards tended to have been lower-middle and lower class. The mean age of their parents’ death were 64.3 ± 17.2 years in males, 59.0 ± 14.9 years in females for the father and 70.9 ± 15.5 years in males, 66.8 ± 16.6 years in females for the mother. The rate of living together with their family or spouse in the female aged was 83.2% higher than in the male aged. They tended to have engaged in hobbies that require less movement. Of the kinds of hobby, “TV watching (47.8% in male and 44.9% in female) was the highest. Ratios of the drinking and the smoking elderly were 30.6%, 25.0% in male and 7.5%, 18.8% in female but they tended to have never drunken and smoked. Of the subjects, 42.9% spend 8~9 hours for sleeping in male and 35.8% spend 10 hours for sleeping in female. They tended to have not done any particular health behavior. The most common diseases were digestive disease in male, arthritis and hypertension in female. Most elderly males (47.3%) and females (61.2%) had 1~2 diseases. (Korean J Community Nutrition 10(1): 111 ~ 121, 2005)