수술로 절제된 간의 국소 결절성 증식의 임상적 특징

황남철,최문석,이준혁,고광철,백승운,유병철,이종철,이광웅,조재원,박철근 대한간학회 2004 Clinical and Molecular Hepatology(대한간학회지) Vol.10 No.2

목적: 간의 국소 결정성 과형성은 일반적으로 특별한 치료가 필요 없는 양성 종양이다. 그러나 드물지만 합병증이 발생한 경우와 진단이 불확실한 경우에는 수술을 시행하게 된다. 이에 저자들은 간절제술을 시행한 국소 결절성 과형성의 임상적, 영상학적 특징들을 알아보고자 하였다. 대상과 방법: 1995년부터 2003년까지 수술을 시행하여 조직을 확인한 국소 결절성 과형성 환자 10명을 대상으로 연령, 성별, 실험실 검사 및 영상 소견과 조직 소견을 분석하였다. 결과: 연령의 중앙값은 37.5세, 남녀 비는 1.5:1이었다. 5예에서는 간세포선종이나 간세포암종을 감별할 수 없어서 수술을 시행하였으며, 수술 후 우연히 진단된 예는 4예이었다. 간세포암종의 위험 인자를 가지고 있었던 예는 4예(B형 간염 바이러스 보유자 3예, 간경변 2예)이었다. CT검사가 시행되었던 6예 중 5예는 동맥기에서 조영 증강을 보였고 문맥기 및 지연기로 감에 따라 주변과 동일(4예)한 또는 감소(2예)되는 양상을 보여 간세포암종과의 감별이 어려웠다. 크기는 3.2±2.2㎝이었으며 위치는 간우엽의 후하구역(S6)에 가장 많았다(30.0%). 4예에서 수술 전 침생검을 시행하였으나 고분화 간세포암종이나 간세포선종과의 감별이 어려웠다. 결론: 임상상, 영상검사 및 간침생검으로도 간세포암종이나 간세포선종과의 감별이 어려운 경우 수술을 시행하였으며 수술 전에는 발견하지 못하였지만 다른 질환으로 인한 수술시 우연히 발견된 경우도 있어 국소 결절성 과형성의 수술 전 진단이 어려운 경우가 적지 않음을 알 수 있었다. Background/Aims: Focal nodular hyperplasia (FNH) is a benign hepatic tumor with few serious complications and no malignant transformation. However, differential diagnosis between FNH and other liver tumors, especially hepatocellular carcinoma, is often difficult. Methods: Clinical features of surgically resected FNH were reviewed. From January, 1995 to February, 2003, 10 patients with surgically resected FNH were enrolled. Their age, sex, results of laboratory examination, imaging studies and pathologic findings were evaluated. Results: Median age was 37.5 years and sex ratio (male:female) was 1.5:1. In 5 cases, resection to exclude hepatic adenoma or HCC was performed. Four cases were diagnosed incidentally after surgery. Four patients had risk factors for HCC, such as hepatitis B virus infection, liver cirrhosis or both. The size of FNH was 3.2 2.2 cm. The most common site of the tumor was segment 6 (30.0%). Differential diagnosis with HCC was difficult in 5 of six cases in whom CT was performed. Although needle biopsies were performed preoperatively in 4 cases, it was difficult to distinguish FNH from hepatic adenoma or HCC. Conclusions: FNH was resected due to uncertainty of diagnosis, or incidentally during hepatectomy in patients with other liver disease. In the former, differential diagnosis with hepatic adenoma or HCC was a major problem despite extensive work-up including dynamic CT or biopsy. (Korean J Hepatol 2004;10:135-141)

전산화단층사진을 이용한 하악골 3차원 영상에서 비대칭진단 계측항목의 재현도에 관한 연구

김고운,김재형,이기헌,황현식 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.5

본 연구는 하악골 3차원 입체영상에서 비대칭계측항목들의 재현도 비교를 통하여 안면비대칭 진단 시 유용한 계측점 설정에 도움이 되고자 시행되었다. 40명의 두경부 전산화단층사진을 이용하여 생성한 3차원 영상에서 하악골 형태를 결정짓는 부위로 하악과두, 하악우각부, 하악정중부를 선택하고 각 부위의 세부위치에 따라, 그리고 측정 시 보는 각도에 따라 구분하여 하악과두의 경우 Cd_(sup_sup) 등 6개, 하악우각부의 경우 Go_(inf_lat) 등 10개, 하악정중부의 경우 Me_(ant), Me_(inf) 등 총 18개의 계측점을 설정한 후 이를 이용하여 하악골 비대칭 시 좌우 차이를 보일 수 있는 25개의 계측항목을 설정 및 계측한 후 조사자간 및 조사자내의 재현도를 비교 평가하였다. 조사자간 재현도의 경우 25개의 계측항목 중 3개를 제외한 모든 계측항목에서, 조사자내 재현도의 경우 2개 항목을 제외한 모든 계측항목에서 높은 재현도를 보였다. 아울러 본 연구에서 설정한 18개의 계측점 중 Go_(mid_lat), Go_(mid_obl)가 포함된 계측항목이 조사자간 및 조사자내 재현도가 떨어지는 경향을 보였다. 이상의 연구 결과 본 연구에서 사용된 18개의 계측점 중 16개의 계측점(과두를 나타내는 Cd_(sup_sup), Cd_(lat_ant), Cd_(lat_lat), Cd_(post_lat), Cd_(post_post), S, 하악우각부를 나타내는 Go_(inf_lat), Go_(inf_inf), Go_(lat_ant),Go_(lat_lat), Go_(post_lat), Go_(post_post), Ag_(lat), Ag_(inf), 하악정중부를 나타내는 Me_(ant), Me_(inf))은 높은 재현도를 보이므로 전산화단층사진을 이용한 하악골 3차원 영상에서 안면비대칭 환자의 진단에 유용하게 사용될 수 있음을 시사하였다. Objective: The purpose of this study was to evaluate the reproducibility of measurements representing asymmetry of the mandible and to identify which landmarks would be more useful in 3-dimensional (3D) CT imaging. Methods: Facial CT images were obtained from forty normal occlusion individuals. Eighteen landmarks were established from the condyle, gonion, and menton areas, and 25 measurements were constructed to represent asymmetry of the mandible; 8 for ramus length, 12 for mandibular body length, 1 for condylar neck length, 2 for frontal ramal inclination, and 2 for lateral ramal inclination. Inter- and intra-examiner reproducibility of the measurements was evaluated. Results: Inter-examiner reproducibility of the measurements proved to be high except for 3 measurements. Intra-examiner reproducibility also proved to be high except for 2 measurements. Interand intra-examiner reproducibility of the measurements including Gonion proved to be low. Conclusions: The results of the present study indicate that the landmarks and measurements constructed in 3D CT images can be used for the diagnosis of facial asymmetry.

합병의 영업성과 개선에 관한 연구 : 외환위기 이후 국내기업을 중심으로

최운열,황재학 서강대학교 경영연구소 2005 서강경영논총 Vol.16 No.2

Production of Transgenic Male Piglet as Research Model for Alzheimer's Disease

Mi-Ryung Park,Kyong-Woon Kim,Jae-Seok Woo,Seongsoo Hwang,In-Sul Hwang1,Tae-Uk Kwak,Ji-Hyun Lim,Se-Pil Park 한국동물생명공학회(구 한국동물번식학회) 2017 발생공학 국제심포지엄 및 학술대회 Vol.2017 No.10

Alzheimer’s disease (AD) is a progressive neurodegenerative disease associated with memory loss and cognitive impairments. An AD transgenic (Tg) pig model would be useful for preclinical testing of therapeutic agents. In this study, we report the use of somatic cell nuclear transfer (SCNT) to produce transgenic pigs over-expressing the human AD related genes (APP, APPswedish, Presenilin 1, and Tau). Transgenic embryos were generated by SCNT of from ear fibroblasts expressing AD genes. A total of 1808 (average 258) SCNT embryos were transferred into 7 recipients. Pregnancy was successfully maintained in one recipient. We obtained 1 cloned male piglet from a surrogate gilts and the weight of piglet was 935 g. But, the male piglet died two days after birth. The piglet expressed AD related genes by PCR and western blot analysis. Transgenes were expressed in multiple tissues, and at especially high levels in brain. AD Tg pig might be very useful for studying the disease and for testing new therapeutics in preclinical studies of human AD.

응급센터에서 기관내 삽관을 시행하지 않은 호흡곤란 환자의 동맥혈 이산화탄소분압과 호기말 이산화탄소분압의 연관성분석

김형국,박승현,오동렬,박규남,이원재,황두영,최승필,이운정,정시경,김세경 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.4

Background: The end-tidal carbon dioxide tension(ETCO₂) is defined as a partial pressure of carbon dioxide at the end of an exhaled breath. The purpose of this study is to determine the correlation between ETCO₂and arterial carbon dioxide tension(PaO₂) in nonintubated patients with respiratory distress in emergency department(ED). Methods: A prospective non-blind study was performed in ED of our university hospitals. Participants included all nonintubated adult patients with respiratory distress requiring arterial blood gas analysis. ETCO₂was measured with a capnography monitor during tidal volume breathing. ETCO₂were recoreded at the time of arterial blood gas sampling. The correlation between ETCO₂and PaCO₂was analyzed in all patients and in subgroups by simple linear regression. Results: Sixty patients were enrolled. In all patients, ETCO₂was 5.72mmHg lower than PaCO₂and correlated well with PaCO₂(r²=0.716). ETCO₂correlated best with PaCO₂in patients who were either acidotic or non-smoking. Conclusion: ETCO₂correlate well with PaCO₂in nonintubated patients with respiratory distress in ED. ETCO₂may be sufficient to reflect PaCO₂in selected patients and obviate the need for repeat arterial blood gas determination.

LC : Usefulness of Ascitic Fluid Lactoferrin Concentration for the Diagnosis of Spontaneous Bacterial Peritonitis

( Jae Jin Hwang ),( Hyun Ju Min ),( Yun Won Jo ),( Jeong Mi Lee ),( Min Jeong Lee ),( Na Young Kim ),( Hong Jun Kim ),( Chang Yoon Ha ),( Hyun Jin Kim ),( Tae Hyo Kim ),( Woon Tae Jung ),( Ok Jae Lee 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background: Spontaneous bacterial peritonitis (SBP) is one of major complications in patients with liver cirrhosis, early diagnosis and treatment of the disease is crucial for reducing mortality. Lactoferrin, an iron-binding protein usually detected in polymorphonuclear neutrophils or exocrine fluid such as breast milk, is known for contributing to the antimicrobial activity of leukocytes to protect our body from enteric bacteria. We aimed to determine the validity of lactoferrin concentration in ascitic fluid for the diagnosis of SBP. Subjects and Methods: We collected ascitic fluid through diagnostic or therapeutic paracentesis from the hospitalized individuals with liver cirrhosis and measured lactoferrin concentration from October, 2008 to March, 2011. A total of 201 specimens from 148 patients were collected for analysis and the concentration of lactoferrin in ascites was calculated by enzyme- linked immunosorbent assay. We compared the concentrations of lactoferrin in ascitic fluid obtained from the cirrhotic patients with and without SBP, and aimed to determine the usefulness of lactoferrin concentration as a diagnostic method for SBP. Results: A total of 53 patients diagnosed with SBP represented higher level of lactoferrin concentration in ascites than the patients without SBP (107.48±40.74 ng/mL vs. 19.97±40.74 ng/ mL, P<0.01). Applying 60 ng/mL of lactoferrin in ascites as a cut-off value for the diagnosis of SBP produced the sensitivity, specificity, positive predictive value and negative predictive value, 90.6%, 75.7%, 57.1% and 95.7%, respectively. Conclusion: The concentration of lactoferrin in ascitic fluid was a rapid and reliable test for the diagnosis of SBP in cirrhotic patients with ascites.

The Simple and Rough Screening Method of Phosphorus Deficient Tolerance Rice

Woon-Ha Hwang,Dae-Wook Kim,Jae-Heok Jeong,Han-Yong Jeong,Hyen-Seok Lee,Kyung-Jin Choi,Gun-Hwi Lee,In-Jung Lee,Sung-Hwan Oh 한국작물학회 2015 Korean journal of crop science Vol.60 No.4

Even though phosphorus (P) is essential element for plant growth and development, it is not enough for crop production in soil. To breed more P deficient tolerance rice, screening and selection in rice population is needed. We tried to develop more simple and rough screening method for breeding of P deficient tolerance rice. In P deficient condition, tiller number was dramatically decreased among yield components in rice. Though this result, we confirmed tiller number could be the best marker in screening of P deficient tolerance rice. 480 rice genetic resources were cultivated in rice bed tray filled with P deficient soil for four weeks and each dry weight was measured. Among them, the 55 kinds of genetic resource were selected then cultivated in paddy field with 3 fertilizer conditions. Plant dry weight and tiller number in ripening stage were shown significant difference according to P condition. Plant dry weight and tiller number in ripening stage was highly correlated especially in P deficient condition. Furthermore, the tiller number in ripening stage and plant dry weight in rough screening were shown high degree correlation. Though these results, we might expect measuring of plant dry weight after cultivation in rice bed tray filled with P deficient soil could be a simple and effective screening method in selection of P deficient tolerance rice.

Genetic relationship among acer species revealed by RAPD and PCR-RFLP

Jae Woo Hwang(黃在禹),Eun Woon Noh(盧銀雲),Jae Soon Lee(李載順),Sook Kyung Park(朴淑京) 한국육종학회 1996 한국육종학회지 Vol.28 No.4

Ten different species of Acer including A. triflorum, A. saccharinum, A. pseudo-sieboldianum, A paimatum var. sanguineum, A. mono, A. ruburm, A. negundo, A. palmatum, A ginnala, and A. tegmentosum were compared with regard to their DNA variation based on RAPD profiles and PCR-RFLP. For RAPD study, only five species(A. triflorum, A. saccharinum, A pseudo-sieboldianum, A. palmatum var. sanguineum, and A. mono) consisting of more than 5 individuals were compared. For PCR-RFLP, 6 species that produced the target bands with the sequence specific primers were considered. Forty four loci were generated by RAPD with 4 arbitrary primers. Similarity between individuals was estimated by calculating the frequency of shared bands out of total bands. Cluster analysis based on the similarity produced two groups. While the first group was exclusively composed of A. pseudo-sieboldianum, the second comprised the remaining 4 species. When the primers specific to the gene sequences rpl2 and psbA in chloroplast DNA were used, A pseudo-sieboldianum again appeared to have different amplification pattern from the rest of Acerspecies examined. Analysis of the amplified psbA-rpl2 region(1.7 kb) by PCR-RFLP revealed that the species in the genus could be readily differentiated from each other by the fragmentation profile. We found that although RAPD worked on Acer species, it costed too much time and labor for the optimization of PCR conditions. On the other hand, the PCR-RFLP technique is very simple and straight forwarded to get reproducible results since it uses very stringent reaction conditions.

건축물내 지하저수조의 수리적 거동과 수질변화 특성 평가

황재운 ( Jae Woon Hwang ),이현동 ( Hyun Dong Lee ),최준향 ( Jun Hyang Choi ),배철호 ( Chul Ho Bae ) 한국물환경학회 2005 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2005 No.-

학교장의 전문성 전환 분석: 규범적 전문성에서 실천적 전문성으로의 전환을 중심으로

황재운(Hwang, Jae Woon) 한국교육행정학회 2022 敎育行政學硏究 Vol.40 No.1

이 연구의 목적은 학교장의 전문성을 규범적 전문성과 실천적 전문성으로 개념화하고, 학교장 승진 임용 시기를 기점으로 전문성 전환이 이루어지는 양상을 탐색하는 데 있다. 이 같은 연구의 목적을 달성하기 위해 연구참여자를 모집해 면담을 통해 자료를 수집하였다. 특히, 이 과정에서 질적 연구방법론의 일종인 프레임워크 분석법을 활용하였고 이론적 분석틀은 Schlossberg의 전환이론에 기초해 연구목적에 부합하도록 재구성하였다. 이 연구의 주요 분석결과는 다음과 같다. 첫째, 학교장 전문성 측면에서 보면 국내에서 학교장이 되었다는 것의 의미는 실천적 전문성보다 규범적 전문성의 성취에 보다 가까운 것으로 현장에서 받아들여졌다. 법령상 규정되어 있는 자격을 확보한 뒤에 획득되는 규범적 전문성이 성공적인 직무수행을 위해 필요한 실천적 전문성보다 상대적으로 부각되어 나타난 것이다. 둘째, 학교장 승진 임용 이후의 실천적 전문성 발달과 관련해 국내 학교장이 보유한 잠재자산은 상황, 자아, 지원, 전략 등의 차원에서 드러났다. 셋째, 학교장은 경력을 쌓으면서 실천적 전문성 증진과 관련된 잠재자산을 점진적으로 강화하는 것으로 관측되었다. 이와 같은 분석결과를 바탕으로 국내 학교장의 전문성 전환과 관련해 다음과 같이 논의를 전개하였다. 첫째, 학교장이 겪는 전문성 전환은 생존형의 양상을 보이고 있다는 면에서 승진 임용을 기준으로 발생하는 전문성 사이의 간극을 줄여줄 수 있는 지원이 요청된다. 둘째, 전문성 전환의 선순환을 구축하는 방안의 일환으로 ‘이질 집단으로서의 학교장’을 인정하고, 개별화된 멘토링 지원을 정교화하는 노력이 필요하다. 셋째, 전문성 전환에서 나타나는 문제의 불식을 도모하려면 실천적 전문성 관련 표준의 마련을 위한 노력이 있어야 하고, 규범적 전문성과의 합일을 지향하는 방향으로 나아가야 한다. The purpose of this study is to shed light on the professionalism of school principals in terms of normative and practical. Also, this study explores the school principal’s transition of professionalism based on the time of promotion. To that end, participants were recruited and data were collected through interviews. For the analysis of the data, this study employs framework analysis. A theoretical framework was constructed based on Schlossberg’s transition theory. The Following are the major findings of this study. First, being a school principal was recognized as achieving normative professionalism rather than practical professionalism. Second, the ‘assets’ related to the development of practical professionalism of the school principal were found to have four factors: ‘Situation’, ‘Self’, ‘Support’, and ‘Strategies’. Third, the 4S system related to the development of practical professionalism of the school principal changed with the accumulation of career. Based on these results, policy suggestions were presented as follows. First, support is required to reduce the gap between professionalism. Second, as part of the plan to establish a virtuous cycle of transition of professionalism, efforts are needed to recognize the “school principal as a heterogeneous group” and support individualized mentoring with persistence. Third, in order to eliminate the problems that arise in the transition of professionalism, practical efforts must be made to prepare standards related to practical professionalism.