서울 서남부지역 노인 인구에서 비만증 유병률과 고지혈증과의 상관성

최경묵,조영직,김경오,김동림,김난희,백세현,안정천,서홍석,오동주,최동섭 대한노인병학회 2000 Annals of geriatric medicine and research Vol.4 No.3

흉쇄관절에 생긴 연쇄상구균 감염 후 반응성 관절염-증례 보고-

안경회,김희상,홍장혁,윤동환 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.6

대장암에서 림프절 전이의 위험인자

홍동민,천봉권,장희경 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Backgroud: Colonic and rectal cancers recently increase in incidence and motality in Korea. Although a variety of therapeutic modality has been applied, the result of therapy for the patients having lymph node metastases is not good. Especially the patient can have lymph node metastases in spite of early colonic and rectal cancer, and high recurrence rate is expected if non-radical therapy without adjuvent modality is applied to these patient in follow-up period. Therefore it is aimed to identify the risk factor affecting lymph node metastasis and to evaluate the possibility of the nodal metastases preoperatively and postoperatively. Methods: This retrospective study of 463 patients having suffered lower anterior resection, Miles operation or colectomy for colonic or rectal adenocarcinoma. Invasiveness, size of the carcinoma, age, vascular invasion, lymphovascular invasion, perineural invasion , sex, and grade of the carcinoma was evaluated as the possible risk factors of lymph node metastases. Results: Resected colonic and rectal adenocarcinoma reveals regional lymph node metastases in 46.3% cases. The nodal metastasis is statistically correlated with increase in tumor stage, tumor grade, and presence of lymphovascular and perineural invasion, and older age (p<0.05). Conclusion: Invasiveness, tumor grade, age, presence of lymphovascular invasion and perineural invasion would be risk factors expecting the regional lymph node metastasis in the colonic and rectal cancers. Therapeutic modality should be determined especially in tumor stage more than T1 because regional lymph node metastasis is expected.

實驗大學에 適用되는 敎養數學의 效率的 運營方案 硏究 : with cmphasis on the Engineering College 理工系大學 中心으로

洪慶和,金東奭 弘益大學校 1978 弘大論叢 Vol.10 No.-

This study intends to establish a new model curriculum that can be effectively applied to the learning of major subjects. Another intention is to improve the direction of learning, the performance of tasts, the evaluation of records, so that students' learning effect of cultural mathematics could be enhanced. it is desired that this study would contribute to making up a new curriculum and to developing new teaching materials.

18개월 여아에서의 아동 학대

홍강의,장경준,문형로,안동현,손세정,박순미 大韓神經精神醫學會 1988 신경정신의학 Vol.27 No.2

A child abuse case of an 18 month-old baby girl with multiple fractures is reported. A comprehensive psychiatric and pediatric diagnostic work-up was carried out, and psychodynamic and family dynamic issues were presented in detail. A therapeutic intervention by pediatric-psychiatric team was attempted, but thwarted by the lack of father's cooperation. It is suggested that child abuse should be considered a major medical social problem in Korea too.

노인인구에서 대사증후군과 인지기능간의 연관성

홍창형,김은아,정해관,이동우,차경렬,이강수,오병훈 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.4

Objective : The purpose of this study is to find out the effect of ApoE genotype in correlation between metabolic syndrome and cognition of the elderly in the community. Methods : A total of 1,305 subjects (440 men and 865 women) aged 60-98 years were analyzed from preliminary data of Gwangju Dementia and MCI Study (GDEMCIS). The metabolic syndrome was assessed as defined by the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history, family history of dementia and stroke, and Korean version-Mini Mental State Examination (K-MMSE). We also examined ApoE genotype and analyzed associated factors with metabolic syndrome. Results : Metabolic syndrome was present in 28.6% of the subjects (13.4% of men and 36.3% of women). On multiple logistic regression analysis, low serum HDL cholesterol was associated with an increased risk for cognitive impairment (K-MMSE score≤17) adjusted by age, sex, educational level, and smoking in the presence of ApoE ε 4 allele (OR 0.95, 95% CI 0.92-0.99). Conclusion : These results suggest that serum HDL cholesterol may affect cognitive function in the elderly in the presence of ApoE ε 4 allele.

인공지반의 조경적 활용에 관한 국내 연구동향 : 옥상녹화를 중심으로

김동찬,서주환,김옥경,승지현,김홍균,최선주,박선영 경희대학교 부설 디자인연구원 2007 예술· 디자인학연구 Vol.10 No.1

This study aims at understanding the trend of researches carried out on the subject of rooftop afforestation. The issue of rooftop afforestation is receiving attention as one of the plans to secure green zones in urban area. While the actual execution of rooftop afforestation in Korea in only in the initial state, thus in not activated, studies on this subject have been actively carried out particularly in terms of the methods of rooftop afforestation. Recently, studies are being actively performed on the creation and effect of rooftop afforestation. However, these studies tend to focus on specific areas. This leads to the necessity to approach the issue of rooftop afforestation with a wider perspective. Therefore, in the study, the previous studies on rooftop afforestation carried out both in and outside the country are categorized as the study on the methods, effect and activation plans of rooftop afforestation, thus are examined to understand the recent trend in the study of rooftop afforestation. The results indicate that domestic studies. which was centered on the methods to promote rooftop afforestation. have been expanding into the study on the methods to establish eco-habit at on rooftop as well as on the environmental and economic effect rooftop afforestation.

Type Ⅳ 과지질혈증에서 나타난 다발성 건 황색종 : 1례 보고 One Case Report

천동욱,김홍태,박봉훈,변영수,홍순만,손경락,문세광 최신의학사 1992 最新醫學 Vol.35 No.10

14세 여환에서 쇄골에 발생한 동맥류성 골 낭종 : 증례보고

김동수,김용민,최의성,손현철,박경진,조병기,홍경호 충북대학교 의과대학 충북대학교 의학연구소 2010 忠北醫大學術誌 Vol.20 No.1

동맥류성 골낭종(aneurysmal bone cyst)은 Jaffe와 Lichtenstein(1942)에 의해 처음 기술된 이래 많은 증례가 보고되었다. 동맥류성 골낭종은 주로 장관 골의 골간단과 척추에서 발생한다. 병인은 정확히 밝혀지지 않았으나, 반응성 현상으로 생각되며, 원발성 또는 다른 병변과 동반될 수 있다. 쇄골 등 기타 골에서 발생하는 경우는 매우 드물다. 저자들은 우측 쇄골에서 동맥류성 골낭종 1예를 경험하여 보고하는 바이다. 14세 여자환자가 우측 견갑부의 우연히 발견된 종괴를 주소로 내원하였다. 환자는 종괴에 대해 이학적 검사 및 혈액 검사상 측이한 소견을 보이지 않았다. 방사선 검사상, 쇄골 내측부에 골 용해성으로 팽윤된 병변이 관찰되었고, 동맥류성 골낭종, 단순 골낭종, 전이성 골종양 등의 의증 하에 절제술을 시행하였다. 절제된 종괴의 육안 소견상, 얇은피질 골로 쌓여 있으며, 노란색 액체로 차있는 4x5cm 종괴가 관찰되었고, 완전 절제술을 시행하였다. 광학현미경상, 혈액으로 차있는 다양한 크기의 낭성 구조가 보였고, 여러 개의 거대세포가 격막을 이루고 있었다. 조직학적 소견과 MRI소견, 임상 소견을 종합하였을 때, 쇄골에서 원발성으로 발생한 동맥류성 골낭종을 진단할 수 있었다. Many cases of aneurysmal bone cyst(ABC) have been reported since Jaffe and Lichtenstein(1942) first reported. Aneurysmal bone cyst mostly occurs in metaphysis of the long bones and vertebral column. The reason for this disease has not be clearly explained yet, but it is estimated as reactive change and can be accompanied with primary lesion or another lesion. It rarely occurs in clavicle or other bones. We report one case of ABC in right clavicle. 14-year-old female patient who accidentally found palpable mass on right shoulder visited hospital. We did not find any specifics regarding this patient's mass after physical exam and blood test. Radiologic exam showed a large expansile mass with osteolytic lesion, The differential diagnosis includes ABC, simple bone cyst, metastatic bone tumor, etc. Based on visual observation on excised 4×5 cm mass, it was covered by thin cortical bone and filled with yellow fluid, and complete excision was done. On histological examination, the mass consist of various size of cystic structures. and several giant cells comprised septae. Based on histological examination, MRI, clinical examination, we made a diagnosis that it was primary anuerysmal bone cyst in clavicle

정신분열병과 Neuregulin 1 유전자의 연합연구

박동연,이유상,조은영,조승희,장용이,전현옥,장수연,윤세창,김종원,홍경수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.3

Objectives : The authors recently found a suggestive evidence of linkage of chromosome 8p21-12 to schizophrenia in Korean multiplex families. Neuregutin 1 (NRGI) was identified in this locus as a positional and functional candidate gene for Schizo-phrenia, through several independent studies with European and Chinese populations. The purpose of this study is to determine whether NRGl is associated with schizophrenia in Korean population. Methods : Three SNPs (SNP8NRG221533, SNP8NRG241930, SNP8NRG243177) and two microsatellites markers (478B14-848,420M9-1395) located at the 5' end of NRGI were genotyped for 242 unrelated schizophrenia patients and the same num-ber of normal controls. Genetic association was tested by χ²-test (df=1). Not only for the whole patients group but also for asubgroup of patients with auditory hallucination. This subtype showed stronger linkage with chromosome 8p12 in the prior study of the authors with multiplex families. Results : G allele of SNP8NRG241930 was significantly in excess in the subgroup of patients with auditory hallucination compared to the control group (p=0.03, 0R=1.76). We also found that 3 SNPs haplotype TTC (p=0.04, 0R=0.58) and five markers haplotype TTC53 (p=0.01,0R=0.49) were associated with schziophrenia with a protective effect. Three SNPs haplotype CGT which is a part of the at-risk haplotype of the Icelandic schizophrenia families was found in excess in the patients group but no significant association was observed. Conclusion : NRGI might either play a mle in the predisposition to schizophrenia or be in linkage disequilibrium with a causal locus of this illness.