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지속적인 직류 자장이 백서의 임의형 피판생존에 미치는 영향에 關한 硏究
백세민,유영준,한흥수,오갑성 大韓成形外科學會 1994 Archives of Plastic Surgery Vol.21 No.3
The present study was undertaken to determine if direct current(DC) electirical fields could improve survival rate of random pattern skin flap in the rat. 20 Sparque- Dawley rats were divided into two groups and caudally based 2cm width and 8cm length random pattern flaps were elevated in all rats. Electrical fields of 9mA were introduced by 1.5V disk button battery. Electrical field was applied for 5days to the stimulation group(B). DC electrical fields shows the enhancement of flap survival by increasing the rate to 33.5%(p<0.01). The enhancement of skin flap survival by application of direct current electrical field has possibility for cover the large skin defect.
신유식,이윤환,서종수,전영흥,정효민,정한식 경상대학교 해양산업연구소 2002 해양산업연구소보 Vol.15 No.-
The purpose of this research is to obtain the characteristics of heat transfer or heat exchange under the vacuum pressure. The general heat transfer or heat exchange can be changed with the experimental environment. In this report, the exothermic calorie and endothermic calorie were measured under the vacuum chamber. These two kinds of calories show the evaporative and condensing sides, respectively, and these calories were measured by using the parameter with flow rate.
폴리에스테르 섬유 감량시스템용 프로세서 타이트레이터 개발
조진호,이흥락,이종현,김명남,구성모,김무영,진경찬,유병희,강민수,김국진 경북대학교 센서기술연구소 1993 연차보고서 Vol.1993 No.-
폴리에스테르 섬유 감량시스템의 제어를 위해서는 처리조 내에서 감량되는 섬유가 목표 감량치에 도달했는지를 판단해 주는 장치가 필요하다. 본 연구에서는 가성소다용액의 초농도 및 섬유 감량 정도의 정확한 측정과 감량 종료시간의 산출 및 이에 따른 종료신호를 발생할 수 있는 폴리에스테르 섬유 감량기 전용의 자동적정장치를 개발하였다. To control caustic soda treatment system for the polyester fabric reduction, we need the device to determine that the fabric has been arrived target reduction value. In this study, we develope an automatic process titrator for the caustic soda treatment system. Major functions of the target titrating system are accurate measurements of the caustic soda concentration and then producing the end point signal for caustic soda treatment system.
조진원,송진영,김창억,민영훈,최창순,우흥정,현인규,김종현,유기철,채승완,손진희 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.1
The Actinomyces species are normal flora of oral cavity and upper intestine characterized as gram-positive, non-spore-forming anaerobic or mjcroaerophilic rods. Actinomycosis is a chronic suppurative and granulomatous disease characterized by abscess, sinus, abundant granulation and mass. The appendix is the commonly involved site among abdominal actinomycosis. Abdominal actinomycosis is often difficult to diagnose before operation because of no reliable clinical features and infrequency of the disease. We report two cases of abdominal actinomycosis which were manifested as acute appendicitis. Those were detected Incidentally tv the pathologist after routine appendectomy. Both patients were successfully treated with appendectomy followed by proper antibiotics use.
갑상선 세포에서 전사보조활성인자인 CBP와 CIITA는 인터페론-감마 활성 부위에 대하여 서로 다른 조절 작용을 나타낸다
유순희,김현진,김도희,김영건,송민호,노흥규,박수정,김호,박은신,채수흥,권오유,한희정 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.3
Background: In the previous studies, we identified that the interferon-γ activated sequence (GAS) in the 5-flanking region of rat ICAM-1 gene is major element for interferon-y-inducible expression of the gene in rat thyroid cells, FRTL-5. We here, investigated the role of transcriptional coactivators, CBP (CREB binding protein) and CIITA (class II transactivator) in the modulation of the activity of GAS which could interacts with signal transducers and activators of transcription-1 and 3 (STAT1 and STAT3). Methods: The expression of CBP RNA and protein were quantitated in FRTL-5 after stimulation with interferon-y (IFN-γ), thyroid stimulating hormone (TSH), forskolin and methimazole. Direct association of CBP with STAT were analyzed by irnmunoprecipitation. The transcriptional roles of CBP and CIITA in the regulation of GAS were assessed by the cotransfection with their expression vectors with reporters; 5-deletion constructs of rat ICAM-1 promoter or 8xGAS-luc constructs, into FRTL-5 thyroid cells. Results: The level of CBP RNA and protein were not changed by the treatment with TSH, IFN-y, forskolin and methimazole in FRTL-5, FRT and BRL liver cells. The CBP could be directly associated with STAT1. Furthernmore, the overexpression of CBP significantly increases the both promoter activities; rat ICAM-1 gene promoter which has GAS element and 8xGAS-luc cassette constructs. However the cotransfection of CI1TA decreased the constitutive and CBP-mediated transactivation of rat ICAM-1 promoter and SxGAS-luc cassette constructs. Conclusion: We identified that the two transcriptional coactivators; CBP and CIITA has differential roles in the regulation of transcriptional activity of GAS drived promoter. CBP increases the GAS activity through the direct binding with STATl, but CIITA inhibited the CBP-mediated transactivation of GAS activity (J Kor Soc Endocrinol 14:493-504, 1999).
Park, Heung-Woo,Lee, Jong-Eun,Kim, Se-Hoon,Kim, Yoon-Keun,Min, Kyung-Up,Kim, You-Young,Cho, Sang-Heon Elsevier 2009 Respiratory medicine Vol.103 No.2
<P><B>Summary</B></P><P><B>Background</B></P><P>Previous investigations have suggested that genetic variations are associated with reduced lung function in early childhood. This study was conducted to evaluate the association between IL13+2044G→A, the functionally relevant single nucleotide polymorphism (SNP) in the gene coding IL13, and lung function in early childhood.</P><P><B>Patients and methods</B></P><P>A total of 1900 subjects aged 10–18years living in Korea, were randomly recruited. Lung function test and methacholine bronchial provocation test were performed. Multiple regression analysis adjusting for sex, age, height, atopy, and history of passive smoking was done to evaluate effect of IL13+2044G→A on lung function.</P><P><B>Results</B></P><P>Mean (±SD) forced expiratory volume in 1s (FEV<SUB>1</SUB>) was 2.66L (±0.60) in subjects with the AA or AG genotype (<I>n</I>=982) and 2.75L (±0.57) in subjects with the GG genotype (<I>n</I>=918). IL13+2044G→A showed a significant association with FEV<SUB>1</SUB> [in the minor allele dominant model (GG <I>vs</I>. AG+AA), <I>P</I><0.001]. Interestingly, the association between FEV<SUB>1</SUB> and IL13+2044G→A remained still significant in subgroup analysis according to the presence of AHR (<I>P</I><0.001 in subjects without AHR and <I>P</I>=0.002 in subjects with AHR). Moreover, FEV<SUB>1</SUB>/FVC (forced vital capacity) ratio also showed a significant association with IL13+2044G→A in both groups (<I>P</I><0.001 in subjects without AHR and <I>P</I><0.001 in subjects with AHR). This cross-sectional study demonstrates that IL13+2044G→A is significantly associated with a reduced lung function in Korean children and adolescents.</P>
3차 의료기관을 방문한 천식 환자에서 아토피 유병률의 변화
박흥우(Heung Woo Park),김상헌(Sang Heon Kim),김상훈(Sang Hoon Kim),장윤혜(Yoon Hae Chang),정희(Hee Chung),이병재(Byung Jae Lee),김윤근(Yoon Keun Kim),조상헌(Sang Heon Cho),민경업(Kyung Up Min),김유영(You Young Kim) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.1
N/A Background: The prevalence of atopy and atopy-related disease has been known to increase during the past decade. Objective : This study was desinged to evaluate the changes of atopy prevalence among asthmatic patients and the causative allergens. Method : A total of 698 asthmatic patients visiting Seoul National University Hospital in 1983, 1990 and 1997 was recruited. Skin prick test with common inhalant allergens was carried out and interpreted as positive when the mean wheal size formed by allergen was larger than 3 mm. Atopy was defined when skin reaction to one or more allegens was positive. Result. The prevalence of atopy among asthmatic patients was 54% in 1983, 48.8% in 1990 and 58% in 1997, respectively. The prevalence of atopy decreased as the age of patients in- creased. Recently, old asthmatic patients ( >55 years) showed a higher tendency to visit the tertiary referral hospital. When the data were analyzed according to age, the prevalence of atopy significantly increased among asthmatic patients aged 15-35 years, in whom the prevalence was 60.4% in 1988 and 81.3% in 1997 (p< 0.05). The positive rate of skin test to Dermatophagoides pteronyssinus, cat fur, mugwort, ragweed, and grass pollen were significantly higher in 1997 than in 1983 (p < 0.05). Conclusion : The prevalence of atopy among asthmatic patients aged 15-85 years showed significant increase in 1997 compared to 1983. The changes of skin response to Dermatophagoides pteronyssinus, cat fur, mugwort, ragweed, and grass pollen contributed to the increase of atopy.
Park, Heung-Woo,Lee, Jong-Eun,Shin, Eun-Soon,Lee, Jae-Young,Bahn, Joon-Woo,Oh, Heung-Bum,Oh, Sun-Young,Cho, Sang-Heon,Moon, Hee-Bum,Min, Kyung-Up,Elias, Jack A.,Kim, You-Young,Kim, Yoon-Keun Elsevier 2006 The journal of allergy and clinical immunology Vol.117 No.4
<P><B>Background</B></P><P>Vascular endothelial growth factor (VEGF) has been suggested to be a key mediator in the development of atopy and T<SUB>H</SUB>2 inflammation.</P><P><B>Objective</B></P><P>We sought to evaluate the effects of variations in the gene coding VEGF receptor (VEGFR) 2 on intermediate phenotypes of asthma in the Korean population.</P><P><B>Methods</B></P><P>A cohort of 2055 children and adolescents responded to a questionnaire concerning asthma symptoms and risk factors and underwent methacholine bronchial challenge and skin tests. The <I>VEGFR2</I> gene, including the promoter area, was sequenced on 24 healthy subjects to discover informative single nucleotide polymorphisms (SNPs; minor allele frequency >2%). After haplotype reconstruction, 4 tagging SNPs (IVS6+54A>G, +889G>A, +1416T>A, and IVS25-92G>A) were scored. These SNPs were also scored in 480 adult asthmatic patients to verify the above genetic association study.</P><P><B>Results</B></P><P>The prevalence of atopy was associated with a single SNP (+889G>A) of VEGFR2 with borderline significance (<I>P</I> = .048; relative risk, 1.13; 95% CI, 1.00-1.28). However, haplotype analysis showed that the atopy prevalence was strongly associated with a haplotype (AGAG) of VEGFR2 (<I>P</I> = .002; relative risk, 1.25; 95% CI, 1.09-1.42). As for airway hyperresponsiveness, neither individual SNPs nor haplotypes were found to be associated. Interestingly, the significant association was also found between atopy and the AGAG haplotype among adult asthmatic patients (<I>P</I> = .008; odds ratio, 1.66; 95% CI, 1.14-2.44).</P><P><B>Conclusions</B></P><P>The present study demonstrated that genetic variations of VEGFR2 are significantly associated with atopy in the Korean population.</P>