커뮤니티공간으로서의 어린이공원 조성에 관한 연구

김연금,김성주,박환지,유다희,최성용,홍승모,Kim, Yun-Geum,Kim, Seong-Joo,Park, Hwan-Ji,Yu, Da-Hee,Choi, Sung-Young,Hong, Seung-Mo 한국조경학회 2008 韓國造景學會誌 Vol.35 No.6

This study deals with the participatory design process of renovating a children's park. The process should proceed with two major elements. Firstly, the children's park should be designed from the perspective of children. Secondly, it should be designed in consideration of the context of the community. This study is divided into two parts. First is the review of theory concerning the meaning and roles of the children's park as a community space, the importance of children's participation in the design and the participatory method of the children. The second is the case study. The site for the case study is Ssial Park in Nowon-Gu, Seoul. The entire process of the case study is with community participation, from identifying the park's problems to the actual construction. At every step, through the participatory programs, the community participates in the decision making. In addition, mutual understanding among participants is pursued through diverse means of communication. The following results of the case study were found. Firstly, diverse participatory programs and the active trial to enable the community to communicate contribute to the sense of ownership and responsibility concerning the park Secondly, the community can negotiate the differences in opinions without needing the help of experts. Of course, there are limits in the case study, such as the fact that the community organization, which is the core of communication and maintenance concerning the park, is not organized through the process of a case study. Another is that more diverse methods, which inform all community members of the participatory process, should have been used.

균류 분화과정의 유전적 조절기작

박범찬,이환희,박윤희,박희문 충남대학교 생물공학연구소 2003 생물공학연구지 Vol.9 No.1

Fungi are well suited for studying mechanism controlling development and cell differentiation in multicellular eukaryotes. The asexual and sexual reproductive cycles are tightly coordinated during the life cycle of Aspergillus nidulans. The asexual (mitotic) reproductive cycle involves the formation of a number of differentiated cell types. Successful formation of multicellular reproductive structures and spores (conidia) requires the establishment of spatiotemporal gradients in essential transcriptional regulators, such as brlA, abaA and wetA. Altered gene expression is coordinated with critical changes in the movement of nuclei and the regulation of the cell division cycle. Therefore, it has been proposed to define a central regulatory pathway. Several early regulatory genes involved in signal transduction pathway controlling asexual sporulation are also required for activating the central pathway. Sexual (meiotic) reproduction is more complex, requiring the differentiation of several specialized tissue types. Although technical difficulties have limited efforts to study the genetics of sexual fruiting-body formation directly, some recent progress has been made. With the recent availability of mutants blocked in sexual development, understanding the genetic interactions between genes that function primarily in determining sexual sporulation will be achieved in the near future.

프리미돈의 한국인에서의 생체이용율시험

권광일,윤민혁,윤희열,박희찬,권준택,심희옥,김동출 충남대학교 약학대학 의약품개발연구소 2004 藥學論文集 Vol.19 No.-

A reversed phase HPLC method was developed and validated for the determination of primidone in human plasma. Propylthiouracil was used as an internal standard. Calibration curves were linear in the concentration range of 10-120 ng/㎖. The coefficient of variation of the intra- and inter-day precision were below 15%. The coefficient of variation of the accuracy were below 15% in the concentration range investigated. A bioavailability study was performed using the validated HPLC method. Twenty four healthy human male volunteers were orally administered 20 mg of primidone. The pharmacokinetic parameters were calculated using WinNonlin. The mean values of AUC_(LAST) was 85.0±17.7 ㎍ hr/㎖, C_(max) was 4.22±1.04 ㎍/㎖, T_(max) was 1.85±1.13 hr, t_(1/2) was 17.7±2.4 hr. The pharmacokinetic parameters and the HPLC method can be used for the desigm of bioequivalence study of primidone.

Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity.

Chung, Ji-Yun,Park, Hee Ra,Lee, Su-Jin,Lee, Sun-Hye,Kim, Jin Sik,Jung, Youn-Sang,Hwang, Sang Hyun,Ha, Nam-Chul,Seol, Won-Gi,Lee, Jaewon,Park, Bum-Joon United States and Canadian Academy of Pathology [e 2013 Laboratory investigation Vol.93 No.6

<P>Parkinson's disease (PD) is the second leading neurodegenerative disease, and is known to be induced by environmental factors or genetic mutations. Among the verified genetic mutations of PD, Parkin, isolated from the PARK2 locus, shows an autosomal recessive inheritance pattern and is known to be an E3 ligase. However, the physiological target of Parkin and the molecular mechanism of Parkin-deficiency-induced PD have not been clearly demonstrated until now. It has recently been proposed that inflammation, suggesting as a causal factor for PD, is enhanced by Parkin deficiency. Thus, we examined the relationship between inflammation-related factors and Parkin. Here, we provide the evidence that Parkin suppresses inflammation and cytokine-induced cell death by promoting the proteasomal degradation of TRAF2/6 (TNF-α receptor-associated factor 2/6). Overexpression of Parkin can reduce the half-lives of TRAF2 and TRAF6, whereas si-Parkin can extend them. However, mutant Parkins did not alter the expression of TRAF2/6. Thus, loss of Parkin enhances sensitivity to TNF-α- or IL-1β-induced JNK activation and NF-κB activation. Indeed, si-Parkin-induced apoptosis is suppressed by the knockdown of TRAF6 or TRAF2. We also observed elevated expression levels of TRAF6 and a reduction of IκB in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mouse model. Moreover, elevated expression levels or aggregation of TRAF6 were detected in approximately half of the human PD tissues (7/15 cases) and 2 cases, respectively. In addition, TRAF6 and Parkin expression levels show a reverse relationship in human PD tissues. Our results strongly suggest that the reduction of Parkin or overexpression of TRAF2/6 by chronic inflammation would be the reason for occurrence of PD.</P>

편측 협응훈련에 의한 운동신경망의 재조직 및 교차훈련의 효과

박지원,김종만,서정환,김연희 한국전문물리치료학회 2002 한국전문물리치료학회지 Vol.9 No.3

We report the reorganization of motor network resulted from intensive unilateral coordination training and the effect of cross education on the untrained side in patient with traumatic brain injury using functional magnetic resonance imaging (fMRI). A 22 year-old male patient who had suffered from diffuse axonal injury for 58 months showed coordination deficit in the left hand at initial examination. Intensive motor training including complex finger movements and coordination activities using a metronome was introduced to the patient 4 hours per day for a week. FMRI was performed on a 3T ISOL Forte scanner. All functional images were analyzed using SPM-99 software. Hand function was improved after training not only in the trained lefr hand, but also in the untrained right hand. There was no activation in the right primary motor area (M1) during left hand movement before training whereas robust activation of left M1 was demonstrated by the right hand movement. Profuse activation of bilateral prefrontal lobes was seen during both hand movements before training. After training of left hand, right M1 became prominently activated during the left hand motion. The activation of bilateral prefrontal lobes disappeared after training not only for the left hand movement but also for the right, which clearly demonstrated the effect of cross education. This case report demonstrated the learning-dependent reorganization of the M1 and the effect of cross education.

노인요양시설 운영방안에 관한 연구

박연희 원광대학교 2005 論文集 Vol.35 No.-

노인은 장기적인 진료가 필요하며 노인보건문제의 해결방법은 건강증진, 치료, 재활 등 다양한 수준에서의 돌봄의 기능이 포함되어야 한다. 이러한 다양한 수준에서 노인을 돌보는 대표적인 곳으로 노인요양시설이 있다. 현대 사회는 노인부양이 더 이상 가족의 부양기능만으로는 해결되기 어려운 문제가 되고 있다. 그러므로 노인의 건강상태가 수발 및 간호 또는 전문적인 의료서비스를 지속적으로 필요로 하게 되는 시점에서 요양서비스의 제공과 보호를 위한 시설보호 서비스의 제공이 필요하다. 노인시설의 필요성과 수요가 증가하고 있는 이 시점에서 노인시설이라는 공동체는 노인 부양의 공간으로서 역할을 할 것이며 노인복지 시설은 서비스를 효과적으로 제공하여 입소노인의 생활만족도를 높이는데 노력해야 한다. 노령화 사회에 적응하기 위해서 운영되고 있는 노인요양 시설의 운영과정에서 고려해야 할 주요 내용은 다음과 같다. 첫째, 대부분의 노인들은 평소 단독주택에서 살기를 선호하는 특성을 보이기 때문에 집단형 중심에서 단독형 중심으로 시설을 운영하는 것이 필요하다. 즉, 유료시설의 개발을 정책적으로 적극 추진하되, 시설 내 각 세대별로 노인에게 단독적으로 소유권을 인정하는 방안을 고려해야 한다. 둘째, 노인들의 사회활동 참여 욕구를 충족시키고 여가를 보람있게 하기 위해 노인시설에 여가시설을 설치·운영하는 것이 필요하며, 건강·복지상담, 취업안내, 건강보험, 연근 등 각종 유용한 정보를 적극적으로 제공하여야 한다. 셋째, 노인요양시설의 수가 종류별로 절대적으로 부족하다는 점을 고려하여 다양한 형태의 시설이 제공되어야 한다. 그동안 비영리 사회복지법인에 의하여 운영되어 왔지만 향후 민간기업체 및 개인이 참여할 수 있도록 관련 법규개정이 고려되어야 할 것이다. 넷째, 향후 노령화 상회를 대비하여 관련시설 전문인력 배출을 고려해야 한다. 노인요양시설 담당인력은 노인전문 인력으로 노인과 관련된 제반의 지식과 보건의료에 대한 기본 지식을 갖추어야 할 것이다. 다섯째, 노인이 되면 누구나 질병에 걸려 있거나 심신기능이 저하하게 되는 데에서 오는 건강 취약성을 스스로 갖게 마련이다. 따라서 이런 점을 고려하여 요양시설은 지역병원과 연계하는 방안을 고려해야 할 것이다.

반복적 경두부 자기자극이 운동학습과 뇌 운동영역 활성화에 미치는 영향 : 예비연구

박지원,김종만,김연희 한국전문물리치료학회 2003 한국전문물리치료학회지 Vol.10 No.3

數種의 腐熟劑 添加가 볏짚의 堆肥化에 미치는 影響

尹奉基,金炳浩,金喜權,朴仁珍 목포대학교 자연자원개발연구소 2000 자연자원연구 Vol.3 No.-

This study was conducted to find out effect of microorganisms added for decomposition of organic matter when manufacturing compost. The microorganisms used were EM, LACTO, SEMIP, BAIMUD circulated in market and 068065 developed in Institute of Agricultural Sciences. Effect of microorganisms inoulation on rice straw was summarized as follows: The number of bacteria, actinomycetes and fungi was 28.7∼76.7(×106), 0∼72.0(×106) and 0∼198.7(×105)cfu/g respectively. The number of bacteria, actinomycetes and fungi between microorganisms was no different. The maximum temperature during composting periods was reached 69∼76℃- at 3 50 5 days after heaping and kept over 65℃ for 7 to 10 days. The number of bacteria, actinomycetes and fungi in compost manufactured with rice straw was 42.8∼206.0(×106), 11.3∼54.7(×106), and 9.8∼42.5(×105)cfu/g respectively. The tendency was similar to control. Degree of decomposition of plot added microorganisms except 068065 and BAIMUD was similar to control at 50 days after heaping. The contents of inorganic elements were 1.26∼1.35% T-N, 1.14∼1.38% P2O5, 0.72∼0.97% K2O, 1.01∼1.74 CaO and 0.63∼1.44% MgO. Contents of T-N, P2O5 , CaO, MgO in compost were increased, but content of K2O was decreased, It was no different between treatments.

간호학생의 중환자실 임상실습 체험 연구

박경숙,황윤영,최은희 성인간호학회 2003 성인간호학회지 Vol.15 No.3

Purpose: The purpose of this study is to investigate the perception of nursing students' on-side clinical experience at intensive care unit(ICU), which will help on developing fundamental tool to enhance the effect of their clinical practice. Method: Van Manens hermeneutic-phenomenological method has been used to analyze the data. participants consisted of 74 third-year nursing students who performed the clinical practice at an ICU in C university hospital. The students got the group interviews and contents of the students clinical diaries. Result: Major concerns related to students clinical practice were found as follows : 「being nervous about unfamiliar machines and situations」,「being frustrated about the patients」,「being stupefied from witnessing a death」,「realizing the importance of health」,「realizing individual patient's precious value through family's love」,「realizing the importance of treating a patient as humanbeing」,「realizing the differences between theory and practice」,「modelizing two aspects of nursing: professional and personal」,「readiness to become a capable nurse」. Conclusion: We are able to obtain in-depth understandings about the nursing students lived experience of clinical practice at the ICU. Based upon this, there is a need to develop a better nursing intervention enhance the effectiveness of the nursing students clinical practice.

용액 중합에 의한 전도성 Poly(amide)/Polypyrrole 복합체의 제조와 그 전기적 성질

박연흠,안찬호,한명희 成均館大學校 科學技術硏究所 1993 論文集 Vol.44 No.1

Poly(amide)/Polypyrrole composite films were prepared by solution ploymerization method. The films obtained by this method exhibited high conductivities. After polymerization of pyrrole for 1 hr, composite films showed the conductivity as high as 10^-3∼10^-2 S/cm and it increased with increasing the concentration of oxidizing agent. The stability of conductivity to ambient air exposure was excellent. As the result of the thermal characterization of composite films by TGA, we found that the composite film was thermally stable.