장벽경색이 선행한 Henoch-Schonlein 자반증 1례

한헌석,하태선,송형근,이상전,안묘순,박범수 충북대학교 의과대학 충북대학교 의학연구소 1993 忠北醫大學術誌 Vol.3 No.1

Henoch-Schonlein 자반증은 피부, 위장관, 관절, 신장 등을 주로 침범하며 소혈관염을 기본 병리 소견으로하는 전신성 혈관 장애 질환이다. 위장관계 증상으로는 복통, 오심 및 구토, 잠혈, 토혈, 흑색변 등이 있을 수 있고, 이러한 증상은 합병증 없이 회복되는 것이 보통이나 드물게는 장중첩증, 장벽경색 및 괴사, 장천공 등의 심한 합병증을 동반할 수도 있다. 이러한 위장관계 증상들은 특징적인 피부 소견에 선행하여 나타날 수도 있으며, 이때는 급성복증에 대한 감별진단이 중요하다. 저자들은 장벽경색이 선행하여 감별진단에 어려움을 겪고 시험적개복술을 시행한 이후에 특징적인 피부 자반이 발현되어 Henoch-Schonlein 자반증으로 진단할 수 있었던 증례를 경험하였기에 이를 보고하고자 한다. 본 증례는 입원 1일전부터 시작된 복통을 주소로 입원한 5세 남아가 배꼽 주위에 심한 경련성 복통을 지속적으로 호소하였고 이학적 소견상 배꼽주위의 압통, 장음의 감소, 흑색변 등이 있었으며 소장조영술상 공장 부위에 미만성의 불규칙한 점막비후 소견을 보여 제 8병일에 시험적개복술을 시행한 결과 근위 공장에 국한된 장괴사의 소견이 발견되어 절제 및 문합술을 실시 하였다. 병리학적 검사에서는 장벽경색의 소견을 보였다. 수술후에 복통은 완화되었으나 경미하게 지속되었고, 제 13병일경에 급성 부고환염이 병발되었다가 회복되었고 제 15병일경에는 하지에서부터 발현된 자반이 3일간 지속되었다. 결구 Henoch-Schonlein 자반증과 이의 합병증으로 발생한 근위 공장의 장벽경색으로 진단하였다. Colicky abdominal pain as symptom of Henoch-Schonlein purpura occurs in up to 70% of patients, and results from submucosal edema and hemorrhage. Abdominal pain and other GI symptoms such as nausea, vomiting, melena and hematemesis resolve mostly without any complications. But rarely life-threatening GI complications such as intussusception, intestinal mural infarction and necrosis, and massive hemorrhage may develope. In 14% of patients, abdominal pain may precede other symptoms, and creats diagnostic difficulties. We reports a case of the Henoch-Schonlein purpura presented with colicky abdominal pain which resulted from intestinal mural infarction and preceded characteristic purpuric skin lesion by several weeks. This 5 year old male patient complained of colicky abdominal pain, nausea and melena. Exploratory laparatomy was done and revealed intestinal mural infarction in proximal jejunum. One week later operation, purpuric skin lesion develiped in both leg and feet, and then, Henoch-Schonlein purpura was diagnosed.

高溫疲勞에서 싸이클依存型 및 時間依存型 疲勞크랙傳播의 遷移 : 싸인應力波 및 사디리꼴應力波에 대하여

成洛元,周原植,韓根祚 東亞大學校 大學院 1984 大學院論文集 Vol.8 No.2

A study on the nonlinear fracture mechanics was made on the low-cycle fatigue crack growth in SUS304 stainless steel under trapezoidal and sine stress wave at 650℃. The high temperature low cycle fatique crack growth behavior was classified into two categories: cycle-dependent and time dependent. The cycle-dependent crack growth rate correlated well with J integral range ?J, whereas the time dependent crack growth rate was characterized by modified J integral Jex. A parameter βwas found useful in predicting the transition from the cycle-dependent crack growth to the time-dependent crack growth. Conducting the experiment of high temperature fatigue crack propagation in trapezoidal, and sine stress wave, following conclusions were obtained. 1. Crack propagation behavior can be classified into cycle-dependent and time-dependent. 2. The transition of cycle-dependent crack propagation to time dependent one could be predicted bt either parameter βor ?J/ ?J?.

「생산적 복지」 정책과 공공고용서비스의 역할 변화

한상근 한국직업능력개발원 2002 직업능력개발연구 Vol.5 No.1

Scholars had discussed workfare policies and public employment service(PES) separately. But workfare policies and public employment service are interdependent. This study analyzed the level and contents of PES that workfare policies demand. Especially, this study focused that the functions of PES historically operate differently according to environmental changes. The early years central activities of PES were job broking and the management of unemployment benefits. Since the middle of the 20th century, labor market information and labor market adjustment program have taken important position. In Korea since departure of Kim Dae-lung Administration workfare policies were declared as nation's central policies. In relation to this point we discussed the following subjects: the precondition of workfare policies, necessity of integrate approach, decentralization, partnership of private and public sector, expansion of labor market information system investment magnification of PES.

대구, 경북지역 대학생의 식사행동 및 일본음식에 대한 인상 및 기호도 조사 연구

한재숙,이연정,최석현,최수근,권상용,최영희 동아시아식생활학회 2004 동아시아식생활학회지 Vol.14 No.1

본 연구는 대구, 경북지역의 대학생(570명)을 대상으로 식사내용, 식사관습, 식사예절, 일본음식에 대한 인상과 시식경험 및 기호도를 조사한 것으로 그 분석결과를 요약하면 다음과 같다. 1. 음식은 항상 일인분씩 담는다’의 경우는 전체응답자의 15.5%에 불과하였고, ‘음식을 큰 접시에 모아서 담는다’의 경우는 ‘가끔 한다’가 44.8%, ‘항상 한다’가 35.8%로 나타나 큰 접시에 모아서 담는 가정이 많았다. ‘저녁은 가끔 가족이 함께 모여서 먹는다’가 59.9%로 가장 많았고, ‘항상 가족이 모여 같은 음식을 먹는다’는 끼니는 아침이 42.3%, 저녁이 23.3%, 점심이 3%로 나타나 아침에 가족이 모여 같은 음식을 먹는 경우가 가장 많았다. 2. ‘식사시 가족의 자리가 정해져 있다’고 한 경우는 전체응답자의 53.5%였고, ‘가족이 모여 식사할 경우, 연장자가 수저를 들기 전에는 먹지 않는다’는 전체의 56.4%였으며, ‘가장에게는 음식의 양이나 수가 많다’는 30.9%였다. 3. 식사예절에 대해 가장 자주 주의를 받는 것은 ‘TV를 보지 않고 먹기’(13.4%), 남기지 않고 먹기(11.5%), ‘수저사용법’(8.0%)의 순으로 나타났다. 반면 ‘식기 부딪히는 소리’(76.9%), ‘입 다물고 먹기’(76.6%), ‘씹는 소리’(74.6%), ‘밥 먹는 모양’(71.4%), ‘수저 사용법’(69.7%)등은 전체응답자의 70% 이상이 ‘주의를 받지 않는다’고 하였다. 4. 음식 만들기에 대한 선호도는 5점 만점에 3.48점으로‘보통 이상’으로 나타났고 국가별 요리에 대한 기호도는 한국요리(4.39점)가 가장 높았고, 그 다음이 중국요리 (3.76점), 이태리요리(3.45점), 일본요리(3.32점) 순이었으며 프랑스요리(3.16점)가 가장 낮은 기호도를 보였다. 음식 만드는 빈도는 한달에 1∼2회 정도로 나타나 대학 생들이 직접 음식을 만드는 빈도는 매우 낮음을 알 수 있었다. 5. 일본 방문경험은 조사대상자의 93.8%가 없었으며, 그중 92.6%가 일본방문을 희망하였고 일본음식에 대한 이미지는 ‘가격이 비싸다’(4.15점), ‘장식이 아름답다’(4.05점), ‘색채가 예쁘다’(3.98점) 등은 높은 점수를 보인 반면에 ‘맵다’(2.21점), ‘기름기가 많다'(2.51점), ’깊은 맛이 있다‘(2.56점) 등은 낮은 점수를 보였다. 6. 일본음식 중 가장 높은 시식경험을 가진 것은 우동(95.3%)이었고 그 다음은 스시(93.1%), 덴뿌라(81.9%)순 이었고, 반면에 니쿠자가(6.4%), 오차즈께(9.3%), 오코 노미야끼(11.1%), 다코야끼(16.0%) 등은 매우 낮은 시식경험을 보였다. 7. 일본음식에 대한 기호도는 우동(3.98점), 스시(3.85점), 덴뿌라(3.69점), 소바(3.43점), 스키야끼(3.12점)는 대체로 높은 기호도를 나타낸 반면 낫또(2.68점), 오차즈께(2.76점), 오코노미야끼(2.87점), 미소시루(2.88점), 다코 야끼(2.88점) 등은 낮은 기호도를 보였다. 이상의 연구결과로 변모해 가는 우리전통 식사예절의 동향 파악이 가능하였고 가족간의 화목과 건강한 사회를 이루기 위한 가족 단란의 식사지침이 요구되었다. 한편 일본음식중에는 우동과 스시가 한국대학생들에게 가장 인기가 높은 음식임을 알 수 있었고 대부분의 일본요리에 대해 장식이 예쁘고 색채가 아름답지만 값이 비싸다는 이미지를 가지고 있어서 가격을 좀 더 낮춘다면 그 이용이 더욱 늘어날 것으로 기대되었다. 또한 낫또, 오차즈께, 오코노미야끼 등 이용도가 낮은 음식에 대해서는 한국인의 입맛에 맞는 요리법을 가미한다면 대중화가 가능하리라고 여겨진다. This study was conducted to investigate the dietary behavior and image and preference of Japanese foods. The Subjects were consisted of 570 university students(243 males and 327 females) in Daegu and Kyungbuk area, Korea. The students responses to the 10 questions about image of Japanese foods were also measured on 5 point Likert scale. Data were presented by using frequency, percentage, chi-square test and T-test. The results of this study were as follows: (1) On the eating habits, 'the whole family has breakfast together with same foods everyday' scored high as 42.3% and 'foods put in a big platter by gathering everyday' as 35.8%. (2) About the eating customs, 53.5% of the subjects responded that the seat was fixed at meal time, 56.4% didn't start to eat before the patriarch started a meal and 30.9% responded that the head of a family had more foods in number and quantity. (3) On the table manners, 13.4% of the subjects were scolded about 'watching TV on eating', 11.5% about 'making left-over foods', 8.0% about 'misuse of spoon and chopsticks'. (4) The preferred ethnic foods by University students was in other of Korean, Chinese, Italian, Japanese and French foods. (5) Among subjects, 93.8% had no experience of visiting Japan and 92.6% wanted to visit Japan. Images on the Japanese foods were 'the price is too expensive' (mean 4.15) and 'the decoration is wonderful'(mean 4.05). But the subjects did not think Japanese foods as 'hot'(mean 2.21) and 'greasy'(mean 2.51). (6) The favorite Japanese food of subjects was Udon(mean 3.98), Sushi(mean 3.85) and Tempura(mean 3.69). So Udon turned out to be the most popular Japanese foods by university students in Daegu and Kyungbuk area, Korea. But they did not prefer Natto(mean 2.68), Ochazuke(mean 2.76), Okonomiyaki(mean 2.87) and Misosirn and did not eat. From the above results, Korean university students preferred Udon to Natto among Japanese traditional foods, and they estimated Japanese foods as 'too expensive'. Therefore, lowering the price and developing the cooking method for Korean taste were needed to increase the intake of Japanese traditional foods by Korean university students and.

數種 漢藥材가 肝癌細胞(Hep G2)와 마우스 腹腔 大食細胞에 미치는 影響

康城溶,韓宗鉉,趙南根 대한본초학회 1997 大韓本草學會誌 Vol.12 No.1

The action mechanism of herb drugs on the cytotoxicity and apoptosis in tumors undoubtedly are diverse. Apoptosis often is particularly prominent near foci of confluent necrosis, where mild ischemia is likely to be involved in its initiation. Apoptosis in tumors found in living body is occured by cytokines released from macrophage or cytotoxic T-lymphocyte, but the mechanism is not known accurately. A variety of cancer chemotherapeutic agents have been shown to induce extensive apoptosis in rapidely proliferating normal cell population, lymphoid tissues and tumors. The way in which anti-cancer drugs induce apoptosis is unknown. However, there is an additional important consequence of the realization that anti-cancer drugs mediate their therapeutic affects by triggering apoptosis. The activated macrophage can selectively destroy tumor cells Therefore, macrophage-mediated tumor cytotoxicity can have a important significance. Recently, it has been reported that some crude drugs stimulates IFN-v production in T-lymphocyte, and IFN-v stimulate nitric oxide production in peritoneal macrophage. The nitric oxide can affect the cytotoxicity and apoptosis in tumor cells. In this study, antineoplastic activity against human hepatocellular carcinoma cell line(Hep G2) was tested in four species of herb drugs. The plant materials were extracted with water, and the cytotoxic activity was tested using a calorimetric tetrazolium assay(MTT assay), the apoptosis was tested using a DNA electrophoresis and flow cytometry. The nitric oxide production from mouse peritoneal macrophage was tested using a Griess method. The four species of herb drugs were Arisaemitis Tuber, Bupleuri Radix and Coptidis Rhizoma extracts against the proliferation of Hep G2 cells showed cytotoxicity at the concentration of less than 100ug/㎖, and Bupleuri Radix and Coptidis Rhizoma extracts increased the cytotoxicity of mitomycin C and Coptidis Rhizoma extracts increased the cytotoxicity of cisplatin on Hep G2 cells. Bupleuri Radix and Coptidis Rhizoma extracts against the proliperation of BALB/c 3T3 cells showed cytotoxicity, and Coptidis Rhizoma extracts aginist the proliperation of mouse thymocytes showed cytotoxicity at the concentration of less than 100ug/㎖. Arisaemitis Tuber extracts increased nitric oxide production from macrophage.

연근의 열수 추출물이 흰쥐의 국소 뇌혈류량과 혈압에 미치는 영향

박성혜,신언환,구재근,이태헌,한종현 동아시아식생활학회 2005 동아시아식생활학회지 Vol.15 No.1

The purpose of this study was to measure the changes of regional cerebral blood flow(rCBF) and blood pressure(BP) in rats, following the intravenous injection of Nelumbo nucifera water extract. The measurement was continually monitored by laser-doppler flowmeter and pressure transducer in anesthetized adult Sprague-Dawley rats for about 2 to 2 and half hours through the data acquisition system composed of MacLab and Macintosh computer, The results of this experiment were as follows. Nelumbo nucifera significantly increased the changes of rCBF in rats. The rCBF of Nelumbo nucifera was not changed by pretreated propranolol, atropine, L-NNA and indomethacin. But the rCBF of Nelumbo nucifera was decreased by pretreated methylene blue. Nelumbo nucifera decreased the BP significantly, The BP of Nelumbo nucifera was not changed by pretreated propranolol, atropine, L-NNA and indomethacin. But the BP of Nelumbo nucifera was decreased by pretreated methylene blue. These results indicated that Nelumbo nucifera might increase the rCBF and decrease the BP which related to guanylyl cyclase activity.

구내 골신장술 후 식립된 전치부 임플란트보철 치험보고

김한석,김명래,이성근,강상원,김기환,김형섭 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.1

Objective : This is to report the effectiveness of intraoral distraction osteogenesis for alveolar augmentation in the extremely atrophied alveolar defects and to review the clinical results of the 2 cases. Subjects and Methods : Anterior segmental osteotomy was performed and the trans-oral alveolar distractors(Martin, Germany) were applied in 2 patients with the severe acquired anterior maxillary and mandibular defect. After latent period for 1 week, the osteomized alveolar segments were distracted by 1 ㎜ a day (0.5 ㎜/l turn) for 8 days in case Ⅰ and 0.6 ㎜ a day(0.3 ㎜/l turn) for 10 days in case Ⅱ. The consolidation period was about 8 weeks in each case. Thereafter, 6 titanium threaded implants(Branemark, Restore) were simultaneously installed with removal of distractor. The implants were tested clinically and radiographically. Results : Amounts of acquired alveolar bone were 8 ㎜ in case Ⅰ and 6 ㎜ in case Ⅱ respectively, with the increased width of the ridge crests and soft tissue expansion. Dental implants installated on the augmented alveolar ridges in 8 weeks after distrction were confirmed as in good osseointegration and in good function without any complications. Conclusion : Intraoral distraction osteogenesis can be a good option for alveolar ridge augmentation of the severely atrophied ridges and soft-tissue defects. However, for the better vector control of distracting segments and for anterior esthetics, customized distraction devices could be considered later.

부산지역 워터프런트의 기후특성에 관한 연구

도근영,이한석,고성철,현번수,유종수 韓國海洋大學校 附設 海洋科學技術硏究所 2002 硏究論文集 Vol.11 No.2

워트프런트는 도심 및 내륙지역과는 다른 독특한 기후특성을 가지고 있으며 이를 고려하지 않고 개발할 경우 시설물의 하자발생, 에너지 및 유지관리비용의 상승을 초래하게 됨은 물론 배후지, 도시기후에 악영향을 미치게 된다. 본 연구는 부산지역의 10개 기상관측지점을 해안선에서 거리에 따라 워터프런트 및 내륙지역으로 분류하고 5년간의 기상데이터를 이용하여 워터프런트의 기후특성에 대해 검토한다. 또한 원터프런트지역임에도 내륙지역과 유사한 기후특성이 나타나고 있는 대연지점을 대상으로 기후특성변화의 원인에 대해 검토한다. The waterfront has distinct climate characteristics different from urban or inland area. These may create not only the rise of energy and maintenance costs for facilities located at waterfront areas, but also negative effects on the climate of the nearby inland area, unless these are treated with particular care. For the present study, the climate characteristics of waterfront were examined with climate data of 10 observation points carefully selected in Busan area. Each weather observation point was classified into either waterfront area of inland area, based on the distance from the coastal line. Special considerations were given to the climate data gathered at the Dae-Yeon weather station because it shows the climate characteristics similar to those of inland area although it is located very near the waterfront area. Results indicates that this peculiar climate condition attributes, at least in part, to the reclamation of frontal coastal area.

개선된 다출력 동적 CMOS 설계 방식을 이용한 고성능 32 비트 CLA가산기 설계 및 구현

송근호,방만식,서정훈,한석붕,이효상,김강철 慶尙大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.13 No.-

In this paper, we designed, implemented and evaluated 32-bit CLA adder with the ENMODL(enhanced NORA Multiple Output Domino Logic) logic style which is new dynamic CMOS logic. The circuit is implemented using 0.8㎛ CMOS double-metal process technology. It operates stably and the addition time is less 3.9 ns. The ENMODL logic style can improve the performance in the high-speed computing circuits depending on the degree of recurrence.

진공차단기용 영구자석형 엑추에이터 최적설계

김한균,김중경,이정근,한성진 東亞大學校附設 情報技術硏究所 2005 情報技術硏究所論文誌 Vol.13 No.1

The vacuum interrupter operated by permanent magnet actuator(PMA) gives outlook on improved characteristic, higher reliability and cost price reduction as well as the feature of simple structure and few component. For the anlysis and design of permanent magnetic actuator, not only electric, magnetic and mechanical phenomena but also material properties should be taken into account. Aim of the present paper is modeling of permanent magnet actuator(PMA) used in medium voltage distribution systems and remodeling by permanent magnetic. Coupled finite element method is used to analysis the modeling and we compared with previous PMA model and improved PMA model.