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난소절제후 Estrogen을 투여한 흰쥐 대동맥에서 Protein Kinase C-α와 Fas 발현의 변화
이왕수,이상엽,안지현,송영빈,김학진,이광재,유재격,김상욱,김태호,김치정,류왕성 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.3
Estrogen is believed to decrease coronary artery disease. Protein kinase C-α(PKCα)appear to be important in signal conduction pathways. Estrogen treatment increases catalytic activity of PKCα,and activation of PKCαcan modulate estrogen receptor levels and responsiveness. And it was reported that activation of PKC can protect cells from apoptosis induced by Fas ligation. But the beneficial effect of estrogen on PKCαwas not clearly demonstrated. The objective of this study was to evaluate the role of PKCαafter ovariectomy and estrogen therapy in rat aorta. The results were summarized as below: 1. The significant pathological changes were not observed in the rat aorta irrelevant to ovariectomy and estrogen therapy. 2. The expression of Fas was decreased in the aorta of estrogen-treated rats than that of ovariectomized rats without estrogen therapy. 3. Increased expression of PKCαwas more marked in the aprta of estrogen-treated rats than that of ovariectomized rat without estrogen therapy. In conclusion,PKCαmay be important in signal conduation pathway on the effect of estrogen. Activation of PKCαby estrogen reduced Fas expression, suggesting that PKCαactivation may play a role in protection against atherasclerosis. Further studies are needed to elucidate the role of PKCαafter estrogen therapy.
ALKBH5 gene is a novel biomarker that predicts the prognosis of pancreatic cancer
Sung Hwan Cho,Mihyang Ha,Yong Hoon Cho,Je Ho Ryu,Kwangho Yang,Kang Ho Lee,Myoung-Eun Han,Sae-Ock Oh,Yun Hak Kim 한국간담췌외과학회 2018 Annals of hepato-biliary-pancreatic surgery Vol.22 No.4
Backgrounds/Aims: Discovery of new prognostic factors for cases in which the pancreatic cancer scoring and staging system does not result in a clear definition is imperative. We examined the role of Human AlkB homolog H5 (ALKBH5) as a prognostic marker for pancreatic cancer. Methods: Patient data were extracted from the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). The prognostic value of ALKBH5 was confirmed via analysis of ALKBH5 and other clinical factors, such as age, sex, and stage, using the time-dependent area under the curve (AUC) of Unos C-index, the AUC value of the receiver operating characteristics (ROC) at three years, the Kaplan-Meier survival curve, and multivariate analysis. Results: ALKBH5 showed excellent prognosis prediction in comparison with existing markers in the two independent cohorts (n=262). Kaplan-Meier survival analysis showed that ALKBH5 expression was positively associated with overall survival (log-rank test, ICGC, p=0.001; TCGA, p=0.01). Notably, comparison of C-index and AUC values in ROC analysis showed that ALKBH5 was associated with high C-index and AUC values compared with other clinical variables (C-index: ICGC, 0.621; TCGA, 0.614 and AUC at three years: ICGC, 0.609; TCGA, 0.558). Multivariate analysis demonstrated that ALKBH5 is an independent prognostic factor (ICGC, p=0.0123; TCGA, p<0.001). Conclusions: These findings contribute to the study of RNA methylation in pancreatic cancer. We believe that ALKBH5 is a new prognostic marker for pancreatic cancer.
DESIGN AND CONSTRUCTION OF AN ADVANCED SPENT FUEL CONDITIONING PROCESS FACILITY (ACPF)
GIL-SUNG YOU,WON-MYUNG CHOUNG,JEONG-HOE KU,IL-JE CHO,DONG-HAK KOOK,KIE-CHAN KWON,EUN-PYO LEE,WON-KYUNG LEE 한국원자력학회 2009 Nuclear Engineering and Technology Vol.41 No.6
KAERI has worked on the development of an advanced spent fuel conditioning process (ACP) since 1997. A hot cell facility, termed the ACPF, has also been developed. The ACPF consists of two air-sealed hot cells. The results of a safety analysis as part of the license procurement process stipulated by the Korean Government showed that the facility was designed safely. After its construction, an integrated performance test was performed. The results of this test confirmed that the facility satisfies the design requirements.
Jumping on water: Surface tension–dominated jumping of water striders and robotic insects
Koh, Je-Sung,Yang, Eunjin,Jung, Gwang-Pil,Jung, Sun-Pill,Son, Jae Hak,Lee, Sang-Im,Jablonski, Piotr G.,Wood, Robert J.,Kim, Ho-Young,Cho, Kyu-Jin American Association for the Advancement of Scienc 2015 Science Vol.349 No.6247
<P>Jumping on water is a unique locomotion mode found in semi-aquatic arthropods, such as water striders. To reproduce this feat in a surface tension-dominant jumping robot, we elucidated the hydrodynamics involved and applied them to develop a bio-inspired impulsive mechanism that maximizes momentum transfer to water. We found that water striders rotate the curved tips of their legs inward at a relatively low descending velocity with a force just below that required to break the water surface (144 millinewtons/meter). We built a 68-milligram at-scale jumping robotic insect and verified that it jumps on water with maximum momentum transfer. The results suggest an understanding of the hydrodynamic phenomena used by semi-aquatic arthropods during water jumping and prescribe a method for reproducing these capabilities in artificial systems.</P>
정상인 및 당뇨병환자 경구당부하시의 Insulin 반응
이상용 ( Sang Yong Lee ),심영학 ( Yung Hak Shim ),박호길 ( Ho Kil Park ),김용수 ( Yong Soo Kim ),김제현 ( Je Hyun Kim ) 대한내과학회 1972 대한내과학회지 Vol.15 No.2
The plasma insulin concentration during 50 gm oral glucose tolerance test was measured in 6 normal and 12 untreated diabetic subjects using the Insulin lmmunoassay Kit modified from Doub1e Antibody Immunoassay Method of Hales and Randle (1963), and the fol
Evaluation on the Radiological Shielding Design of a Hot Cell Facility
Il-Je Cho,Dong-Hak Kook,Jeong-Hoe Ku,Won-Myung Choung,Gil-Sung You,Eun-Pyo Lee,Seong-Won Park 한국방사성폐기물학회 2004 방사성폐기물학회지 Vol.2 No.1
한국원자력연구소에서는 고온의 용융염 매질 하에서 사용 후 핵연료를 환원시키는 차세대관리종합공정 연구를 수행 중에 있다. 추후 본 기술개발을 실증시험 하기 위해서는 방사선 차폐능이 확보된 핫셀이 필수적이며, 핫셀은 최대 1,385TBq의 방사능량에 대한 차폐 안전성을 가져야 한다. 최대 방사선원에 대한 핫셀의 차폐능을 확보하기 위하여, 본 연구에서는 실증시험 시 사용후핵연료부터 발생하는 중성자 및 감마선에 의한 선량률이 법적 허용선량치보다 낮게 유지되도록 핫셀의 차폐 설계에 대한 안전성을 평가하였다. QAD-CGGP 및 MCNP-4C 코드를 이용하여 핫셀 차폐체의 설계치에 대한 차폐 계산을 수행하였다. 작업구역에 대한 감마선 차폐계산 결과 QAD-CGGP 코드는 2.10, 2.97 mSv/h, MCNP-4C 코드는 1.60, 2.99 mSv/h 이었으며, 서비스 구역은 1.01, 7.88 mSv/h 로 평가되었다. 그리고 MCNP-4C코드를 이용하여 중성자에 의한 선량률을 계산한 결과, 중성자에 의한 선량률은 감마에 의한 선량률의 약 20% 이하치를 나타내었다. 따라서 선량률 대부분은 감마선에 의한 영향임을 알 수 있었다. 본 연구를 통하여 핫셀의 차폐 설계치가 작업구역의 선량 제한치 0.01 mSv/h 와 서비스 구역에서의 선량 제한치 0.15 mSv/h를 만족시키는 것을 확인할 수 있었다. The hot cell facility for research activities related to the lithium reduction of spent fuel, which is designed to permit safe handling of source materials with radioactivity levels up to 1,385 TBq, is planned to be built. To meet this goal, the facility is designed to keep gamma and neutron radiation lower than the recommended dose-rate in normally occupied areas. The calculations peformed with QAD-CGGP and MCNP-4C are used to evaluate the proposed engineering design concepts that would provide acceptable dose-rates during a normal operation in hot cell facility. The maximum effective gamma dose-rates on the surfaces of the facility at operation area and at service area calculated by QAD-CGGP are estimated to be mSv/h, respectively. And those calculated by MCNP-4C are mSv/h, respectively, The dose-rates contributed by neutrons are one order of magnitude less than that of gamma sources. Therefore, it is confirmed that the radiological design for hot cell facility satisfies the Korean criterion of 0.01 mSv/h for the operation area and 0.15 mSv/h for the service (maintenance) area.