병식 평가 척도-한국판(SUMD-K)의 신뢰도와 타당도 검증

송지영,김기태,이서경,김용희,노준호,김종우,장환일,반건호,강원섭 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.4

Objectives : This study was conducted to evaluate the reliability and the validity of the Korean version of the Scale to Assessment Unawareness of Mental Disorder (SUMD-K). Methods : The subjects were 55 schizophrenic patients between ages of 26 and 58 who were recruited from the psychiatric unit of the university hospital and the out-patient clinic. The SUMD-K and insight scale of PANSS were applied to the patients. Results : The range of inter-rater (Spearman's rho) of the general items of SUMD-K were .97-.98 on the current illness and .58-.98 on the past illness. The correlation coefficient between the sum and the general items of the SUMD-K showed high scores. The concurrent validity between SUMD-K and insight item of PANSS was high (scores between .59-.96). However,the reliability and the validity of the attribution items of symptoms showed low scores compared to the current symptoms. Conclusion : The SUMD-K was confirmed in its reliability and validity. It can be a useful clinician-rating scale for evaluating insight in schizophrenic patients as well as patients with other neuropsychiatric conditions.

정신분열병 및 정신분열형 장애에 대한 올란자핀의 효과와 안전성

안용민,강대엽,권준수,김창윤,김철응,반건호,신영민,이기철,이동우,이중서,조현상,채정호,김용식 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 본 다기관 공동임상연구는 국내 환자를 대상으로 새로운 항정신병약물인 올라자핀의 치료 효과와 안전성을 확인하고자 시행되었다. 방 법 : 1999년 7월부터 2000년 3월까지 국내 10개 병원에 방문한 정신분열병 및 정신분열형 장애 105명을 대상으로 비대조 개방 임상연구를 시행하였다. 중등도 이상의 정신병 증상을 지니거나, 부작용으로 약물교체가 필요한 경우 또는 기분장애 증상의 치료가 필요한 환자를 대상으로 하였다. 2∼7일간의 약물 배설기간 후에 1일 10mg의 올란자핀을 투여하였고, 이후로 3∼7일 간격으로 용량을 조절하여 총 8주간 투여하였다. 치료 효과는 PANSS(Positive and Negative Syndrome Scale), BPRS(Brief Psychiatric Rating Scale), CGI(Clinical Global Impression-Severity), MADRS(Montgomery-Asberg Depression Rating Scale), HAM-A(Hamilton Rating Scale for Anxiety)로 판정하였다. 안전성 평가는 자발적인 이상반응 보고, 활력징후와 혈액 검사 및 SAS(Simpson-Angus Scale), BARS(Barnes Akathisia Rating Scale), AIMS(Abnormal Involuntary Movement Scale)척도를 이용하였다. 결 과 : 105명중에서 85.7%인 90명이 8주간의 치료를 완료하였다. 평균 최빈 용량은 일일 16.1(±4.7)mg이었고, 종료시점에서의 BPRS전체 점수가 기저 상태에 비해 40%이상 감소된 반응군은 69.5%이었다. PANSS의 양성 증후군과 일반정신병리 뿐만 아니라 음성 증후군 소척도에서도 유의한 감소를 보였으며, 이 감소들은 치료 초기부터 나타나서 8주간 지속되었다. 43.8%의 피험자가 중등도 이상의 우울증상을 같이 지니고 있었으며, 올란자핀에 의해 MADRS와 HAM-A가 유의하게 감소하였다. 치료 기간 동안에 활력징후에는 뚜렷한 변화가 없었으나 체중은 8주간 지속적으로 증가하였다. SAS와 AIMS는 감소하였으며, 정좌불능증을 제외한 나머지 추체외로 증상의 발생비율도 낮았다. 임상적인 증상이나 징후를 동반하지 않는 ALT/SGPT의 상승을 보였지만 프로락틴을 포함하는 대부분의 혈액 검사상 뚜렷한 이상 변화는 없었다. 결 론 ; 비록 본 임상연구가 비대조 개방 임상연구로서 많은 제한점을 가지고 있지만, 올란자핀이 기존 약물에 내약성을 보이거나 기분증상을 동반하는 정신병에 치료 효과가 있었다. 그리고 기존 항정신병약물 치료시에 문제가 되었던 추체외로 증상과 고프르로락틴 혈증을 포함하는 대부분의 부작용면에서 안전성을 보여 주었다. Objective : This multicenter clinical trial was carried out to investigate the efficacy and the safety of olanzpine for the treatment of Korean patients. Mothod : 105 patients with schizophrenia and schizophreniform disorder, visited at 10 mental or university hospitals, had received an open and non-comparative treatment with olanzapine for 8 weeks. Patients had psychotic or depressive symptoms with the severity above moderate degree or intolerable side effects to previous antipsychotics. After a wash-out period of 2-7 days, 10mg olanzapine was prescribed initially to all the patients, and then the dosage could be adjusted within the range of 5-20mg/day of olanzapine by 3-7 days. Results : 90(85.7%) of 105 patients completed the 8-weeks trial and the mean modal dose of olanzapine was 16.1(±4.7%)mg/day. At the end of the trial, 73 patients(69.5%) were classified as responder, which was defined as 40% or more improvement in BPRS(Brief Psychiatric Rating Scale) score comparing to baseline. There was a significant reduction in the scores of PANSS(Positive and Negative Syndrome Scale)and subscales including negative symptom scores and CGI. Also weekly analysis showed that the reductions in scores were kept on for the whole period of the trial. 43.8% of all the patients had depressive symptoms at the baseline and total scores of MADRS(Montgomery-Asberg Depression Rating Scale) and HAM-A(Hamilton Rating Scale for Anxiety) were also reduced after the trials. Vital signs revealed no clinically significant changes but continuous weight gain was observed during the treatment with olanzapine. The scores of SAS(Simpson-Angus Scale) and AIMS(Abnormal Involuntary Movement Scale) for assessing the EPS(extrapyramidal symptoms)and tardive dyskinesia respectively were significantly decreased and only a few patients reported EPS as adverse events. Although mild and clinically non-significant of ALT/SGPT was observed, most laboratory parameters including plasma prolactin level showed to significant changes during the trial. Conclusions : Although this trial had many limitations because it was a non-comparative and open study, olanzapine showed high efficacy on the positive, negative and depressive symptoms in schizophrenia and schizophreniform disorder.In addition to that, olanzapine showed a substantially favorable safety profile, such as low incidence of EPS and hyperprolactinemia.

The Antioxidant Effect of the Rhaponticum uniflorum Extracts on the Oxidative Stress in H₂O₂ induced Human Keratinocytes

So Hee Ahn,Won Yeoung Choi,Ji Won Jeong,Geon Woo Park,Su Yeon Kang,Eun Jeong Kim,Su Rim Sin,Eun Seo Jang,Gye Won Lee,Young Ho Cho 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

In this study, To investigate the antioxidant activities of Rhaponticum uniflorum extracts (RUE), we assessed scavenging activities on DPPH, ABTS radicals, and reducing power. The DPPH and ABTS radical scavenging activities (SC50) of RUE were 96.97±1.19 μg/mL and 31.26±0.13 μ g/mL, respectively, and the reducing power significantly increased dose-dependent manner. To study the antioxidant effecters of RUE in H₂O₂ induced human keratinocytes, expression of Nuclear factor erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) were determined by Western blot and qRT-PCR. RUE induced the expression of HO-1, a critical target enzyme of Nrf2, in a concentration-dependent manner. The expression of HO- 1 mRNA was also induced in H₂O₂-treated HaCaT cells but no significant difference in the level of HO-1 mRNA was observed. Taken together, these results suggest that RUE may be useful as a potential ingredient for anti-aging products.

급성 심근 경색증과 혈장 Paraoxonase activity와의 관계

김건영,윤상준,박근호,조영신,장성종,장경식,홍순표 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

연구배경: 혈장 파라옥소나제의 감소는 HDL-cholesterol의 항 산화작용의 중요한 요소로 알려져 있어 이의 감소는 항산화작용의 저하로 인해 동맥경화의 진행을 촉진시킬 수 있어 허혈성심장병의 주요 위험인자로 추정하고 있다. 본 연구에서는 급성 심근 경색증 환자를 대상으로 혈장 파라옥소나제의 활성도를 측정하여 정상군과 비교하여 혈장 파라옥소나제 활성도의 감소가 급성 심근 경색증의 위험인자인지 알아보고자 하였다. 대상 및 방법: 급성 심근 경색증으로 입원한 39 명의 환자(남자 : 여자 = 19 : 20, 평균나이: 61±4.3세)와 정상 대조군 36명(남자 : 여자 = 17 : 19, 평균나이: 55±10세)을 대상으로 정맥혈을 채혈 후 파라옥소나제 활성도와 LDL-cholesterol, total cholesterol, HDL-cholesterol를 측정하였다. 두 군간의 비교는 Student T-test를 이용하였다. 결과: 건강 대조군과 급성 심근 경색 환자군 간에 측정치를 비교해본 결과 혈장 콜레스테롤 수치는 182.10± 12mg/dl, 194.87± 40mg/dl이고 HDL 콜레스테롤은 54±5.4mg/dl, 37.52± 13mg/dl 였다. LDL 콜레스테롤은 94.45±13mg/d1, 122±34mg/d1로 급성 심근 경색증 환자의 경우 통계학적으로 의미있는 차이를 보였다. (P<0.05). 그러나 혈장 파라옥소나제 활성도는 건강 대조군 112.35±15U/ml, 급성심근 경색증 환자군 96.10±43.50U/ml로 급성 심근 경색증 환자군이 건강 대조군에 비해 낮은 수치를 보이는 경향이 있었으나 통계학적으로 유의한 차이(P=0.071)는 보이지 않았다(Table 2참조). Background : Human plasma paraoxonase is a HDL-associated ester hydrolase that catalyzes the hydrolysis of organophosphates, aromatic carboxylic acid esters and carbamates. HDL has been implicated in the prevention of LDL lipid peroxidation. Low paraoxonase activity in the Plasma may have responsibility to the development of coronary artery disease partially because oxidized LDL has intimate relationship with atherosclerosis. We studied plasma paraoxonase activities in the plasma of acute myocardial infarction patients in order to evaluate the relationship between these enzyme activities and the acute myocardial infarction. Materials and Methods : plasma samples were obtained from 39 individuals with acute myocardial infarction(M: 19 cases, F: 20cases, mean age: 61(4.3 years) and 36 individuals of healthy control(M: 17 cases, F: 19cases, mean age: 55(10 years). We determined paraoxonase activities, total cholesterol, LDL-cholesterol &DL-cholesterol levels in the plasma samples. Paraoxonase activities were measured spectrophoto metrically in 0.1M Tris-HCl buffer (pH=7.4) at 25℃ with paraoxon as substrate(5.5mM) at 405 nm. We used student T-test to compare the results of both groups. Results : Comparison of the results between myocardial infarction patients and normal control groups revealed that plasma total cholesterol, HDL-cholesterol and LDL-cholesterol levels showed statistically significant differences between groups but plasma paraoxonase activity does not. Conclusion : Our study showed that there was no significant difference of plasma paraoxonase activity between acute myocardial infarction and normal population. So low plasma paraoxonase activity may not be a risk factor of acute myocardial infarction. but further prospective large scale study will be needed to conclude.

다이아몬드 터닝머신을 이용한 알루미늄반사경의 절삭특성

김건희,고준빈,김홍배,원종호 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.4

A 110 mm diameter aspheric metal secondary mirror for a test model of an earth observation satellite camera was fabricated by ultra-precision single point diamond turning(SPDT). Aluminum alloy for mirror substrates is known to be easily machinable, but not polishable due to its ductility. A harder material, Ni, is usually electrolessly coated on an Al substrate to increase the surface hardness for optical polishing. Aspheric metal secondary mirror without a conventional polishing process, the surface roughness of Ra=10nm, and the form error of Ra=λ/12(λ=632.8nm) has been required. The purpose of this research is to find the optimum machining conditions for reflector cutting of electroless-Ni coated Al alloy and apply the SPDT technique to the manufacturing of ultra precision optical components of metal aspheric reflector.

고분자 전해질을 이용한 한외여과에서 마그네슘의 제거에 대한 교반시간의 영향

김승건,이호원,강영주 濟州大學校 海洋硏究所 2003 해양과환경연구소 연구논문집 Vol.27 No.-

This paper was to investigate the effect of mixing time on the rejection of magnesium in polyelectrolyte enhanced ultrafiltration with PSS[poly(sodium-4-styrenesulfonate)] and PDDA[poly(diallyldimethylammonium chloride)]. The removal ratio of magnesium, the rejection ratio of polyelectrolyte, and the Permeate flux were stable within 10 min of mixing. PSS is more effective than PDDA in the removal of magnesium. When PSS of 2.000 ㎎/L was used. the removal ratio of magnesium was 78%. The rejection ratios of PSS and PDDA in Mg solution were up to 95.9% and 95.7%. respectively.

빌트인 모터를 이용한 2축 제어 미세 가공기 개발

김건희,김효식,양순철,이상용,국명호,이선규,김윤중,홍권희 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

This paper describes development of low cost precision machine that has combined the Build-in Motor with a vacuum chuck. This study mainly aims to find out a cutting condition for maintaining optimum surface condition and to examine cutting characteristics of the precision machine that is equipped by diamond bites. The cutting materials is Al alloy. Several experiments were carried out to find out the main factors that affect the surface roughness such as principal axis RPM(rotation per minute), feeding speed, and cutting depth. As a result, we obtain The optimum cutting condition of the developed precision machine.

신체형 환자의 애착 특성

김용희,송지영,반건호,김종우,신용선 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The purpose of this study was to evaluate the relationship betseen attachment style and somatization in patients with somatoform disorder. Methods : Data was collected by self-report questionnaires. 134 normal subjects and 30 patients with somatoform disorder were enrolled in this study. All subjects completed a psychometric assessment that consisted the Revised Adults Attachment Scale(RAAS), Inventory of Parent and Peer Attachment (IPPA), Sungshin Self-concept Inventory (SSCI), and SCL-90-R. Results : 1) Somatoform patients showed more anxious attachment style than normal control. 2) Anxious attachments were combined with mistrust of their parents, emotional instability, and interpersonal mistrust which may play a significant portion of variance in somatization. Conclusion : We found that patients with somatoform disorder had more anxious attachment style than normal subjects. Insecure attachment patterns may significantly explain the phenomenon of somatization.

초정밀가공기를 이용한 Zerodur의 연삭 특성에 관한 연구

김주환,김건희,한정열,김석환,원종호 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-

We explored a new rough grinding technique on optics materials such as Zerodur. The facility used is a NANOFORM-600 diamond turning machine with a custom grinding module and a range of diamond resin bond wheel. The grinding parameters such as workpiece rotation speed, depth of cut and feed rate were altered while grinding the workpiece surfaces of 20mm in diameter. Surface roughness is measured by Form Talysurf series2. Our target is to define grinding conditions producing the surface roughness better than 0.02μm Ra and the form accuracy of around 0.2μm PV.

정신분열증 입원환자에서 니코틴과 항정신병 약물의 상관관계 규명을 위한 니코틴 패취 적용 연구

반건호,유희정,윤도준,김종우,이기철 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1

연구목적 : 정신분열증 환자는 흡연율이 높고, 그에 따라 항정신병 약물 투여량이 늘어나고, 약물에 의한부작용은 오히려 감소한다고 알려져 있다. 이러한 연구에서 방법론적 문제로는 실제 니코틴 용량을 측정하지 않았다는 점이다. 본 연구는 담배보다 니코틴의 주요 대사물인 코티닌을 측정하여 방법론적 오류를 최소화하고자 하였다. 방법 : 정신분열증으로 진단받은 입원환자 중 니코틴 패취군 8명, 대조군 8명을 설정하였다. 5일간 패취를 붙인 후 혈액에서 코티닌을 측정하였고, 정신증상의 정도를 알기 위하여 PANSS, 약물의 추체외로 부작용 측정을 위하여 ESRS를 실시하였다 일일 약물용량을 chlorpromazine 동량으로 환산하여 기록하였다. 결과 : 코티닌 수치와 정신증상, 추체외로부작용, 약물용량 사이에는 유의한 차이가 없었다. 결론 : 코티닌은 항정신병 약물의 작용에 영향을 미치지 못하였다. 단, 향후 연구에서는 니코틴 패취의 양을 증량하여 사용하므로써, 코티닌 용량에 따라 항정신병 약물효과에 영향을 미칠 수 있는지를 검증해야 할 것이다.