니세틸 정(아세틸-엘-카르니틴 500 mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,김은아,정현철,심영순,임동구,오인준,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetiler^TM (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^TM (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07 7.98㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 500㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^TM tablet. The powers (1-β) for AUC_t and C_max were 94.87% and 87.17%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_max, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^TM tablet is bioequivalent to Nicetile^TM tablet.

비유피-4 정(염산프로피베린 20㎎)에 대한 건일염산프로피베린 정의 생물학적동등성

조혜영,박은자,강현아,백승희,김세미,박찬호,오인준,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.5

The purpose of the present study was to evaluate the bioequivalence of two propiverine hydrochloride tablets. BUP-4 (Jeil Pharm. Co., Ltd.) and Kuhnil Propiverine Hydrochloride (Kuhnil Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The propiverine release from the two propiverine hydrochloride formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with a variety of dissolution media (pH 1.2, 4.0, 6.8 buffer solutions, water and blend of polysorbate 80 into pH 6.8). Twenty six healthy male subjects, 23.73 ± 2.79 years in age and 67.04 ± 7.93 kg in body weight, were divided into two groups and a randomized 2 x 2 cross-over study was employed. After one tablet containing 20 mg as propiverine hydrochloride was orally administered, blood was taken at predetermined time intervals and the concentrations of propiverine in serum were determined using HPLC method with UV detector. The dis-solution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC" C _(max) and T _(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC, C_(max), and untransformed T_(max). The results showed that the differences between two formulations based on the BUP-4 were 0.17%, 7.98% and 4.55% for AUC,, C_(max), and respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically trans-formed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.88)-log(l .12) and log(0.90)-log(l.15) for AUC, and _(max), respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Kuhnil Propiverine Hydrochloride tablet was bioequivalent to BUP-4 tablet.

간흡충 감염증의 진단에서 피내반응 검사의 유용성 검토

최재철,오승환,정해진,신정환,박기형,이은엽,장철훈 대한임상미샐물학회 2003 Annals of clinical microbiology Vol.6 No.2

Time-dependent network analysis reveals molecular targets underlying the development of diet-induced obesity and non-alcoholic steatohepatitis.

Oh, Hea-Young,Shin, Su-Kyung,Heo, Hyoung-Sam,Ahn, Ji-Sook,Kwon, Eun-Young,Park, Jung Han Yoon,Cho, Yun-Young,Park, Hae-Jin,Lee, Mi-Kyung,Kim, Eun Jung,Jung, Un-Ju,McGregor, Robin A,Hur, Cheol-Goo,Choi New Century Health Publishers 2013 GENES AND NUTRITION Vol.8 No.3

<P>Prolonged high-fat diet leads to the development of obesity and multiple comorbidities including non-alcoholic steatohepatitis (NASH), but the underlying molecular basis is not fully understood. We combine molecular networks and time course gene expression profiles to reveal the dynamic changes in molecular networks underlying diet-induced obesity and NASH. We also identify hub genes associated with the development of NASH. Core diet-induced obesity networks were constructed using Ingenuity pathway analysis (IPA) based on 332 high-fat diet responsive genes identified in liver by time course microarray analysis (8 time points over 24?weeks) of high-fat diet-fed mice compared to normal diet-fed mice. IPA identified five core diet-induced obesity networks with time-dependent gene expression changes in liver. These networks were associated with cell-to-cell signaling and interaction (Network 1), lipid metabolism (Network 2), hepatic system disease (Network 3 and 5), and inflammatory response (Network 4). When we merged these core diet-induced obesity networks, Tlr2, Cd14, and Ccnd1 emerged as hub genes associated with both liver steatosis and inflammation and were altered in a time-dependent manner. Further, protein-protein interaction network analysis revealed Tlr2, Cd14, and Ccnd1 were interrelated through the ErbB/insulin signaling pathway. Dynamic changes occur in molecular networks underlying diet-induced obesity. Tlr2, Cd14, and Ccnd1 appear to be hub genes integrating molecular interactions associated with the development of NASH. Therapeutics targeting hub genes and core diet-induced obesity networks may help ameliorate diet-induced obesity and NASH.</P>

Reconstitution of human olfactory receptor protein produced from Eschericia coli for the development of protein-based olfactory biosensor

Eun Hea OH,Sang Hun LEE,Hyun Seok SONG,Jong Hyun LIM,Tai Hyun PARK 한국생물공학회 2009 한국생물공학회 학술대회 Vol.2009 No.4

한국의 모성임금 패널티에 관한 연구

오혜은 ( Oh Hea Eun ) 한국사회복지정책학회 2017 사회복지정책 Vol.44 No.3

한국은 2014년 현재 성별 임금격차가 OECD 34개국 중 가장 큰 나라이며, 2002년 이후로 14년째 압도적인 1위를 차지하고 있어, 개선 속도도 더딘 상황이다. 과거에는 이러한 임금의 성별 격차에 대해 성별 인적 자본의 차이, 직업의 차이로 설명하였으나 최근에는 자녀 양육과 같은 가족적인 요인에 초점을 두고 설명한다. 대표적인 것이 모성임금 패널티이다. 모성임금 패널티는 자녀가 있는 여성이 자녀가 없는 여성에 비해 낮은 임금을 받고 있는 현실을 의미한다. 본 연구는 한국에서 이와 같은 모성임금 패널티가 나타나는지와 연령별, 학력별 하부 집단간에 차이가 있는지 실증하는 것을 주요한 목적으로 한다. 이를 위하여 한국노동패널 3-15차 데이터를 이용하여 21-50대 여성들을 대상으로 고정효과 모형으로 실증 분석하였다. 주요 연구 결과는 다음과 같다. 첫째, 자녀유무가 여성의 시간당 임금에 미치는 영향을 분석한 결과, 자녀가 있는 경우가 자녀가 없는 경우에 비해 시간당 임금이 약6.6% 낮은 것으로 나타나, 모성임금 패널티가 관찰되었다. 둘째, 자녀수에 따른 모성임금 패널티를 추정한 결과, 자녀가 한명 있을 경우에 약5.8%, 2명의 자녀가 있을 경우에 약9.8%의 시간당 임금이 감소하는 것으로 나타났다. 마지막으로 자녀 연령이 여성의 시간당 임금에 미치는 영향을 추정하였으나, 모두 통계적으로 유효하지 않았다. 다음으로 연령별, 학력별 하부 집단별로 자녀 유무, 자녀 수가 여성의 시간당 임금에 미치는 영향을 분석한 결과, 20대를 제외한 집단과 고졸이하 저학력 집단에서의 모성임금 패널티는 전체 표본에서 보다 큰 것으로 나타났다. 자녀 연령에 따른 모성임금 패널티는 전체 표본과 동일하게 통계적으로 유의미 하지 않았다.결론으로 모성임금패널티는 출산 장려 정책, 일-가정 양립 정책 측면에서 우선적으로 해결해야 할 과제임을 강조하였다. Traditionally, the gender wage gap has been explained by gender difference in the level of human capital, labor supply, and job characteristics. Recently, woman`s educational level of woman is close to men, woman`s labor market participation rate has increased. One of the major contributors to this wage gap is the motherhood penalty. Motherhood penalty is the wage gap between women with children and those without children. This paper is purposed to the effect of children on women`s wages in South Korea and analyzed whether there is a difference in motherhood penalty between the sample with excluded 20`s and less than high school. The data used for the analysis are from national representative data The Korea Labor and Income Panel Study (KLIPS) on employed 21-50 years women from 2000 to 2012 year. I estimate Equation using fixed effects to account for sample heterogeneity. The results reveal mothers face a wage penalty of approximately 6.6 percent per child. especially wage penalties are 5.8 percent for mothers with one child and 9.8 percent for mothers with two children. but children`s age is not effect to women`s hourly wages. also motherhood penalites were larger in thesample with excluded 20`s and less than high school. The motherhood penalties need to continuous concerns for advocates of fertility policies, work-life balance policies in South Korea.

경력단절 이후 자영업을 선택한 여성의 노동시장 이행 궤적 -집단기반궤적모형을 중심으로-

오혜은 ( Hea Eun Oh ),최미향 ( Mihyang Choi ),홍경준 ( Kyung-Zoon Hong ) 한국사회복지정책학회 2021 사회복지정책 Vol.48 No.3

본 연구의 목적은 경력단절 이후 자영업을 선택한 여성들의 노동시장 이행 궤적을 분석하고, 이를 유형화하는 것이다. 그간 선행연구들에서 여성의 자영업 선택을 재취업 이후 하나의 노동시장 진입 유형으로만 다루었고, 일회적인 사건으로만 다루어 장기적인 관점이 부족한 점을 연구의 배경으로 삼았다. 이를 실증 분석하기 위하여 한국노동패널 1차-22차 자료를 이용하였고, 집단기반궤적모형을 활용하여 분석하였다. 이 분석 방법은 한 집단 내 다양한 그룹의 변화 궤적을 파악할 수 있다는 장점을 가지고 있다. 분석 결과 경력단절 이후 자영업을 선택한 여성들의 노동시장 이행 궤적은 임금근로 전환형, 자영업 유지형, 유급노동 이탈형으로 구분되어, 다양한 유형이 있음을 확인하였다. 유급노동 이탈형을 준거집단으로 할 경우, 연령이 감소할수록 임금근로 전환형에 속할 가능성이 높았다. 또한 전문대졸 이상일수록, 자영업 진입 첫해의 개인소득이 높을수록 유급노동 이탈형에 비해 자영업 유지형에 속할 가능성이 높았고, 경력단절 직전 일자리가 임금근로자일수록, 자영업 시작 시기가 2008-11년 사이에 속할수록 자영업을 유지할 가능성이 낮았다. 돌봄을 사유로 경력 단절된 여성들만을 대상으로 한 분석에서 6세 이하의 자녀의 존재는 유급노동을 이탈할 가능성을 증가시키는 요인이었다. 이와 같은 연구 결과를 근거로 임금근로와 비임금근로 간 이동을 지원할 수 있는 실업자 전직 프로그램, 자영업자의 아동 돌봄을 지원하기 위한 양육 프로그램의 필요성을 제시하였다. This study aims to identify various labor market transition trajectories of women who chose self-employment after career interruptions and their characteristics. Previous studies treated women’s choice of self-employment as a one-time event, therefore lacked a long-term perspective. This study performed group-based trajectory modeling using the Korean Labor & Income Panel Data to analyze the women’s labor market transition trajectories from a long-term perspective. This modeling has the advantage of being able to identify various subgroups that have heterogeneous trajectories in one group. The results of the analysis showed that there were various types of labor market transition trajectories of women who chose self-employment after career interruptions, divided into type of transition to wage labor, self-employment continuation type, and type of leaving the paid labor market. The characteristic of the type of transition to wage labor compared to the type of leaving the paid labor market was that the probability of belonging to the type of transition to wage labor decreased with the age. The characteristics of the self-employment continuation type compared to the type of leaving the paid labor market were that the higher the educational background and the income in the first year of entry into self-employment, the higher the probability of belonging to the self-employment continuation type. And the higher the probability of being a wage laborer before the career interruption and the probability of starting self-employment in 2008∼2011 was, the lower the probability of belonging to the self-employment continuation type was. The results of the analysis including only women whose careers were interrupted due to care-related reasons demonstrated the presence of children under the age of six increased the likelihood of leaving the paid labor market. Based on these results, the necessities of a child care program that fits in the working conditions of the self-employed and a career shift program that supports movements between paid employment and self-employment were suggested.

韓国における老人長期療養保険が家族の就業変化に及ぼす影響

吳慧恩(Oh, Hea Eun) 동아시아일본학회 2014 일본문화연구 Vol.0 No.50

The purpose of this study is to analyze how the enforcement of long-term care insurance for the aged affects family employment. Specifically, this study will assess whether long-term care insurance for the aged helps families, who have been formerly engaged in caring for the aged, to participate in the labor market. To accomplish this research, an analysis was conducted on 3- and 6-year data from the Korea Welfare Panel Study regarding people between age 20 and 64 living with senior citizens age 65 and older. The treatment group consisted of families that used long-term care insurance for the aged, whereas the control group consisted of those that did not. After determining the employment status of the two groups, changes in employment duration were estimated using the difference in differences method. The results of the analysis showed that the enforcement of long-term care insurance for the aged turned out to be (1) effective in promoting employment of family members that include senior citizens. (2) When examined by gender and marital status, no influence on male family members or married couples was observed, indicating that the policy promotes employment of unmarried women in general. (3) Analysis of employment duration also showed an increase for the unmarried group.

시간과 소득의 동시 빈곤에 관한 연구 - 남녀 가구주를 중심으로 -

오혜은 ( Oh Hea Eun ) 한국사회복지정책학회 2017 사회복지정책 Vol.44 No.1

소득과 시간은 유한한 자원이며, 인간다운 생활을 유지하기 위하여 반드시 필요한 요인 중에 하나이다. 그럼에도 불구하고 시간 빈곤에 관한 연구는 소득 빈곤에 비해 소수에 불과하다. 특히 시간과 소득의 동시 빈곤에 관한 연구는 가구 유형을 중심으로 분석되어 성별과 같은 개인 차이에 초점을 두고 분석된 연구는 더욱 드물다. 이에 본 연구는 남녀 가구주를 대상으로 남성 유배우 가구주, 여성 유배우 가구주, 남성 무배우 가구주, 남성 유배우 가구주 네 집단으로 나누고, 네 집단 간에 시간 빈곤과 시간과 소득의 동시 빈곤 양상에 있어서 차이가 있는지 분석하는 것을 목적으로 하였다. 이를 위하여 한국노동패널 17차년도 부가조사 데이터를 활용하였으며, 시간 빈곤은 자유시간을 기준으로 설정하였고, FGT 지수 측정, Probit 분석을 실시하였다. 주요 연구 결과는 다음과 같다. 첫째, 시간 빈곤에 대한 FGT 지수 측정 결과 시간 빈곤율, 빈곤갭, 빈곤갭 제곱에서 비율이 높은 집단은 여성 유배우 가구주, 여성 무배우 가구주 순으로 나타나 여성 가구주가 남성 가구주에 비해 시간 빈곤에 취약함을 확인 하였다. 둘째, 소득 빈곤과 관련하여 분석하면, 소득 빈곤층에 속하는 여성 유배우 가구주의 시간 빈곤율이 가장 높아, 저소득층 여성 유배우 가구주의 경우 소득 빈곤의 고통 뿐 아니라 시간 빈곤의 고통에도 시달리는 경우가 많았다. 마지막으로 Probit 분석을 통하여 네 집단이 시간 빈곤, 소득 빈곤, 시간과 소득의 동시 빈곤에 영향을 미치는 요인인지 분석 하였다. 분석 결과 여성 유배우 가구주, 여성 무배우 가구주는 시간 빈곤에 빠질 위험이 높았고, 여성 무배우 가구주는 시간과 소득의 동시 빈곤에 유의미한 영향을 미쳤다. Income and time are limited resources and necessities to maintain a life with dignity. Nevertheless, less research has been conducted on time poverty than on income poverty. Particularly, much research on poverty of both time and income has been based on households, while little has focused on individual differences like gender. Therefore, this study aimed to analyze the differences between male and female householders in the characteristics of time poverty and poverty of both time and income. Toward this end, householders were divided into four groups; male householders with spouse, female householders with spouse, male householders with no spouse, female householders with no spouse. also the study used the data from the Supplementary Survey of the 17th Year Korean Labor and Income Panel Study. Time poverty was determined by free time as the standard, and the calculation of Foster-Greer-Thorbecke (FGT) poverty indices and probit analysis were performed. The key study results are as follows: first, the FGT indices measurement on time poverty showed that female householders with spouse, female householders with no spouse had a higher time poverty headcount ratio, a higher time poverty gap, and a higher squared time poverty gap than male householders, verifying that female householders were more prone to time poverty than male householders; second, regarding income poverty, low-income female householders with spouse showed the highest time poverty headcount ratio, indicating that many of them were suffering not only from income poverty, but also from time poverty; finally, the probit analysis was conducted to determine whether the head of a householder`s type is a factor in income poverty, time poverty, and poverty both time and income. Its result showed that, while having a female householder with spouse, female householder with no spouse had a significant effect on time poverty and female householder with no spouse had a significant effect on poverty both time and income.

Characterization of Novel Acarbose Fructoside Synthesized by Using Levansucrase

Hea-Jin Woo,Sun-Hwa Jung,Yong-Hyeon Jeong,Chanwook Oh,Da-hyeon Lee,Eun-Seong Seo,Doman Kim 한국생물공학회 2009 한국생물공학회 학술대회 Vol.2009 No.10