FCT 5 : Fractional laser-assisted topical imiquimod 5% cream treatment for recalcitrant common warts in children

( Hyun Chang Ko ),( Jeong Min Kim ),( Hyun Ho Cho1 ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Conventional destructive modalities for warts like cryotherapy or laser ablation have some limitations that are excruciating pain during procedure, in especially pediatric patients. Imiquimod is a topical immune response modifier that was approved for treating genital and perianal warts. But, thick stratum corneum of common warts may act as a barrier against drug permeation via the skin. Objectives: To evaluate efficacy and safety of above treatment. Methods: Eleven pediatric patients (6 female and 5 male, mean age 12.5 years) were included in this study. The lesions were treated by fractional 2940 nm Er:YAG laser for achieving the penetration of stratum corneum with 1 or 2 weeks intervals. Then, imiquimod 5% cream was self-applied once daily for 5 days a week. Assessment of response and adverse effects was performed every 2 weeks until complete clearance or up to maximum of 48 weeks. Pain during procedure was checked by VAS (0-10). Results: 8 out of 11 (72.7%) patients experienced complete clearance of all warts lesions. Mean duration of total treatment was 29.7 (16-48) weeks. Mean number of fractional laser treatment was 17.5 (8-37) times. No significant adverse effect was observed. VAS score of the pain during fractional laser treatment was 2.4 (1-4), comparing with 6.2 (5-8) during cryotherapy. Conclusion: Fractional ErYAG laser-assisted topical 5% imiquimod cream is an effective and safe treatment option for recalcitrant common warts of the children do not tolerate pain well.

1997년 포항지역에서 유행한 소아 무균성 뇌막염의 임상상

조성민,김나연,정진화,김수근,임현술 동국대학교 의학연구소 1998 東國醫學 Vol.5 No.-

1997년 포항지역에서 유행한 소아 무균성뇌막염의 임상상을 고찰하고 이 질환의 발생과 환자가 당시에 사용하던 식수와의 관계를 알아보기 위하여 1997년 5월부터 1997년 10월까지 동국대학교 의료원 포항병원소아과에 내원하여 무균성뇌막염으로 진단 받은 78명의 환아들을 대상으로 의무기록의 후향적 분석 및 식수에 관한 전화 조사를 실시하였다. 환아의 남녀비는 1.23:1이었으며 5-6세군에서 가장 많았다. 월별 분포는 5월에 시작하여 10월까지 발생하였으나 6월과 9월에 점유율이 높았다. 임상 증상 및 증후로는 발열이 가장 많았고(96.2%), 구토(89.7%), 두통(84.6%), 경부강직(73.1%), 인두 발적(71.8%), 식욕부진(52.6%) 등의 순으로 나타났다. 혈액검사 소견으로 백혈구수가 10,000/㎣ 이상으로 증가한 경우가 54.5%였고, 혈침치가 20mm/h 이상인 경우가 29.0%였으며, C반응단백이 0.5mg/dl 이상인 경우가 84.1%였다. 뇌척수액 검사소견은 백혈구수가 13-860/㎣으로 평균 241.2/㎣였고, 단백량은 평균 78.4mg/dl, 당량은 평균 70.8mg/dl였다. 합병증이나 후유증이 발생한 경우는 없었다. 발병 당시의 식수에 관한 전화 조사는 46명에서 가능하였는데 생수를 끓이지 않고 먹는 경우가 13명(28.3%), 생수를 끊여 먹는 경우가 11명(23.9%), 상수를 끓이지 않고 먹는 경우는 2명(4.3%), 상수를 끓여 먹는 경우는 20명(43.5%)으로 전체적으로 보면 물을 끓여 먹는 경우가 31명(67.4%), 물을 끓이지 않고 먹는 경우는 15명(32.6%)으로 나타났다. 본 조사에서는 무균성뇌막염이 발생하지 않은 대조군의 설정이 되지 않았고, 표본의 크기가 매우 작으며, 식수 이외의 물을 통한 전파에 관한 조사가 이루어지지 않아 본 조사 자료만으로는 무균성뇌막염의 발생과 식수와의 관계를 밝히기 어려웠다. 이를 밝히기 위해서는 지역 주민을 대상으로 한 역학조사와 무균성뇌막염이 유행할 당시에 식수 및 식수 이외에 사용하는 물에 대한 역학 조사 및 바이러스 검사 등이 필요할 것으로 생각한다. This study was performed to evaluate the clinical features of aseptic meningitis in Pohang City in 1997 and its relationship to drinking water. We reviewed the clinical records of 78 aseptic meningitis patients who had been admitted to Dongguk University Pohang Hospital, and investigated the drinking water of patients by telephone survey. The results were as follows: 1) The ratio of male to female was 1.23:1. 2) The aseptic meningitis occurred in children of all age groups, but was most prevalent in 5-6year old children. 3) All the cases developed from May to October, but they showed two peaks in June and September. 4) Fever was the most common clinical manifestation(96.2%), followed by vomiting(89.7%), headache(84.6%), neck rigidity(73.1%), pharyngeal injection(71.8%), and anorexia(52.6%). 5) On admission leukocytosis(WBC > 10,000/㎣) on peripheral blood was showed in 64.5%, and increased erythrocyte sedimentation rate(≥ 20 mm/h) in 29.0%, and increased C-reactive protein(≥ 0.5 mg/dl) in 84.1%. 6) On CSF examination, leukocyte count was in the range of 13 to 860/㎣ (mean 241.2/㎣), protein in the range of 0 to 253 mg/dl(mean 78.4 mg/dl), and glucose in the range of 35 to 115 mg/dl(mean 70.8 mg/dl). 7) There was no case who developed any complication. 8) On the telephone survey about the drinking water, we were able to do the survey in 46 cases, raw underground water was used in 13 cases(23.8%), boiled underground water in 11 cases(23.9%), raw tap water in 2 cases(4.3%), and boiled tap water in 20 cases(43.5%). We could not identify the close relationship between the drinking water and aseptic meningitis because of the small sample size, the absence of control group, and the difficulties in the study of past event. Epidemiologic and virologic studies of drinking water will be necessary.

도시체계의 형성과정

조현수 평택대학교 1996 論文集 Vol.8 No.-

수산물채취 잠수부에서 발생한 중증감압병 37예 분석

조수헌,양대현,최헌 大韓産業醫學會 1989 대한직업환경의학회지 Vol.1 No.1

1986년 12월부터 1988년 11월까지 2년간 지방공사 강남병원 고압산소치료센타에 내원하였던 489명의 감압병환자중 신경계증상 등 중증증상을 보인예는 39명이었다. 이중 수산물채취 잠수작업중 중증감압병에 이환되어 미해군 재가압치료표에 따라 치료가 끝난 37명에 대하여 일반적 특성 및 잠수의학적 특성에 관한 자료를 조사하였다. 중증감압병환자의 67.5%가 25∼34세 연령층에 있었으나 10.8%는 45∼49세의 고연령층 이었다. 1년 미만의 잠수경력을 가진 예가 21.6%이었으며, 잠수기술은 70%가 체계적인 교육보다는 현장에서 잠수작업을 거들면서 기술을 습득하였다. 감압병 발병당일의 잠수형태에서는 31∼50m의 수심에서 2∼8회의 반복잠수 후에 흉부통증 또는 하지감각장애 등의 증상이 나타났는데, 증상발현은 수면부상후 30분이내에 83.7 %가 그리고 3시간이내에 100% 나타났다. 증상발현후 재가압치료를 받기까지의 경과시간은 평균 18시간으로, 재가압치료를 받아 완치된 경우에 있어서는 평균 12일의 입원기간중 11.3회의 고압산소요법을 실시하였다. 중증감압병의 경과 및 회복에는 발생전날의 반복잠수와 주증상발현후 재가압 치료까지의 경과시간이 지연되는 경향을 보였다. Hospital records were reviewed for 486 divers who have been diagnosed as decompression sickness(DCS) at Kangnam General Hospital between December 1986 and November 1988. Among 39 cases classified as serious DCS(type II), the patients had been fishery diving in 97.4% of the cases. The ages of the afflicted divers ranged from 22 to 47 years, with a mean of 31.5% years. The divers were experienced being less than one year in 21.6% and 70% of them learned diving skill by self-taught. In 86.5% of the cases the divers had made multiple divies ranged in depth from 31 to 50 meters. Thirty-one(83.7%) of the patients noted their symptoms within 30 minutes of surfacing. The spinal cord was most often affected, and the most common symptoms were 'numbness' or 'tingling' in one or more extremities and discomfort or pain on the chest. Recompression treatment was delayed for 18 hours in average after the onset of dysbaric symptoms and this treatment is more likely to be effective the sooner that it commences after the onset of dysbaric symptoms.

적절한 용량 이하의 경구용 향응고제 사용 중 발생한 뇌출혈 환자의 임상 양상

조수진,황흥곤,나찬영,이영탁,최현배,조태구 世宗醫學硏究所 2000 世宗醫學 Vol.17 No.2

연마 다듬질 가공면의 표면 미세형상 평가에 관한 연구

조남규,김현국,권기환,한창수,안유민,이성환,박균명 한국공작기계학회 2000 한국공작기계학회 추계학술대회논문집 Vol.2000 No.-

This paper describes the statistical analysis techniques for the surface roughness assessment of polished surfaces. In experiments, the polishing process of the sample surfaces which are manufactured by ball end mill is consist of two steps; the cusp removal process and the surface finishing process. For the cusp removal process, the criterion of cusp removal was established from the power spectrum analysis to assess the change of the cusp removal rate. For the finishing process, the surface was polished by the rotational CBN tool and vibration wood tool. And the surface quality of polished surface was assessed using the functional parameters based on the statistical values of surface profiles. Consequently, the surface finish performance of the polished surface using the vibration wood tool was improved.

한국 재래 우 및 산양 위장관의 somatostatin cell에 대한 면역조직화학적 분포

조성환,김현수,박배근,윤원기,손화영 충남대학교 수의과대학 동물의과학연구소 1995 動物醫科學硏究誌 Vol.3 No.-

The relative frequency and distribution of somatoatatin immunoreactive cells were investigated by the immunohistochemical method in the gastrointestinal tract of the Korean native cattle and goat. The results obtained were as follows: In the Korean native cattle, somatoststin cells were a few in the pyloric and duodenal region and rarely seen in fundic region, jejunum, ileum, cecum, proximal colon, central coil, distal colon and rectum. In the Korean native goat, somatostatin cells were the most numerous in the pyloric region and the next in the fundic region. And they were a few in the duodenum, not detected in the cecum and sparse in the jejunum, ileum, proximal colon, central coil, distal colon and rectum.

Co-계비정질 리본의 자기특성에 미치는 열처리 효과에 관한 연구

조치현,신용진,문현욱,서강수 明知大學校 産業技術硏究所 1993 産業技術硏究所論文集 Vol.12 No.-

This thesis describes the effect of annealing on the magnetic properties of Co-bsaed amorphous. The basic composition of the chosen samples were Co82Si2B15 of zero magnetostriction. The sample was melted in the quartz tube with 0.5[mm∮) nozzle. and the single roll technique was used to make a amorphous ribbon, under Ar-gas pressure 0.6〔kg/cm2] and ro11 speed 28[m/sec]. The average width and thickness of sample ribbons 2.4[mm] and 45(㎛). The sample ribbons were annealed to improve the magnetic properties at temperature of 325,350,375,400 and 450℃ respectively, for 15,30,45,60 and 120 [min] at each temperature. And I have measured high per meability of 8,000∼ 13,000 through the annealed amorphous ribbons. Especially, when the amorhpous samples were annealed at 325 for 45min, the permeability of the ribbon was 13,589. Consequently. I had effects of the improvment of permeability and the average loss at the low-frequency region.

Renca 마우스 종양모델에서 지구성운동이 종양형성에 미치는 영향

조정제,안현종,김성수,김창주 대한스포츠의학회 2003 대한스포츠의학회지 Vol.21 No.1

Subcutaneous injection of cells from renal adenocarcinoma line, renca, into Balb/c mice induces fast growing solid tumors. This method has been used to speculate the efficacy of cytokine treatment for tumor regression. The present study was designed to investigate the effect of treadmill exercise on tumor growth using renca mouse tumor model. We also examined the expression pattern of several genes related to immune response after exercise training for 4 weeks. Exercise training reduced the size of tumor mass compared to that of non-exercised group in tumor cell recipient mice. Natural killer(NK) cell activity showed no significant difference between exercised and non-exercised groups in tumor cell non-recipient mice. Although NK cell activity of non-recipients was higher than tumor cell recipients, NK cell activity of exercised group was significantly lower than non-exercised group among tumor cell recipients. There were no significant differences in mRNA expressions of cytokines. scavenger receptors, and neuropeptieds which are related to immune response, while mRNA expression of TGF-beta was significantly reduced both in spleen and in tumor mass by treadmill exercise. Based on the results presented in this study, endurance exercise has shown the possibility to suppress tumor formation.

화순 백암리유적 조사보고

조현종,은화수 한국고고미술연구소 2005 고고학지 Vol.14 No.-

화순 백암리 유적은 전라남도 화순군 능주면 백암리의 전(田) 355-3번지에 위치하며 민묘 이장작업의 과정에서 한국식동검(韓國式銅劍)과 동과(銅戈)가 발견됨으로써 유구의 잔존여부를 확인하기 위해 발굴조사가 이루어졌다. 조사결과, 유구는 남동-북서방향으로 길게 이어지는 낮은 구릉의 정상부와 사면에서 송국리형주거지와 적석목관묘가 확인되었다. 백암리 유적은 청동유물이 다량 출토된 대곡리 유적과 직선거리로 약 3.75km에 위치한다. 주거지는 평면 형태가 원형이고 중앙에 타원형 구덩이를 갖춘 송국리형이다. 주거지에서의 출토유물은 석기, 옥, 점토대토기편 등으로 점토대토기가 출토되었다는 점에서 축조 시기는 상대적으로 늦다고 볼 수 있다. 적석목관묘는 훼손되기는 하였지만 매장유적에 사용한 돌의 존재를 통해 적석목관묘로 파악할 수 있었다. 적석목관묘에서 수습된 유물은 한국식동검, 동과, 정문경(精文鏡), 관옥(管玉), 삼각형 석촉(石鏃), 흑도편(黑陶片) 등이다. 백암리 한국식동검은 동부가 길고 등대가 봉부까지 굵게 이어져 공주·연기·당진·장수 등지의 유적에서 철기가 출현한 이후 동검들에서 많이 보이는 특징을 갖추고 있다. 정문경은 2구식으로 함평 초포리유적 및 장수 남양리 유적과 관련되는 시점으로 추정해볼 수 있다. 이상과 같은 정황으로 보아 백암리 유적은 비록 철기가 확인되지는 않았지만 철기가 유입되고 확산되는 단계의 시기에 해당하는 것으로 추정된다. 따라서 백암리 유적은 기원전 2세기 전후하여 조영된 것으로 볼 수 있다. The Baekam-ri site was accidentally found during movement of a modem burial in April 2003. During the process, a so-called Korean-style bronze dagger and a spearhead were discovered at the location. Subsequent excavation revealed that the archaeological features at the site were mostly located on the top and side of the hill (68 meters above the sea level). They were arranged linearly along the southeast-northwest axis. The excavated archaeological features include a pit-dwelling and a stone-mounded wooden coffin tomb. The pit-dwelling is so-called Songguk-ri style. It has circular plane shape and an oval pit is placed in the center. The oval pit has one central posthole and two additional postholes whose axis does not run over the central posthole. This probably indicates that the pit-dwelling was renovated at least one time. The artifacts excavated from the site include stone tools, jade ornament, and ring-rimmed pottery. The discovery of ring-rimmed pottery indicates that the site was occupied relatively late during the Bronze period. The long axis of the tomb is aligned to the north and south and is perpendicular to the ridge of the hill. The coffin was placed underground. The artifacts recovered from the tomb include a so-called Korean-style bronze dagger, a bronze spearhead, a fine-grained bronze mirror, some tubular jade, a triangular stone arrowhead, and pieces of black burnished pottery. The Korean-style bronze dagger from Baekam-ri shows stylistic features that postdate the appearance of iron tools. Furthermore, the fine-grained mirror is in the transitional stage from the three-decoration-zone style to the two-decoration-zone style. Accordingly, despite the absence of iron tools in the Baekamri artifact assemblage, this site is dated to about second century B.C., when iron tools appeared in the Korean-style bronze dagger culture.