가청수중음에 의한 넙치의 행동에 관한 기초적 연구 : 1.육상수조 양식장내의 환경소음

이유철,이창헌,최찬문,박용석,서두옥 제주대학교 해양연구소 1997 해양자원연구소연구보고 Vol.21 No.-

A fundamental experiment was carried out to confirm the behaviour of Bastard halibut Paralichthys olivaceus to audible underwater sound in a breeding ground around the coast of Cheju Island. To find characteristics of breeding water tank and experiment water tank. ambient noise, undcrwater noise and feeding sound of fish were measured and analyzied respectively. The results of measurement are as follows: 1. The maximum sound pressure level of ambient noise in breeding water tank was 81dB. average maximum sound level of underwater noise was 81dB at 120Hz. 2. The maximum sound pressure level of ambient noise in experiment water tank was 76dB and underwater noise was 84.2dB at 130Hz. 3. The maximum sound pressure level of feeding sound was 85dB at 120Hz.

위장관의 원발성 B 세포 악성 림프종의 재분류와 bcl-2, cyclin D1, bcl-6 및 p53 발현의 의미

서정균,김태원,김병수,조은택,박찬국,김만우,이미자,전호종 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : In recent years, the REAL (Revised European American Lymphoma) classification provided a new category of MALT (mucosa-associated lymphoid tissue) lymphoma and mantle cell lymphoma in B cell lymphomas. We have analyzed the expression of bcl-2, cyclin D1, bcl-6 and p53 and correlated with the subtypes and histologic grade of primary gastrointestinal B cell lymphoma. Also we investigated the usefulness of immunophenotypic features in diagnosis of low grade B cell lymphoma. Materials and Methods : Twenty-two cases of primary gastrointestinal B cell lymphoma were recategorized in low grade MALT lymphoma, low/high grade MALT lymphoma, high grade MALT lymphoma, and diffuse large cell lymphoma according to the morphological findings. We investigated the expression of bcl-2, cyclin D1, bcl-6 and p53 by immunohistochemical method. Results : The bcl-2 protein expression was higher in the low grade MALT lymphoma than in the high grade lymphoma. The cyclin D1 protein expression was negative in all cases. The expression of bcl-6 and p53 protein was negative in all low grade MALT lymphoma. Conclusion : The results suggest that we can differentiate the low grade lymphoma from the high grade lymphoma by immunohistochemical staining for bcl-2, bcl-6, and p53 protien.

수중 가청음에 대한 멸치 어군의 행동 반응

이창헌,문종욱,박용석,최찬문,서두옥 제주대학교 해양연구소 1998 해양자원연구소연구보고 Vol.22 No.-

A field experiment was carried out to confirm the effect of underwater sound on the luring of fish school using a surface speaker at the coast of Cheju Island. Underwater sounds that were emitted for the luring of fish school were the pure sound of which frequencies were 200Hz and 300Hz. 1. The sound pressure level of 100Hz. 200Hz. 300Hz. 500Hz and 1000Hz classified by the depth of water at sea were 95dB. 100dB. l00dB 80dB and 60dB at 1m. 90dB. 95dB. 88dB. 70dB and 45dB at 10m. 87dB, 90dB. 82dB. 65dB and 42dB at 20m respectively. 2. The effect of the emitted pure sound of 200Hz and 300Hz was remarkable for luring of fish school in about 30 minutes after sound emission. Then Sound pressure was 120 - 130dB. The lured fish school was the shoal of anchovy 3. The fact that anchovy school geathered at 200Hz and 300Hz suggested that this fish school did not show sensitive response to the change of frequencies.

Aspergillus awamori와 Zymomonas mobilis로 구성된 고정화혼합 배양계의 에탄올 생산에 미치는 Triton, PVA 및 PEG의 영향

이상원,서권일,박석규,손봉수,김홍출,성찬기 순천대학교 기초과학연구소 1995 基礎科學硏究誌 Vol.6 No.-

The effects of triton-X 100, PVA and PEG on the ethanol production and raw starch hydrolysis by co-immobilized A. awamori and Z. mobilis (A-Z system) were investigated. When gel beads containing A. awamori(1.25 × 10 exp (9) spores/ℓ - gel) and Z. mobilis(0.5g cell/ℓ - gel) were cultured in 2% raw starch solution at 30℃ for 120 hours, ethanol concentration, ethanol yield (Y_p/s) and pH of culture broth were 2.8g/ℓ, 0.16 and 3.8~4.0, respectively. Ethanol production and starch hydrolysis by addition of PVA was efficient, compared to that of PEG and ethanol concentration in culture broth with 0.2% PVA was 3.56g/ℓ. At A-Z 36 culture system with changing silicon check valve for cotton plug at 36 hours in A-Z culture system, ethanol yield on glucose, Y_p/s = 0.36, showed 2 times higher than that of control culture system(cotton plug culture). Ethanol production and productivity by cultivating 85g gel beads at 30℃ in a 1ℓ jar fermentor(220rpm) of medium 500㎖ were 32g/ℓ and 1.8g/ℓ/day, respectively. After 12 hours of cultivation, gel beads were distinguished oxygen-rich surface for A. awamori from oxygen-deficient central part for Z. mobilis.

생후 6일째(P6) 쥐와 성체 쥐의 해마체에서 시냅스의 발달과 프로테아좀 활성에 관한 연구

이찬혁,김형태,서혜명 한양대학교 이학기술연구소 2005 이학기술연구지 Vol.8 No.-

유비퀴틴-프로테아좀 시스템(ubiquitin-proteasome system: UPS) 은 세포내에서 비정상적인 단백질을 분해하는 기능을 담당하며, 그기능의 상실은 생체의 비정상적인 발달단계나 여러 퇴행성 신경질환의 병리학적 진행을 이해하는데 중요한 것으로 생각된다, 본 연구에서는 생후 6일째의 쥐(P6) 와 성체 쥐 뇌의 해마체에서 시냅스의 발달을 대표할수 있는 nerve growth factor(NGF)와 synaptophysin 의 발현 정도를 측정하고 더불어 프로테아조 활성의 차이를 알아보고자 하였다, 먼저 우리는 P6쥐 의 해마체에서 성체 쥐에 비하여 NGF의 발현이 1.3배 증가된 것을 확인하였고, 또한synaptophysin의 양이 특이적으로 감소된 것을 볼수 있었다, 흥미롭게도 P6쥐의 해마체에서 성체 쥐와 비교하여 유의성 있게 높은 프로테아좀 활성을 관찰 할수 있었다, 이와 같은 연구를 통하여 쥐 뇌의 발달 과정에 있어서 프로테아좀 활성의 조절은 시냅스의 발달과 밀접하게 연관되어 있다고 추정된다. Dysfunction of ubiquitin-proteasome system (UPS)has been proposed or implicated in the pathological processing of several neurodegenerative diseases and abnormalities in development . To address th differences of UPS in the sysnaptic development we determined the proteasome activities in the hippocampus of postnatal day 6 (P6) and adult rats. Using ELISA and western blot we found that the hippocampal NGF expression level is 1.3 times higher and synaptophysin level is significantly lower in P6 compared to adult Interestingly P6 rats in development showed 3~5 times higher hippocampal proteasome activities compared to adults. These results suggest that ubiquitin-proteasome are potentially related to synaptic divelopment.

폐 내 병변으로 인한 소아 급성 호흡부전의 원인 질환과 예후

이혜영,박지숙,최희라,서지현,김점수,임재영,최명범,박찬후,우향옥,윤희상 대한소아과학회 2004 小兒科 Vol.47 No.5

좌측흉수로 발현된 Boerhaave 증후군 1예

이준,변유미,조민근,조주연,원경준,김영대,박찬국,김만우,유재근,서홍주,이석기 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

구토 후 발생한 토혈을 주소로 내원한 환자에서 좌측 늑막 삼출 동반 시 식도 파열의 가능성을 고려하여 흉수 천자 및 지속적인 흉부 단순 촬영의 추적관찰이 필요하며 식도 파열이 배제된 후 환자의 생체 징후 및 토혈 양을 파악하여 내시경 검사 시기를 신중히 결정하는 것이 좋을 것으로 생각된다. 본 증례는 토혈을 주소로 내원하여 Mallory-Weiss 증후군 의심 하에 내시경을 통한 치료 시행 후 추적 관찰에 의해 진단된 Boerhaave 증후군을 경험하였기에 보고하는 바이다. Boerhaave's syndrome is a spontaneous perforation of the esophagus most commonly resulting from a sudden increase in intraesophageal pressure combined with negative intrathoracic pressure caused by straining or vomiting. Surgery should generally be performed within 24 hours because mortality approached 30 to 50 percent in which surgery was delayed. Therefore, early diagnosis and prompt surgical repair are critical for survival. We have experienced a case of Boerhaave's syndrome in a patient presenting with hematemesis with left pleural effusion without any signs or symptoms of pneumomediastinum or pneumothorax.

수면확성기의 음향특성에 관한 연구

이창헌,문종욱,박용석,최찬문,서두옥 제주대학교 해양연구소 1998 해양자원연구소연구보고 Vol.22 No.-

To obtain the fundamental data on a surface speaker made to lure fish school by pure sound, three surface speakers were made of moving coil driver units of 75W and 50W respectively. Their frequency characteristic was measured in the range of 200 - 4mHz that could be used in luring fish school. The results of the measurements in air and sea are follows. 1. The input and output wave forms of a surface speaker were similar to each other in measurement frequencies in air. Then sound pressure of a surface speaker made of 75W driver units among them was over 130dB(0dB re 20μ Pa) in the range of 300 - 400Hz maximally. 2. When the surface speaker with 75W driver units emitted the measurement frequencies at sea. Sound pressure classified by the depth of water were over 140dB at 1m and 120dB at 20m(0dB re 1μ Pa) respectively.

Box-Jenkins 모형을 이용한 X￣관리도와 CUSUM관리도의 민감도 분석

송서일,이보근,조영찬 동아대학교 공과대학부설 생산기술연구소 1997 生産技術硏究所硏究論文集 Vol.2 No.2

It is revealed that, as the use of automated manufacturing is increasing and the process inspection technology is improvements in industry for recently years, the data from mass production system is exhibited some degree of autocorrelation. The operation characteristics of traditional control charts developed under the assumption of independence may be adversely affected by the presence of serial correlation. Therefore, we try to explain a autocorrelated construction by being in contact with a time-series models, so called the Box-Jenkins forecast models, which has been proposed as a very good forecasting tool and allows to distinguish the variations resulted from a autocorrelation structure from one due to unusual but assignable causes. In this paper, autoregressive/moving average parameters in the use of Box-Jenkins forecast models is estimated, and a sensitivity analysis is given by comparing X control chart with CUSUM control chart for the variation of error or forecast residuals.

좌각차단을 동반한 심부전증 환자에 실시한 양심실 심박조율기 치료 : 증례 보고

김찬욱,차태준,김성만,김민대,권성일,서수홍,최병주,주승재,이재우 고신대학교 의학부 2002 高神大學校 醫學部 論文集 Vol.17 No.1

Epidemiological studies suggest that 30-50% of patients diagnosed with symptomatic congestive heart failure(CHF) have electrocardiographic evidence of a major intraventricular conduction delay, which may worsen left ventricular systolic and diastolic dysfunction through asynchronous ventricular contraction and paradoxical interventricular septal wall motion. Biventricular pacing is an emerging therapy allowing simultaneous electrical stimulation of the both ventricles with an implantable pacing system and it improves hemodynamics and well-being of patient by reducing ventricular asynchrony. Recently, we underwent biventricular DDD pacemaker implantation in a patient with CHF and Left bundle branch block and was significantly improved exercise tolerance and quality of life in that patient.