랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구

김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.

여성 외음부에 발생한 선상 편평상피세포암종

김창옥,양기화,강석진,이안희,김병기,김선무 대한병리학회 1991 Journal of Pathology and Translational Medicine Vol.25 No.1

정신분열병 환자에서 존속살인의 임상적 특성

안병훈,최상섭,안성호,하태현,김선범,권경희,김정현 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.4

Objectives : This study aimed to describe the demographic, clinical and offense characteristics of the patients with Schizophrenia who committed parricide. This study also investigated the risk factors of parricide by comparing with characteristics of stranger killers to prevent the tragic offense. Methods : The sample consisted of 88 schizophrenic patients who committed homicide, 59 of them committed parricide and 29 of them killed strangers. Medical chart review regarding demographic and clinical characteristics as well as offense Characteristics was conducted. The information that was difficult to be obtained through chart review was acquired by direct interview. Results : Parricide group had earlier age of onset, more conflicts with the victims, more violence history toward victims and more offense provoking events than stranger killing group. Parricide group showed higher rate of past treatment than that of stranger killing group. However drug compliance at the time of offense was low in both groups. Offense provoking events in the parricide group included blaming, threatening a forced hospitalization or medication toward patients. The most common Psychiatric symptoms associated with homicide were threat/control override (TCO) symptoms, delusional perception, commanding auditory hallucination and especially with parricide, Capgras syndrome (CS). Conclusion : Interaction between psychotic symptoms such as TCO, CS and underlying emotion toward victims are likely to be associated with parricide. Mental health professionals are expected to play an important role in preventing this tragic offense by active history taking of the violence and effective management with active caregiver education/intervention of intrafamilial conflicts.

우리나라 산업의 정밀측정기술 수준분석

안웅환,남경희,안병덕,박병선 한국생산성학회 2003 生産性論集 Vol.17 No.3

The precision measurement technology is the infrastructure of industry technology and thus it is the critical element in the quality and hi-tech products. Nevertheless, the precision measurement technology in Korean industry is the lower level of the advanced state. In this study, we survey the demand of precision measurement technology including instrument and technologies in Korean industry, and provide the objective data on the level of precision measurement technology based on the report "A Study on the Current Status of Precision Measurement in Korea(KRISS, 2001)" . We summarize contents on the precision measurement technology in Korean industry, provide the assessment model for the level of precision measurement technology, and analyze the results of these. The level of the precision measurement technology of National Standards Institution, MISS, approaches those of the advanced state, but levels of the precision measurement technology in Korean industry are 2-3 years behind levels of National Standards Institution. Analysis model and results are analyzed for the important index to compare the levels of the precision measurement technology in Korean industry. Therefore, it is expected to provide the development for precision measurement technology and improve the system of precision measuring instruments, level of precision and accuracy, calibration, technical manpower for measurement etc. in Korean industry.

안면 비대칭의 평가를 위한 기준에 관한 정보 두부 방사선 계측학적 연구

백선호,안병근,김선해,손홍범,한호진,강수만 대한치과교정학회 1993 대한치과교정학회지 Vol.23 No.1

This study was undertaken to investigate the middle having the least difference between the right and left structures among the lines that had been used in the study of the craniomaxillofacial asymmetry. The sample of this study consisted of twenty six Korean girls(average 18.9 years old) having normal facial appearance and occlusion. On the frontal cephalometric films of the sample, we divided the whole craniomaxillifacial area into four portions, i.e., cranial, upper facial, lower facial, and dental portion. So, we have found the midlines having the least difference in the whole craniomaxillofacial area itself, and in the each divided four portions, furtherly in the other portions from aimed portion. The findings were as follow : 1. In the whole craniomaxillofacial area, the connecting line between crista galli and anterior nasal spine and the perpendicular bisecting line between right and left foramen rotundrums were suitable for the midline. 2. In the cranial portion, established all six lines were suitable for midlines. In the other portions, the perpendicular bisection line between both condylion, the line passing the contact point between right and left mandibular central insisiors among the perpendicular lines between right and left mandibular central incisial tips were suitable midlines for evaluating the asymmetry of cranial portion. 3. In the upper facial portion, the perpendicular bisecting line between right and left zygions was the most suitable midline. In the other portions, the line between the crista galli and the most superior point of the odontoid process, the perpendicular bisecting line between right and left gonions, the perpendicular bisecting line between right and left condylions, and perpendicular bisecting line between right and left foramens rotundum were suitable midlines for evaluating the asymmetry of the upper facial portion. 4. In the dental portion, the perpendicular bisecting lines between right and left buccal cusps of both maxillary first molars and between right and left mandibular first molars were suitable midlines. In the other portions, the perpendicular bisecting line between right and left landmarks crossing the lesser wing of the connecting line between crista galli and prosthion were suitable midlines for evaluating the asymmetry of dental portion. 5. In the lower facial portion, the perpendicular bisecting lines between right and left condylions and between right and left gonions were suitable midlines. In the other portions, the line between the crista galli and anterior nasal spine, the perpendicular bisecting line between right and left foramen rotundums, and the perpendicular bisecting lines between right and left buccal cusps of both mandibular first molars and between right and left maxillary first molars were suitable midlines for evaluating the asymmetry of the lower facial portion.

蜂毒藥鍼이 脊髓內 痛症關聯 神經細胞의 活性에 미치는 影響

鄭善喜,李栽東,高炯均,安秉哲,崔道永,朴東錫 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

In spite of the use of Bee Venom aqua-acupuncture in the clinics, the scientific evaluation of effects is not enough. Bee Venom aqua-acupuncture is used according to the stimulation of acupuncture point and the chemical effects of Bee Venom. The aims of this study is to investigate the analgegic effects of the Bee Venom aqua-acupuncture, through the change of writhing reflex and the change of c-fos in secondary neurons in the spinal cord. Materials and Methods : Pain animal model was used acetic acid method. The changes of writhing reflex of the mice which were derived pain by injecting acetic acid into the abdomen, after stimulating Bee Venom aqua-acupuncture on Chungwan(CV12) were measured. We used Fos immunohistochemical technique to study the neuronal activity in the spinal cord. Results : 1.Expression of c-fos in superficial dosal horn(SDH), nucleus proprius(NP) and neck of dorsal horn(N) on 6~9th thoracic spine decreased significantly at 2.5×10-4g/kg Bee Venom aqua-acupuncture, compared with saline-acetic acid group. 2.The numeral change of Fos-LI neurons on the NP, N, and ventral gray(V) on 6~9th thoracic spine, SDH on 9~11th thoracic spine, and SDH and V on 11~13th thoracic spine decreased significantly at Chungwan(CV12) Bee Venom aqua-acupuncture, compared with saline-acetic acid group. 3.The correlation between the numbers of writhing reflex and Fos-LI neurons in T6-13 segment was statistically statistically significant at Chungwan(CV12) Bee Venom aqua-acupuncture. Conclusion : This study shows that the Bee Venom aqua-acupuncture on Chungwan(CV12) decreases the numbers of Fos-LI neurons. As the analgegic effects of Bee Venom aqua-acupuncture is recognized. Bee Venom aqua-acupuncture treatment is expected for pain modulation. In order to use it in many ways. more researches are needed for the dose and stability of Bee Venom aqua-acupuncture.

정상교합과 부정교합에서의 상·하악골과 제 1 대구치 위치에 관한 비교연구

윤병모,안병근,이건주,김선해,박영주,한호진 대한치과교정학회 1993 대한치과교정학회지 Vol.23 No.4

There has been so much controversies about the position of upper and lower jaws, and their first permanent molars in normal occlusion and Angle's class ⅠㆍⅡㆍⅢ malocclusions. So, the purpose of this study is to compare the position of upper and lower jaws, and their first molars in normal occlusion and Angle's class ⅠㆍⅡㆍⅢ malocclusions by lateral cephalometric analysis. The sample consisted of one hundred and twenty girls(thirty in each group) who had completed growth. The findings of this study were as follows : 1. In class Ⅰ malocclusion, both maxilla and mandible were slightly posterior position than normal occlusion, but they showed harmonious relationship. 2. In class Ⅱ malocclusion, the mandible was greatly retruded, and the maxilla was also slightly retruded to the cranial base as compared with normal occlusion. 3. In class Ⅲ malocclusion, the maxilla was significantly retruded to the cranial base, but no significant difference was found in mandibular position as compared with normal occlusion. 4. The maxillary first molar was located at posterior position in class Ⅱ malocclusion, and anterior position in class Ⅲ malocclusion to the cranium, so that the rotation of mandible was influenced by that. 5. The mandibular first molar showed constant relationship to the mandible in all four group, but different position to the cranial base in direct proportion to the mandibular position. 6. On the treatment planning of class Ⅲ malocclusion, it seems to be better to promote the mandibular horizontal growth by ingibiting the verbical growth of masillary molar area, and on the treatment planning of class Ⅲ malocclusion, it seems to be better to promote the antero-inferior growth of maxilla and to promote the mandibular vertical growth by inducing the vertical growth of maxillary molar area.

고정식 교정장치에 의한 균혈증의 발생가능성에 관한 연구

임순모,안병근,김선해,박영주,한호진,이윤상 대한치과교정학회 1993 대한치과교정학회지 Vol.23 No.4

The purpose of this study was to investigate a possibility of chronic or intermittent bacteremia in patients undergoing orthodontic treatment with fixed orthodontic appliance. Orthodontic patients who had been injured by orthodontic appliances and/or suffered from gingivitis were selected. They had not taken any antibiotics for 1 month. The number of subjects were 21 including 7 males and 14 females. Blood samples of the subjects were cultured and, IgG, IgA and IgM levels in the serum were quantified. The author found following results. 1. No bacterial growth was found in 7-day culture of all the samples. 2. The immunoglobulin levels in serum were confined in normal range. 3. This study could not deny the possibility of transient bacteremia episode undergoing orthodontic treatment.

Development of Sun-Glint Prediction Program For The Communication, Ocean and Meteorological Satellite

Park Jae-Ik,Choi Kyu-Hong,Park Sang-Young,Lee Byoung-Sun,Ahn Yu-Hwan 한국우주과학회 2004 한국우주과학회보 Vol.13 No.2

3급 부정교합 환자와 정상인에 있어서 하악소설과 Sigmoid Notch간의 거리에 관한 비교연구

박해승,안병근,이건주,김선해,박영주,유기준 한림대학교의료원 1994 人間科學 Vol.18 No.2