Clinical characteristics of pediatric patients infected with SARS-CoV-2 versus common human coronaviruses: a national multicenter study

Sol In Suk,Lee Eun,양현종,Lee Yong Ju,Yum Hye Yung,Lee Mi-Hee,Chu Mi Ae,Moon Hui jeong,김효빈,서주희,Shim Jung Yeon,Ahn Ji Young,Jang Yoon Young,Chung Hai Lee,Chung Eun Hee,Kim Kyunghoon,김봉성,김철홍,Park Yang,신미용 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.3

Background: Human coronaviruses (HCoV) cause mild upper respiratory infections; however, in 2019, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged, causing an acute respiratory disease pandemic. Coronaviruses exhibit marked epidemiological and clinical differences.Purpose: This study compared the clinical, laboratory, and radiographic findings of children infected with SARS-CoV-2 versus HCoV.Methods: SARS-CoV-2 data were obtained from the Korea Disease Control and Prevention Agency (KDCA) registry and 4 dedicated coronavirus disease 2019 (COVID-19) hospitals. Medical records of children admitted with a single HCoV infection from January 2015 to March 2020 were collected from 10 secondary/tertiary hospitals. Clinical data included age, sex, underlying disease, symptoms, test results, imaging findings, treatment, and length of hospital stay.Results: We compared the clinical characteristics of children infected with HCoV (n=475) to those of children infected with SARS-CoV-2 (272 from KDCA, 218 from COVID-19 hospitals). HCoV patients were younger than KDCA patients (older than 9 years:3.6% vs. 75.7%; P<0.001) and patients at COVID-19 hospitals (2.0±2.9 vs 11.3±5.3; P<0.001). Patients with SARS-CoV-2 infection had a lower rate of fever (26.6% vs. 66.7%; P<0.001) and fewer respiratory symptoms than those with HCoV infection. Clinical severity, as determined by oxygen therapy and medication usage, was worse in children with HCoV infection. Children and adolescents with SARS-CoV-2 had less severe symptoms.Conclusion: Children and adolescents with COVID-19 had a milder clinical course and less severe disease than those with HCoV in terms of symptoms at admission, examination findings, and laboratory and radiology results.

Diatom-inspired Synthesis of Micelle-templated Silica Nanoparticle with Enhanced Mass Transfer and Stability as Biocatalyst

Ae Sol LEE,Chang Sup KIM 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.4

Bioinspired Synthesis of Micelle-templated Silica Nanocapsules for Biocatalysts

Ae Sol LEE,Chang Sup KIM 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10

Enzymes have various advantages compared to chemical catalysts, including their high selectivity to a substrate and less production of byproducts. However, it remains a challenge to use enzymes in practical applications due to their low stability under harsh conditions. In this study, we developed biocatalytic silica nanoparticles templated from R5 peptide- and enzyme-functionalized micelle using two-phase biosilicification. Carbonic anhydrase (CA) was used as a target enzyme, which catalyzes a hydration reaction of carbon dioxide. Each CA and silica forming peptide R5 was covalently conjugated with NHS-ester functionalized hydrophilic ends of triblock copolymer F127 (F127-CA and F127-R5). CA- and R5 peptide-functionalized micelles (F127-CA/R5 micelle) were prepared by controlling a molar ratio of F127-CA and F127-R5. Biocatalytic silica nanoparticles (F127-CA/R5 micelle@SiNP) were synthesized from F127-CA/R5 micelles using the two-phase biosilicification method. F127-CA/R5 micelle@SiNP showed a porous structure with a thin silica layer. Furthermore, it showed enhanced thermal and storage stability compared to the free enzymes without a reduction in activity. We expected that this proposed method would present a direction for the use of enzymes as biocatalysts in practical applications.

기후변화 시나리오 앙상블을 통한 오미자의 재배적지 변화 예측

이솔애 ( Sol Ae Lee ),이상혁 ( Sang-hyuk Lee ),지승용 ( Seung-yong Ji ),최재용 ( Jaeyong Choi ) 한국환경영향평가학회 2016 환경영향평가 Vol.25 No.1

Predicting possible distributed area of Schisandra chinensiswhich has long term cultivation period among non-timber forest products is needed to be studied to deal with climate change. Hence, distribution of Schisandra chinensis in the 2050s and 2070s was predicted under two scenario, RCP 4.5 and RCP 8.5, with ensemble of 5 climate models used in IPCC AR5. According to estimation using RCP 4.5, distribution of Schisandra chinensis in 2050s appeared to decrease 43% of current area and appeared to decrease 57% in 2070s respectively. Moreover, According to estimation using RCP 8.5, distribution of Schisandra chinensis in 2050s appeared to decrease 55% of current area and appeared to decrease 85% in 2070s. As a final outcome, Schisandra chinensiswas estimated to extinct in the future except Gangwon-do and Gyeongsangbuk-do when analyzing change between current distributed area and future distributed area. As a result, those areas were classified as vulnerable areas to climate change. Therefore, Gangwon-do and Gyeongsangbuk-do were thought to be ideal for growing Schisandra chinensis. The result from this study can be used to provide basic information for selecting proper area of Schisandra chinensis considering climate change effect.

Distribution of the bacterial contamination level of domestic fishery products (raw or processed) according to the type of food chain

Young Hoon Lee,Ji Seop Song,Jin Song Shin,Ki Won Lee,Han Sol Park,Chan Min Lee,Eunjin Choi,Hary Yu,Min Suk Rhee,Sun Ae Kim,Tae Jin Cho 한국식품영양과학회 2022 한국식품영양과학회 학술대회발표집 Vol.2022 No.10

Implication from the food practices for the foodborne outbreak investigation supported by epidemiological technologies and whole genome analysis

Chan Min Lee,Ki Won Lee,Ji Seop Song,Jin Song Shin,Han Sol Park,Young Hoon Lee,Soo Jin Park,Sun Ae Kim,Tae Jin Cho 한국식품영양과학회 2022 한국식품영양과학회 학술대회발표집 Vol.2022 No.10

연구논문(硏究論文) : DMZ 주변 훼손지의 생태복원 평가지표 개발

이상훈 ( Sang Hoon Lee ),이상혁 ( Sang Hyuk Lee ),이솔애 ( Sol Ae Lee ),최재용 ( Jae Yong Choi ) 한국환경복원기술학회 2015 한국환경복원기술학회지 Vol.18 No.1

DMZ is considered as an ecologically sensitive landscape and one of the highest biodiversity regions in the Republic of Korea. There have been, albeit the significant value, increased interests in developing this region for a variety of purposes including tourism and commemorative events. As this region has been already facing a range of problems derived from previous development, natural disaster and invasive species, the necessity for active management of ecological health within this region has been increased, which weighs the importance of executing ecological restoration. The objective of this study was to develop evaluation indices as an effective management means of properly evaluating ecological restoration and sustainably maintaining the restored conditions on a long-term scale. Through literature review existing evaluation indices related to restoration were collected, and then the most suitable indices were selected based upon two interviews and one questionnaire survey targeting experts in the relevant field to ecological restoration. They were categorized by two major division and their subclasses (Ecological base - vegetation structure & composition, habitat characteristics, soil environment; landscape ecology - connectivity, landscape patch, boundary & surrounding) and 40 indices. These indices were considered helpful to comprehensively evaluate ecological restoration on degraded environments within ecologically sensitive areas, and sustainably manage target areas by employing a long-term monitoring approach. As this result played a meaningful role in providing the fundamentals of evaluating ecological restoration, it should develop a suitable evaluation system through further research.

기후변화 영향에 따른 호두나무 재배지역 변화 예측

이상혁 ( Sang Hyuk Lee ),이상훈 ( Peter Sang-hoon Lee ),이솔애 ( Sol Ae Lee ),지승용 ( Seung Yong Ji ),최재용 ( Jae Yong Choi ) 한국농림기상학회 2015 한국농림기상학회지 Vol.17 No.4

본 연구에서는 호두나무에 대하여 단기임산물 재배적지도를 바탕으로 기후변화를 고려한 전국의 재배가능지역을 MaxEnt 모델을 이용하여 추출하였다. RCP 4.5 및 8.5 시나리오와 HadGEM2-AO모델을 이용하여 2050년대와 2070년대의 기후변화에 따른 재배지역 변화를 예측하였다. 분석결과, 미래의 재배적지면적을 현재수치와 비교하였을 때, RCP 4.5에서는 충청남도, 전라북도, 전라남도에 이르는 우리나라 서쪽 지역이 주로 감소할 것으로 나타났으며, RCP 8.5에서는 경상북도, 경상남도 일부 지역을 중심으로 감소할 것으로 나타났다. 하지만, 평균고도가 600m 이상으로 높은 지역인 강원도는 2070년대 RCP 4.5에서 18.3%, RCP 8.5에서 56.6%가 증가할 것으로 나타나 기후변화의 영향 정도에 따라 전국적으로 재배가능지역의 차이가 있는 것으로 나타났다. 현재 호두 생산량이 가장 많은 지역을 분석한 결과 공주시, 김천시, 영동군은 2070년대에는 RCP 8.5에서 재배지역의 감소가 클 것으로 예상되었으며, 공주시는 RCP 4.5에서 감소폭이 더 큰 것으로 나타났다. 무주군과 천안시는 현재의 재배가능지역이 모든 시나리오에서 유지될 것으로 나타났다. 본 연구의 결과는 미래 기후변화에 따른 영향이 불가피한 상황에서 예상되는 피해를 최소화하고 경쟁력 있는 임산물 생산을 위한 기후변화 영향평가 자료로 활용될 것으로 판단된다. The objective of our study was to predict future cultivation areas for walnut trees (Juglans sinensis), using the cultivation suitability map provided from Korea Forest Service and MaxEnt modelling under future climate conditions. The climate conditions in 2050s and 2070s were computed using the Regional Climate Prediction (RCP) 4.5 and 8.5 scenarios with the HadGEM2-AO model. As a result, compared to the present area, the cultivation area of the western Korea including Chungcheongnamdo, Jeollabuk-do, Jeollanam-do decreased on a national scale under RCP 4.5, and those of Gyeongsangbukdo and part of Gyeongsangnam-do decreased under RCP 8.5. However, Gangwon-do which is located in higher altitude over 600 meters than other regions showed increases in cultivation areas of 18.3% under RCP 4.5 and of 56.6% under RCP 8.5 by 2070s. The predicted map showed large regional variations in the cultivation areas with climate change. From the analysis of current top ranking areas, the cultivation areas in Gimcheon-si and Yeongdong-gun dramatically decreased by 2070s under RCP 4.5 and 8.5; that of Gongju-si decreased more under RCP 4.5; and those of Muju-gun and Cheonan-si sustained the areas by 2070s under both scenarios. The results from this study can be helpful for providing a guide for minimizing the loss of walnut production and proactively improving productivity and quality of walnuts with regard to unavoidable climate change in South Korea.

치매환자의 공격적 행동과 치료사의 심리적 소진의 관계 및 대처방법 분석연구

이다솔(Lee Da-Sol),김시은(Kim Si-Eun),양영애(Yang Yeong-Ae) 고령자치매작업치료학회 2020 고령자.치매작업치료학회지 Vol.14 No.2

목적: 본 연구는 치매환자를 일대일로 응대하는 치료사들이 어떠한 공격적 행동 양상을 경험하고 대처하는지 알아보고 공격적 행동에 따른 심리적 소진과의 관계를 비교하고자 한다. 연구방법: 2020년 10월 15일부터 11월 2일까지 작업치료사, 물리치료사 면허증을 소지하고 의료재활기관과 사회복지기관에서 치매환자를 대상으로 작업치료 및 물리치료 업무를 수행하고 있는 치료사 62명을 대상으로 설문조사를 실시하였다. 연구결과: 치매환자의 공격적 행동 빈도수가 높을수록 작업치료사와 물리치료사의 심리적소진의 점수도 높았으며 통계적으로 유의한 결과가 나타났다. 치매환자의 공격적 행동에 따른 대처행동은 언어적 토론, 신체적 억제, 행동제한, 발생요인제거, 무반응, 휴식, 화학적 억제, 기분전환, 회피, 신체적 공격 순으로 나타났으며 구체적으로는 공격적 행동에서 모두 언어적 토론이 가장 높은 빈도수를 보였다. 결론: 본 연구에서는 각 기관에서는 치매환자의 공격적 행동에 대한 대처행동에 관한 교육 및 프로그램과 재활적 치료 접근법의 기초자료를 제공하고 작업치료사와 물리치료사는 심리적 소진에 대한 적절한 관리가 필요할 것이다. Objective : This study aims to investigate the aspects of aggressive behaviors the therapists who were coping with dementia patients one on one experience and cope with and to compare the relationship with psychological burn-out according to the aggressive behaviors. Methods : This study conducted a survey with 65 therapists who were performing the tasks of occupational therapy and physical therapy for dementia patients at medical rehabilitation institutions and social welfare institutions, holding the licenses of an occupational therapist and a physical therapist from October 15 through November 2, 2020. Results : The higher the frequency of the dementia patient’s aggressive behavior, the higher the score of the psychological burn-out of the occupational therapists and physical therapists became, and the result was statistically significant. The behaviors for coping with the dementia patients’ aggressive behaviors appeared in the following order: Linguistic discussion, physical suppression, behavior restriction, the removal of the cause of occurrence, unresponsiveness, rest, chemical suppression, diversion, evasion, and physical aggression, and concretely, the linguistic discussion showed the highest frequency in all the aggressive behaviors. Conclusion : Through this study, it is found that each institution should provide education and program on the behavior for coping with dementia patients’ aggressive behaviors and the baseline data on the rehabilitative therapeutic approach and that occupational therapists and physical therapists should appropriately manage their psychological burn-out.

Clinical Characteristics and Treatment Outcomes of Pulmonary Diseases Caused by Coinfections With Multiple Nontuberculous Mycobacterial Species

Kim Sol,Woo A La,Yong Seung Hyun,Leem Ah Young,Lee Su Hwan,Lee Sang Hoon,Kim Song Yee,Chung Kyungsoo,Kim Eun Young,Jung Ji Ye,Kang Young Ae,Park Moo Suk,Kim Young Sam,Park Youngmok 대한의학회 2024 Journal of Korean medical science Vol.39 No.20

Background: Coinfections with multiple nontuberculous mycobacterial (NTM) species have not been widely studied. We aimed to evaluate the clinical characteristics and treatment outcomes in patients with NTM-pulmonary disease (PD) caused by coinfection with multiple NTM species. Methods: We retrospectively reviewed patients with NTM-PD at a tertiary referral hospital in Korea between March 2012 and December 2018. Coinfection was defined as two or more species of NTM pathogens isolated from the same respiratory specimen or different specimens within three months. Results: Among 1,009 patients with NTM-PD, 147 (14.6%) NTM coinfections were observed (average age 64.7 years, 69.4% women). NTM species were identified more frequently (median 6 vs. 3 times, P < 0.001) in the coinfection group than in the single species group, and follow-up duration was also longer in the coinfection group (median 44.9 vs. 27.1 months, P < 0.001). Mycobacterium avium complex (MAC) and M. abscessus and M. massiliense (MAB) were the dominant combinations (n = 71, 48.3%). For patients treated for over six months in the MAC plus MAB group (n = 31), sputum culture conversion and microbiological cure were achieved in 67.7% and 41.9% of patients, respectively. We divided the MAC plus MAB coinfection group into three subgroups according to the target mycobacteria; however, no statistical differences were found in the treatment outcomes. Conclusion: In NTM-PD cases, a significant number of multiple NTM species coinfections occurred. Proper identification of all cultured NTM species through follow-up is necessary to detect multispecies coinfections. Further research is needed to understand the nature of NTM-PD in such cases.