하악 고정성 임프란트를 이용한 퇴축된 하악골의 수복

정영진,박원희,안원준,이명렬,이영수,유광희,심광섭 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.2

Transmandibular implants are used limitedly such as on remaining symphyseal basal bone of atrophic mandible, on the bony defect of symphyseal area due to trauma or tumor as surgical implants. Among the more recent advances in oral implantology are the Fixed Mandibular Implant (FMI)based on the pioneering studies and clinical applications by Irwin Small of the USA and the development very high success rates for providing attachments and abutments in areas of the oral cavity severely compromised by either atrophy or surgical loss of osseous tissues. We will present a case report of regabilitation of totally edentulous mandible with advanced alveolar atrophy using Fixed Mandibular implant (F.M.I).

정밀어태치먼트의 완압정도에 따른 하악국소의치의 지지조직에 대한 3차원 유한요소 응력분석

정연진,우순섭,이영수,심광섭,유광희 한양대학교 의과대학 1999 한양의대 학술지 Vol.19 No.1

The purpose of this study was to evaluate the stress distribution developed in the supporting structures by mandibular distal extension removable partial dentures with 4 different precision attachments. The examined precision attachments were Mini SG attachment, CM box attachment. Mini Dalbo attachment, Technoroach attachment. Concentrated force(vertical force 200N, horizontal force 50N) was applied on the artificial 2nd molar of the removable partial dentures and distributed force(vertical force 100N, horizontal force 25N) was applied on the each artificial 1st, 2nd molars of removable partial dentures. Total 4 cases were compared and analyzed with 3-dimensional finite element method. And then, stress distribution patterns were analyzed and compared. The results were as follows. 1. In case of concentrated force; Maximal stress distribution was showed on the alveolus under artificial 2nd molar and then, stress mainly distributed on the residual alveolus of the denture base. 2. In case of distributed force; Maximal stress distribution was showed on the distal alveolar crest of distal abutment, and then, stress mainly distributed on the alveolus of mesial and distal abutments. 3. The stress of residual alveolus of non rigid attachment was greater than that of rigid attachment. 4. The stress of abutments of rigid attachment was greater than that of non rigid attachment.

돼지 신장세포(PK15)의 이종이식 거부반응에 대한 재조합 IL-18의 영향

최연실,김은미,김영관,박상연,심정현,윤도영,강형식,명평근 충남대학교 생물공학연구소 2004 생물공학연구지 Vol.10 No.1

Various cytokines including IL-1β, IL-2, IL-4, IL-10, IL-12p40, IFN-γ, and TNF-α have been recently reported to play important roles in both host and donor cell activations during xenotransplantation. Interleukin (IL)-18, a proinflammatory cytokine, can induce IL-4 and IL-13 production in T cells, NK cells, B cells, mast cells, and basophils. IL-18 has the capacity to stimulate innate immunity and both Th1-and Th2- mediated responses, but little is known to involve in the xenograft rejection. In order to investigate the role of IL-18 in xenograft rejection, we transplanted the pig kidney (PK15) cells to C57BL/6 mouse with or without intraperitoneal injection of mouse recombinatant IL-18. It was analyzed the population of T cell, B cell and NK cell in the mice transplanted with PK 15 cells and recombinant IL-18 by flow cytometry. We found that splenic CD3+ T cells were increased in mice injected PK15 cells with recombinant IL-18. These results suggest that recombinant IL-18 is critical in the xenograft rejection by increasing T cell population of the recipients.

돼지 신장세포(PK15)의 이종이식 거부반응에 대한 재조합 IL-18의 영향

최연실,김은미,김영관,박상연,심정현,윤도영,강형식,명평근 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8

Various cytokines including IL-1β, IL-2, IL-4, IL-10, IL-12p40, IFN-r, and TNF-α have been recently reported to play important roles in both host and donor cell activations during xenotransplantation. Interleukin (IL)-18, a proinflammatory cytokine, can induce IL-4 and IL-13 production in T cells, NK cells, B cells, mast cells, and basophils. IL-18 has the capacity to stimulate innate immunity and both Th1-and Th2- mediated responses, but little is known to involve in the xenograft rejection. In order to investigate the role of IL-18 in xenograft rejection, we transplanted the pig kidney (PK15) cells to C57BL/6 mouse with or without intraperitoneal injection of mouse recombinatant IL-18, It was analyzed the population of T cell, B cell and NK cell in the mice transplanted with PK 15 cells and recombinant IL-18 by flow cytometry. We found that splenic CD3+ T cells were increased in mice injected PKl5 cells with recombinant IL-18. These results suggest that recombinant IL-18 is critical in the xenograft rejection by increasing T cell population of the recipients.

A Study on Spiritual Resilience from the Bible Perspective: Focusing on Recovery from Spiritual Suffering.

Shim, Jung-Yeon 한국실천신학회 2021 신학과 실천 Vol.- No.75

This study's purpose is to consider the biblical perspective of spiritual resilience- i.e., the ability to recover from spiritual suffering-and to outline its components. To this end, the study examines the definitions and characteristics of spiritual distress that have already been identified and then proposed new components of spiritual resilience as the ability to recover from spiritual distress. The study found that spiritual suffering lies at the heart of all suffering, often including a sense of disconnection from God, meaninglessness. Spiritual resilience can be defined as the capacity required to alleviate spiritual suffering, an essential capacity that must be cultivated by saints existing in a corrupt world of depravity. Spiritual resilience is based on two forms of knowledge: knowledge of God and an understanding of the suffering from a biblical perspective. Knowledge of God includes the image of God in the Bible, God who knows our suffering, and God who comforts us on the last day. Understanding pain from a biblical point of view involves understanding pain through the doctrines of creation, depravity, and redemption, discovering the meaning of pain as a process of sanctification, and perceiving suffering as the process of full recovery to come. Based on these two forms of underlying knowledge, the capacity of spiritual resilience made up of intellectual, emotional, and willful internal competencies and the capacity of the faith community, external competency. Finally, this study recommends a specific application of the concept of spiritual resilience in Christian education and counseling.

Association of wheezing phenotypes with fractional exhaled nitric oxide in children

Shim, Jung Yeon The Korean Pediatric Society 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.5

Asthma comprises a heterogeneous group of disorders characterized by airway inflammation, airway obstruction, and airway hyperresponsiveness (AHR). Airway inflammation, which induces AHR and recurrence of asthma, is the main pathophysiology of asthma. The fractional exhaled nitric oxide (FeNO) level is a noninvasive, reproducible measurement of eosinophilic airway inflammation that is easy to perform in young children. As airway inflammation precedes asthma attacks and airway obstruction, elevated FeNO levels may be useful as predictive markers for risk of recurrence of asthma. This review discusses FeNO measurements among early-childhood wheezing phenotypes that have been identified in large-scale longitudinal studies. These wheezing phenotypes are classified into three to six categories based on the onset and persistence of wheezing from birth to later childhood. Each phenotype has characteristic findings for atopic sensitization, lung function, AHR, or FeNO. For example, in one birth cohort study, children with asthma and persistent wheezing at 7 years had higher FeNO levels at 4 years compared to children without wheezing, which suggested that FeNO could be a predictive marker for later development of asthma. Preschool-aged children with recurrent wheezing and stringent asthma predictive indices also had higher FeNO levels in the first 4 years of life compared to children with wheezing and loose indices or children with no wheeze, suggesting that FeNO measurements may provide an additional parameter for predicting persistent wheezing in preschool children. Additional large-scale longitudinal studies are required to establish cutoff levels for FeNO as a risk factor for persistent asthma.

Analysis of Harvesting Part for Radish Harvester

( Yeon-jun Jung ),( Hyeon-ho Jeon ),( Hee-jong Jung ),( Taek-jin Kim ),( Jong-yeal Shim ),( Tae-ho Han ),( Chang-hyun Choi ),( Hae-yoon Tak ),( Yong-joo Kim ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

The agricultural labors are rapidly decreasing due to the aging of the agricultural population and the feminization. In Korea, radishes account for around 78.1% of the root vegetables in 2014, and the ratio of labor in harvesting and transporting work is about 26.7%. Therefore, it needs to develop the agricultural mechanization technology, especially radish harvester, because radish harvester of pulling type is directly contacted with soil during harvesting. Then, strength analysis of harvesting part is needed. In this study, finite element analysis was carried out using ANSYS Workbench in order to find out the weak point of the harvesting part of the harvester. The 3D model of the harvesting part including driving pulleys, shafts, and V-belts was designed by using CATIA V5 R18. The maximum load of 16.82 Nm measured in the field test was input to the driving shaft. The driving pulleys, shafts, and V-belts were simulated, and analyzed the deformation and equivalent stress. Simulation results revealed the maximum deformation and equivalent stress on the driving shaft. The results showed that the driving shaft of the radish harvester is the weakest point. Thus, the simulation results should be sufficiently considered during the design of the driving part of the harvesting part.

CASE REPORT : A Case of Segniliparus rugosus Pulmonary Infection in an Immunocompetent Patient with Non-cystic Fibrosis

( Jung Yeon Lee ),( Gyu Rak Chon ),( Tae Young Jung ),( Heung Sup Sung ),( Tae Sun Shim ),( Kyung Wook Jo ) 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.77 No.5

Segniliparus species is a novel genus that is reported to be the new emerging respiratory pathogens. Here, we report a very rare case of S. rugosus pulmonary infection in an immunocompetent patient with non-cystic fibrosis. The organism was identified by 16S rRNA gene sequencing. The patient was successfully treated with antibiotics.

Wheezing in infants and preschoolers: phenotypes and treatment options

Shim Jung Yeon 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.1

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Current perspectives on atypical pneumonia in children

Shim, Jung Yeon The Korean Pediatric Society 2020 Clinical and Experimental Pediatrics (CEP) Vol.63 No.12

The major pathogens that cause atypical pneumonia are Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila. Community-acquired pneumonia (CAP) caused by M. pneumoniae or C. pneumoniae is common in children and presents as a relatively mild and self-limiting disease. CAP due to L. pneumophila is very rare in children and progresses rapidly, with fatal outcomes if not treated early. M. pneumoniae, C. pneumoniae, and L. pneumophila have no cell walls; therefore, they do not respond to β-lactam antibiotics. Accordingly, macrolides, tetracyclines, and fluoroquinolones are the treatments of choice for atypical pneumonia. Macrolides are the first-line antibiotics used in children because of their low minimum inhibitory concentrations and high safety. The incidence of pneumonia caused by macrolide-resistant M. pneumoniae that harbors point mutations has been increasing since 2000, particularly in Korea, Japan, and China. The marked increase in macrolide-resistant M. pneumoniae pneumonia (MRMP) is partly attributed to the excessive use of macrolides. MRMP does not always lead to clinical nonresponsiveness to macrolides. Furthermore, severe complicated MRMP responds to corticosteroids without requiring a change in antibiotic. This implies that the hyper-inflammatory status of the host can induce clinically refractory pneumonia regardless of mutation. Empirical macrolide therapy in children with mild to moderate CAP, particularly during periods without M. pneumoniae epidemics, may not provide additional benefits over β-lactam monotherapy and can increase the risk of MRMP.