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가와사끼병 환아에서 대량 정맥 감마글로불린 용량에 따른 혈청내 TNF-α 와 IFN-γ 농도의 비교
김봉성,심정연,박경희,김영휘,홍수종 대한 소아알레르기 및 호흡기학회 1999 소아알레르기 및 호흡기학회지 Vol.9 No.2
목 적 : 급성기 가와사끼병 환아에서 고용량 정맥 감마글로불린 1 gm/㎏과 2 gm/㎏ 정맥 투여후 혈관손상 과정에 작용하는 사이토카인으로 알려져 있는 TNF-α와 IFN-γ의 변화를 비교하였다. 방 법 : 서울중앙병원 소아과에 입원한 가와사끼병 환아 14명에 대해 급성기에 2군으로 나누어 각각 정맥 감마글로불린을 1 gm/㎏, 2 gm/㎏씩 1회 투여하고 투여 직전, 투여 후 5일, 14일에 혈청내 TNF-α및 IFN-γ 농도를 ELISA로 측정하였다. 결 과 : 1) 정맥 감마글로불린 1 gm/㎏ 투여군과 2 gm/㎏ 투여군에서 TNF-α 측정치를 비교하였을 때 투여전과 투여후 5일째와 14일째 모두 통계학적으로 유의한 차이가 없었다. 2) 정맥 감마글로불린 1 gm/㎏ 투여군과 2 gm/㎏ 투여군에서 IFN-γ 측정치를 비교하였을 때 투여전과 투여후 5일째와 14일째 모두 통계학적으로 유의한 차이가 없었다. 결 론:가와사끼병 환아에서 고용량 정맥 감마글로불린 1 gm/㎏과 2 gm/㎏ 정맥 투여후 급성기에 말초혈액 단핵구에서 생산된 혈청내 TNF-α와 IFN-γ 농도의 억제 효과는 차이가 없었다. 앞으로 정맥 감마글로불린의 적절한 용량 선정을 위해 임상적 예후에 관한 전향적 연구가 필요한 것으로 생각한다. Purpose : Recently, the protocol of high dose of intravenous immunoglobulin has been preferred in the treatment of acute stage of Kawasaki disease. In this study, we have compared the serum concentrations of TNF-α and IFN-γ in the patients with Kawasaki disease between intravenous immunoglobulin of 1 gm/㎏ and 2 gm/㎏ groups. Methods : Fourteen patients admitted to Asan Medical Center were enrolled in this study. These patients met the diagnostic criteria of Kawasaki disease divided into two groups by the dose of intravenous immunoglobulin, 1 gm/㎏ and 2 gm/㎏. The concentrations of TNF-α and IFN-γ using ELISA methods were measured before and after the 5th and 14th days of intravenous immunoglobulin. Results : The serum levels of TNF-α and IFN-γ showed no statistically significant difference between 1 gm/㎏ and 2 gm/㎏ group of intravenous immunoglobulin on before the treatment and the 5th, 14th days after the infusion of intravenous immunoglobulin. Conclusion : There is no difference of serum concentrations of TNF-α and IFN-γ between the intravenous immunoglobulin of 1 gm/㎏ and 2 gm/㎏ doses in an acute stage of Kawasaki disease. The dose of immunoglobulin in a treatment of Kawasaki disease needs to be examined in future studies.
인삼양위탕(人蔘養胃湯)의 면역(免疫) 증강효과(增强效果)에 관(關)한 연구(硏究)
김봉성,정규만,Kim Bong-Sung,Jeong Gyu-Mahn 대한한방소아과학회 1994 대한한방소아과학회지 Vol.8 No.1
In order to investigate the effects of Insamyangwee Tang on cell-mediated and humoral immune response, solid extract of Insamyangwee Tang (sample A), mixture of individual solid extract of Insamyangwee Tang (sample B) were administered orally for 14 days. The auther used ICR mice having a body weight of about 20-22g as experimental animals dividing them into three groups-Saline, Sample A and Sample B group. All of the mice were sensitized i.v. with $10^8$ sheep red blood cells(SRBC) and challenged i.d. with $10^8$ SRBC 4 days later. Such immune responses as delayed-type hypersensitivity(DTH), rosette forming cells(RFC), hemagglutinin titers(HA titers) and hemolysin titers(HL titers) were measured at 24 hours after challenge. The results were as follow: 1. DTH in Sample A & Sample B group was increased, as compared with Saline group, with satistical significance. 2. RFC in Sample A & Sample B group were increased, as compared with Saline group, with statistical significance. 3. HA titers in Sample A & Sample B group were not increased, as compared with Saline group, with statistical significance. 4. HL titers were increased just only in Sample A group with statistical significance. The inference from the above results is that Sample A group is better than Sample B group, and Insamyangwee Tang enhance the cell-mediated and humoral immune response.
The macrophage migration inhibitory factor protein superfamily in obesity and wound repair
김봉성,Norbert Pallua,Jürgen Bernhagen,Richard Bucala 생화학분자생물학회 2015 Experimental and molecular medicine Vol.47 No.-
The rising number of obese individuals has become a major burden to the healthcare systems worldwide. Obesity includes not only the increase of adipose tissue mass but importantly also the altered cellular functions that collectively lead to a chronic state of adipose tissue inflammation, insulin resistance and impaired wound healing. Adipose tissue undergoing chronic inflammation shows altered cytokine expression and an accumulation of adipose tissue macrophages (ATM). The macrophage migration inhibitory factor (MIF) superfamily consists of MIF and the recently identified homolog D-dopachrome tautomerase (D-DT or MIF-2). MIF and D-DT, which both bind to the CD74/CD44 receptor complex, are differentially expressed in adipose tissue and have distinct roles in adipogenesis. MIF positively correlates with obesity as well as insulin resistance and contributes to adipose tissue inflammation by modulating ATM functions. D-DT, however, is negatively correlated with obesity and reverses glucose intolerance. In this review, their respective roles in adipose tissue homeostasis, adipose tissue inflammation, insulin resistance and impaired wound healing will be reviewed.