무용수 자화의 유형과 심리적 기능

하지혜,김기화 한국무용연구학회 2010 한국무용연구 Vol.28 No.1

본 연구는 무용수의 자화(self-talk)유형을 탐색하고, 탐색된 자화의 심리적 기능을 구명할 목적으로 진행 되었다. 이를 달성하기 위해 서울 경기 내의 무용학과에 재학 중인 대학생 100명을 대상으로 개방형 설문을 실시하여 자화의 유형과 심리적 기능을 수집한 뒤, 본 연구자와 스포츠 심리학 전공자 2인, 무용 전공자 5인으로 구성된 전문가 회의와 귀납적 내용분석을 통해 결과를 도출하였다. 그 결과, 자화의 유형은 총 370개의 사례가 수집되었으며, 24개의세부영역으로 분류되었고, 이는 5가지 일반영역으로 범주화되었다. 5가지 자화의 유형은 동작지침, 자기격려, 동기유발, 수행전략, 수행방해로 나타났다. 최종 범주화 된 일반영역의 반응 비율로는 동작지침(27.3%)이 가장 높게 나타났으며, 그 뒤로 자기격려(24.6%), 수행방해(17.6%), 동기유발(16,5%), 수행전략(14%) 순으로 나타났다. 이를 통해 무용수가 성공적인 수행을 위해 외적으로는 동작의 필수적인 지침을 각인하고, 내적으로는 자신감 및 각성을 조절하고자 여러가지 유형의 자화를 사용하는 것을 확인할 수 있었다. 또한 자화의 심리적 기능은 총 162개의 사례가 수집되었으며, 13개의세부영역으로 분류되었고, 이는 4가지 일반영역으로 범주화되었다. 4가지 자화의 심리적 기능은 긍정적 정서로 전환, 집중력 향상, 수행의 긍정적 평가, 무력감 유발로 나타났다. 최종 범주화 된 일반영역의 반응 비율로는 긍정적 정서로 전환(49.4%)이 가장 높게 나타났으며, 그 뒤로 수행의 긍정적 평가(21%), 집중력 향상(17.9%), 무력감 유발(11.7%) 순으로 나타났다. 이를 통해 자화는 무용수의 의욕을 감소시키거나 표현력을 감소시키는 등 무용수의 심리에 부정적인 영향을 미치기도 하지만, 대부분 긍정적인 영향을미치는 것을 확인할 수 있었다. 본 연구 결과는 향후 무용수의 성공적인수행을 위한 자화 훈련의 기초자료를 제공할 것으로 기대되며, 후속 연구에서 무용 현장에서의 직접적인 관찰과 면담을 통해 실제 수행과 연결된 분석연구를 진행할 수 있을 것으로 사료된다. This study is intended to find the pattern of self-talk for dancers and study the psychological effect. For this study, an open-ended questionnaire survey was conducted for 100 college students who studied in the department of dance within the Seoul and Gyeonggi area. The collected data on the pattern and psychological effect of self-talk for dancers was analyzed by the meetings of expert groups with two sports psychology majors and five dance majors and inductive approaches. The deduced results are as follows. A total of 370 self-talk patterns were collected, classified into 24 sub-sections, and categorized into five sections. The five sections include guidelines for movements, self-encouragement, motivation, accomplishment strategy, and accomplishment obstacle. The response rate of finally-categorized sections was the highest 27.3% in guidelines for movements, followed by 24.6% in self-encouragement, 17.6% in accomplishment obstacle, 16.5% in motivation, and 14% in accomplishment strategy. These results have revealed that, for successful accomplishment, dancers use several patterns of self-talk to externally learn the essential guidelines for movements and internally control self-confidence and awakening. Also, a total of 162 psychological effects were collected, classified into 13 sub-sections, and categorized into 4 sections. It has been found that the four psychological effects of self-talk are conversion into positive emotion, improvement of concentration, positive evaluation of accomplishment, and induction of feelings of helplessness. The response rate of finally-categorized sections was the highest 49.4% in conversion into positive emotion, followed by 21% in positive evaluation of accomplishment, 17.9% in improvement of concentration, and 11.7% in induction of feelings of helplessness. These results have revealed that while self-talks have an unfavorable effect on the psychology of dancers by reducing their desire or expression, most of them have a favorable effect on the psychology of dancers. It is expected that these results will provide dancers with basic data of self-talk training for their successful accomplishment. It is also believed that, in the follow-up study, actual accomplishment-related analytical studies can be conducted by direct observation and interviews in the scene of dance.

계량약리를 활용한 특수환자집단에서의 의약품 연구·평가 동향

하지혜,변지영,이충희,안미령 한국에프디시규제과학회(구 한국에프디시법제학회) 2023 FDC법제연구 Vol.18 No.1

‘绕口令’을 활용한 한국인 초급 학습자 성조 교육 효과 분석 - 제2성과 제3성을 중심으로

하지혜,신우선,이효영 대한중국학회 2023 중국학 Vol.85 No.-

The aim of this study is to develop a comprehensive and effective teaching methodology that specifically emphasizes the third and second tones of modern standard Chinese for Korean beginner learners. To achieve this goal, the study proposes the utilization of Chinese tongue twisters, known as ‘ràokǒulìng’ (绕口令), as instructional materials. These tongue twisters, with their intricate and challenging phonetic patterns, offer an engaging and interactive way for learners to practice and master the targeted tones. In order to validate the efficacy of this approach, the study plans to implement the proposed teaching methodology in real educational settings. To accomplish this, Chapter 2 provides a detailed outline of the instructional design plan, Chapter 3 analyzes the implementation process and class outcomes, and finally, Chapter 4 summarizes the research findings and proposes potential areas for future research. By conducting this study and presenting its findings, the aim is to contribute to the field of Chinese language education, offering a practical and innovative approach for Korean learners to improve their pronunciation skills and enhance their overall language learning experience.

홍경천의 면역활성이 증진된 용매별 분획 추출물

하지혜,김철희,정향숙,김영,오성호,김승섭,정명훈,마충제,남종현,황백,최근표,박욱연,이현용 한국약용작물학회 2009 한국약용작물학회지 Vol.17 No.3

This study was performed to compare the effects of immuno-modulating activities of Rhodiola sachalinensis A. Bor. fractionized by consecutive solvent separation. The Cytotoxicity of all fractionized extracts on human kidney cell (HEK293) was lower than crude extracts. Generally, the butanol and chloroform extracts showed less cytotoxicity on about 10.07% and 9.67% than the crude extracts. For human immune B and T cell growth, chloroform fraction showed the highest cell growth compared to the control. The secretion of cytokines (IL-6, TNF-α) on human B and T cells were increased by adding chloroform extracts. Also, NK cell growth was significantly improved up to nearly 30% by adding the supernatant of B cell medium grown with the chloroform fraction. It was also found that chloroform fraction could yield higher nitric oxide production from macrophage than untreated control cells. Differentiation of HL-60 cells was increased up to 131.9% after treatment with chloroform fraction extracts, compared to the control. These results indicate that the chloroform fraction of R. sachalinensis have high immune activation activity than others fractions and the crude extracts, implying that this chloroform fractions could be used a new functional material.

병풀 추출물의 식용 나노입자화를 통한 면역 활성 증진

하지혜,권민철,김영,김승섭,정명훈,황백,이현용 한국약용작물학회 2009 한국약용작물학회지 Vol.17 No.4

Phosphatidylcholine was used to encapsulate aqueous extracts of Centella asiatica, and its biological activity was compared with another aqueous extracts. Nanoparticle of C. asiatica was made by encapsulation to w/o type spherical liposome which of aqueous extracts seized with oil phase as 78.2 nm average diameter. Cytotoxicity of the nanoparticle was measured on human skin fibroblast cells, CCD-986sk, and showed lower cytotoxicity on 1.0 mg/ml of highest concentration as 28% than that of another extracts. The nanoparticle showed the highest promotion of human B and T cell growth up to 138% and 135%, respectively, compared to the control. and the NK cell growth was promoted up to 8% higher than the control in proportion to secretion of IL-6 and TNF-α from immune cell growth. Also nanoparticle showed highest inhibition activity of hyaluronidase on 1.0 mg/ml of highest concentration as 60.5%. It seems that because of enhanced biological application of aqueous extracts on cell through nano-encapsulation process.

파삼의 항암활성 증진이 가능한 고압 추출 공정

하지혜,김영,김승섭,정명훈,정헌상,정재헌,유광원,이현용 韓國藥用作物學會 2009 한국약용작물학회지 Vol.17 No.6

The low quality fresh ginseng was extracted by water at 80℃ and 240bar for 20min (HPE, High pressureextraction process). The cytotoxicity on human normal kidney cell (HEK293) and human normal lung cell (HEL299) of theextracts from HPE showed 28.43% and 21.78% lower than that from conventional water extraction at 100℃ in adding themaximum concentration of 1.0㎎/㎖. The human breast carcinoma cell and lung adenocarcinoma cell growth were inhib-ited up to about 86%, in adding 1.0㎎/㎖ of extracts from HPE. This values were 9-12% higher than those from conven-tional water extraction. On in vivo experiment using ICR mice, the variation of body weight of mice group treated freshginseng extracts from HPE of 100㎎/㎏/day concentration was very lower than control and other group. The extracts fromHPE was showed longer survival times as 35.65% than that of the control group, and showed the highest tumor inhibitionactivities compared with other group, which were 70.64% on Sarcoma-180 solid tumor cells. On the high performance liq-uid chromatogram (HPLC), amount of ginsenoside-Rg2, Rg3, Rh1 and Rh2 on fresh ginseng were increased up to 43-183%by HPE, compared with conventional water extracts. These data indicate that HPE definitely plays an important role ineffectively extracting ginsenoside, which could result in improving anticancer activities. It can be concluded that low qualityfresh ginseng associated with this process has more biologically compound and better anticancer activities than that fromnormal extraction process.

천연 수용성 설포라판의 나노입자화를 통한 면역 활성 증진

하지혜,한재건,정향숙,오성호,권민철,최영범,고정림,이현용 한국약용작물학회 2008 한국약용작물학회지 Vol.16 No.6

This study was performed to investigate improving immune activities of natural water-soluble sulforaphane extracted from Brassica oleracea var. italica by nano encapsulation process. The nanoparticles of the sulforaphane extracted with ultrasonification process at 60℃ promoted human B and T cell growth, about 7~35% compared to the control. The secretion of IL-6 and TNF-α from T cells were also enhanced as 2.6×10-4pg/cell and 2.1×10-4 pg/cell, respectively, by the adding nano samples. NK cell activation was improved about 8%, compare to the control in adding cultured medium of T cell added nano samples. It was also found that sulforaphane extracted from B. oleracea var. italica had highly inhibitory activity on hyaluronidase as IC50 about 200 μg/ml. It can be concluded that natural water-soluble sulforaphane samples by nano-encapsulation, each size is 200 nm, extracted from B. oleracea var. italica has high immune activities through higher efficiency of bio-activation than conventional extracts.

의약품의 글로벌 개발·평가 동향 - 전주기적 안전관리 패러다임을 중심으로 -

하지혜,이경선,나한성,김영훈,신희정,김해든,서두원,최종열,김지연,김재환,정면우 한국에프디시규제과학회(구 한국에프디시법제학회) 2013 FDC법제연구 Vol.8 No.2

상급종합병원 간호사의 인공심박동기 관련 지식과 교육요구도

하지혜,강숙정 병원간호사회 2018 임상간호연구 Vol.24 No.2

Purpose: This study aimed to examine nurses’ knowledge levels and educational needs related to an artificial pacemaker. Methods: Participants were 100 nurses working in cardiovascular departments from two university hospitals in Seoul. This study was a descriptive study using a survey for estimating knowledge levels and educational needs related to an artificial pacemaker among nurses. Data were analyzed by SPSS 23.0 program using frequency, percentage, mean and standard deviation, t-test, and ANOVA. Results: Nurses’ knowledge levels were significantly different depending on working units (F=3.32, p=.014) and years of clinical experience (F=2.85, p=.042). Nurses who received education about an artificial pacemaker were higher in the knowledge level of complications after an implantation procedure (t=3.45, p<.001) than nurses who did not receive the education. Conclusion: Discharge education is critical for patients with artificial pacemaker implantation to go back to their daily activities. When developing artificial pacemaker education program for hospital nurses, factors such as nurses’ working department and years of clinical experience years and updated information of an artifical pacemaker need to be considered.

Real-time PCR을 이용한 Epstein-Barr Virus DNA 검사 평가

하지혜,박용정,심정은,김현숙 대한진단검사의학회 2016 Laboratory Medicine Online Vol.6 No.1

Background: Epstein-Barr virus (EBV) is known to be the causative agent of infectious mononucleosis and EBV-related malignancies. In this study, we compared the results of three real-time PCR kits for EBV DNA assays. Methods: A total of 300 whole blood samples submitted for quantitative EBV PCR between January 2013 and September 2014 at Severance Hospital were included. The samples were tested by using the Artus EBV RG PCR Kit (Qiagen, Germany), AccuPower EBV Quantitative PCR Kit (Bioneer, Korea), and Real-Q EBV Kit (BioSewoom, Korea). Samples with discordant results between the three kits were confirmed by direct sequencing. Results: The result concordance rate and kappa coefficient (K) were 86.3% and 0.69 for Artus–AccuPower, 93.3% and 0.85 for Artus–Real-Q, and 92.3% and 0.83 for AccuPower–Real-Q, respectively. The correlations between the three kits were found to be significant, with a correlation coefficient of r=0.854 for Artus–AccuPower, -0.802 for Artus–Real-Q, and -0.977 for AccuPower–Real-Q, respectively (P<0.0001). If the real-time PCR concordant results of 258 samples and the direct sequencing results of 42 real-time PCR discordant samples were assumed to be true, the sensitivity/specificity values were 0.921/0.976 for Artus, 0.902/0.965 for AccuPower, and 0.967/1.000 for Real-Q. Conclusions: The three real-time PCR kits showed excellent sensitivities and specificities. All these kits would be acceptable for clinical and therapeutic management of EBV. However, some discordant results between the kits indicate the need for caution in clinical diagnosis and staging. Further implementation of standardized methodology would be needed for EBV DNA assays. 배경: Epstein-Barr virus (EBV)는 전염성 단구증, 악성종양의 원인으로 밝혀져 있다. 현재 국내에서 시판되는 EBV 검사 시약 중 real-time PCR을 이용한 3종류의 시약을 비교하여 보았다. 방법: 2013년 1월부터 2014년 9월까지 연세의대 세브란스병원에 EBV PCR 검사가 의뢰된 검체 중 검체량이 충분한 300검체를 임의로 선택하였다. Artus EBV RG PCR Kit (Qiagen, Germany), AccuPower EBV Quantitative PCR Kit (Bioneer, Korea), 그리고 Real-Q EBV Kit (BioSewoom, Korea)를 비교하였다. 결과: 세 가지 시약으로 검사한 결과 정성 검사 기준으로 각 검사들의 일치율과 Kappa 계수는 86.3%, 0.69 (Artus-AccuPower), 93.3%. 0.85 (Artus-Real-Q) 그리고 92.3%, 0.83 (AccuPower-Real-Q)이었다. 세 시약 결과 간의 상관성은 유의하였는데, 상관계수 r=0.854 (Artus-AccuPower), -0.802 (Artus-Real-Q), 그리고 -0.977 (AccuPower-Real-Q)이었다. 하나라도 결과가 불일치한 42검체는 sequencing 결과를 참으로 가정하여 민감도와 특이도를 구하였을 때 0.921/0.976 (Artus), 0.902/0.965 (AccuPower), 그리고 0.967/ 1.000 (Real-Q)이었다. 결론: 세 가지 real-time PCR을 이용한 EBV 검사는 모두 민감도와 특이도가 우수하였다. 임상 검사실에서는 각자의 조건에 따라 선택하면 좋을 것이다. 그렇지만 임상적 진단과 추적 검사 시 동일한 시약을 사용하는 것이 필요하며, 앞으로 표준화된 검사 방법이 필요할 것으로 생각된다.