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최근표,서정길,김상무,CHOI Geun-Pyo,SEO Jung-Gil,KIM Sang-Moo 한국수산과학회 2003 한국수산과학회지 Vol.36 No.4
Antioxidative activities of low molecular weight biocompounds purified from anchovy (Engraulis japonicus) sauce fermented at $15\pm3^{\circ}C$ for 5 years were investigated. The fermented anchovy sauce showed 5 peaks on gel chromatography pattern. Antioxidant activity of peak 2 was $82.7\%$ followed by $42.6\%$ of peak 1. Main antioxidant compounds of peak 1 were glutamic acid and lysine, but those of peak 2 were not confirmed by amino acid sequence analysis.
Chitosan 및 oligochitosan 첨가에 의한 창란젓의 숙성 중 미생물상 변화
최근표,김우재,김상무 한국키틴키토산학회 2000 한국키틴키토산학회지 Vol.5 No.2
Low-salt-fermented Alaska pollack, Theragra chglcogrammma, tripe, which is one of the traditional fishery products in Korea, has about 30 days of shelf-life. In order to extend the shelf-life of salted-fermented Alaska pollack tripe, effects of chitosan and oligochitosan on the microflora changes of salt-seasoned Alaska pollack tripe fermented at 5℃ were investigated. The growths of total viable cell, lactic acid bacteria, proteolytic bacteria, and mold of salt-seasoned Alaska pollack tripe with each 5fe chitosan and oligochitosan were inhibited during fermentation at 5t There was no big difference between chitosan and oligochitosan in inhibition effects on the microflora growth of salt-fermented Alaska pollack tripe.
각종 변이원에 대한 쇠비름 추출물의 돌연변이 억제 효과
최근표,정성원,김은정,함승시 동아시아식생활학회 1997 동아시아식생활학회지 Vol.7 No.4
This study was performed to determine the effects of antimutagenicity of Porturaca oleracea L. in Korea. In Ames test, the ethanol extract of Poturaca oleracea L. inhibited mutagenic activity of N-methyl N'-nitro N-nitrosoguanidine(MNNG), 4-nitroquinoline-l-oxide (4NQO), benzo(α)pyrene(B(α) P) and 3 amino-1.4-dimethyl-5H-pyrido-(4,3-b)indole (Trp-P-1) in Salmonella typhimurium TA98 and TA100. But hot-water extract Porturaca oleracea L. only inhibited mutagenic activity of MNNG in Saltmonella typhimurium TA100. On 4NQO, the ethanol extract 100~1,600㎍ /plate of Porturaca oleracea L. showed a slight inhibitory effect of 13~48%, 4~47% in TA98 and TA100, respectively, but on MNNG, it showed higher inhibitory effect of 6~86% in TA100. And the treatment of 1,600㎍/plate of ethanol extract of Porturaca oleracea L. had strong antimutagenicity with 74-87% inhibition against TA98 and TA100 induced by B(a)P and with 85~93% inhibition against TA98 and TA100 induced by Trp-P-1. The ethanol extract was fractionated with ether, chloroform, ethylacetate, butanol and water. Among them, most of the fraction except water fraction showed strong antimutagenicity effects against mutation induced by 4-NQO, MNNG, B(a)P and Trp-P-1. Chloroform fraction had strong antimutagenicity with 91% inhibition against TA100 induced by MNNG, diethyl etherfraction had strong antimutagenicity with 92%, 98% inhibition against TA98 and TAI00 induced by 4NQO, Chloroform fraction had strong antimutagenicity with 97% inhibition against TA100 induced by B(a)P and diethyl etherfraction had strong antimutagenicity with 98% inhibition against both strain induced by Trp-P-1, respectively.
약용식물의 Angiotensin Converting Enzyme 저해활성 탐색
최근표,정병희,이동일,이현용,이진하,김종대 한국약용작물학회 2002 한국약용작물학회지 Vol.10 No.5
50가지 식물자원을 대상으로 혈압상승을 주도하는 효소인 angiotensin converting enzyme의 저해활성을 검색하였다. 그결과 추출물농도 1mg/ml에서 50%이상의 높은 저해활성을 보인 식물은 산뽕나무, 머위, 산부추, 돌나물, 꿀풀, 쇠비름, 마가목, 복분자, 속새, 감초, 창포 등 11종으로 나타났다. 또한 1mg/ml농도에서 목단, 곰취, 도인, 길경, 만형자, 참취, 익모초, 산조인, 가래나무, 석곡, 오갈피, 목향 등 12종은 40~49%의 비교적 높은 ACE 억제활성을 보였다. 1mg/ml에서 30~39%의 억제율을 보인 식물은 백부자, 백출, 세신, 당귀, 인삼, 천궁, 치자 등이었으며 현호색, 행인, 단삼, 백작약, 두충 강활 박하, 진피, 방기, 고본, 구기자, 홍화, 포황, 음양곽, 원지등은 10~29%의 낮은 저해활성을 보였다. 앞으로 ACE 억제활성이 높은 식물자원의 유효성분에 대한 물질확인과 동물모델을 이용한 효능검증에 대하여 더 많은 연구가 있어야 할 것으로 사료된다. Angiotensin converting enzyme(ACE) belongs to the class of zinc protease and plays an important role in the regulation of blood pressure. In this experiment, we investigated the inhibitory activities of medicinal plant extracts on ACE. Fifty medicinal plants were selected and the extracts were prepared by refluxing with 70% methanol. Among the extracts, eleven medicinal plant extracts such as Sedum sarmentosum Bunge, Petasites japonicus(s.et z.) Max, Rubus coreanus, Morus bombycis Koidz, Acorus calamus var. angustatus, Glycyrhiza glabra, Equisetum hyemale, Portulaca oleracea L., Prunella vulgaris var. lilacina Nakai, Sorbus commixta Hedl, Allium thunbergii showed more than 50% inhibitory activities, and Paeonia suffruticosa Andr., lnula helenium, Acanthopanax senticosus Harms, Dendrobium moniliforme, Juglans mandshurica, Zizyphus jujuba, Leonurus artemisia, Aster scaber Thunb, Vitex rotundifolia, Platycodon grandiflorum, Prunus persica, Ligularia fischeri showed 40~49% inhibitory activities. Therefore these extracts which contain high ACE inhibitory activities may be useful as antihypertension agents and to the treatment of hypertension.
최근표 ( Choe Geun Pyo ),김상무 ( Kim Sang Mu ),신일식 ( Sin Il Sig ) 한국키틴키토산학회 2003 한국키틴키토산학회지 Vol.8 No.3
오징어 연골에서 추출한 βchitosan의 향균활성을 검토하였다. Gram negative bacteria의 경우, 탈아세틸화도에 관계없이 분자량이 작아짐에 비례하여 향균활성이 증가하였으며 농도에 따른 차이는 거의 없었다. Gram positive bacteria의 경우 Gram negative bacteria는 달리 탈아세틸화도가 높은 90% βchitosan이 향균활성이 높았다. yeast의 경우 Saccharomyces diastaticus (NCYC361)에서는 향균활성이 있었으나 Hansenula anomala (CBS2872)에서는 향균활성이 없었다. Mold의 경우 Aspergillus parasiticus (ATCC20235)와 Penicillium funciculosum (ATCC9644) 등 chitosan 분해효소를 생산하는 진균류에는 향균활성이 없었으며, 심지어 5,000ppm 높은 농도에서도 증식이 가능하였다. Antimicrobial activity of β-chitosan manufactured from domestic squid(Todarodes pacificus) pen was analyzed on various bacteria, yeasts, and molds. Antibacterial activity against gram negative bacteria increased as the molecular weight of β-chitosan decreased regardless of deacetylation degree, but β-chitosan concentration did not affect greatly. Antibacterial activity of β-chitosan with 90% deacetylation degree and 200-220 kDa molecular weight against gram positive bacteria was the highest. β-chitosan had hte antifungal activity on Saccharomyces diastaticus, but no on Hansenula anomal, while no activity on molds, Aspergillus parasiticus and Penicillium funciculosum, producing chitosanase. The growth of these molds was possible on 5,000 ppm of β-chitosan.