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        • KCI등재

          New Manufacturing Method for Fe-Si Magnetic Powders Using Modified Pack-Cementation Process

          변지영,Jang Won Kim,한정환,장평우 대한금속·재료학회 2013 METALS AND MATERIALS International Vol.19 No.2

          This paper describes a new method for making Fe-Si magnetic powders using a pack-cementation process. It was found that Fe-Si alloy powders were formed by a reaction of the pack mixture of Fe, Si, NaF,and Al2O3 powders at 900 °C for 24 h under a hydrogen atmosphere. Separation of the Fe-Si alloy powders was dependent on the particle size of the Fe powders in the pack. For small Fe powders, magnetic separation in a medium of strong alkali solution was recommended. But, for relatively larger Fe powders,the Fe-Si alloy powders were easily separated from Al2O3 powders using a magnet in air atmosphere. The Si content in the Fe-Si magnetic powders were easily controlled by changing the weight ratio of Si to (Si+Fe) in the pack.

        • KCI등재

          초등학생의 방과후 생활무용 참가가 정서 및 학교생활적응에 미치는 영향

          변지영,현보람 한국융합과학회 2019 한국융합과학회지 Vol.8 No.1

          Purpose : The objective of this study was to examine the effects on the emotion and adaptation to school life of participants in dance for all in accordance with the sociodemographic characteristics of elementary school students. Methods : The use of purposive sampling targeting the students of elementary schools in Sejong Metropolitan Autono mous City and Daejeon Metropolitan City, total 420 subjects including 220 participants in dance for all and 200 nonparticipants were selected, and total 372 questionnaires were used for the final analysis. Using the SPSS 25.0, the soc iodemographic characteristics and the degree of participation in dance for all were understood through the frequency a nalysis. In order to verify the effects of participation in after-school dance for all on the emotion and adaptation to school life of elementary school students, the correlation analysis and multiple regression analysis were performed. R esults: Regarding the effects of participation in after-school dance for all on the emotion of elementary school stude nts(Hypothesis2), the‘period of participation in dance for all’(β=.16, p<.05),‘'frequency of participation in dance for all’(β=.23, p<.05), and‘immersion of students participating in dance for all’(β=.56, p<.001) had significantly positiv e effects on the‘emotion’. However, the intensity of participation in dance for all did not have significant effects on it. The‘period of participation in dance for all’(β=.23, p<.01), 'frequency of participation in dance for all’(β=.22, p <.05), and‘immersion of students participating in dance for all’(β=.56, p<.001) had significantly positive effects on t he‘adaptation to school life’. However, the intensity of participation in dance for all did not have significant effects on it. Conclusion : Like this, the participation in after-school dance for all had positive effects on the emotion and a daptation to school life of elementary school students, Despite the relations of participants in dance for all, emotion, and adaptation to school life, the relevant researches have been insufficient in dance studies. Therefore, this study aim s to contribute to the formation of knowledge about dance studies, and also to suggest the basic data necessary for t eaching elementary school students participating in after-school dance for all. 연구목적 : 본 연구의 목적은 초등학생의 사회인구통계학적 특성에 따른 생활무용참가자의 정서 및 학교생활적응에 미치는 영향을 규명하기 위해 수행되었다. 연구방법 : 본 연구는 세종특별자치시 및 대전광역시에 소재한 초등학교에 재학 중인 학생들을 대상으로 유의표집법을 활용하여 생활무용 참가자220명을 표집 하였으며 216부를 최종자료로 하였다. 본 연구는 SPSS 25.0을 이용하여 빈도분석을 통해 연구대상자들의 생활무용 참가정도를 파악하였으며, 초등학생의 방과후 생활무용 참가정도가 정서 및 학교생활적응에 인과적 영향을 미치는 지를 검증하기 위하여 다중 회귀분석을 실시하였다. 결론 : 초등학생의 방과후 생활무용 참가정도가 정서에 미치는 영향은 ‘생활무용 참가기간’(β=.16, p<.05), ‘생활무용 참가빈도’(β=.23, p<.05)는 ‘정서’를 정적으로 유의하게 예측하는 것으로 나타났다. 그러나 생활무용 참가강도는 유의한 영향을 미치지 못하는 것으로 나타났다. ‘생활무용 참가기간’(β=.23, p<.01), ‘생활무용 참가빈도’(β=.22, p<.05)는 ‘학교생활적응’을 정적으로 유의하게 예측하는 것으로 나타났다. 그러나 생활무용 참가강도는 유의한 영향을 미치지 못하는 것으로 나타났다. 이와 같이 초등학생의 방과후 생활무용 참가자 정서 및 학교생활적응에 긍정적인 영향을 미치는 것으로 나타났다. 생활무용참가자, 정서 및 학교생활적응간의 관련성에도 불구하고 무용학 연구영역에서는 관련연구가 매우 미흡한 실정이다. 그러므로 본 연구는 무용학 지식체 형성에 기여함은 물론, 초등학생 방과후 생활무용 참가 학생들을 지도하는데 필요한 기초자료로 제시하고자 한다.

        • KCI등재

          The influences of CYP2C9*1/*3 genotype on the pharmacokineticsof zolpidem

          변지영,김영훈,김세형,이충민,정의현,채원기,장춘곤,이석용,이윤정 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.9

          Zolpidem is predominantly metabolized by CYP3A4, and to a lesser extent by CYP2C9, CYP1A2, CYP2D6 and CYP2C19. The aim of this study was to identify the effects of CYP2C9*3 allele on the pharmacokinetics of zolpidem. Healthy male subjects were divided into two genotype groups, CYP2C9*1/*1 and CYP2C9*1/ *3. They received a single oral dose of 5 mg zolpidem, and the plasma concentrations of zolpidem were determined up to 12 h after drug administration. In addition, since zolpidem is metabolized at a high rate by CYP3A4, the effect of CYP2C9*3 allele on the pharmacokinetics of zolpidem was also observed in the condition where CYP3A4 was suffi-ciently inhibited by the steady-state concentration of clarithromycin, a potent CYP3A4 inhibitor. For this, clarithromycin 500 mg was administered twice daily for 5 days. Plasma concentrations of zolpidem were determined using liquid chromatography-tandem mass spectrometry method. The overall pharmacokinetic parameters of zolpidem were not significantly different between two CYP2C9 genotypes. Even with the potent CYP3A4 inhibitor clarithromycin present at steady-state concentrations, there were no significant differences in the exposure of zolpidem, except for elimination half-life (t1/2). In conclusion, our study suggests that CYP2C9*1/*3 genotype does not affect the plasma exposure of zolpidem.

        • KCI등재후보

          A Novel Slury-Making Process for AZ91-Alloy Rheocasting

          변지영,김선진,윤진국 한국주조공학회 2003 한국주조공학회지 Vol.23 No.3

          . 본 논문은 레오캐스팅용 AZ91 합금 슬러리를 제조하는 새로운 방법에 관한 것이다. 그 원리는 AZ91 합금 액상에서 Mn의 용해도차에 의해 생성되는 Al 8 (Mn,Fe) 5 정출물을 α−Mg 초정 생성을 위한 불균일 핵생성 자리로 사용하고자 하는 것이다. 제조된 슬러리의 미세조직 분석결과 Al 8 (Mn,Fe) 5 정출물이 α−Mg 내에 위치하고 있어, 이로부터 정출물이 효과적으로 불균일 핵생성 자리로 작용하고 있음을 알 수 있었다. 또한 Mn 함량의 증가는 Al 8 (Mn,Fe) 5 정출물 수를 증가시켜 고상분율이 일정할 때 슬러리 내 α−Mg 고상의 크기를 감소시키고 구형도를 향상시킨다. 이외에도 냉각속도 및 유지시간이 슬러리 미세조직에 미치는 영향에 대해서도 보고하였다.

        • KCI등재

          Effects of diltiazem, a moderate inhibitor of CYP3A4, on the pharmacokinetics of tamsulosin in different CYP2D6 genotypes

          변지영,이윤정,김영훈,김세형,이충민,배정우,장춘곤,이석용,최창익 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.5

          Tamsulosin, a selective antagonist of the a1-adrenoceptor, is primarily metabolized by CYP3A4 andCYP2D6, and tamsulosin exposure is significantlyincreased according to the genetic polymorphism ofCYP2D6. In this study, we investigated the effects of diltiazem,a moderate inhibitor of CYP3A4, on the pharmacokineticsof tamsulosin in subjects with different CYP2D6genotypes. Twenty-three healthy Korean male subjectswith CYP2D6*wt/*wt (*wt = *1 or *2) and CYP2D6*10/*10 were enrolled in the prospective, open-label, twophaseparallel pharmacokinetic study. On the first day ofstudy (day 1), each subject received a single 0.2 mg oraldose of tamsulosin. After a washout period of 1 week, onday 8, the subjects were given a 60 mg oral dose of diltiazemthree times daily for four days. On day 10, 1 h afterthe morning dose of diltiazem, they received a single0.2 mg oral dose of tamsulosin. The pharmacokineticparameters of tamsulosin in those with and without diltiazemtreatment were compared in subjects with differentCYP2D6 genotypes. After diltiazem treatment, the Cmaxand AUCinf of tamsulosin in each CYP2D6 genotype groupwere significantly increased (p\0.0001 for all). The CL/Fof tamsulosin was also significantly decreased after diltiazemtreatment (both p\0.0001). However, diltiazem didnot affect the t1/2 of tamsulosin in each genotype group. Inconclusion, diltiazem significantly increases exposure totamsulosin regardless of the genotype of CYP2D6. Doseadjustment in the daily maintenance dose of tamsulosinmay improve tolerability and safety in patients receivingdiltiazem.

        • KCI등재

          슬라이딩 모드 제어를 이용한 HDD 하이브리드 제어기 설계 및 안정성 평가

          변지영,곽성우,유관호 대한전기학회 2004 전기학회논문지 D Vol.53 No.10-D

          This paper presents the design of a new controller for the read/write head of a hard disk drive. The general controller for seeking is the time-optimal control. However if we use only the time optimal control law, this could be vulnerable to chattering effect. To solve this problem, we propose a modified controller design algorithm in this paper. The proposed controller consists of bang-bang control for seeking and sliding-mode control for tracking. Moreover, to test the robustness and stability of control system, a bounded disturbance is selected to maximize a severity index. Simulation results show the superiority of the proposed controller through comparison with time optimal VSC(variable structure control).

        • KCI등재

          Effects of genetic polymorphisms of CYP2C19 on the pharmacokinetics of zolpidem

          변지영,김영훈,김세형,이충민,정의현,채원기,장춘곤,이석용,이윤정 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.8

          Zolpidem is indicated for the short-term treatmentof insomnia and it is predominantly metabolized byCYP3A4, and to a lesser extent by CYP2C19, CYP1A2,and CYP2C9. Therefore, we evaluated the effects ofCYP2C19 genetic polymorphisms on the pharmacokineticsof zolpidem in healthy male subjects. Thirty-two malesubjects were recruited and all subjects were classified intothree groups according to their genotypes: CYP2C19EM(CYP2C19*1/*1, n = 12), CYP2C19IM (CYP2C19*1/*2or *1/*3, n = 10), and CYP2C19PM (CYP2C19*2/*2, *2/*3 or *3/*3, n = 10). The pharmacokinetic parameters ofzolpidem were compared in three CYP2C19 genotypegroups after zolpidem administration with or without aCYP3A4 inhibitor at steady-state concentration. Plasmaconcentrations of zolpidem were determined up to 12 hafter drug administration by liquid chromatography-tandemmass spectrometry method. The maximum plasma concentration(Cmax) differed, but mean total area under theplasma concentration–time curve (AUCinf), half-life (t1/2),and apparent oral clearance (CL/F) of zolpidem administeredalone did not significantly differ among the threedifferent CYP2C19 genotype groups. Furthermore, whenzolpidem was administered with a CYP3A4 inhibitor atsteady-state concentration, there were no significant differencesin any of the pharmacokinetic parameters ofzolpidem in relation to CYP2C19 genotypes. In conclusion,we did not find any evidence for the impact of CYP2C19genetic polymorphisms on the pharmacokinetic parametersof zolpidem.

        • 국가 지하수 관측망의 충적 및 암반 지하수의 지구화학적 특성

          변지영,김여상,구민호 공주대학교 과학교육연구소 2004 과학교육연구 Vol.35 No.-

          본 연구의 목적은 현재 설치된 국가 지하수 관측망의 지하수를 광역적이고 특징적인 지질에 따라서 구분하고, 동일 지점의 천부지하수와 암반지하수의 지구화학적 특성을 비교 분석하는 것이다. 102개 관측소에 있는 148개 지하수공의 자료가 분석되었다. 35개 관측소의 75개 지하수공의 자료는 지역적인 지질 특성을 반영하고 있으나, 지하수 유형의 진화 여부로는 충적지하수공과 암반지하수공의 지구화학적 특성이 거의 구별되지 않는다. 이는 관측공 대부분이 깊이 100m 미만의 우물이기 때문에 암반지하수가 충적지하수의 수질특성을 반영하였기 때문인 것으로 판단된다. 35개 관측소 중 30개 관측소는 관입화성암류(불국사화강암, 대보화강암)와 변성암 지대에 위치하고 있으며, 이들의 수질 유형은 Ca-Na-HCO_(3)와 Ca-Mg-HCO_(3)이다. 각 이온들의 농도는 TDS에 대하여 정의 관계를 가지고 있으며, pH에 대해서는 관련성이 없고, NO_(3)에 대해서는 일부 관측소에서 관련성이 높게 나타났다. Water quality data obtained from 148 monitoring wells of the National Groundwater Monitoring Network are analyzed to investigate the hydrogeochemical characteristics of alluvium and bedrock groundwaters of Korea. Although 70 cells data of 35 sites reflects the influence of the water-rock interaction, the distinctive differences of geochemical characteristics between the alluvium and the bedrock groundwater are not found. This is interpreted that bed rock groundwater reflects the water properties of alluvium groundwater because most of monitoring wells are installed at depths less than 100m. The 30 sites among 35 sites are located in the area of the intrusive granitic rocks and metamorphic rocks, and their chemical water types determined by Piper diagram are Ca-Na-HCO_(3) and Ca-Mg-HCO_(3), mainly due to the dissolution of the plagioclase in the granitic and metamorphic rocks. The concentrations of major ions are linearly proportional to TDS, not correlated with pH, and highly correlated with NO_(3) in some sites.

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