마음챙김 명상 프로그램이 알코올 의존 환자의 정서자각에 미치는 효과 : 예비 연구

하미지(Mi Ji Ha),박영민(Young Min Park),이성근(Seong Keun Lee) 한국중독정신의학회 2013 중독정신의학 Vol.17 No.2

Objectives : The aim of this study was to determine whether Mindfulness-Based Recovery Program from Addiction (MB-RA) produced positive effects on emotional awareness in a group of alcohol dependent inpatients. Methods : Nineteen alcohol dependent inpatients finished the final 8-week follow-up assessment. Among them, 9 subjects participated in the 8-week MBRA program with weekly sessions (meditation group), and the other 10 received the usual treatment (control group). Both groups were assessed by Toronto Alexithymia Scale (TAS-20) and Empathy Quotient (EQ) at baseline and at 4 weeks and 8 weeks of MBRA treatment. Results : The meditation group showed significant improvements in TAS-20 total score and cognitive empathy score of EQ at the end of the study. It showed a tendency that the EQ total score of the meditation group was a little higher than that of the control group. Conclusion : The results of this study suggested the potential benefits of mindfulness meditation trainings by improving emotional awareness for alcohol dependences.

해양 유류유출사고와 건강영향에 관한 해외 연구사례 분석

하미나,이원진,이승민,정해관,Ha, Mi-Na,Lee, Won-Jin,Lee, Seung-Min,Cheong, Hae-Kwan 대한예방의학회 2008 예방의학회지 Vol.41 No.5

Objectives : Our objective is to review and summarize the previous studies on the health effects of exposure to oil spills in order to make suggestions for mid- and long-term study plans regarding the health effects of the Hebei Spirit oil spill occured in Korea. Methods : We searched PubMed to systemically retrieve reports on the human health effects related to oil spill accidents. The papers' reference lists and reviews on the topic were searched as well. Results : We found 24 articles that examined seven oil spill accidents worldwide over the period from 1989 to August 2008, including the Exxon Valdes, Braer, Sea Empress, Erika, Nakhodka, Prestige and Tasman Spirit oil spills. Most of the studies applied cross-sectional and short-term follow-up study designs. The exposure level was measured by assessing the place of residence, using a questionnaire and environmental and personal monitoring. Studies on the acute or immediate health effects mainly focused on the subjective physical symptoms related to clean-up work or residential exposure. Late or mid-term follow-up studies were performed to investigate a range of health effects such as pulmonary function and endocrine, immunologic and genetic toxicity. The economic and social impact of the accidents resulted in the socio-psychological exposure and the psychosocial health effects. Conclusions : Studies of the health effects of exposure to oil spills should consider a range of health outcomes, including the physical and psychological effects, and the studies should be extended for a considerable period of time to study the long-term chronic health effects.

허베이스피릿호 유류유출사고 방제작업 참여자의 보호장비착용 효과

이승민,하미나,김은정,정우철,허종일,박석건,권호장,홍윤철,하은희,이종성,정봉철,이정애,임호섭,최예용,조용민,정해관,Lee, Seung-Min,Ha, Mi-Na,Kim, Eun-Jung,Jeong, Woo-Chul,Hur, Jong-Il,Park, Seok-Gun,Kwon, Ho-Jang,Hong, Yun-Chul,Ha, Eun-Hee,Lee, Jong-Se 대한예방의학회 2009 예방의학회지 Vol.42 No.2

Objectives : To assess the protective effects of wearing protective devices among the residents and volunteers who participated in the cleanup of the Hebei Spirit oil spill. Methods : A total of 288 residents and 724 volunteers were surveyed about symptoms, whether they were wearing protective devices and potential confounding variables. The questionnaires were administered from the second to the sixth week following the accident. Spot urine samples were collected and analyzed for metabolites of 4 volatile organic compounds(VOCs), 2 polycyclic aromatic hydrocarbons(PAHs), and 6 heavy metals. The association between the wearing of protective devices and various symptoms was assessed using a multiple logistic regression adjusted for confounding variables. A multiple generalized linear regression model adjusted for the covariates was used to test for a difference in least-square mean concentration of urinary biomarkers between residents who wore protective devices and those who did not. Results : Thirty nine to 98% of the residents and 62-98% of volunteers wore protective devices. Levels of fatigue and fever were higher among residents not wearing masks than among those who did wear masks(odds ratio 4.5; 95% confidence interval 1.23-19.86). Urinary mercury levels were found to be significantly higher among residents not wearing work clothes or boots(p<0.05). Conclusions : Because the survey was not performed during the initial high-exposure period, no significant difference was found in metabolite levels between people who wore protective devices and those who did not, except for mercury, whose biological half-life is more than 6 weeks.

직업성 요통환자에서 재활 프로그램(Back School Program) 도입의 비용-편익분석

주영수,하미나,한상환,권호장,조수헌,김창엽,김선민,Ju, Yeong-Su,Ha, Mi-Na,Han, Sang-Hwan,Kwon, Ho-Jang,Cho, Soo-Hun,Kim, Chang-Yup,Kim, Sun-Min 대한예방의학회 1996 예방의학회지 Vol.29 No.2

Although occupational low back pain accounts for $20\sim40%$ of all occupational illness and injury, there are limited numbers of studies regarding the effectiveness of back school program. The objective of this study was to evaluate the economic benefit of back school program for early return to work of occupational low back pain patients in the current occupational injury compensation and management system. The cost-benefit analysis in this study was conducted to evaluate the relative magnitude of benefit to cost. The total cost was estimated by calculating the value of components in back school program according to governmental budget protocol. The back school program was consisted of three major approaches, pain center, work-hardening program and funcional restoration program and each of components had various facilities and experts. The total amount of cost was estimated as 250,866,220 won per year. The most promising type of back school program were quite intensive (a 3 to 5-week stay in a specialized center), therefore, if we adopted the 5-week stay course, 10 courses could be held in a year. Following to the medical act, 20 patients per doctor could participate in a each course, ie, total 200 patients in a year. As a result, we could estimate the cost of 1,254,331 won a patient. We estimated the benefit by using data of a few local labor offices about average medical treatment beneficiary and off-duty beneficiary of 46 occupational low back pain patients in 1994. Ullman and Larsson (1977) mentioned that the group of chronic low back pain patients who participated in back school program needed less time to recover by 48.4% of beneficiary duration. And in the trying to estimate the benefit, we asked 10 rehabilitation board certificate doctors about reduction proportion of treatment cost by introducing back school program. The answered reduction proportions were in the range of $30\sim45%$, average 39%. As a final result, we could see that the introduction of back school program in treatment of chronic occupational low back pain patients could produce the benefit to cost ratio as 3.90 and 6.28. And we could conclude that the introduction of back school program was beneficial to current occupational injury compensation and management system.

설문지에 의한 대기오염의 호흡기계 증상 발현에 관한 조사연구

권호장,조수헌,김선민,하미나,한상환,Kwon, Ho-Jang,Cho, Soo-Hun,Kim, Sun-Min,Ha, Mi-Na,Han, Sang-Hwan 대한예방의학회 1994 예방의학회지 Vol.27 No.2

A cross-sectional study was conducted in an effort to investigate the effect of air pollution on respiratory symptoms. Two groups of female aged more than 20 living in the unpolluted rural area of Taebul (n=159) and urban area of Taegu (n=140) were selected. The ATS-DLD-78 questionnaire was translated into Korean and administered with minor modification. The proportion of smoker was less than 1% in both area. Exposure to smoking and higher educational level were more frequent in Taegu. Age-adjusted prevalence rates of 'chronic cough', 'chronic sputum', 'wheezing', and 'dyspnea' were higher in Taegu than in Taebul. In particular, the prevalence rate of 'chronic sputum' in Taegu was found to be higher, which was statistically significant. Exposure to smoking and education level were not concerned with all respiratory symptom prevalence rates. In conclusion, this study Indicates that an urban factor is related to the rates of respiratory symptoms in Korea.

허베이스피릿호 유류유출사고 방제작업에 참여한 주민의 정신건강

송민교,홍윤철,정해관,하미나,권호장,하은희,최예용,정우철,허종일,이승민,김은정,Song, Min-Kyo,Hong, Yun-Chul,Cheong, Hae-Kwan,Ha, Mi-Na,Kwon, Ho-Jang,Ha, Eun-Hee,Choi, Ye-Yong,Jeong, Woo-Chul,Hur, Jong-Il,Lee, Seung-Min,Kim, Eun-Jung 대한예방의학회 2009 예방의학회지 Vol.42 No.2

Objectives : Our objective was to examine and evaluate the psychological health of the residents of Taean during the cleanup of the Hebei Spirit(HS) oil spill and to review some factors associated with the results. Methods : A community survey of 71 men and women was conducted 8 weeks after the HS oil spill. Questionnaires used were the PWI(Psychological Well-being Index) scale for psychosocial distress, the CES-D(Center for Epidemiologic Studies-Depression) scale for depressive symptoms, and a questionnaire created to assess suicidal impulses. Results : The overall prevalence of high-risk psychosocial distress among the study group was 64.2%. The percentages of respondents with scores on the CES-D Scale above 16 and above 21 were 77.6% and 62.7%, respectively. The percentage of respondents categorized as having suicidal impulses was 18.3%. When compared with unexposed groups in the general population taken from various sources, the residents of Taean were 6.5 times as likely to have high stress and 9.4-9.7 times as likely to be depressed. No significant difference in the rate of suicidal impulse was found between the residents of Taean and the general population. Factors associated with high stress, depression, and suicidal impulses were age, a change in income, educational level, number of days working on the cleanup, and positive responses to questions about "affected daily activity" and "hospital visit due to work on cleanup". Conclusions : The results suggest that the HS oil spill had a significant impact on the psychological health of residents of Taean, but the comparability of the unexposed groups is a limitation of the study.

크롬 폭로가 자매염색분체교환 빈도 및 8-hydroxydeoxyguanosine 농도에 미치는 영향

한상환,조수헌,김헌,하미나,주영수,박수민,권호장,김용대,정명희,Han, Sang-Hwan,Cho, Soo-Hun,Kim, Heon,Ha, Mi-Na,Joo, Young-Soo,Park, Soo-Min,Kwon, Ho-Jang,Kim, Yong-Dae,Chung, Myung-Hee 대한예방의학회 1995 예방의학회지 Vol.28 No.2

크롬염 안료제조공장 근로자를 대상으로 크롬 폭로와 말초혈액 림프구의 8-OH-dG 농도의 상관성을 직접 관찰함으로써 크롬의 암 발생기전에 산소유리기(oxygen free radical)가 관여하는지 여부와 크롬폭로에 따라 자매염색분체교환 빈도가 증가하는지를 밝힐 목적으로 본 연구를 수행하였다. 안료공장에 1년 이상 근무한 근로자 38명을 대상으로 설문지를 통하여 근무기간, 연령, 성, 크롬 폭로와 관련된 자각적 증상 등을 조사하였으며, 이들의 크롬 폭로 수준을 평가할 수 있는 생물학적 지표로서 혈중 및 크레아티닌 보정 요중 크롬 농도를 측정하였다. 크롬에 의한 생물학적 영향지표로서 말초혈액 림프구로 부터 dG에 대한 8-OH-dG의 몰 농도비를 측정하였으며, 분열 중기의 세포 30개를 관찰하여 세포당 자매염색분체교환 빈도를 계수하여 염색체 46개당 평균 자매 염색분체교환 빈도로 환산하였다. 분석결과 현재 크롬 폭로 수준을 판단하는 생물학적지표로 가장 많이 사용되는 크레아티닌 보정 요중 크롬 농도와 림프구에서의 dG에 대한 8-OH-dG의 물 농도비는 유의한 상관관계(r=0.47, p<0.01)를 보이는 것으로 분석되었으며, 현재의 흡연수준을 보정하고 분석한 결과에서는 상관계수가 증가하는 결과(r=0.62, p<0.05)를 나타내었다. 한편 자매염색분체교환 빈도와 크롬 폭로수준간에는 유의한 상관관계가 관찰되지 않았다. 이러한 결과는 크롬의 발암성에 DNA 부가체(adduct)의 형성이 중요한 기전일 수 있다는 기존의 연구결과와 일치하며, 따라서 8-OH-dG는 크롬에 의한 발암성을 예측할 수 있는 생물학적 영향지표로서 활용될 수 있음을 시사한다고 할 수 있다. To elucidate some DNA adducts as a biological marker for workers of chromate pigment, the effects of chromium exposure on the formation of 8-hydroxydeoxyguanosine(8-OH-dG) and sister chromatid exchanges(SCEs) frequency in 38 workers of a pigment plant in Bucheon which utilized lead chromates, were examined. The chromium contents of venous blood and urine were measured as working environmental exposure level. The concentrations of 8-OH-dG in DNA isolated from lymphocytes were determined with high performance liquid chromatography and electrochemical detector and denoted as a molar ratio of 8-OH-dG to deoxyguanosine(dG). The SCEs frequency were analyzed in DNA isolated from lymphocytes. A significant correlation was found between creatinine adjusted urine chromium concentration and the molar ratio of 8-OH-dG to dG(r=0.47, p<0.01). After adjusting the current smoking habit, the correlation coefficient was increased(r=0.62, p<0.05). However, there was no significant correlation between the SCE frequency and chromium exposure. This significant results between molar ratio of 8-OH-dG to dG and chromium exposure are in good agreement with in vitro studies that support the importance of DNA adduct formation for the carcinogenic effect of chromium.

대규모 유류유출사고 대비 환경보건 대응계획 수립을 위한 기반연구

김영민,정해관,김종호,김종헌,고금숙,하미나,Kim, Young-Min,Cheong, Hae-Kwan,Kim, Jong-Ho,Kim, Jong-Hun,Ko, Kum-Sook,Ha, Mi-Na 대한예방의학회 2009 예방의학회지 Vol.42 No.2

Objectives : This study presents a scientific basis for the establishment of an environmental health contingency plan for dealing with accidental coastal oil spills and suggests some strategies for use in an environmental health emergency. Methods : We reviewed the existing literature, and analyzed the various fundamental factors involved in response strategies for oil spill. Our analysis included data derived from Hebei Spirit oil spill and used air dispersion modeling. Results : Spill amounts of more than 1,000 kl can affect the health of residents along the coast, especially those who belong to vulnerable groups. Almost 30% of South Korean population lives in the vicinity of the coast. The area that is at the highest risk for a spill and that has the greatest number of people at risk is the stretch of coastline from Busan to Tongyeong. The most prevalent types of oil spilt in Korean waters have been crude oil and bunker-C oil, both of which have relatively high specific gravity and contain volatile organic compounds, polycyclic aromatic hydrocarbons, and metals. In the case of a spill of more than 1,000 kl, it may be necessary to evacuate vulnerable and sensitive groups. Conclusions : The government should establish environmental health planning that considers the spill amount, the types of oil, and the distance between the spot of the accident and the coast, and should assemble a response team that includes environmental health specialists to prepare for the future oil spill.

일부 초등학교 교실의 실내공기오염물질 분포 조사에 관한 연구

노영만(Young-Man Roh),김종철(Jong Cheol Kim),이철민(Cheol Min Lee),김윤신(Yoon Shin Kim),하미나(Mina Ha),권호장(Ho-Jang Kwon),정춘화(Chun Hwa Jeong),백종민(Jong-Min Paik),권영규(Young Gyu Kwon) 한국실내환경학회 2007 한국실내환경학회지 Vol.4 No.3·4

This study was surveyed to evaluate and recognize the distribution characteristics of indoor air pollutants(IAPs) such as the total volatile organic compounds(VOCs), formaldehyde(HCHO), PM10, carbon dioxide(CO₂), nitrogen dioxide(NO₂), ozone(O₃) and radon in 10 elementary schools located in urban, rural, and industrial complex area from November 2005 to February 2006. The average concentration of IAPs were 117.9㎍/㎥ as in PM10, 1,971ppm as in CO₂, 486.6㎍/㎥ as in TVOC. These chemical"s concentration was exceeded the indoor air standards of the Department of Education in Korea. The indoor concentrations of ozone and toluene was lower than that of outdoor and other pollutants showed the opposite tendency. In schools located industrial complex area, the outdoor concentration of TVOC was higher than that of urban and rural area. Based on the results above, PM10, CO₂, TVOC have to be in the order of priority to improve the indoor environment in school. Also it should be performed in the detailed survey considered by the seasonal variation because this study showed cross-sectional results.

인천과 아산지역 소아청소년의 흡입 알레르겐 감작률 및 다항원 감작과 알레르기질환 발병과의 관계

김형영 ( Hyung Young Kim ),서주희 ( Ju Hee Seo ),정영호 ( Young Ho Jung ),이은 ( Eun Lee ),양송이 ( Song I Yang ),하미나 ( Min A Ha ),권호장 ( Ho Jang Kwon ),임종한 ( Jong Han Lim ),김환철 ( Hwan Chul Kim ),이기재 ( Kee Jae Lee ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.1

Purpose: Sensitization to allergens is considered as major mechanism of allergy and related to the development of allergic diseases. The objective of this study was to evaluate overall sensitization rates of inhalant allergens and the relationship between polysensitization and prevalence of allergic diseases in children and adolescents. Methods: A cross-sectional pilot study of 122 elementary school students, 114 middle school students, and 115 high school students from Incheon and Asan was conducted by using the International Study of Asthma and Allergies in Childhood (ISSAC) questionnaire. The skin prick tests were performed with 14 common inhalant allergens on 339 students. Results: The inhalant allergen that has a significantly different sensitization rate according to age was Dermatophagoides farinae. And the inhalant allergen that has significantly different sensitization rate according to region was Japanese hop. In addition, girls have higher sensitization rate to any mold allergens than boys. In case of having sensitization more than two allergens, the risks of diagnosis of asthma and allergic rhinitis on questionnaire were increased. Asthma is related to sensitization of dog or cat and allergic rhinitis is related to sensitization of house dust mites. However, atopic dermatitis is not related to sensitization of any inhalant allergens. Conclusion: The sensitization rates of inhalant allergens may differ among age, gender, and region in children and adolescents of Incheon and Asan area. The polysensitized children and adolescents with inhalant allergens showed higher prevalences of allergic diseases such as asthma and allergic rhinitis on questionnaire than monosensitized group. (Allergy Asthma Respir Dis 1?1):41-49, 2013)Allergy Asthma Respir Dis 1(1):41-49, 2013)