류마토이드 관절염에서 슬관절의 관절경적 활액막 절제술

정재훈,박일성,양동현,Chung, Jae-Hoon,Park, Il-Sung,Yang, Dong-Hyun 대한관절경학회 1997 대한관절경학회지 Vol.1 No.1

There has been a controversy about the effectiveness of the synovectomy of the knee in the rheumatoid arthritis. So we studied to determine if the arthroscopic synovectomy of the knee was of benefit in the rheumatoid arthritis. We ana lysed 25 knees of 15 patients who underwent the arthroscopic synovectomy of the knee joint for their rheumatoid arthritis from Jun. 1995 to Oct. 1996. The average follow-up period was 20.1 months($12\~28$ months). The results were as follows; 1. Satisfactory results were obtained in 20 knees $(80\%)$ for the pain and the effusion each, 23 $(92\%)$ for the range of motion and 19 $(76\%)$ for the functional capacity. 2. In the overall results for the pain. effusion. range of motion and the functional capacity. we obtained excellent results in 14 knees $(56\%)$ and satisfactory results in 9 knees $(32\%)$. 3. In the patient's self assessment, 11 patients $(44\%)$ were delighted and 10 patients $(40\%)$ were satisfactory. 4. In the overall results according to the articular cartilage damage, satisfactory results were obtained in 15 $(93\%)$ out of 16 knees in Grade I and II, and 6 $(75\%)$ out of 8 knees in Grade III and IV. In conclusion, arthroscopic synovectomy could be one of very useful treatments for the rheumatoid knee. But further study is needed to get the long-term results of the synovectomy because there's many reports saying gradual decrease of good results with increasing time. And continuous and proper medical treatment including DMARDs, is needed to effectively control the rheumatoid arthritis even after the synovectomy.

한국인 대학생군 대상의 청.장년층 대사이상증후군 위험성 평가

정재훈,이보름,임성진,장제관,이명구,이종길,임성실,Chung, Jae-Hun,Lee, Bo-Reum,Lim, Sung-Jin,Jang, Je-Kwan,Lee, Myung-Koo,Lee, Chong-Kil,Lim, Sung-Cil 대한약학회 2009 약학회지 Vol.53 No.1

Metabolic syndrome, defined as the clustering of several metabolic disorders including obesity (waist circumference ${\geq}90$ if male or ${\geq}80$ if female, cm), dyslipidemia ($TG{\geq}150$ or HDL-C<40 if male or <50 if female, mg/dl), hypertension ($BP{\geq}130/85mmHg$) and hyperglycemia (fasting plasma $glucose{\geq}110mg/dl$), increases the cardiovascular risk of the general population. Recently, risk of this syndrome arises in young adults world widely. Therefore, we randomly selected and evaluated the risk of metabolic syndrome of total 43 people (group I-22, group II-21) for 2 years. Group I was 22 peoples (15 males, 7 females) with age of 22 thru 35 year old (average 28 year old) and group II was 21 people (19 male, 2 female) with age of 22 thur 32 years old (average 24 year old) in Cheongju area from March 1st thru 30th of 2008 in Cheongju area from September 1st thru 30th of 2007 in order to find out how serious this phenomenon is in young adult of Korea. 13.95% (n=7) of total people has a metabolic syndrome by NCEP/ATPIII definition among this group (group I-6, group II-1). Those of 6 have 3 or over risk factor for metabolic syndrome such as obesity, hypertension, fasting blood glucose and hypetriglyceridemia at the same time (group I-5, group II-1). Group I have more risk factor because of more higher age than group II. Therefore we need aggressively to monitor and provide them for early diagnosis, educational programs and assistance for lifestyle changes in order to prevent metabolic syndrome among young adults.

방사성 동위원소를 이용한 핵의학과 검사에서 병동 간호사의 방사선 피폭선량 평가

정재훈,이충운,유연욱,서영덕,최호용,김윤철,김용근,원우재,Jeong, Jae Hoon,Lee, Chung Wun,You, Yeon Wook,Seo, Yeong Deok,Choi, Ho Yong,Kim, Yun Cheol,Kim, Yong Geun,Won, Woo Jae 대한핵의학기술학회 2017 핵의학 기술 Vol.21 No.1

Purpose Radiation exposure management has been strictly regulated for the radiation workers, but there are only a few studies on potential risk of radiation exposure to non-radiation workers, especially nurses in a general ward. The present study aimed to estimate the exact total exposure of the nurse in a general ward by close contact with the patient undergoing nuclear medicine examinations. Materials and Methods Radiation exposure rate was determined by using thermoluminescent dosimeter (TLD) and optical simulated luminescence (OSL) in 14 nurses in a general ward from October 2015 to June 2016. External radiation rate was measured immediately after injection and examination at skin surface, and 50 cm and 1 m distance from 50 patients (PET/CT 20 pts; Bone scan 20 pts; Myocardial SPECT 10 pts). After measurement, effective half-life, and total radiation exposure expected in nurses were calculated. Then, expected total exposure was compared with total exposures actually measured in nurses by TLD and OSL. Results Mean and maximum amount of radiation exposure of 14 nurses in a general ward were 0.01 and 0.02 mSv, respectively in each measuring period. External radiation rate after injection at skin surface, 0.5 m and 1 m distance from patients was as following; $376.0{\pm}25.2$, $88.1{\pm}8.2$ and $29.0{\pm}5.8{\mu}Sv/hr$, respectively in PET/CT; $206.7{\pm}56.6$, $23.1{\pm}4.4$ and $10.1{\pm}1.4{\mu}Sv/hr$, respectively in bone scan; $22.5{\pm}2.6$, $2.4{\pm}0.7$ and $0.9{\pm}0.2{\mu}Sv/hr$, respectively in myocardial SPECT. After examination, external radiation rate at skin surface, 0.5 m and 1 m distance from patients was decreased as following; $165.3{\pm}22.1$, $38.7{\pm}5.9$ and $12.4{\pm}2.5{\mu}Sv/hr$, respectively in PET/CT; $32.1{\pm}8.7$, $6.2{\pm}1.1$, $2.8{\pm}0.6$, respectively in bone scan; $14.0{\pm}1.2$, $2.1{\pm}0.3$, $0.8{\pm}0.2{\mu}Sv/hr$, respectively in myocardial SPECT. Based upon the results, an effective half-life was calculated, and at 30 minutes after examination the time to reach normal dose limit in 'Nuclear Safety Act' was calculated conservatively without considering a half-life. In oder of distance (at skin surface, 0.5 m and 1 m distance from patients), it was 7.9, 34.1 and 106.8 hr, respectively in PET/CT; 40.4, 199.5 and 451.1 hr, respectively in bone scan, 62.5, 519.3 and 1313.6 hr, respectively in myocardial SPECT. Conclusion Radiation exposure rate may differ slightly depending on the work process and the environment in a general ward. Exposure rate was measured at step in the general examination procedure and it made our results more reliable. Our results clearly showed that total amount of radiation exposure caused by residual radioactive isotope in the patient body was neglectable, even comparing with the natural radiation exposure. In conclusion, nurses in a general ward were much less exposed than the normal dose limit, and the effects of exposure by contacting patients undergoing nuclear medicine examination was ignorable. 목적: 핵의학 검사를 시행한 병동 환자의 시간과 거리에 따른 방사선량률을 측정하여 방사성동위원소 투여를 받은 환자가 병동 간호사에게 미치는 피폭을 예측하고 실제 총 피폭량과 비교하여 보고자 한다. 대상 및 방법: 병동에서 근무하고 있는 간호사 14명을 대상으로 열형광 선량계와 광자극 선량계를 이용하여 방사선 피폭선량을 측정하였고 핵의학 검사를 시행한 환자 50명(PET/CT 20명, Bone scan 20명, Myocardial SPECT 10명)을 대상으로 방사성동위원소 투여 직후와 검사시행 직후에 표면, 50cm, 1m에서 외부 방사선량률을 측정하였다. 측정 결과를 바탕으로 유효반감기를 도출한 후 병동 간호사가 받을 수 있는 피폭량을 예측하였다. 그리고 열형광선량계와 광자극선량계로 측정된 병동 간호사의 실제 총 피폭량과 비교 하였다. 결과: 병동 간호사 14명을 대상으로 한 피폭선량 측정결과 평균값과 최대값은 각각 분기당 0.01 mSv, 0.02 mSv 이었고 핵의학 검사를 시행 받은 환자의 선량률은 표면, 50cm, 1m 거리 순으로 PET/CT는 $376.0{\pm}25.2{\mu}Sv/hr$, $88.1{\pm}8.2{\mu}Sv/hr$, $29.0{\pm}5.8{\mu}Sv/hr$ 이고 Bone scan은 $206.7{\pm}56.6{\mu}Sv/hr$, $23.1{\pm}4.4{\mu}Sv/hr$, $10.1{\pm}1.4{\mu}Sv/hr$이고 Myocardial SPECT는 $22.5{\pm}2.6{\mu}Sv/hr$, $2.4{\pm}0.7{\mu}Sv/hr$, $0.9{\pm}0.2{\mu}Sv/hr$이다. 또한 검사를 시행한 후 측정한 선량률은 표면, 50cm, 1m 거리 순으로 PET/CT는 $165.3{\pm}22.1{\mu}Sv/hr$, $38.7{\pm}5.9{\mu}Sv/hr$, $12.4{\pm}2.5{\mu}Sv/hr$ 이고 Bone scan은 $32.1{\pm}8.7{\mu}Sv/hr$, $6.2{\pm}1.1{\mu}Sv/hr$, $2.8{\pm}0.6{\mu}Sv/hr$이고 Myocardial SPECT는 $14.0{\pm}1.2{\mu}Sv/hr$, $2.1{\pm}0.3{\mu}Sv/hr$, $0.8{\pm}0.2{\mu}Sv/hr$이다. 위의 결과를 바탕으로 유효반감기를 도출한 후 검사종료 30분 후 원자력안전법에서 규정하는 일반인 선량한도까지 도달하는데 걸리는 시간을 반감기를 고려치 않고 보수적으로 계산하면 PET/CT는 표면, 50cm, 1m 거리 순으로 7.9시간, 34.1시간, 106.8시간이며 Bone scan은 40.4시간, 199.5시간, 451.1시간이고 Myocardial SPECT는 62.5시간, 519.3시간, 1313.6시간이다. 결론: 본 연구 결과에 의하면 병동 간호사는 일반인 선량한도 보다 훨씬 적은 피폭량을 받는 것으로 나타나, 실질적으로 판단할 때 핵의학 검사를 시행한 환자로 인하여 받는 피폭의 영향은 미미한 것으로 판단된다.

THEODOLITE로 측정한 14 m 전파망원경의 주경면 모양

정재훈,김현구,김태성,정현수,박용선,Jung, Jae-Hoon,Kim, Hyun-Goo,Kim, Tai-Seong,Chung, Hyun-Soo,Park, Yong-Sun 한국천문학회 1997 天文學論叢 Vol.12 No.1

In order to reduce the small scale fluctuation resulting from shearing holograpy(Park et. al. 1997), differential panel adjustments were performed for 14 m radio telescope of Taeduk Radio Astronomy Observatory with T2 theodolite It appears that this method improves the surface accuracy by about $50\;{\mu}m$. The measured surface accuracy is, at best, $170\;{\mu}m$. The beam efficiency at 86.2 GHz is estimated to be 44% We also found that the elevation at which Park et. al. performed holography was too low.

정신과의사가 알아야 할 갑상선질환의 A부터 Z까지

정재훈,Chung, Jae-Hoon 한국정신신체의학회 2006 정신신체의학 Vol.14 No.2

갑상선질환은 비교적 흔한 질환으로 임상의사들이 쉽게 접할 수 있다. 그러나 갑상선질환 환자들은 전형적인 증상을 호소하는 경우부터 흔치 않는 임상상으로 병원을 찾는 경우까지 매우 다양하다. 간혹 정신과의사들이 심한 갑상선기능항진증을 조증 또는 가벼운 정신분열증으로 또는 심한 갑상선기능저하증을 우울증으로 자칫 오진하기 쉽다. 또한 갑상선 종양은 촉지되지 않는 경우까지 포함하여 전인구의 30% 이상에서 발견되고, 이중 최소 5% 이상은 악성종양이므로 갑상선 종양 환자의 접근 및 치료에 대해서도 개괄적인 이해가 필요하다. Thyroid disease is highly Prevalent, and many Physicians encounter the Patients with thyroid disease on many occasions. However, many doctors may make an erroneous diagnosis because of its variable clinical manifestation. Thyroid tumor is the most common disease which is detected in more than 30% of general population. Recently, the incidence of thyroid cancer is increasing to be a leading position in female cancer. Therefore, clinical physicians should be familiar with thyroid disease due to its high prevalence and heterogeneous clinical features.

가상현실 시스템(Virtual Reality System)을 이용한 훈련이 척수손상환자의 앉기 균형 및 일상생활동작에 미치는 영향

정재훈,Chung, Jae-Hoon 대한물리치료학회 2009 대한물리치료학회지 Vol.21 No.2

Purpose: This study was examined the effect of training using a Virtual Reality System on the sitting balance and Activities of Daily Living for patients with a spinal cord injury. Methods: The subjects were divided into an experimental (6 persons) and control group (5 persons). The experimental group trained the 5 programs, three times per week for 6 weeks using the Virtual Reality System and five days for week using conventional physical therapy. The control group trained five days for a week using conventional physical therapy. Results: The difference in the mean Spinal Cord Independence Measurement (SCIM) score in the experimental and control groups was increased to 8.33 and 6.60 (p=0.79), respectively. The difference in the mean functional reaching test in experimental and control group increased to 4.21 and 1.09 (p=0.25), respectively. The difference in the mean sitting time in experimental and control group increased to 41.05 and 10.33 (p=0.66), respectively. There was a difference in the mean of all variances but these differences were not statistically significant. Conclusion: These results suggest that training using the Virtual Reality System increased the SCIM, functional reaching test and sitting time in people with a spinal cord injury.

A Transcriptional Feedback Loop Modulating Signaling Crosstalks between Auxin and Brassinosteroid in Arabidopsis

정재훈,Minsun Lee,Chung-Mo Park 한국분자세포생물학회 2010 Molecules and cells Vol.29 No.5

Auxin and brassinosteroid (BR) play essential roles in diverse aspects of growth and developmental processes in plants mainly through coordinate regulation of cell divi-sion, elongation, and differentiation. Consistent with the overlapped roles, accumulating evidence indicates that the two growth hormones act in a synergistic as well as in an interdependent manner in many cases, although the un-derlying molecular mechanisms are not fully understood. Here, we demonstrate that auxin and BR signaling path-ways are interconnected at the transcriptional level via a negative feedback loop. An Arabidopsis activating tagging mutant dlf-1D exhibited dwarfed growth with small, dark-green leaves and reduced fertility. Hormone feeding as-says revealed that the mutant phenotype is caused by the reduction of endogenous BR level. Consistent with this, a gene encoding the CYP72C1 enzyme that catabolizes BR was up-regulated. Notably, the transcript level of the ARF8 transcription factor gene, which modulates the expression of auxin-responsive genes, was significantly elevated in the mutant. In addition, the ARF8 gene expression was significantly reduced by BR but induced by brassinazole, a BR biosynthetic inhibitor. On the other hand, two BR cata-bolic pathway genes, DLF (CYP72C1) and BAS1, were in-duced by auxin. Our observations indicate that at least part of auxin and BR signaling pathways are unified through a transcriptional feedback control of the DLF and ARF8 genes.

Sensar(R) 와 Acrysof(R) 의 중심이탈과 경사도 비교

정재훈 ( Jae Hun Chung ) , 정성근 ( Sung Kun Chung ) 대한안과학회 2003 대한안과학회지 Vol.44 No.1

국내 단독형 수소충전소 모니터링 연구

정재훈(Jae Hoon Chung),김부근(Pookeun Kim),김경식(Kyungsik Kim),하기역(Kiyeok Ha),정승배(Seungbae Jeong),김영구(Young-Gu Kim) 한국가스학회 2018 한국가스학회 학술대회논문집 Vol.2018 No.5

수종약제가 태반조직호흡에 미치는 영향

정재훈(JH Chung),김동성(DS Kim),김규진(KJ Kim),권병일(BI Kwon) 대한산부인과학회 1964 Obstetrics & Gynecology Science Vol.7 No.2

1. 임신각기에 있어서의 정상인체태반의 조직호흡을 Warburg 표준검압법에 의하여 측정하였다. 2. 임신 6주에서는 QO2가 2.80, 14주에서 2.44, 16주에서 2.15, 20주에서 2.01, 28주에서 1.29, 40주에서는 1.21로서 임신주수가 진행함에 따라 대체적으로 점차 감소됨을 보았다. 3. Pitocin을 첨가한 태반의 산소소모능은 임신각기에서 비첨가군보다 약간 항진되는 경향을 보여 주고 있었다. 4. Methotrexate를 첨가한 태반의 산소소모능은 임신각기에서 약간 감소됨을 알 수 있다. 5. Endoxan, nitromin 첨가군에서도 전반적으로 조직의 산소소모능이 억제되는 경향을 보여 주었고 임신 40주태반에 있어서는 그 산소소모능을 약 50%로 감소시키는 것 같은 양상을 볼 수 있었다. Very few human tissuse other than the placental tissue are readily available for in vitro studies. Despite this fact, little is known about the influence of metabolites or pharma cological agents upon this tissue. Any knowledge that may be obtained about the behavior of this complex organ, further-more, may assist in understanding some unsolved problems of human reproduction. Experimental drugs used are pitocin, Methotrexat. Endoxan (Cyclophosphamide) and Nitromin. The tissuse were obtained in various gestational ages and normal term placenta. The rate of oxygen consumption of fresh human placental tissue was measured by Warburgs standard manometric technique. The result obtained are summarized as follows: 1) Progressive decline in oxygen uptake with advancing pregancy from QO 2.80μ 102/mg dry weight/hour at 6 weeks gestation. 2.44 at 14 weeks. 2.15 at 16 weeks, 2.01 at 20 weeks, 1.29 at 28 weeks and 1.21 at term. 2) The QO2 of human placenta in various gestation is stimulated by pitocin. 3) The QO2 of human placental tissue is depressed by Methotrexate. 4) The QO2 of human placental tissue is depressed by Endoxan (Cyclophosphamide) and Nitromin. These drugs exerted depression of exygen uptake at term placenta significantly.