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주물사업장에서 발생하는 호흡성분진의 농도 및 석영함유량에 관한 연구
박용선,노영만,김현욱,한진구,안연순,강성규,김정만 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1
This study was performed to measure and evaluate the concentration of respirable dust and quartz content at molding and shakeout process in the foundry. The 129 samples in 30 foundries were collected using 10mm Dorr-Oliver nylon cyclone and analysed for quartz concent by Fourier Transform Infrared Spectroscopy. The average quartz concentrations in the respirable dust was 0.0273mg/㎡ and ranged from 0.0007 to 0.3757mg/㎥. The average quartz concentrations of shakeout process wsa significantly higher than that of molding in the foundry. The average of respirable dust in foundry 102129mg/㎡ and ranged from 0.1524 to 7.0428mg/㎥. But there is no significant difference between molding and shakeout processes. The average contents of quartz for OEL-MOL was 2025% and ranged from 0.05 to 32.79% The non-compliance rates for quartz were 22.96% in Korea-OEL and 34.01% in ACGIH-TLV and NIOSH-REL, and 35.03% in OSHA-PEL. The airbome dust in the foundry was effectively controlled when local exhaust ventilation and/or wetting system were operated. The result of this study therefore showed that the engineering controls and periodic environmental suveillance in foundry will be very important for preventing the health effects of workers exposed to quartz.
고열을 동반한 혈액 및 혈액종양 환자의 세균감염에 대한 Ceftazidime(Fortum^(�))의 효과
박용선,김영철,김정일,최인선,박경옥 中央醫學社 1990 中央醫學 Vol.55 No.12
To assess the clinical efficacy of ceftazidime (Forturn�) for initial menagement of febrile patients with blood disease and hematologic malignancy, w ; conducted a trial using ceftazidime alone or combination with piperacillin and aminoglycoside in 24 patients during the last 8 months. The results were as follows. 1. We had "Cure" in 13 cases (54 %), "Improvement" in 6 cases (25 %), and "Failure" in 5 cases (19 %), namely, overall clinical response rate was 79 %. 2. Therapeutic response rates according to inital granulocyte count were 92 %, and 64 % in patients above and below 500/mm3 respectively. 3. There were no differences in response rates according to underlying diseases and sites of infection. 4. In MDI, response rate (100 %) was superior to that of CDI (71 %), possibly due to early addition of sensitive antibiotics. 5. Only in 2 cases, mild nausea was noted after N injection and, no deterioration of liver and renal function was demonstrated. These results indicated that ceftazidime, alone or combination with other drugs, could be suitable as an initial drug in febrile patients with blood disease and hematologic malignancy without notable side effects.
박용선,노영만,김치년 한국환경보건학회 2002 한국환경보건학회지 Vol.28 No.1
Tobacco smoke was confirmed as a human carcinogen by many research results. Because many adolescents stay long time in the PC game room, they are exposed to much of tobacco smoke. To evaluate the effect of passive smoking in the PC game room, airborne nicotine concentrations in 2 PC game rooms in Sung-nam city and urinary cotinine concentrations were measured for 20 adolescents. And the subjects were interviewed for duration and time in PC game room and smoking pattern. Subjects are composed of each of 10 smokers(5 males and 5 females) and 10 nonsmokers(5 males and 5 females). They stayed for three hours in the PC game room without smoking. Concentrations of nicotine in smokers and nonsmokers were 129.72 μg/3 and 99.99 μg/m3, respectively. Urinary cotinine concentrations were increased as time goes on after exposure to nicotine and showed maximum value at 9.45 hours after nicotine exposure and were 32.21 and 110.66 μg/L for nonsmoker and smokers. The more using time and frequency in PC game room, the higher urinary cotinine maximum concentration and the longer using duration, also the more increase urinary cotinine concentration. Urinary cotinine has a tendency to increase by passive smoking. Therefore, it is recommended that the effective control for indoor air quality and extensive research be needed to reduce nicotine concentration by passive smoking in the PC game room.
Analysis of coenzyme Q<sub>10</sub> in human plasma by high performance liquid chromatography
박용선,박상범,송선미,김용우,이경률,Park, Yong-Sun,Park, Sang-Boem,Song, Sean-Mi,Kim, Yong-Woo,Lee, Kyoung-Ryul The Korean Society of Analytical Sciences 2009 분석과학 Vol.22 No.6
코엔자임 큐텐은 비타민과 유사한 물질로 체내 중 미토콘드리아에 주로 분포 되어 있으며 항산화 작용을 나타낸다고 알려져 있다. 본 연구는 27-44세의 건강한 성인 남 녀 24명을 대상으로 하였고 혈장내 코엔자임 큐텐의 농도를 정량 평가하기 위하여 UV 검출기가 장착된 고성능액체 크로마토그라피를 사용 하였다. 혈장 내 코엔자임 큐텐을 분리하기 위해서 메탄올로 지방단백질을 제거하였고 노말헥산을 이용하여 액체-액체 추출법으로 코엔자임 큐텐을 용해 시켰다. 그 후 원심분리를 실시하여 노말헥산과 제단백된 물질을 층분리 시키고 상층액을 다른 유리 시험관에 옮겨 담았다. 옮겨진 노말헥산 층은 질소 가스를 이용하여 증발 농축을 시켰으며 남은 잔사에 순수한 에탄올로 재용해 시켜 검사 장비 내로 주입 하였다. 이 때 사용된 컬럼은 C18 역상 컬럼이었고 275 nm의 파장이 이용되었으며 메탄올과 에탄올을 85:15로 섞은 이동상을 1.7 mL/min의 유속으로 흘렸다. 본 검사 방법의 정량한계(limit of quantitation : LOQ, N/S=10)는 0.02 mg/L로 평가 되었고 0.1-2.0 mg/L의 농도 범위에서 검량선을 작성 하였다. 대상군 24명의 혈장 중 코엔자임 큐텐의 농도는 0.41-0.98 mg/L의 범위에서 분포 하고 있었으며 평균 농도는 $0.62{\pm}0.13mg/L$ 였다. 본 연구의 결과 본 검사 방법은 특수성을 가지고 있었으며 혈장 내 $CoQ_{10}$을 분석하는데 충분한 정량한계를 가지고 있었기에 임상에 적용이 가능하고 연구 기관에서 사용하기에 적합하다고 사료 된다.
박용선,김정민 한국항해항만학회 2022 한국항해항만학회 학술대회논문집 Vol.2022 No.2
2017년부터 현재까지 국제해사기구(IMO)에 제출된 자율운항선박 관련 의제 문서 중 인력과 관련된 의제 문서들의 내용 검토를통해 동향을 파악하여, 현 시점까지의 운항과 관련된 용어들의 정의와 및 우리나라를 비롯한 협약국가들의 운항인력과 관련된 개발 동향을 알아보고자 한다.