L - Ascorbic Acid 가 Guinea Pig 에서 혈장 지질과산화값 , Prostaglandin 생합성 , 광용혈 , Superoxide Dismutase 및 Catalase 활성에 미치는 영향

이정원,이태녕,모수미,이진호,이대형,박수남,이보경 ( Joung Won Lee,Tae Young Lee,Sumi Mo,Jin Ho Lee,Dae Hyung Lee,Soo Nam Park,Bo Kyung Lee ) 생화학분자생물학회 1987 BMB Reports Vol.20 No.4

Three levels of L-ascorbic acid(AsA) were orally given to 20 male Hartley guinea pigs weighing average 428 g for five weeks. AsA level was 0, 2.5, and 100 mg per 100 g body weight per day in the deficient, the adequate, and the excess group, respectively. Plasma lipid peroxide value(TBA value) of deficient was increased to the highest among the three groups and both the adequate and the excess groups exhibited the lower TBA values, suggesting the antioxidant action of AsA. In the excess of AsA, plasma TBA value was greatly lowered one day after the feeding, but TBA value after 5 weeks was elevated comparable to that of the adequate. Aspirin administrating experiment suggested that this elevation was due to increased. production of prostaglandin(PG) endoperoxides induced by excess AsA. Thus it could be concluded that excess AsA actually inhibited the tissue lipid peroxidation in vivo. The activities of both superoxide dismutase(SOD) and catalase in erythrocytes demonstrated the elevations in the deficient comparing with the auequate, but not any significant variations in the excess. SOD activities were correlated with TBA value in liver (r = .324) and with percent hemolysis in erythrocytes (r = .323). Photohemolysis of erythrocyte was increased not only in the AsA deficient but also in the excess comparing with the adequate. A new finding that the large excess administration of AsA in guinea pig demonstrated a significant stimulation of PG endoperoxide biosynthesis, would suggest an important biochemical implication on vitamin C as an activator of phospholipase A₂ and/or PG endoperoxide synthetase. The stimulation of PG biosynthesis might be associated with the enhanced photohemolysis, and this problem needs to be further investigated.

L-Ascorbic Acid가 Guinea Pig에서 혈장 지질과산화값, Prostaglandin 생합성, 광용혈, Superoxide Dismutase 및 Catalase활성에 미치는 영향

이정원,이태녕,모수미,이진호,이대형,박수남,이보경,Lee, Joung-Won,Lee, Tae-Young,Mo, Su-Mi,Lee, Jin-Ho,Lee, Dae-Hyung,Park, Soo-Nam,Lee, Bo-Kyung 생화학분자생물학회 1987 한국생화학회지 Vol.20 No.4

L-Ascorbic acid(AsA)를 결핍, 석정, 과잉(적정의 40배)의 세 수준으로 나누어 guinea pig(평균체중 428g, male)에게 5주동안 경구 투여했을때, 적정 및 과잉으로 공급된 AsA는 AsA 결핍군에서 나타난 혈장 및 간조직의 매우 상승된 지질과산화값(TBA값)을 저하시켰으며 이 효과는 과잉공급시 더욱 컸다. 이는 AsA가 항산화작용을 통해 지질 과산화를 억제하였음을 의미한다. 그러나 과량군의 혈장 TBA값은 적정군의 혈장 TBA값 수준에 머물렀는데 이는 과잉의 AsA가 동시에 혈장 TBA값에 포함되어지는 prostaglandin (PG) endoperoxide의 생합성을 촉진했기 때문이다. 그리고 superoxide dismutase(SOD)와 catalase 활성은 AsA결핍시 특히 적혈구에서 증가경향을 보였으나 과잉 공급인 경우엔 별 변화가 없었다. 동물 개개의 SOD활성도는 간조직에서는 TBA값과 (r = .324) 적혈구에서는 용혈수준과 (r = .323) 상관관계 (p < 0.1)가 있었다. AsA의 대량공급이 지질의 과산화반응을 억제한다는 의의 이외에 PG생합성의 촉진수단으로서 중요한 구실을 할 수 있다는 주목할만한 vitamin C의 새로운 생화학적 의의를 시사한다. 또한 AsA의 과량공급은 적혈구의 $^1O_2$에 의한 광용혈을 적정량 공급군에 비해 촉진시키는 결과를 보이고 있다. 이 광용혈 촉진의 생화학적 의의는 PG endoperoxide 생합성 활성화의 결과와 연관성이 있을 것으로 보이며 PG endoperoxides 촉진문제와 더불어 앞으로 검토해야 될 문제로 사료된다. Three levels of L-ascorbic acid(AsA) were orally given to 20 male Hartley guinea pigs weighing average 428 g for five weeks. AsA level was 0, 2.5, and 100 mg per 100g body weight per day in the deficient, the adequate, and the excess group, respectively. Plasma lipid peroxide value(TBA value) of deficient was increased to the highest among the three groups and both the adequate and the excess groups exhibited the lower TBA values, suggesting the antioxidant action of AsA. In the excess of AsA, plasma TBA value was greatly lowered one day after the feeding, but TBA value after 5 weeks was elevated comparable to that of the adequate. Aspirin administrating experiment suggested that this elevation was due to increased. production of prostaglandin(PG) endoperoxides induced by excess AsA. Thus it could be concluded that excess AsA actually inhibited the tissue lipid peroxidation in vivo. The activities of both superoxide dismutase(SOD) and catalase in erythrocytes demonstrated the elevations in the deficient comparing with the auequate, but not any significant variations in the excess. SOD activities were correlated with TBA value in liver (r = .324) and with percent hemolysis in erythrocytes (r = .323). Photohemolysis of erythrocyte was increased not only in the AsA deficient but also in the excess comparing with the adequate. A new finding that the large excess administration of AsA in guinea pig demonstrated a significant stimulation of PG endoperoxide biosynthesis, would suggest an important biochemical implication on vitamin C as an activator of phospholipase $A_2$ and/or PG endoperoxide synthetase. The stimulation of PG biosynthesis might be associated with the enhanced photohemolysis, and this problem needs to be further investigated.

유사어 벡터 확장을 통한 XML태그의 유사성 검사

이정원,이혜수,이기호,Lee, Jung-Won,Lee, Hye-Soo,Lee, Ki-Ho 한국정보과학회 2002 정보과학회논문지 : 소프트웨어 및 응용 Vol.29 No.9

XML(extensible Markup Language)문서가 웹 문서의 표준으로 자리 매김 할 수 있는 가장 큰 성공요인은 사용자가 문서 타입을 기술할 수 있는 유연성(flexibility)이다. 그러나 XML의 유연성으로 야기되는 문제점은 동일한 의미를 표현하기 위해 XML문서 작성자마다 서로 다른 태그명과 구조를 사용한다는 점이다. 즉 서로 다른 태그 집합, 요소(element), 속성(attribute)에 대한 서로 다른 이름 또는 다른 문서 구조로 인해 다른 태그로 표현된 문서는 서로 다른 부류의 문서로 간주되기 쉽다. 따라서 본 논문은 XML태그에 내재된 의미 정보(semantic information)와 구조 정보(structured information)를 추출하여 의미적으로 최대한 유사한 동의어로 확장하고, XML문서의 확장된 태그간의 의미적 유사도를 비교 분석할 수 있는 개념 기반의 태그 패턴 매처(Tag Pattern Matcher)를 설계 구현하였다. 두 XML문서의 태그간의 의미적 유사도에 가중치를 부여하여 기존의 비구조적인(semi-structured) 문서를 위한 벡터 스페이스 모델(vector space model)을 확장함으로써 두 XML문서가 유사한지를 파악할 수 있다. The success of XML(eXtensible Markup Language) is primarily based on its flexibility : everybody can define the structure of XML documents that represent information in the form he or she desires. XML is so flexible that XML documents cannot be automatically provided with an underlying semantics. Different tag sets, different names for elements or attributes, or different document structures in general mislead the task of classifying and clustering XML documents precisely. In this paper, we design and implement a system that allows checking the semantic-based similarity between XML tags. First, this system extracts the underlying semantics of tags and then expands the synonym set of tags using an WordNet thesaurus and user-defined word library which supports the abbreviation forms and compound words for XML tags. Seconds, considering the relative importance of XML tags in the XML documents, we extend a conventional vector space model which is the most generally used for document model in Information Retrieval field. Using this method, we have been able to check the similarity between XML tags which are represented different tags.

송전철탑 Compact화에 따른 전기환경 영향 연구

이정원,이원교,이동일,Lee, Jung-Won,Lee, Won-Kyo,Lee, Dong-Il 한국전기전자재료학회 2010 전기전자재료학회논문지 Vol.23 No.8

The continuous increase demand for electric power leads to the additional construction of transmission facilities, but it is not easy to acquire right-of-way for transmission facilities. Therefor, there is a need for compact tower that can be built on a narrow right-of-way the compact tower with polymer insulation arm is a solution. It can be upgrading conventional 154 kV transmission line voltages to 345 kV levels. However transmission voltage is increasing, environment interference (corona noise, radio interference, etc.) will occur gradually. This environment interference is depending on the electrical clearances of tower and configuration of conductors. Therefore the analysis of the factors of environmental interference is necessary in order to upgrading transmission voltage. This paper presents the design factor of a compact tower to meet the environmental interference standard.

지역사회 획득 소아 요로 감염에서 Extended-Spectrum ${\beta}-Lactamase$ 생성

이정원,신지선,서정완,이미애,이승주,Lee Jung-Won,Shin Jee-Sun,Seo Jeong-Wan,Lee Mi-Ae,Lee Seung-Joo 대한소아신장학회 2004 Childhood kidney diseases Vol.8 No.2

Purpose: Appropriate antibiotic therapy is important in childhood urinary tract infection and the selection of anibiotics is based on antimicrobial sensitivity of Escherichia coli. Extended-Spectrum ${\beta}-Lactamase(ESBL)$ is an enzyme produced by gram-negative bacilli that has the ability to hydrolyse penicillins, broad-spectrum cephalosporin and monobactam. There have been many reports of outbreaks of hospital infection by ESBL-producing organism. However, community-acquired infection with ESBL-producing organism are rare. This study was performed to retrospectively identify the incidence, characteristics and risk factors of ESBL (+) E. coli in community-acquired childhood UTI. Methods: In 288 children admitted in Ewha Womans University Hospital with E. coli UTI from Mar 2001 to February 2003, ESBL was isolated. ESBL was confirmed by the utilization of an automatized machine(Vitek GNS 433 card) using liquid medium dilution method according to National Committee for Clinical Laboratory Standard. The clinical characteristics, risk factors, antimicrobial resistance and treatment effectiveness were compared with ESBL(-) E. coli UTI. Results: Of 288 E. coli isolates, 31(10.8%) produced ESBL and 93.5%(29/31) occurred in infants younger than 6 month of age(P<0.01). No significant differences were noted in prior antibiotic use, prior admission history and underlying urogenital anomaly. Antimicrobial resistance was significantly higher in ESBL(+) E. coli compared with control patients (P<0.05). Although ceftriaxone showed 100% resistance in ESBL(+) E. coli, bacteriologic sterilization rate after ceftriaxone therapy was higher(96.8%). However, the recurrence rate of febrile UTI within 6 months was higher(25.8%) than control patients(6.6%). Conclusion: Epidemiologic study is required to find out any new risk factors of community-acquired ESBL(+) E. coli UTI and changes in selection of empirical antibiotics should be considered.

하수오환(何首烏丸)이 노화(老化)유발 백서(白鼠)의 항산화능에 미치는 영향

이정원,이송실,백진웅,이상재,김광호,Lee Jeong-Won,Lee Song-Shil,Baek Jin-Woong,Lee Sang-Jae,Kim Kwang-Ho 대한예방한의학회 2004 대한예방한의학회지 Vol.8 No.1

Hasuohwan(何首烏丸) composed of Polygonum multiflorum Thunb and some medical herbs are known as formula of senescence delay effect. The aim of this study is to investigate the effect of Hasuohwan(何首烏丸) on antioxidant enzyme activity such as Thiobarbituric acid reactive substance(TBARS) in rat plasma and liver, Superoxide dismutase(SOD), Glutathione peroxidase(GSH-px), Catalase(CAT) in rat erythrocyte and liver. Rats were sacrificed and TBARS was measured in rat plasma and liver. SOD, GSH-px and CAT were measured in rat erythrocytes and liver. TBARS in plasma concentrations of HSO group was significantly lower than those of control group. RBC and liver GSH-px activities of HSO group were significantly higher than those of control group. According to above results, it is considered that Hasuohwan is effective in inhibiting lipid peroxidation and increasing antioxidative enzyme activities in D-galactose induced aging rat. Therefore, Hsuohwan is considered in effective of senescence delay.

Fracture resistance of zirconia and resin nano ceramic implant abutments according to thickness after thermocycling

이정원,차현석,이주희,Lee, Jung-Won,Cha, Hyun-Suk,Lee, Joo-Hee The Korean Academy of Prosthodonitics 2017 대한치과보철학회지 Vol.55 No.2

Purpose: The aim of this in vitro study is to investigate load bearing capacity of esthetic abutments according to the type of material and wall thickness. Materials and methods: 70 specimens equally divided into seven groups according to their abutment wall thicknesses. The abutments prepared with titanium 0.5 mm wall thickness were used as a control group (Ti-0.5), whereas zirconia abutments and resin nano ceramic abutments with wall thickness 0.5 mm, 0.8 mm and 1.0 mm were prepared as test groups (Zir-0.5, Zir-0.8, Zir-1.0 and RNC-0.5, RNC-0.8, RNC-1.0). All specimens were tested in a universal testing machine to evaluate their resistance to fracture and all of them underwent thermo-cycling before loading test. Mean fracture values of the groups were measured and statistical analyses were made using two-way ANOVA. Results: Zir-1.0 showed the highest mean strength ($2,476.3{\pm}342.0N$) and Zir-0.8 ($1,518{\pm}347.9N$), Ti-0.5 ($1,041.8{\pm}237.2N$), Zir-0.5 ($631.4{\pm}149.0N$) were followed. The strengths of RNC groups were significantly lower compared to other two materials (RNC-1.0 $427.5{\pm}72.1$, RNC-0.8 $297.9{\pm}41.2$) and the strengths of all the test groups decreased as the thickness decreases (P < .01). RNC-0.5 ($127.4{\pm}35.3N$) abutments were weaker than all other groups (P < .05). Conclusion: All tested zirconia abutments have the potential to withstand the physiologic occlusal forces in anterior and posterior regions. In resin nano ceramic abutments, wall thickness more than 0.8 mm showed the possibility of withstanding the occlusal forces in anterior region.

일개대학 학생의 한의학 브랜드 개성 인식에 대한 기초연구

이정원,Lee, Jeong Won 대한예방한의학회 2016 대한예방한의학회지 Vol.20 No.3

Objectives : The purpose of this study is to determine the Korean medicine brand personality awareness of university students and to determine how the Korean medicine brand personality affects the perceived value. Methods : The data for this study were collected through a self-administered survey to 173 subject from students enrolled in the University in B city. Frequency analysis, factor analysis, t-test, ANOVA, multiple regression analysis were used for the statistical analysis. Results : The result of factor analysis, seven factors were extracted. That was refinement, pleasure, trust, warmhearted, capacity, handsomeness, individuality. Overall, capacity, trust, warmhearted, handsomeness scores of Korean medicine brand personality score was higher than individuality, pleasure, refinement. Especially warmhearted, capacity affects the perceived value. Conclusions : Seven Korean medicine brand personality factors were extracted. Warmhearted, capacity affects the perceived value. It is necessary to develop the Korean medical management strategy and Korean medical policy.

영유아에서 초음파 감시하 치골상부 방광천자와 도뇨관 채뇨의 비교

이정원,이승주,Lee, Jung-Won,Lee, Seung-Joo 대한소아신장학회 2007 Childhood kidney diseases Vol.11 No.1

Purpose : Suprapubic aspiration(SPA) has been considered the "gold standard" for obtaining urine in non-toilet trained infants. Ultrasound(US)-guided SPA improves the success rate of the procedure and reduces the complications. However, many physicians perceive SPA as invasive and prefer the use of urethral catheterization (Ucat). We compared the success rate, complications and accuracy of US-guided SPA and Ucat. Methods : 121 infants who visited Ewha Womans University Mokdong Hospital with suspected urinary tract infection(UTI) were investigated. For the first study, the study infants were randomly assigned to either the US-guided SPA(n=32) or Ucat(n=32) groups. The success rate and complications of both procedures were compared. For the second study, US-guided SPA and Ucat were performed simultaneously(n=57). The accuracy of urethral catheterization was subsequently analyzed. The criteria for success was defined as the collection of more than 0.5 mL of urine. UTI was diagnosed by the presence of uropathogens over 105 colony-forming units (CFU)/mL. Results : The overall success rate of the US-guided SPA was 96.9%(71.9% in first attempts, 25.0% in second attempts) which was not significantly different compared to 96.9%(90.6% in first attempts, 6.3% in second attempts) in the Ucat(P>0.05) group. The aspirated urine volume was $7.4{\pm}3.7mL$ in the US-guided SPA group, which was not significantly different to $4.5{\pm}2.6mL$ in the Ucat(P>0.05) group. The accuracy of Ucat in comparison to the US guided SPA was low with sensitivity 59.5%, specificity 86.6%, false-positive rate 13.3% and false-negative rate 40.5%. Conclusion : US-guided SPA should be encouraged as the best method to collect the urine in non-toilet trained infants with UTI.

우라늄 및 희토류(稀土流) 산화물(酸化物)의 황화반응(黃化反應)에 대한 열역학적(熱力學的) 고찰(考察)

이정원,이재원,강권호,박근일,Lee, Jung-Won,Lee, Jae-Won,Kang, Kweon-Ho,Park, Geun-Il 한국자원리싸이클링학회 2012 자원리싸이클링 Vol.21 No.1

In order to evaluate the feasibility of selective sulfidization of uranium and rare-earth(RE) oxides, an analysis on thermodynamic data, such as $M-O_2-S_2$ phase stability diagram and changes of Gibbs free energy for sulfidization of uranium and rare-earth oxides were carried out. Comparing $RE-O_2-S_2$ with $U-O_2-S_2$ phase stability diagram at wide range of sulfur potential, $UO_2$ remains unreacted, while RE oxides are sulfidized. The Gibbs free energy change(${\Delta}G^{\circ}$) of sulfidization of RE oxides is lower than that of uranium oxides. Thus, the selective formation of RE sulfides is possible during sulfidization of RE and uranium oxides at lower temperature. $CS_2$ was selected as a sulfidizing agent, because it is a stronger sulfidizing agent than other agents and reacts at lower temperature.