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고지영,김선용,신인숙,박창서,조정신,이장렬,김기덕 大韓口腔顎顔面 放射線學會 1994 Imaging Science in Dentistry Vol.24 No.1
Neurofibromatosis, or Von Recklinghausen's disease is inhereted as an autosomal dominent neurocutaneous systemic disease. It is characterized by multiple Cafe-au-lait spots, generlaized cutaneous neurofibromas. It affects one in 3000 births. We observed the clinical, radiologic and histopathologic findings of 3 cases of neurofibromatosis and obtained following results. 1. All patients had multiple Cafe-au-lait spots and neufibromas. 2. Two patients had radiographic changes of pressive erosion and mesodermal dysplasia. 3. Two patients had plexiform neurofibromas and 1 patient had diffuse neurofibromas. Conclusively, we classified these 3 cases as NF-Ⅰ.
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成基泰,金知學,李興吉,辛逸善,金芳植,閔彰東 忠州大學校 1996 한국교통대학교 논문집 Vol.31 No.2
For resonable curriculum modification and development corresponding with training to competent high-level, engineering as educational object of industrial university this research was carried out as following process ; 1. Collection and analysis of present curriculum in civil engineering department of domestic industrial university including the curriculum of foreign industrial university. 2. Organization of advisory committee for insustry school cooperation and visiting insustry and interview. 3. Organization of all Korea Civil Engineering Department chief committe. 4. Result of research through the questionnaire for all Korea representative industry and academic could be summarized as follows : 1) Wide contact between college education and industry field should be strengthened, and field experiment education was strengthened to consider of ability, and construction management was edited compulsory major. 2) For the adapting trend of variety and subdivision of construction skill EDPS education was edited compulsory 3) The curriculum was endeavoured to fundamental science. 4) The curriculum enlarged the range of the optional subject which is able to manage the flexible curriculum for characterization of each local industrial university and endeavoured consideration of field adapting ability by classifing the civil design into Construction design and integration, Hydraulic design and integration, Earth design and integration. 5) The curriculum of academic theories and experiments were unificated into single subject for the purpose of flexible management 6) The curriculum was edited in the ration which is 20 to 80 between liberal and majoring arts in presentation on the basis of all accounts of opinion from the academic and field worker, and emphasized the importance of language education editing industrial English conversation because of demand of much ability along with foreign advance of construction technique. 7) The curriculum was emphasized in the necessity of the field experimental trained based on the information by all opinion. By operationg this curriculum, it is expected that the relationship between industry and academic will be efficiently considered.
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푸드뱅크 기탁식품의 안전성 확보를 위한 HACCP 제도 적용
김철재,박현신,배현주,이지해,양일선,강혜승 한국식생활문화학회 2002 韓國食生活文化學會誌 Vol.17 No.3
The purpose of this study was to analyze the problems arising from the actual conditions of the Foodbank, and to implement the HACCP system as a solution in terms of increasing the safety of donated food within the Foodbank. In order to apply HACCP system, the entire Foodbank working process such as preparation, collection, transportation, division, and distribution was considered and analyzed to decide the application point for CCPs. Donated foods mainly consisted of processed foods, raw materials, lunch boxes, and cooked foods from mass catering establishments, which dominated over the others in terms of quantity. Cooked foods were divided into three groups based on menu-types and processing methods. Temperature, pH, and aw were measured on cooked foods, and Total Plate Count, Coliforms, E. coli, Salmonella spp., Staphylococcus aureus, Listeria monocytogenes, and E. coli O157:H7 were conducted in order to apply a HACCP plan. Form these experiments, temperature, pH, and aw of donated food were likely contributed to microbial growth. Donated foods before HACCP implementation showed high numbers in terms of total plate count and Coliforms, both well over the acceptable standard levels. By setting the CCPs on maintenance of donated food below 10℃ and using a 75 ℃ reheating method, microbiological hazard levels were able to be controlled and lowered. From these results, it is concluded that in order to guarantee food safety, foods donated to the Foodbank must not only maintain a reasonable level of initial microbiological growth, but also must be handled properly through time and temperature controls within the Foodbank system. Furthermore, in terms of implementing the HACCP plan within the Foodbank management structure, basic food safety and sanitation measures, such as reheating facilities and various cold chain systmes such as refrigerated vehicle for food transportation are importantly needed. The training and education of Foodbank personnel and management in areas such as awareness of hygiene and safe food handling and practice are also required and necessary.
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문제중심학습(Problem Based Learning; PBL) 패키지 개발 : 지각·조정장애상황을 중심으로
김애리,김영경,송영선,신경림,안혜정,이지순,조계화 성인간호학회 2001 성인간호학회지 Vol.13 No.3
The Purpose of this study is to present an actual example for procedures for developing a PBL package based on philosophical backgrounds derived from Problem-based learning. To perform a systemic study on the operations of an intergrated curricula under multi-disciplines, a research team made up of several professors with different academic backgrounds was formed. Among the four situations for the patients with perception-adjustment disorder, especially a procedure for the development of PBL package which can be used in the emergency room situation has been proposed. The little(2000)'s PBL package model has been applied for this study. Tha package includes course objectives, learning objectives, concept map, situation scenario. tutor guide, and evaluation method. It is believed that learning objectives achievement procedures designed as a part of a problem-based learning package development procedures for the nursing of patients with perception-adjustment can be achieved at the same level as the learning objectives for the science of nursing founded by the Korean Nurses Association.
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Escherichia coli 패혈증 환자에 합병된 대칭적 하지 말단 괴사증 1예
남해성,유진홍,권순석,민준기,조현선,박민경,심병주,남유정,이지인,김진수,길욱현,조근종,신완식 대한감염학회 2005 감염과 화학요법 Vol.37 No.6
We have encountered a rare case of symmetrical peripheral gangrene complicating Escherichia coli sepsis in a 47-years-old male. He was successfully treated with antibiotics, anticoagulants, and vasodilator. To our knowledge, this is the first report on symmetrical peripheral gangrene complicating E. coli sepsis in Korea.
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Effectiveness of Adjuvant Chemotherapy with 5-FU/ Leucovorin and Prognosis in Stage II Colon Cancer
Sun Hee Jee,Sun Mi Moon,Ui Sup Shin,Hoe Min Yang,황대용 대한대장항문학회 2011 Annals of Coloproctolgy Vol.27 No.6
Purpose: The aims of this study were to investigate the survival results and the prognostic factors of adjuvant chemother- apy in stage II colon cancer in the sparsity of Korean data. Methods: From 1993 to 2006, 363 curatively resected pathologic stage II colon cancer patients were enrolled. Six cycles of adjuvant chemotherapy was performed: intravenous bolus 5-fluorouracil (5-FU) 500 mg/m2 with leucovorin 20 mg/m2 for 2 hours daily for 5 days, followed by a 3-week resting period (n = 308). Fifty-five patients received only curative surgery. A high risk of recurrence was defined as the presence of one or more of the following factors: T4 tumor, lympho-vascular in- vasion, perineural invasion, perforation, obstruction, retrieved lymph node < 12, and poorly differention. The median fol- low-up period was 68 months (1 to 205 months). Results: The five-year overall survival (OS) rate was 90.1%, and the five-year disease-free survival (DFS) rate was 84.7%. Among high-risk patients, the OS and the DFS rates of the treatment group were significantly higher than those of the non-treatment group (OS: 90.6% vs. 69.1%, P < 0.0001; DFS: 85.9% vs. 54.1%, P < 0.0001). Among low-risk patients, the survival results of the treatment group were also significantly superior (OS: 97.7% vs. 88.2%, P < 0.0001; DFS: 93.0% vs. 80.0%, P = 0.001). In the multivariate analysis, adjuvant chemotherapy was a significantly favorable prognostic factor for overall survival (hazard ratio, 0.41; 95% confidence interval, 0.22 to 0.75; P = 0.004). Conclusion: In our population, adjuvant chemotherapy showed superior survival to curative surgery alone and signifi- cantly reduced the risk of death. A nationwide multicenter randomized trial is needed. Purpose: The aims of this study were to investigate the survival results and the prognostic factors of adjuvant chemother- apy in stage II colon cancer in the sparsity of Korean data. Methods: From 1993 to 2006, 363 curatively resected pathologic stage II colon cancer patients were enrolled. Six cycles of adjuvant chemotherapy was performed: intravenous bolus 5-fluorouracil (5-FU) 500 mg/m2 with leucovorin 20 mg/m2 for 2 hours daily for 5 days, followed by a 3-week resting period (n = 308). Fifty-five patients received only curative surgery. A high risk of recurrence was defined as the presence of one or more of the following factors: T4 tumor, lympho-vascular in- vasion, perineural invasion, perforation, obstruction, retrieved lymph node < 12, and poorly differention. The median fol- low-up period was 68 months (1 to 205 months). Results: The five-year overall survival (OS) rate was 90.1%, and the five-year disease-free survival (DFS) rate was 84.7%. Among high-risk patients, the OS and the DFS rates of the treatment group were significantly higher than those of the non-treatment group (OS: 90.6% vs. 69.1%, P < 0.0001; DFS: 85.9% vs. 54.1%, P < 0.0001). Among low-risk patients, the survival results of the treatment group were also significantly superior (OS: 97.7% vs. 88.2%, P < 0.0001; DFS: 93.0% vs. 80.0%, P = 0.001). In the multivariate analysis, adjuvant chemotherapy was a significantly favorable prognostic factor for overall survival (hazard ratio, 0.41; 95% confidence interval, 0.22 to 0.75; P = 0.004). Conclusion: In our population, adjuvant chemotherapy showed superior survival to curative surgery alone and signifi- cantly reduced the risk of death. A nationwide multicenter randomized trial is needed.
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Adiponectin Concentrations: A Genome-wide Association Study
Jee, Sun Ha,Sull, Jae Woong,Lee, Jong-Eun,Shin, Chol,Park, Jongkeun,Kimm, Heejin,Cho, Eun-Young,Shin, Eun-Soon,Yun, Ji Eun,Park, Ji Wan,Kim, Sang Yeun,Lee, Sun Ju,Jee, Eun Jung,Baik, Inkyung,Kao, Lind Elsevier 2010 American journal of human genetics Vol.87 No.4
<P>Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage). Another 2,304 subjects were used for follow-up replication studies with selected markers. In the discovery phase, the top SNP associated with mean log adiponectin was rs3865188 in <I>CDH13</I> on chromosome 16 (p = 1.69 × 10<SUP>−15</SUP> in the initial sample, p = 6.58 × 10<SUP>−39</SUP> in the second genome-wide sample, and p = 2.12 × 10<SUP>−32</SUP> in the replication sample). The meta-analysis p value for rs3865188 in all 6,305 individuals was 2.82 × 10<SUP>−83</SUP>. The association of rs3865188 with high-molecular-weight adiponectin (p = 7.36 × 10<SUP>−58</SUP>) was even stronger in the third sample. A reporter assay that evaluated the effects of a <I>CDH13</I> promoter SNP in complete linkage disequilibrium with rs3865188 revealed that the major allele increased expression 2.2-fold. This study clearly shows that genetic variants in <I>CDH13</I> influence adiponectin levels in Korean adults.</P>
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Bilirubin and Stroke Risk Using a Mendelian Randomization Design
Lee, Sun Ju,Jee, Yon Ho,Jung, Keum Ji,Hong, Seri,Shin, Eun Soon,Jee, Sun Ha American Heart Association 2017 Stroke Vol. No.
<P>Conclusions-There is no evidence that bilirubin level is causally associated with risk of stroke in Koreans. Therefore, bilirubin level is not a risk determinant of stroke.</P>
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