도인승기탕에 의한 당뇨병성 혈관장애 개선효과

이윤정,김언국,김혜윰,윤정주,이소민,이용표,이건목,강대길,이호섭,Lee, Yun Jung,Kim, Eon Kuk,Kim, Hye Yoom,Yoon, Jung Joo,Lee, So Min,Lee, Yong-Pyo,Lee, Geon Mok,Kang, Dae Gill,Lee, Ho Sub 대한한의학방제학회 2013 大韓韓醫學方劑學會誌 Vol.21 No.1

Objectives : Diabetes mellitus is the leading cause for vascular complications such as atherosclerosis. The present study is to investigate whether Doinseunggi-tang (DST) improves diabetic vascular dysfunction in type II diabetes. Methods : The db/db mice were treated with high fat/high cholesterol diet and DST (200 mg/kg/day) for 8 weeks. Results : DST significantly lowered blood glucose and systolic blood pressure. In addition, DST also markedly decreased total plasma cholesterol, triglyceride, and LDL-cholesterol, whereas increased the HDL-cholesterol. Vascular relaxation of aortic rings by acetylcholine or SNP was ameliorated by DST in a dose-dependent manner. Damage of vascular intima and hypertrophic of media was improved by DST. Immunohistological study revealed that DST attenuated the increase of ICAM-1, VCAM-1, and ET-1 expression in thoracic aorta. Conclusions : Taken together, DST suppressed hyperglycemia and diabetic vascular dysfunction in type II db/db mice. The present data suggests that Doinseunggi-tang may be prevent a development of diabetic atherosclerosis.

Salmonella typhimurium 에서 무산소 환경 유도유전자들에 대한 조절유전자들의 특성 및 클로닝

이윤정,방일수,이인수,이영록,박용근 ( Yun Joung Lee,Iel Soo Bang,In Soo Lee,Yung Nok Lee,Yong Keun Park ) 한국환경생물학회 1993 환경생물 : 환경생물학회지 Vol.11 No.2

New regulatory loci which participate in the anaerobic environment inducible gene(ani) expression in Salmonella typhimurium were identified. These regulators (oxr) showed negative regulatory effect on the anaerobiosis inducible operon fusions of this organism in aerobic environment (oxr 107 and oxr 108 to ani 2001, oxr 109 to ani 2007). They were identified as the trans-acting regulators, and increased β-galactosidase activity of ani-lacZ fusion strains up to about 10-240 fold in aerobic environment. By using the library of S. typhimurium chromosomal DNA, two negative regulators (oxr 101 and oxr 109) were cloned. The insert fragment of each clone, pPK32 for oxr 101 and pPK33 to oxr 109 were 7.8Kb and 9.3Kb, respectively. The recombinant plasmid pPK32 didn`t complement the mutation effect of oxr 101 on minimal media but rich media, pPK33 complemented the mutation effect of oxr 109 on both minimal and rich media.

고지혈증 동물모델에서 홍삼과 천마 혼합투여에 의한 혈관 염증 개선연구

이윤정,김혜윰,윤정주,이소민,고정현,이호섭,최경민,강대길,Lee, Yun-Jung,Kim, Hye-Yoom,Yoon, Jung-Joo,Lee, So-Min,Kho, Joung-Hyun,Lee, Ho-Sub,Choi, Kyung-Min,Kang, Dae-Gill 대한한의학방제학회 2012 大韓韓醫學方劑學會誌 Vol.20 No.1

Objectives : This experimental study was designed to investigate the inhibitory effects of combination with Korean red ginseng and Gastrodia rhizoma on vascular dysfunction in high-fat/cholesterol diet-induced hyperlipidemia. Methods : Sprague-Dawley rats were fed with 7.5% cocoa butter and 1.25% cholesterol for 10 weeks, with Panax ginseng (PG), and mixtures of Panax ginseng and Gastrodia rhizoma (PGM), respectively. Results : Chronic treatment with PG and PGM significantly decreased body weight. The aortic expression of cell adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin were markedly increased in hyperlipidemia rats. Interestingly, PGM significantly decreased cell adhesion molecules expression. However, there was no significant decrease in PG group. In addition, PG and PGM group inhibited high-fat/cholesterol diet-induced cytokine such as monocyte chemoattractant protein (MCP-1) mRNA expression. Furthermore, PG and PGM group significantly decreased c-reactive protein protein (CRP) level. Especially, PGM significantly accentuated the decrease of MCP-1 mRNA expression and CRP level. Conclusions : the present study provides an evidence that combination with Panax ginseng and Gastrodia rhizoma enhances anti-vascular protective effects through suppression of vascular inflammation in hyperlipidemic rats.

비중격만곡증 환자의 눈물주머니코안연결술의 임상예후

이윤정,문상원,조희윤,정진혁,Yoon Jung Lee,M,D,Sang-Won Moon,M,D,Hee Yoon Cho,M,D,Jin-Hyeok Jeong,M,D 대한안과학회 2008 대한안과학회지 Vol.49 No.5

Purpose: Septal deviation has few subjective symptoms. However, a difficulty remains in doing DCR (dacryocystorhinostomy) in these patients. We investigate the clinical course of DCR in patients with a septal deviation. Methods: Acquired nasolacrimal duct-obstructed patients who had undergone DCR with septal deviation from 2003 to 2006 in our hospital were retrospectively analyzed. We measured the septal distance using paranasal computed tomography taken preoperatively and compared the sex and age of patients, the kinds of operations, outcome of surgery, and ocular and nasal complications in our analysis. Results: Twenty-two eyes of 22 patients with a mean age of 55.3 years (range 29~74) were analyzed (4 males, 18 females). Mean septal distance was 4.84 mm (range 2.18~6.99 mm). Nineteen eyes had endonasal DCR, and three had external DCR. Two had DCR combined with septoplasty. Three had septoplasty as a secondary operation, Nasal complication was synechiae in 9 eyes. DCR success was seen in 15 eyes, and DCR failure in 7 eyes. Septal distance was not correlated with DCR success but was correlated with nasal complication (Mann-Whitney test, p=0.003) Conclusions: In the case of DCR with septal deviation, the surgical technique used will need to minimize the mucosal injury and ensure appropriate nasal correction to prevent future complications.

국내외 기록관리학 대학원 교육과정에 관한 비교 연구

이윤정,정연경,Lee, Yun-Jung,Chung, Yeon-Kyoung 한국문헌정보학회 2021 한국문헌정보학회지 Vol.55 No.1

This study examined the curriculum of 23 graduate schools of archival sciences in the United States, Canada, the United Kingdom, and Australia and 25 graduate schools of archival sciences in Korea, and compared core knowledge categories. The average number of courses in Korea and other countries was similar, but each university in other countries set required courses, and few in Korea. As a result of comparison by knowledge category, all knowledge categories in North America were opened as individual courses, while the UK and Australia did not open knowledge categories of outreach, instruction, advocacy, and knowledge categories of professionalism separately. In Korea, the category of outreach, instruction, advocacy, the knowledge category of professionalism, and the knowledge category of information technology have not been established separately, while courses related to history and administration are subdivided. In order to reform the archival science education in Korea, the knowledge categories for archival professionals should be prepared and the guidelines and certification standards for the education should be established. 본 연구는 미국, 캐나다, 영국, 호주의 23개 기록관리학 대학원과 국내 25개 기록관리학 대학원의 교육과정과 교과목을 조사하고 기록관리 지식범주를 중심으로 비교·분석하였다. 국내와 국외의 평균 과목수는 비슷하나 국외는 대학마다 필수과목을 설정하였고 국내는 필수과목을 거의 설정하지 않았다. 북미는 모든 지식범주가 개별 교과목으로 개설되었지만, 영국과 호주는 아웃리치, 지도, 옹호와 전문직 지식범주에서 개별 교과목이 개설되지 않았다. 한국은 아웃리치, 지도, 옹호와 전문직 지식, 정보기술 지식범주에서 개별 교과목이 별도로 개설되지 않은 반면, 역사학과 행정학 관련 과목이 세분화되어 있었다. 우리나라는 기록관리 교과목 개편을 위해 가이드라인과 인증기준을 제정하여 기록전문가가 배워야 할 지식범주를 설정하는 것이 시급하며, 디지털 기록을 전문적으로 관리할 수 있는 정보기술 지식범주의 확충이 필요하다.

전자코와 GC/MS를 이용한 포도 품종별 저장 조건에 따른 휘발성 향기 성분 연구

이윤정,이기택,Lee, Yun-Jeung,Lee, Ki-Teak 한국식품영양과학회 2007 한국식품영양과학회지 Vol.36 No.7

품종에 따른 포도를 이용하여 3일 동안 $4^{\circ}C$와 실온에 각각 저장함에 따라 변화하는 전체적인 향의 패턴을 전자코를 통하여 분석하였고 SPME-GC/MS 분석 결과를 통하여 휘발성분을 분리 동정하였다. 대표적인 포도의 주요 휘발 성분은 alcohols, esters, acids, terpenes 등으로 GC/MS 분석 결과 butanoic acid/ethyl ester와 1-hexanol, hexanoic acid/ethyl ester, phenylethyl alcohol 등이 주요 성분으로 동정되었다. 캠벨은 다른 품종에 비해 다양한 휘발 성분이 동정되었고 레드글로브와 머루 품종에서는 1-hexanol, 2-decene, 8-methyl-(z)/1-dodecanol 등을 제외한 나머지 휘발 성분은 거의 나타나지 않았다. 또한 전자코를 이용하여 휘발성 향기성분 패턴 분석결과 $4^{\circ}C$와 실온 저장한 시료의 제 1주성분 값의 기여율은 각각 99.30, 99.36%로 품종에 따라 구분이 가능하였다. $4^{\circ}C$ 저장 시 저장 기간에 따른 제 1주성분 값의 변화 범위는 실온에서 저장한 것에 비해 적었음을 확인할 수 있었다. Volatile flavor compounds of 4 grape species (Campbell, Sheridan, Red globe, and Meoru) were identified during 3-day storage at either $4^{\circ}C$ or room temperature. Each sample was analyzed by solid-phase micro-extraction (SPME) method combined with gas chromatography-mass spectrometry. Also electronic nose composed of 12 different metal oxide sensors was used to differentiate flavors of grapes. Sensitivities (delta $R_{gas}/R_{air}$) of sensors from electronic nose were obtained by principal component analysis (PCA). Proportion of the first principal component was 99.30% at $4^{\circ}C$ and 99.36% at room temperature, respectively. In our result, flavor patterns of grape can be differentiated according to the storage period. The major volatile flavor compounds were 1-hexanol, hexanoic acid and its ethyl ester, and phenylethyl alcohol with the presence of butanoic acid and its ethyl ester, acetic acid, benzeneacetic acid and its ethyl ester.

유지요소의 크기와 형태가 간접복합레진과 금속간의 결합강도에 미치는 영향

이윤정,전영찬,정창모,Lee, Yun-Jung,Jeon, Young-Chan,Jeong, Chang-Mo 대한치과보철학회 2007 대한치과보철학회지 Vol.45 No.5

Purpose: The purpose of this study was to investigate the effect of sire and shape of retention element on the bond strength of indirect composite resin and metal. Material and method: The metal disk specimens, each 6mm in diameter, were cast from CrCo alloy. They were divided into 8 groups by applied retention element. retention bead group $B2\;({\phi}\;0.2mm),\;B4\;({\phi}\;0.4mm),\;B6\;({\phi}\;0.6mm),\;B8\;({\phi}\;0.8mm)$, retention crystal group C2 (0.2mm), C5 (0.5mm), C8 (0.8mm) and sandblasting group SB ($110{\mu}m\;Al_2O_3$ blasting) as control. Eighty-eight metal specimens were veneered with $TESCERA^{(R)}$ Indirect resin system. One specimen of each group was sectioned and the resin-metal bonding pattern at the interface was observed under measuring microscope. Other specimens were then tested for tensile bond strength on an Instron universal testing machine at a crosshead speed of 2mm/min. Results: 1. Compared to sandblasting, beads or crystals increased the resin-metal bond strength (P<.05). 2. 0.2mm retention crystals were most effective in improving the resin-metal bond strength (P>.05). 3. 0.2mm beads showed the highest bond strength among retention bead groups, but there was no statistically significant difference (P>.05). 4. Retention crystals tend to be higher in bond strength than retention beads due to wider surface area. 5. The larger retention element, the larger the undercut for the mechanical retention, but the gap at resin-metal interface was also increased. Conclusion: Within the limitations of this study, 0.2mm retention crystals were most effective in improving the resin-metal bond strength.

사체를 이용한 아래눈꺼풀지방의 해부학적 연구

이윤정,강일봉,신선영,백두진,Yoon Jung Lee,M,D,Il Bong Kang,M,D,Sun Young Shin,M,D,Doo Jin Paik,M,D 대한안과학회 2007 대한안과학회지 Vol.48 No.7

Purpose: This study investigated the anatomy of infraorbital fat and the relationship between surrounding structures and infraorbital fat. Methods: Forty-one orbits from adult Korean cadavers were dissected. Among them 20 orbits were male and 21 orbits were female. The cadavers were perfused and embalmed in formalin solution. The skin and orbicularis oculi muscle were dissected to expose the arrangement and compartments of infraorbital fat. A punctal probe was used to find a deeper fat compartment lying under the another compartment. The width of each compartment and the distances from the inferior orbital rim and from the lower lid margin to the topmost point of each compartment were measured using a digital caliper. The distance from the top of the medial compartment and lower lid margin to the first appearance of the inferior oblique muscle, located between the medial and the central fat compartments, were measured, respectively. Results: The width of the medial compartment was 11.49±2.54 mm, the central compartment was 21.78±5.69 mm, and the lateral compartment was 17.94±4.99 mm. The distance from the inferior orbital rim to the medial compartment was 8.13±2.72 mm, to the central compartment was 9.91±3.44 mm, to the lateral compartment was 9.58±3.76 mm. The distance from the lower lid margin to the medial compartment was 5.55±1.22 mm, to the central compartment was 7.09±3.22 mm, and to the lateral compartment was 5.41±3.07 mm. The distance from the inferior oblique muscle to the medial compartment was 9.09±2.63 mm, and to the lower lid margin was 13.60±2.27 mm. Conclusions: Our study evaluates the normal anatomy of the infraorbital fat compartments in Korean patients and suggests a useful index for lower blepharoplasty and lower orbital surgery.

TRIB: 블로그 댓글 분류 및 시각화 시스템

이윤정,지정훈,우균,조환규,Lee, Yun-Jung,Ji, Jung-Hoon,Woo, Gyun,Cho, Hwan-Gue 한국정보처리학회 2009 정보처리학회논문지D Vol.16 No.5

최근 들어 블로그나 인터넷 게시판 등은 사람들의 정보 공유나 의견 교환의 중요한 매체가 되고 있으며, 많은 수의 블로그들이 사회적 문제들을 반영하고 있다. 온라인 커뮤니티에서 많은 사용자들은 댓글을 통해 인터넷 뉴스나 블로그 게시물에 대한 자신의 의견을 적극적으로 표현하고 있다. 블로그 사용이 활발해짐에 따라 수만개 이상의 댓글들이 등록되는 블로그들도 쉽게 찾을 수 있다. 대부분의 블로그나 인터넷 포털사이트의 경우 게시물이나 댓글들을 순차적인 목록 형태로 제공하므로 자신이 원하는 내용의 댓글을 검색하거나 전체 댓글에 대한 전반적인 파악이 힘들다. 본 논문에서는 게시물에 달린 많은 수의 댓글들을 분류하고, 이를 시각화 하는 시스템인 TRIB (Telescope for Responding comments for Internet Blog)를 제안한다. TRIB는 미리 정의된 사용자 정의 사전을 이용하여 댓글을 내용에 따라 분류하여 시각화한다. 또한, 사용자들의 관심과 흥미를 고려한 개인화 된 뷰를 제공한다. TRIB의 유용성을 보이기 위해서 1,000개 이상의 댓글을 가진 인터넷 게시물들을 대상으로 한 실험을 통해 TRIB 시스템의 댓글 분류와 시각화 성능을 보인다. In recent years, Weblog has become the most typical social media for citizens to share their opinions. And, many Weblogs reflect several social issues. There are many internet users who actively express their opinions for internet news or Weblog articles through the replying comments on online community. Hence, we can easily find internet blogs including more than 10 thousand replying comments. It is hard to search and explore useful messages on weblogs since most of weblog systems show articles and their comments to the form of sequential list. In this paper, we propose a visualizing and clustering system called TRIB (Telescope for Responding comments for Internet Blog) for a large set of responding comments for a Weblog article. TRIB clusters and visualizes the replying comments considering their contents using pre-defined user dictionary. Also, TRIB provides various personalized views considering the interests of users. To show the usefulness of TRIB, we conducted some experiments, concerning the clustering and visualizing capabilities of TRIB, with articles that have more than 1,000 comments.

근·현대사 이후 한국인의 최다 선호 일반의약품의 추이에 대한 연대별 분석 및 종합적 의의에 대한 평가

이윤정,강태진,임성실,Lee, Yun Jeong,Kang, Tae Jin,Lim, Sung Cil 대한약학회 2016 약학회지 Vol.60 No.3

Over-the-counter (OTC) drugs refer to medicines that are generally safe when used according to the product label. We aimed to assess and reflect upon changes in perception of health and health-related demands by decades in Korea according to the consumption and sales trends of OTC drugs. This study was conducted by literature search on the production and sale rankings of OTC drug market in Korea. Changes in the OTC drug market were analyzed and organized by decades to evaluate changes in drug demands and the influence of national and societal factors. There was a specific trend in the most popular drugs by decades. In the 1950s, drugs of top necessity were antibiotics and helminthics. In the 1960s, the pharmaceutical industry quickly grew and invigorators, such as Bacchus$^{(R)}$, Alps$^{(R)}$, Aronamin$^{(R)}$, were top manufactured drugs. Popularity of these invigorating drinks and vitamin products continued until the 1990s. In 1990s, sales of topical nonsteroidal anti-inflammatory drugs (Ketotop Plaster$^{(R)}$, Trast Patch$^{(R)}$), and in 2000s, gum disease medicine (Insadol$^{(R)}$) and liver and intestine supplement (Ursa$^{(R)}$) were prominent. However, after the separation of prescribing and dispensing in 2000, the sales of OTC drugs decreased dramatically from 58.7% of the total market share in 1990s to 39.6% in 2000 and this trend has continued. In 2012, thirteen OTC drugs were allowed to be sold in convenience stores, and as the sales of health functional foods have been expanding beyond pharmacies, sales of invigorators and nutritional supplements in pharmacies have continued to decrease. As government's drug expenditure will continue to grow, reclassification of OTC drugs based on established safety information and deliberate team efforts on continued development of OTC drugs to meet the health demands of Koreans are required by the healthcare professionals, pharmaceutical industries, and the government.