응급실에 내원한 비출혈 환자에서 RapidRhino와 epinephrine 동반 사용의 유용성

이영준,윤영탁,김영식,정루비,이규현,유우성 대한응급의학회 2024 대한응급의학회지 Vol.35 No.1

Objective: RapidRhino is widely used in emergency departments (EDs) to treat epistaxis, and we have used RapidRhino plus epinephrine empirically. In this study, we evaluated the effectiveness of RapidRhino plus epinephrine compared to RapidRhino with saline. Methods: This prospective randomized study was performed on patients with epistaxis who visited our ED between October 2021 and January 2023. Patients were randomized to RapidRhino plus epinephrine or RapidRhino groups by drawing numbers. Subgroup analyses were performed on patients who received or did not receive anticoagulants or antiplatelets. Results: The overall success rates for RapidRhino with saline and RapidRhino with epinephrine were both high (92% and 94%, respectively), but the 10-minute success rates of RapidRhino with saline and RapidRhino with epinephrine were 57.4% and 78%.0%, respectively, which was a significant difference (P=0.001). In patients administered anticoagulants, initial success rate of RapidRhino with epinephrine was higher than that of RapidRhino with saline (83.3% and 62.9%, respectively, P=0.046), and these results were confirmed by adjusted logistic regression analyses-for all patients (adjusted odds ratio [aOR]=2.42; 95% confidence interval [CI], 1.28-4.58) and for patients treated with anticoagulants (aOR=6.31; 95% CI, 1.17-34.17). Conclusion: RapidRhino with epinephrine may be more effective at controlling hemorrhage than RapidRhino. The combined administration of RapidRhino and epinephrine might reduce the time spent in emergency departments by epistaxis patients.

Individually position-addressable Cu nanofiber electrode array printing

이영준,김태식,민성용,( Wentao Xu ),정수훈,서홍규,이태우 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1

We fabricated highly aligned Cu nanofiber (NF) array with regular line spacing and orientation using our own printing method called Electrohydrodynamic Nanowire Printing (ENP). Printed Cu NF had average diameter of 710 nm and resistivity of 14.1 μΩ·cm which is comparable with that of bulk Cu (Resistivity of bulk Cu = 1.7 μΩ·cm). We also demonstrated the pentacene thin film field-effect transistors with individual Cu NF as source/drain electrodes and achieved field-effect hole mobility of 0.14cm²·V^-1·s^-1. These results show that highly aligned Cu NF array can be used for the nano-electrodes of various electronic applications, and our approach will be a promising strategy in the field of next generation electronics.

Ginkgo biloga 잎 추출물의 1,2,4-benzenetriol에 대한 항산화 효과에 대한 연구

이영준,김태연,정해원 한국환경보건학회 2001 한국환경보건학회지 Vol.27 No.1

Ginkgo biliba has been used for bronchitis and asthma in oriental countries and its leaf extract(GBE) contains 24% ginkgoflavone glycoside and 6% terpenoid. Flavonoids and terpenoids are known to have various antioxidant effects such as scavenging of free radicals and chelation of transtional metals. Antioxidant effect of GBE against 1,2,4-benzenetriol(BT), one of toxic metabolites of benzene, was demonstrated throughbsister chromatid exchange(SCE) analysis, single cell gel electrophoresis(SCGE) analysis, DNA cleavage assay and lipid peroxidation production analysis. The means of SCE frequencies at 10, 25 and 50$\mu$M concentration of BT were 7.72, 8.02, 9.22 respectively. In addition of GBE with concentration of 50, 200 and 500$\mu\textrm{g}$/$m\ell$, SCE frequencies were decreased significantly.(p<0.05) According to SCGE analysis, BT induced DNA damage in a dose-dependent manner at concentration of 10 and 50 $\mu$m and the DNA damage induced by BT was significantly protected by GBE(p<0.001). No genotoxicity was observed by GBE treatment alone on DNA cleavage. The effect of BT on lipid peroxidation product, Malondiadehyde(MDA), was increased with concentration of BT(10 and 50 $\mu$M) and reduction in MDA was noted when GBE was added. From above results it is suggested that GBE could protect the cell and DNA from pro-oxidant effect by reactive oxigen species induced by BT.

화학물질에 대한 토양 흡착 및 탈착 등록시험 사례 연구

이영준,민석기,이창호,이윤하,손산호,송은희,임기현,정혜림,김평열 환경독성보건학회 2022 한국독성학회 심포지움 및 학술발표회 Vol.2022 No.10

Designable Ag nanofiber electrode array printing for various electronic devices

이영준,민성용,김태식,정수훈,김호범,원주연,정재경,이태우 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1

We fabricated designable Ag nanofibers (NFs) through simple, extremely fast and low-cost printing process called Electrohydrodynamic Nanowire Printing. Ag NFs had a comparable resistivity of 5.1 μΩ·cm with bulk Ag (Resistivity of bulk Ag = 1.6 μΩ·cm) and an average diameter of 500 nm which is the smallest dimension among the directly-printed electrode ever reported. Grid patterned Ag NF arrays with line pitch of 100 μm had very high transmittance over 94% (sheet resistance ~ 25 Ω /S□) which is fully-transparent with naked eye. Using Ag NFs as transparent electrodes, we also successfully demonstrated various electronic applications. Our approach will be a promising strategy in the field of next generation electronics.

데이터 리터러시 교육에서 적용할 프로세스 단계 도출을 위한 데이터 과학 수명 주기 분석

정재리(JaeRi Jeong),김성원(Seong-Won Kim),이은경(Eunkyoung Lee),이영준(Youngjun Lee) 한국컴퓨터교육학회 2023 한국컴퓨터교육학회 학술발표대회논문집 Vol.27 No.2

인공지능 기술이 분야에 관계없이 활용되고 일상 생활에서 인공지능과의 상호작용이 보편화되어 인공지능과 인공지능에서 발생하는 다양한 데이터를 이해하고 활용할 수 있는 AI 리터러시와 데이터 리터러시가 실생활에서 필요한 능력으로 간주되고 있다. 2022 개정 교육과정의 정보과에서도 이러한 사회의 흐름을 반영하여 ‘인공지능 기초’ 과목을 개편하고 ‘데이터 과학’ 과목을 신설하였다. 교육과정에서는 데이터 과학 프로젝트를 통해 학생들이 데이터 기반의 전체적인 문제 해결 과정을 체험할 것을 권하고 있다. 이를 위해 본 연구에서는 중고등 교육 관점에서 데이터 리터러시를 정의하고, 중고등학생을 대상으로 하여 데이터 리터러시 교육에서 적용할 프로세스 단계를 도출하기 위해 데이터 과학 분야의 프로세스 모델 및 생명 주기를 비교‧분석하였다. 분석 결과 도출된 단계는 문제 정의 및 이해, 데이터 수집 및 준비, 데이터 활동, 평가 및 결과 활용 4단계로 도출되었고, 2022 개정 교육과정에 데이터 과학 교과의 내용과 비교한 결과 교육과정에 나타난 문제해결 과정과도 대응되었다.

한문학 2013년 연구동향

정내원,권은지,전염순,고성은,김해나,최혜미,이명기,이미진,안솔잎,뢰정,임유의,김혜진,이도경,이영준,양윤희,이미흔,이송희 고전문학한문학연구학회 2014 고전과 해석 Vol.17 No.-

디지털 리터러시 함양을 위한 온라인 협업 도구 활용 방안

정재리(Jae-Ri Jeong),이소율(So-yul Yi),이영준(Youngjun Lee) 한국컴퓨터교육학회 2022 한국컴퓨터교육학회 학술발표대회논문집 Vol.26 No.2

디지털 리터러시(Digital Literacy) 교육 연구 동향 분석

정재리(Jae-Ri Jeong),이다겸(Dagyeom Lee),이소율(So-yul Lee),이영준(Youngjun Lee) 한국컴퓨터정보학회 2022 한국컴퓨터정보학회 학술발표논문집 Vol.30 No.2

재생 중인 흰쥐 간의 형태학적 변화 및 PCNA 발현에 미치는 rrhGM-CSF의 영향

정진주,허시현,김지현,윤광호,이영준,한규범,김완종,Jeong, Jin-Ju,Heo, Si-Hyun,Kim, Ji-Hyun,Yoon, Kwang-Ho,Lee, Young-Jun,Han, Kyu-Boem,Kim, Wan-Jong 한국현미경학회 2010 Applied microscopy Vol.40 No.2

Granulocyte macrophage-colony stimulating factor (GM-CSF)는 과립구 및 대식세포뿐만 아니라 상피세포의 증식과 분화를 자극하는 당단백질이며, 최근 생산된 벼세포 유래 재조합 GMCSF(rrhGM-CSF)는 감염원으로부터 안전하고 당사슬이 매우 풍부하여 물질의 안정성 혹은 효과의 지속성을 높여 주는 것으로 알려졌다. 본 실험에서는 간 재생 능력이 우수한 흰쥐를 실험모델로 하여 간의 78%를 제거한 후, 간 재생을 유도하는 과정에서 rrhGM-CSF를 처리하고, 시간 경과에 따라 형태변화의 차이와 더불어 단백질 발현 분석법과 면역조직화학법을 이용하여 PCNA 발현에 미치는 효과에 대해서 알아보고자 하였다. rrhGMCSF는 간 재생 속도를 뚜렷이 증가시키지는 못하였으나, 대조군에 비해 실험군에서는 재생 초기에 간 세포판의 붕괴와 재구성 시기를 다소 앞당기는 것으로 관찰되었다. 증식 중인 세포에서 증가하는 것으로 알려져 있는 핵단백질인 proliferating cell nuclear antigen (PCNA)의 간 조직에서의 분포와 발현 정도를 보면 부분간절제 후 12시간과 24시간에서는 PCNA 단백질이 두 그룹에서 조금씩 발현되다가 간 절제 3일과 5일이 경과한 실험군에서 단백질이 높게 발현되었다. 간 재생이 진행될수록 간 조직 전체에서 고르게 PCNA 양성반응이 나타났으며, 대조군 보다 실험군에서 반응성이 더 뚜렷한 것으로 나타났다. 이러한 결과들로 보아 부분 간절제 후 간 재생을 유도하는 과정에서 rrhGM-CSF가 세포분열을 촉진시키는 인자들 중의 하나로 작용하여 간 재생에 효과를 나타낼 수 있을 것으로 사료된다. Liver regeneration is a result of highly coordinated proliferation of hepatocytes and nonparenchymal liver cells. Partial hepatectomy (PH) is the most often used stimulus to study liver regeneration because, compared with other methods that use hepatic toxins, it is not associated with the tissue injury and inflammation, and the initiation of the regenerative stimulus is precisely defined. Granulocyte macrophage-colony stimulating factor (GM-CSF), which is a cytokine able to regulate the proliferation and differentiation of epithelial cells, was first identified as the most potent mitogen for bone marrow. Particularly, rrhGM-CSF, which is highly glycosylated and sustained longer than any other types of GM-CSF in the blood circulation, was specifically produced from rice cell culture. In this experiment, effects of rrhGM-CSF administration were evaluated in the regenerating liver after 78% PH of rats. Morphological changes induced by PH were characterized by destroyed hepatocyte plate around the central vein and enlarged nuclear cytoplasmic ratio and increased hepatocytes with two nuclei. And then, proliferation of liver cells (parenchymal and nonparenchymal) and rearrangement of plates and lobules seemed to be carried out during liver regeneration. These alterations in the experimental group preceded those of the control. Since proliferating cell nuclear antigen (PCNA) is known to be a nuclear protein maximally elevated in the S phase of proliferating cells, the protein was used as a marker of liver regeneration after PH in rats. PCNA levels by western blot analysis and immunohistology were compared between the two groups. PCNA protein expression of two groups at 12 hr and 24 hr after injury showed similar pattern. The protein expression showed the peak at 3 days in both groups, however, the protein level of the experimental group was higher than that of the control. On immunohistochemical observations, the reaction product of PCNA was localized at the nuclei of proliferating cells and the positive reaction in experimental group at 3 days was clearly stronger than that in control group. The results by Western blotting and immunohistology for PCNA showed similar pattern in terms of the protein levels. In conclusion, rrhGM-CSF administration during liver regeneration after 78% PH accelerated breakdown and restoration of the hepatic plate and expression of PCNA. These results suggest that rrhGM-CSF might play an important role during liver regeneration in rats.