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      • KCI등재

        Antioxidant and anti-inflammatory effects of solar salt brined kimchi

        윤예랑,최윤정,김예솔,천서영,이미애,정영배,박성희,민성기,양호철,서혜영 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.5

        Salt is an essential ingredient in the kimchi fermentation process. Solar salt has antioxidant, anti-cancer, and anti-obesity properties. The aim of this study was to determine the antioxidant and anti-inflammatory effects of solar salt brined kimchi. Purified salt (PS), dehydrated solar salt (DSS), 1-year aged solar salt (SS1), and 3-years aged solar salt (SS3) were investigated. Anti-inflammatory effects were determined by analyzing cytotoxicity, nitric oxide (NO) production, and inflammation-related gene expression in lipopolysaccharide-treated RAW264.7 cells. Antioxidant activities of DSS, SS1, and SS3 were higher than that of PS. Solar salt significantly inhibited NO production with low cytotoxicity and decreased inflammation-related gene expression. Kimchi containing solar salt (DSSK, SS1K, and SS3K) showed higher antioxidant activity than PSK. Additionally, DSSK, SS1K, and SS3K significantly inhibited NO production and decreased the expression of inflammation-related genes. Owing to the antioxidant and anti-inflammatory effects, using solar salt in kimchi preparation could have potential health benefits.

      • KCI등재

        Antioxidant activity and calcium bioaccessibility of Moringa oleifera leaf hydrolysate, as a potential calcium supplement in food

        윤예랑,오수진,이민정,최윤정,박성진,이미애,민성기,서혜영,박성희 한국식품과학회 2020 Food Science and Biotechnology Vol.29 No.11

        Moringa oleifera leaf (ML) is rich in vitaminsand minerals, specially abundant calcium, therefore it iswidely used as a calcium supplement for food. This studyaimed to investigate the antioxidant activity and calciumbioaccessibility of M. oleifera leaf hydrolysate (MLH) as acalcium supplement for kimchi. MLH was prepared underthree different proteases, two different protease contents,and three different incubation times. Total phenol content(TPC), total flavonoid content (TFC), and antioxidantactivities were investigated. Cellular activity and calciumbioaccessibility were also investigated. The highest calciumlevel of MLH was observed in 3% Protamex treatmentfor 4 h. TPC, TFC, and antioxidant activities of MLHin Protamex and Alcalase treatments were higher thanthose in Flavourzyme treatment (p\0.05). Moreover,high cell viability and alkaline phosphatase activity werealso observed in C2C12 cells. Kimchi containing MLHshowed high calcium accessibility compared to kimchialone. Taken together, the application of MLH could havepotential as a calcium supplement for kimchi production.

      • KCI등재

        Lipid-Lowering Effect of Hot Water-Soluble Extracts of Saururus chinensis Bail on Rats Fed High Fat Diets

        윤예랑,송영옥,김미정,권명자,김현주,Yeong Bok Song,송경빈 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.2

        We evaluated the inhibition of low-density lipoprotein (LDL) oxidation inhibition by a hot water-soluble ex-tract of Saururus chinensisBail (HWSCB) in vitroand the lipid-lowering effects of HWSCB in rats fed high fat diet (HFD).HFDs were supplemented with 5% HWSCB (HFSCB5 group), 10% HWSCB (HFSCB10 group), or 1% tannic acid (Tanningroup). The Tannin group served as a positive control for the study, based on tannic acid’s known lipid-lowering effect andwater-soluble characteristics. LDL oxidation was dose-dependently inhibited in the presence of HWSCB, and the effect ofHWSCB was comparable to that of vitamin C. Significant reductions in triglyceride (P. .05) and cholesterol (P. .05) lev-els in the plasma and liver of the HFSCB5, HFSCB10, and Tannin groups were observed. High-density lipoprotein choles-terol was elevated (P. .05), but LDL was decreased in a dose-dependent manner for the HFSCB samples. These results wereassociated with a significant decrease in the atherogenic index for the HFSCB samples, especially for HFSCB10. In addition,fecal excretion of triglyceride with HWSCB supplementation was greater than with tannic acid supplementation. The find-ings of this study suggest that HWSCB may reduce plasma and hepatic lipids, especially triglyceride, in rats fed high fat diet.

      • KCI등재

        Antioxidant activities of brown teff hydrolysates produced by protease treatment

        윤예랑,박성희 한국영양학회 2018 Journal of Nutrition and Health Vol.51 No.6

        Purpose: Various plants, herbal medicines, and marine foodstuffs have been used in kimchi preparation to improve its overall quality. Teff, which is rich in minerals and starches, facilitates stable blood glucose levels and is well-suited for use in gluten-free products; hence, it can be used to reinforce the mineral composition of kimchi. In this study, we probed the antioxidant activities of hydrolysates prepared by treatment of brown teff with three proteases under different conditions. Methods: The mineral composition of brown teff was determined by inductively coupled plasma spectrophotometry-mass spectrometry, and we established optimal hydrolysis conditions by determining the total phenol and flavonoid contents of teff hydrolysates obtained using three different proteases (protamax, flavourzyme, and alcalase), two different protease concentrations (1 and 3 wt%), and three different incubation times (1, 2, and 4 h). The antioxidant activity of the hydrolysates was further investigated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, total antioxidant capacity (TAC), and ferrous reducing antioxidant power (FRAP) assays. Results: Brown teff was rich in I, K, Mg, and Ca, and the highest total phenol content (24.16 μg/mL), total flavonoid content (69.08 μg/mL), and TAC were obtained for 1 wt% protamax treatment. However, the highest DPPH scavenging activity and FRAP values were observed for hydrolysates produced by alcalase and flavourzyme treatments, respectively. Conclusion: Treatment of brown teff with proteases affords hydrolysates with significantly increased antioxidant activities and high total phenol and flavonoid contents, and these antioxidant activities of teff hydrolysates have the potential to enhance the quality and functionality of kimchi in future applications.

      • KCI등재

        Kimchi Methanol Extract and the Kimchi Active Compound, 3′-(4′-Hydroxyl-3′,5′-Dimethoxyphenyl)Propionic Acid, Downregulate CD36 in THP-1 Macrophages Stimulated by oxLDL

        윤예랑,김현주,송영옥 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.8

        Macrophage foam cell formation by oxidized low-density lipoprotein (oxLDL) is a key step in the progression of atherosclerosis, which is involved in cholesterol influx and efflux in macrophages mediated by related proteins such as peroxisome proliferator-activated receptor c (PPARc), CD36, PPARa, liver-X receptor a (LXRa), and ATP-binding cassette transporter A1 (ABCA1). The aim of this study was to investigate the beneficial effects of kimchi methanol extract (KME) and a kimchi active compound, 3-(40-hydroxyl-30,50-dimethoxyphenyl)propionic acid (HDMPPA) on cholesterol flux in THP-1-derived macrophages treated with oxLDL. The effects of KME and HDMPPA on cell viability and lipid peroxidation were determined. Furthermore, the protein expression of PPARc, CD36, PPARa, LXRa, and ABCA1 was examined. OxLDL strongly induced cell death and lipid peroxidation in THP-1-derived macrophages. However, KME and HDMPPA significantly improved cell viability and inhibited lipid peroxidation induced by oxLDL in THP-1-derived macrophages (P < .05). Moreover, KME and HDMPPA suppressed CD36 and PPARc expressions, both of which participate in cholesterol influx. In contrast, KME and HDMPPA augmented LXRa, PPARa, and ABCA1 expression, which are associated with cholesterol efflux. Consequently, KME and HDMPPA suppressed lipid accumulation. These results indicate that KME and HDMPPA may inhibit lipid accumulation, in part, by regulating cholesterol influx- and efflux-related proteins. These findings will thus be useful for future prevention strategies against atherosclerosis.

      • KCI등재

        조직재생을 위한 효과적인 성장인자의 활용

        윤예랑,김해원,장준혁 한국생체재료학회 2013 생체재료학회지 Vol.17 No.4

        Growth factors (GFs) are soluble-secreted signaling proteins capable of instructing specific cellular responses including cellular growth, proliferation, migration and differentiation. GFs are expected to be effective in tissue regeneration.However, due to the short biological half-life, lack of long-term stability and possible toxicity, GFs show the limitation on practical application. Currently, sophisticated biomaterials systems that control the biological release of growth factors represent a new strategy for tissue regeneration. Here, we introduce the functions of GFs and the combinational applications of GFs and biomaterials.

      • KCI등재

        차별경험이 2차 베이비붐 세대의 자원봉사참여에 미치는 영향: 기회평등과 노력성취에 대한 인지적 평가를 중심으로

        윤예,이현민,김욱진 한국콘텐츠학회 2019 한국콘텐츠학회논문지 Vol.19 No.1

        이 연구에서는 차별경험과 2차 베이비붐 세대의 자발적 시민참여활동의 관계를 살펴보았다. 구체적으로, 2차 베이비붐 세대가 겪는 차별경험이 기회평등과 노력성취에 대한 부정적 평가를 매개로 자원봉사참여수준에 미치는 영향을 구조방정식모형을 통해 점검하였다. 분석자료는 동그라미 재단의 「2016년 한국사회 기회불평등에 대한 조사」에서 확보하였다. 분석대상은 설문조사 당시 만 42세부터 만 48세였던 2차 베이비부머 474명으로 제한하였다. 모형검증 결과, 차별경험은 기회평등과 노력성취에 대한 인지적 평가를 매개로 2차 베이비붐 세대의 자원봉사참여수준에 부정적 영향을 미친다는 사실을 확인하였다. 연구결과를 바탕으로 2차 베이비붐 세대의 자원봉사활동을 진흥할 수 있는 정책방안들을 제시하였다. In this study, we explored the relationship between experienced discrimination and volunteering activities among the 2nd baby boom generation. Specifically, applying structural equation modeling, we examined how the effect of experienced discrimination on volunteering among the 2nd baby boom generation is mediated by the negative perception of equal opportunity and achievement by personal merit. Data were obtained from the 2016 National Survey on Unequal Opportunity from the Circle Foundation. The research sample was comprised of 474 baby boomers ages 42 to 48 at the time of survey. Results indicated that perceived discrimination affects the level of volunteering among the 2nd baby boom generation, through the negative perception of equal opportunity and achievement by personal merit. Based on the findings, we presented policy implications that could promote volunteering activities among the 2nd baby boom generation.

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