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원지언,추지연,Hyunah Caroline Choi,Yun Chen,박현준,Héctor José Dueñas 대한남성과학회 2018 The World Journal of Men's Health Vol.36 No.2
Purpose: The aim of this study was to investigate the safety and effectiveness of tadalafil 5 mg once daily (quaque die [everyday], QD)among Korean men with benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) in a real-world clinical setting. Materials and Methods: This was a single-country, prospective, observational cohort study in which patients newly prescribedtadalafil 5 mg QD for the treatment of BPH/LUTS were followed-up for 12±2 or 24±2 weeks, or to the last treatment,during post-marketing surveillance. Safety was evaluated in terms of the frequency of treatment-emergent adverse events(TEAEs) and serious adverse events (SAEs). Effectiveness was assessed by changes in the International Prostate Symptom Score(IPSS) from baseline to each endpoint. Results: All patients receiving ≥1 dose of tadalafil 5 mg QD (N=637) were included in the safety population. Two percentof patients (n=13) experienced 15 TEAEs of mild (n=10; 66.7%) or moderate (n=5; 33.3%) severity. No severe TEAEs and noSAEs were reported. Effectiveness evaluations included all patients receiving tadalafil who had both baseline and endpointobservations (12-week, N=265; 24-week, N=44). Compared with baseline, the mean IPSS total score (±standard error) significantlyimproved by 4.7±0.3 and 6.4±0.7 points at the 12- and 24-week endpoints, respectively (p<0.0001), with significantimprovements also observed on the storage, voiding, and quality of life subscores. In total, 69.1% of the patients had a clinicallymeaningful ≥3-point improvement in the IPSS total score. Conclusions: Tadalafil 5 mg QD was well tolerated and effective in Korean men with BPH/LUTS in a real-world clinical setting.
The Effect of Antiviral Therapy on Serum Cholesterol Levels in Chronic Hepatitis C
장은선,원지언,정재일,이상협,김진욱,정숙향 거트앤리버 소화기연관학회협의회 2011 Gut and Liver Vol.5 No.3
Background/Aims: The aims of this study were to evaluate the effect of antiviral therapy on serum total cholesterol (TC) levels and to investigate the factors related to serum TC changes in chronic hepatitis C (CHC) patients. Methods: A total of 94 CHC patients, the majority of whom were infected with genotype 1 or 2 and were receiving antiviral therapy, were consecutively enrolled. TC levels before treatment, at week 4, at the end of treatment (EOT), and 24 weeks after the EOT were analyzed, along with factors related to pre- and post-treatment TC levels. Results: Pretreatment TC levels in the sustained virologic response (SVR) group (167±3.6 mg/dL) and the non-SVR group (158±8.3 mg/dL) were similar, and both decreased during antiviral therapy. The TC levels 24 weeks after the EOT significantly increased in the SVR group (183±4.7 mg/dL), but not in the non-SVR group (160±7.1 mg/dL, p=0.044) after adjusting for the pretreatment TC levels. The grade of hepatic fibrosis, as measured by the METAVIR score or the aspartate aminotransferase-platelet ratio index (APRI), but not viral load (p=0.119), was an independent variable associated with the pretreatment TC levels (METAVIR score, p=0.011; APRI, p=0.033). After adjusting for the presence of a SVR by longitudinal data analysis using generalized estimating equations, the independent variable APRI was associated with the serum TC level after antiviral therapy (p=0.014), whereas a SVR was associated with the serum TC level only with marginal statistical significance (p=0.084). Conclusions: Serum TC levels increased in the SVR group after antiviral therapy for CHC; however, this was probably due to an improvement in liver fibrosis rather than the eradication of virus.
골육종 환자에서 발생한 Clostridium sordellii 균혈증 1예
문선유,이승순,원지언,김영수,김효정,김한성,강희정,정두련 대한감염학회 2006 Infection and Chemotherapy Vol.38 No.1
Clostridium sordellii is a gram-positive spore forming anaerobic bacillus, rarely encountered in human infection. It produces several exotoxins which contribute to myonecrosis, pulmonary infection, obstetric infection and bacteremia. C. sordellii bacteremia is very rare and has been reported in few patients with malignancy or immunosuppression. To date, there has been no report in Korea. Mortality is high when deep site infection exists regardless of underlying pathology and immune status. In contrast, superficial skin and subcutaneous tissue infection has a favorable prognosis. We present a case of C. sordellii bacteremia in a patient with osteosarcoma. The patient was admitted for the treatment of the infection at the ulcerative osteosarcoma lesions of the leg, and C. sordellii bacteremia was demonstrated. He was successfully treated with intravenous ampicillin/sulbactam for two weeks. Clostridium sordellii는 다른 Clostridium 종에 비하여 인체 감염을 유발하는 경우가 드문데, 균혈증은 세계적으로 몇 개의 증례만이 보고되었으며 국내에선 아직 보고된 바 없다. 악성종양이나 면역 저하 환자에서 주로 발생하는 C. sordellii 균혈증은 특히 심부 감염에 동반된 경우 사망률이 높다. 저자 등은 골육종 환부의 연조직 감염과 관련된 C. sordellii 균혈증 1예를 경험하여 보고하는 바이다.