구연 : 만성 C형간염에 대한 항바이러스치료 지속반응자에서 혈청 총 콜레스테롤의 상승

장은선,원지언,정재일,이상협,김진욱,정숙향 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.3(S)

Study on Application Case of Scrum Methodology using Visibility

장은선,김능회 한국인터넷방송통신학회 2019 Journal of Advanced Smart Convergence Vol.8 No.3

Viewed in the rate of change in the web environment, it is very difficult to remain the initial planning at the time until the time of launch, and there is a need for a method to accommodate changes and satisfy market demands during the development process. Unlike the traditional waterfall approach of maintaining initial planning, scrum is one of the agile methodologies that enables flexibility to respond to changes in the market and customers' needs and drive customer satisfaction and business success. However, to apply the scrum to a project in actual, the practice method itself is relatively simple but not easy to apply. The reason is that the members of the organization need to understand and participate in scrum's philosophy and principles and the continuous observation and change management should be carried out. Therefore, in this paper, we presented the feature dashboard and customized scrum methodology to enable continuous observation and change management using visibility, and we shared the case that periodically reflected inspection and adaptation with the explanation of the main points. Also, based on the experience with participants, the strengths and weakness of the feature dashboard and the customized scrum methodology are summarized.

Effectiveness of 4-Week Oral Taurine Treatment for Muscle Cramps in Patients with Liver Cirrhosis: A Single-Arm Pilot Study

장은선,황성호,김진욱,정숙향 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.1

Purpose: Painful muscle cramps are a common complication in liver cirrhosis patients, and no effective treatment is available. This pilot study aimed to evaluate whether taurine supplementation improves muscle cramps in Korean cirrhotic patients. Materials and Methods: Ten cirrhotic patients who experienced muscle cramps one or more times/week were enrolled in thisprospective single-arm study and administered with an oral taurine solution (1 g/50 mL) thrice a day for 4 weeks. Taurine wasdiscontinued for the subsequent 4 weeks. The frequency and intensity of muscle cramps were evaluated using a questionnaire atweeks 0, 2, 4, 6, and 8 after the start of treatment. Results: At baseline, the median frequency of muscle cramps was six times/week, and all patients had severe pain. Muscle crampscores (frequency×intensity) decreased in seven patients by weeks 4 and 8 after treatment initiation. Compared to baseline musclecramp scores [median 21, interquartile range (IQR): 8–84], median muscle cramp scores were lower at week 4 (6.5, IQR: 3–12,p=0.126) and week 8 (5, IQR: 1.5–56, p=0.066). All five patients whose baseline plasma taurine levels were below the normal limitshowed increased taurine levels at week 4; 60% of them experienced improvements in their muscle cramps. Of the five patientswith normal or higher taurine levels, 80% experienced an improvement in symptoms at week 4. The safety and tolerability of the4-week taurine therapy were excellent. Conclusion: Oral taurine therapy for 4 weeks improved muscle cramps safely in cirrhotic patients.

The Effect of Antiviral Therapy on Serum Cholesterol Levels in Chronic Hepatitis C

장은선,원지언,정재일,이상협,김진욱,정숙향 거트앤리버 소화기연관학회협의회 2011 Gut and Liver Vol.5 No.3

Background/Aims: The aims of this study were to evaluate the effect of antiviral therapy on serum total cholesterol (TC) levels and to investigate the factors related to serum TC changes in chronic hepatitis C (CHC) patients. Methods: A total of 94 CHC patients, the majority of whom were infected with genotype 1 or 2 and were receiving antiviral therapy, were consecutively enrolled. TC levels before treatment, at week 4, at the end of treatment (EOT), and 24 weeks after the EOT were analyzed, along with factors related to pre- and post-treatment TC levels. Results: Pretreatment TC levels in the sustained virologic response (SVR) group (167±3.6 mg/dL) and the non-SVR group (158±8.3 mg/dL) were similar, and both decreased during antiviral therapy. The TC levels 24 weeks after the EOT significantly increased in the SVR group (183±4.7 mg/dL), but not in the non-SVR group (160±7.1 mg/dL, p=0.044) after adjusting for the pretreatment TC levels. The grade of hepatic fibrosis, as measured by the METAVIR score or the aspartate aminotransferase-platelet ratio index (APRI), but not viral load (p=0.119), was an independent variable associated with the pretreatment TC levels (METAVIR score, p=0.011; APRI, p=0.033). After adjusting for the presence of a SVR by longitudinal data analysis using generalized estimating equations, the independent variable APRI was associated with the serum TC level after antiviral therapy (p=0.014), whereas a SVR was associated with the serum TC level only with marginal statistical significance (p=0.084). Conclusions: Serum TC levels increased in the SVR group after antiviral therapy for CHC; however, this was probably due to an improvement in liver fibrosis rather than the eradication of virus.

DMLS (Direct Metal Laser Sintering) 기술을 이용한 가철성 국소의치 수리 증례

장은선,장근원,변재준,공대룡,송주헌,이경제,Jang, Eun-Sun,Jang, Geun-Won,Byun, Jae-Joon,Kong, Dae-Ryong,Song, Joo-Hun,Lee, Gyeong-Je 대한치과보철학회 2020 대한치과보철학회지 Vol.58 No.3

최근 치과 분야에서 디지털 기술의 발전으로 DMLS (Direct Metal Laser Sintering) 기술을 사용하여 의치의 금속구조물 제작이 가능하다. 이 방법에서 인상은 구강 스캔이나 모델 스캔으로 대체 할 수 있으며, 기존 주조 소환 방법에서 왁스 패턴은 CAD 소프트웨어에서 설계되고, 설계된 STL (standard template library) 파일을 DMLS 기법을 통해 국소의치의 최종 구성 요소를 제작할 수 있다. 치과 분야에서 디지털 기술 이용의 장점은 적합도와 정확성에 있다. 본 증례에서 지지 및 간접 유지 역할을 하는 교합면 레스트의 파절이 발생한 환자에서 DMLS 기술과 레이저 용접 기술을 사용하여 국소의치를 수리하였으며, 기능적, 심미적으로 만족스러운 결과를 보였다. In recent years, digital technology has been developed in dentistry, which denture frameworks can be manufactured using DMLS (Direct Metal Laser Sintering) technique. A traditional impression method can be replaced by oral scanning and wax pattern production process can be achieved by the use of CAD/CAM techniques. The designed STL files can be sent to DMLS devices to fabricate final components of removable partial dentures (RPD). The advantages of digital dentistry are concision and precision. In this case study, a fracture of occlusal rests providing support and indirect retention was repaired by DMLS and laser welding techniques. It shows satisfactory results in adaptation accuracy and functional properties of the repaired denture.

환자 치료식 기준 강화를 통한 환자 만족도 향상

장은선 한국의료QA학회 2009 가을학술대회 Vol.2009 No.3

精神科 外來通院患者의 藥物服用實態에 對한 硏究

장은선,정혜자,문민정,윤덕심 한국병원약사회 1989 병원약사회지 Vol.6 No.4

This study was intended to enhance drug compliance and to increase drug therapeutic effect of psychiatric patients by investigativing concepts and attitudes of psychiatric outpatients. The survey was performed by questionaire method to psychiatric and internal medicine outpatients who visited to Korea University Kuro Hospital in two weeks of September 1989. According to these results, only 1.1% of psychiatric outpatients showed negative attitude to drug itself. But their drug compliance reached to 58.7% compare to 50.0% of internal medicine outpatients. In order to assist regular drug compliance of patients, it is thought to recommend simpler drug administration schedule supervisor for tacking drug, education for drug therapy period and habituation, adequate therapy for drug side effects.

청소년의 스트레스와 비합리적 신념 및 자살생각의 관계 -고등학교 재학중인 여학생을 대상으로-

장은선,김광웅,조유진 한국청소년학회 2007 청소년학연구 Vol.14 No.5

The purpose of this study was to investigate the effects of female adolescent's stress and irrational belief on suicidal ideation. The goal of this study is to find out the influence of irrational belief's moderating effect on suicidal ideation. The subjects of this study were 313 girl students in the 1st and 2nd grade in high schools located in Seoul and Gyeonggido. All subjects were tested with Adolescent's Stress Inventory, Irrational Belief Inventory and Suicidal Ideation Questionnaire (SIQ) Scale. The collected data was analyzed by the SAS statistics program. The frequency and percentage were calculated to investigate the general characteristics of the subject. To investigate the reliability of the general characteristics of the scale, Cronbach α coefficient was calculated, and the collected data was analyzed by simple regression analysis and multiple moderating regression analysis. The major findings of this study are as follows. Firstly, the higher the family stress and self-esteem stress, the more suicidal ideation they have. Secondly, it appears that if the irrational belief is high the suicidal ideation is also high. Thirdly, it shows that the more irrational belief they have in family stress, the suicidal ideation is higher. This research confirms the influence of female adolescent's stress and irrational belief on desire of committing suicide, which is significant for providing information about adolescent's suicidal ideation. 본 연구는 자살생각이 남성보다 여성이 더 높다는 선행연구에 근거하여 여학생 중심의 청소년을 대상으로 스트레스와 비합리적 신념 및 자살생각의 관계를 살펴보고자 하였다. 연구대상은 서울과 경기도에 위치한 인문계 고등학교에 재학중인 1, 2학년 여학생 313명이었고, 자료 분석은 SAS통계프로그램을 이용하여 단순회귀 및 조절적 중다회귀분석(Multiple Moderating Regression Analysis)을 실시하였다. 연구 결과, 스트레스와 비합리적 신념 및 자살생각의 관계는 가정스트레스, 자아스트레스, 비합리적 신념과 자살생각이 통계적으로 유의미한 관계가 있는 것으로 나타났다. 또한, 스트레스 중 가정스트레스와 자아스트레스가 청소년 여학생의 자살생각에 영향을 주었으며, 또한 비합리적 신념이 자살생각에 영향을 주는 것으로 나타났다. 즉 스트레스 중 가정스트레스, 자아스트레스가 높을수록 자살생각을 더 많이 하였으며, 비합리적 신념이 높을수록 자살생각을 더 많이 하는 것으로 나타났다. 그리고 청소년 여학생의 스트레스가 자살생각에 미치는 영향에 대한 비합리적 신념의 조절효과를 살펴본 결과 가정스트레스가 자살생각에 미치는 영향을 비합리적 신념이 조절하는 것으로 나타났다. 즉 가정스트레스가 높은 청소년의 경우 비합리적 신념이 자살생각을 가중시켜 자살생각이 높게 나타났음을 알 수 있다. 이상과 같은 결과를 토대로 청소년의 스트레스와 비합리적 신념 및 자살생각의 관계를 확인하여 청소년의 자살예방에 정보를 제공하고자 하였다.

부록 / 제 3 회 ( 1986 학년도 ) 졸업생 졸업 논문 요약 : 한국 전래 동화의 구조와 의미

장은선 새얼어문학회 1987 새얼語文論集 Vol.3 No.-

이산화탄소 지중저장의 환경 관리를 위한 미국과 유럽연합의 법·제도 현황과 시사점

장은선,윤성택,최병영,정다위,강헌,Jang, Eunseon,Yun, Seong-Taek,Choi, Byoung-Young,Chung, David,Kang, Hun 한국지하수토양환경학회 2012 지하수토양환경 Vol.17 No.6

Though geologic storage of $CO_2$ (GS) is considered as an attractive technological option to enormously reduce greenhouse gases emission into the atmosphere, many concerns on potential environmental and health risks associated with $CO_2$ leakage have been raised. In particular, groundwater contamination due to the brine displacement by a pressure build-up and the acidification by leaked $CO_2$ is paid a special attention. Therefore, integrated regulatory frameworks have been established by law in many countries to secure the permanent containment of injected $CO_2$. Regulatory frameworks deal with entire processes of GS, including site selection, monitoring and post-closure environmental management. This review paper provides a summary of regulatory frameworks in USA (U.S. EPA Geologic Sequestration Rule) and EU (Geologic $CO_2$ Sequestration Directive). The regulatory framework to properly address environmental issues should be established for the deployment of CCS projects in Korea.