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옥민호,이은영 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
To perform auditory tasks such as soundlocalization in the space, auditory neurons in the brain mustdistinguish sub-millisecond temporal differences in signalsfrom two ears. Such high temporal resolution is possiblewhen each neuron in the ascending auditory pathway firesbrief action potential at very accurate timing. Various preandpostsynaptic machineries ensuring such high temporalprecision of auditory synaptic transmission have beenidentified. Of particular, in this review, the role of K?channels in shortening the duration of synaptic potentialswill be discussed. First, the contribution of K? channels toAP firing of general auditory neurons will be discussed. Then, the focus will be moved to the inner hair cell (IHC)-auditory afferent nerve fiber (ANF) synapses, the firstsynapses of ascending auditory pathway. Molecular andimmunohistological techniques have revealed various K?channels in the cell bodies and their processes of ANFs. Since the development of patch-clamp recordings from theANF dendrites in 2002, it became possible to monitor theIHC-ANF synaptic transmission in greater detail. Asrevealed in brain auditory synapses, several different K?channels appear to participate in reducing the duration ofsynaptic potentials at the IHC-ANF synapses. In addition,K? channels at the ANF dendrites might act as potentialtargets of efferent feedback from the brain. The hypothesisis that, upon loud sound exposure, efferent neurotransmittersreleased onto the ANF dendrites activate certain K?channels and prevent excitotoxicity of ANFs. Therefore,K? channels of the ANF dendrites might provide potential sites of pharmacological actions to prevent noise-inducedhearing loss.
Leptin as a Key Between Obesity and Cardiovascular Disease
강기운,옥민호,이성규 대한비만학회 2020 The Korean journal of obesity Vol.29 No.4
Obesity increases the risk of cardiovascular disease through various influencing factors. Leptin, which is predominantly secreted by adipose tissue, regulates satiety homeostasis and energy balance, and influences cardiovascular functions directly and indirectly. Leptin appears to play a role in heart protection in leptin-deficient and leptin-receptor-deficient rodent model experiments. Hyperleptinemia or leptin resistance in human obesity influences the vascular endothelium, cardiovascular structure and functions, inflammation, and sympathetic activity, which may lead to cardiovascular disease. Leptin is involved in many processes, including signal transduction, vascular endothelial function, and cardiac structural remodeling. However, the dual (positive and negative) regulator effect of leptin and its receptor on cardiovascular disease has not been completely understood. The protective role of leptin signaling in cardiovascular disease could be a promising target for cardiovascular disease prevention in obese patients.
고지방식이 마우스 동물모델에서 갯방풍 부탄올 분획물의 심혈관 보호 효과 및 주요 성분
임현진,김현정,옥민호,조정희,안병관,조현우,한동설,권한솔 한국생약학회 2016 생약학회지 Vol.47 No.1
In our search for natural products affecting blood circulation, the n-butanol fraction from whole plant of Glehnia littoralis Fr. Schm. (GLB) improved blood lipid parameters, and ameliorated obesity in high-fat-diet (HFD)-fed C57BL/6 mouse model. Hyperlipidemia was induced by high-fat-diet for 4 weeks, and then GLB was orally administrated with 400 mg/kg/day for 4 weeks. GLB-treated group showed that the gain in body weight was significantly attenuated, the levels of total cholesterol and triglyceride significantly lowered on blood chemical analysis, and significantly prolonged the mice bleeding time when compared with those of HFD control group. Concomitantly, phytochemical composition of GLB was investigated by HPLC-hyphenated spectroscopy, and two major phenolic compounds, rutin and chlorogenic acid were identified in the GLB. Taken together, these results indicate that GLB has cardiovascular protective effects and could be a natural medicine candidate for the prevention of cardiovascular disease.
배민석,이지이,김용표,옥민호,Ju-Seon Shin,이광열,Hyunhee Lee,Sun Young Lee,김영준 한국대기환경학회 2012 Asian Journal of Atmospheric Environment (AJAE) Vol.6 No.1
A comparison of analytical approaches for Levoglucosan (C6H10O5, commonly formed from the pyrolysis of carbohydrates such as cellulose) and used for a molecular marker in biomass burning is made between the four different analytical systems. 1) Spectrothermography technique as the evaluation of thermograms of carbon using Elemental Carbon & Organic Carbon Analyzer, 2) mass spectrometry technique using Gas Chromatography/mass spectrometer (GC/MS), 3) Aerosol Mass Spectrometer (AMS) for the identification of the particle size distribution and chemical composition, and 4) two dimensional Gas Chromatography with Time of Flight mass spectrometry (GC×GC-TOFMS) for defining the signature of Levoglucosan in terms of chemical analytical process. First, a Spectrothermography, which is defined as the graphical representation of the carbon, can be measured as a function of temperature during the thermal separation process and spectrothermographic analysis. GC/MS can detect mass fragment ions of Levoglucosan characterized by its base peak at m/z 60, 73 in mass fragment-grams by methylation and m/z 217, 204 by trimethylsilylderivatives (TMS-derivatives). AMS can be used to analyze the base peak at m/z 60.021, 73.029 in mass fragment-grams with a multiple-peak Gaussian curve fit algorithm. In the analysis of TMS derivatives by GC×GC-TOFMS, it can detect m/z 73 as the base ion for the identification of Levoglucosan. It can also observe m/z 217and 204 with existence of m/z 333. Although the ratios of m/z 217 and m/z 204 to the base ion (m/z 73) in the mass spectrum of GC×GC-TOFMS lower than those of GC/MS, Levoglucosan can be separated and characterized from D (-) +Ribose in the mixture of sugar compounds. At last, the environmental significance of Levoglucosan will be discussed with respect to the health effect to offer important opportunities for clinical and potential epidemiological research for reducing incidence of cardiovascular and respiratory diseases.
조영창,Bok Yun Kang,이성호,Mina Lee,김현정,옥민호,Ik-Soo Lee 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.11
Artemisinin can be isolated from Artemisia annua L. In addition to its well-known anti-malarial activity, artemisinin has antitumor and anti-microbial effects. In this study, we investigated the effect of artemisinin on the production of IL-12p40, which is important in the generation of T helper 1 responses. Artemisinin significantly induced IL-12p40 production in LPS-stimulated RAW264.7 macrophage cells. To elucidate the signaling molecules regulated by artemisinin in induced IL-12p40 production, the DNA-binding activity of several transcription factors and activation of mitogen-activated protein kinase (MAPK)s were investigated. The band intensities of NF-κB, AP-1, and SP1, and the activation of p38 MAPK and ERK were not changed by artemisinin. However, the induced phosphorylation of JNK was significantly decreased by artemisinin, and inhibition of the JNK signaling pathway further increased IL-12p40 production in LPS-stimulated RAW264.7 macrophage cells. Taken together, these data suggest that artemisinin induces the production of IL-12p40 in LPS-stimulated macrophage cells by inhibiting JNK activity.