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양지열,이옥준,손승명,우창곡,정유숙,양예원,권지현,이기형,한혜숙 대한암학회 2018 Cancer Research and Treatment Vol.50 No.3
Purpose Malignant pleural effusions (MPEs) are often observed in lung cancer, particularly adenocarcinoma. The aim of this study was to investigate epidermal growth factor receptor (EGFR) mutation status in lung adenocarcinoma-associated MPEs (LA-MPEs) and its correlation with efficacy of EGFR tyrosine kinase inhibitor (TKI) therapy. Materials and Methods Samples comprised 40 cell blocks of pathologically-confirmed LA-MPEs collected before the start of EGFR TKI therapy. EGFR mutation status was re-evaluated by peptide nucleic acid clamping and the clinical outcomes of EGFR TKItreated patients were analyzed retrospectively. Results EGFR mutations were detected in 72.5% of LA-MPE cell blocks (29/40). The median progression- free survival for patients with EGFRmutations in LA-MPEs was better than that for patients with wild-type EGFR (7.33 months vs. 2.07 months; hazard ratio, 0.486; 95% confidence interval, 0.206 to 1.144; p=0.032). The objective response rate (ORR) of 26 patients with EGFR mutations in LA-MPEs among the 36 patients with measurable lesions was 80.8%, while the ORR of the 10 patients with wild-type EGFR in LA-MPEs was 10% (p < 0.001). Among the 26 patients with EGFR mutations in LA-MPEs, the ORR of target lesions and LA-MPEs were 88.5% and 61.5%, respectively (p=0.026). Conclusion EGFRmutation status in cell blocks of LA-MPEs confirmed by pathologic diagnosis is highly predictive of EGFR TKI efficacy. For patients with EGFRmutations in LA-MPEs, the response to EGFR TKIs seems to be worse for pleural effusions than for solid tumors.
권지민,안성열,양지호,김계중,이주연 대한안과학회 2022 대한안과학회지 Vol.63 No.12
목적: 망막중심정맥폐쇄가 동반된 서서히 진행되는 목동맥해면굴샛길 1예를 보고하고자 한다. 증례 요약: 66세 남자 환자가 우안 충혈, 안구돌출을 주호소로 내원하였다. 당시 최대교정시력은 우안 0.8, 좌안 0.5였고, 세극등현미경검사에서 우안 결막의 혈관 확장과 결막밑출혈이 관찰되었다. 목동맥해면굴샛길 의심하 전산화단층촬영, 전산화단층촬영 혈관조영술, 자기공명영상 등 비침습적 영상검사를 시행하였다. 검사 상 동정맥단락을 나타내는 혈관이상 소견이 관찰되지 않았고, 이에 면밀히 경과 관찰하였다. 약 1달 후 결막혈관 확장 악화 및 목동맥해면굴샛길이 망막중심정맥의 혈류정체를 일으킨 것으로 추정, 망막중심정맥폐쇄가 동반된 소견이 관찰되어 확진하기 위해 경대퇴 대뇌혈관조영술을 시행하였고, 이에 목동맥해면정맥동루로 확진할 수 있었다. 망막중심정맥폐쇄에 대해 우안 항혈관내피성장인자 유리체강 내 주사를 시행하였고, 우안 최대교정시력 1.0으로 호전되어 추후경과 관찰 예정이다. 결론: 천천히 진행되는 목동맥해면굴샛길의 경우 특징적인 안구 증상 외 망막정맥폐쇄 등 드문 안구 내 질환이 동반될 수 있으므로면밀한 평가를 통해 신속히 진단하고 치료하는 것이 중요하다.
증 례 : 분지형 점액분비성낭종 환자에서 발생한 침윤성 췌장암의 심각한 임상 경과: 증례 3예
배대환 ( Dae Hwan Bae ),양지열 ( Ji Youl Yang ),김근모 ( Keun Mo Kim ),김형우 ( Hyung Woo Kim ),윤웅수 ( Woong Su Yoon ),조병하 ( Byung Ha Cho ),김진영 ( Jin Young Kim ),한정호 ( Joung Ho Han ),박선미 ( Seon Mee Park ) 대한췌담도학회 2015 대한췌담도학회지 Vol.20 No.4
Branch duct intraductal papillary mucinous neoplasms of the pancreas (BD-IPMN) without malignant features rarely developed into invasive cancer. However, invasive cancer is aggressive once an invasive change occurs. We report three cases of invasive cancers which developed in patients with BD-IPMN and they showed grave clinical courses. All patients were diagnosed with BD-IPMN < 3 cm without malignant features on imaging. Invasive cancer was detected at 2.5 years, 3.0 years, and 4.0 years after BD-IPMN detection in each patient. The intervals of invasive cancer and the last follow-up were 9 months, 3 years, and 1.5 years in the three patients, respectively. All patients were diagnosed with locally advanced pancreas invasive cancers and were treated with palliative chemotherapy or conservative management. The patients died at 3 months, 9 months, and 10 months after the diagnosis of invasive cancers, respectively. We report three cases of invasive cancer developed in BD-IPMN patients and followed fatal courses.
정유숙,한혜숙,이효덕,양지열,정지원,최문기,권지현,전현정,오태근,이기형,김승택 대한암학회 2016 Cancer Research and Treatment Vol.48 No.4
Purpose Dexamethasone is a mainstay antiemetic regimen for the prevention of chemotherapyinduced nausea and vomiting. The aim of this pilot study was to assess the incidence of and factors associated with steroid-induced diabetes in cancer patients receiving chemotherapy with dexamethasone as an antiemetic. Materials and Methods Non-diabetic patients with newly diagnosed gastrointestinal cancer who received at least three cycles of highly or moderately emetogenic chemotherapy with dexamethasone as an antiemetic were enrolled. Fasting plasma glucose levels, 2-hour postprandial glucose levels, and hemoglobin A1C tests for the diagnosis of diabetes were performed before chemotherapy and at 3 and 6 months after the start of chemotherapy. The homeostasis model assessment of insulin resistance (HOMA-IR) was used as an index for measurement of insulin resistance, defined as a HOMA-IR 2.5. Results Between January 2012 and November 2013, 101 patients with no history of diabetes underwent laboratory tests for assessment of eligibility; 77 of these patients were included in the analysis. Forty-five patients (58.4%) were insulin resistant and 17 (22.1%) developed steroid-induced diabetes at 3 or 6 months after the first chemotherapy, which included dexamethasone as an antiemetic. Multivariate analysis showed significant association of the incidence of steroid-induced diabetes with the cumulative dose of dexamethasone (p=0.049). Conclusion We suggest that development of steroid-induced diabetes after antiemetic dexamethasone therapy occurs in approximately 20% of non-diabetic cancer patients; this is particularly significant for patients receiving high doses of dexamethasone.
재발성 급성 담관염을 보인 담도 과오종과 선천성 간섬유증을 동반한 1예
김기배 ( Ki Bae Kim ),지명진 ( Myoung Jin Ji ),양지열 ( Ji Youl Yang ),한정호 ( Joung Ho Han ),채희복 ( Hee Bok Chae ),박선미 ( Seon Mee Park ),강민호 ( Min Ho Kang ),성노현 ( Ro Hyun Sung ),윤세진 ( Sei Jin Youn ) 대한췌담도학회 2015 대한췌담도학회지 Vol.20 No.2
담도 과오종과 선천성 간섬유증은 태생기에 간판 기형에 의해 생기는 섬유 낭성 질환에 속한다. 담도 과오종은 증상을 유발하지 않고 우연히 발견되는 질환이지만, 선천성 간섬유증은 25%에서 담관염이 발생하고 증상이 발생하면 항생제 투여부터 수술까지 적극적 치료가 필요하다. 저자들은 복부 영상 소견으로 담도 과오종으로 진단하고 경과 관찰하던 64세 남자가 2년간 반복적인 담관염이 발생한 원인을 찾기 위해 시행한 간 생검에서 담도 과오종과 선천성 간섬유증이 병합된 것으로 진단한 증례를 경험하여 문헌고찰과 함께 보고한다. Biliary hamartoma and congenital hepatic fibrosis belong to fibrocystic disorders originating from ductal plate malformation. A 66-year-old man who had incidentally been diagnosed with biliary hamartoma two years ago presented to us with recurrent acute cholangitis. In the first episode, he had presented with septic shock and was treated with endoscopic retrograde cholangiopancreatography (ERCP) and cholecystectomy under the diagnosis of acute cholecystitis and cholangitis. However, during a two-month follow-up period, the patient experienced four episodes of acute cholangitis. Because he showed normal ERCP, and biliary hamartoma is usually asymptomatic, a liver biopsy was performed. Pathology revealed combined features of biliary hamartoma and congenital hepatic fibrosis, characterized as periportal fibrosis and intrahepatic ductular dysplasia. During follow-up for the last six months, he had experienced two episodes of acute cholangitis and was treated with antibiotics. A follow-up abdominal CT scan revealed aggravated hepatosplenomegaly compared to that of two years ago. We report a case of combined congenital hepatic fibrosis and biliary hamartoma and a literature review. Korean J Pancreatobiliary 2015;20(2):105-110