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성중경,고장현,이미영,김보환,남수민,김재현,유진희,김소희,홍순원,이은영,최란,정춘희 연세대학교의과대학 2010 Yonsei medical journal Vol.51 No.3
Purpose: The vascular endothelial growth factor (VEGF) expression of podocyte is one of the well-known major factors in development of diabetic nephropathy. In this study, we investigated the effects of aldose reductase inhibitor, fidarestat on diabetic nephropathy, and renal VEGF expression in a type 1 diabetic rat model. Materials and Methods: Twenty four Sprague-Dawley male rats which were performed intraperitoneal injection of streptozotocin and normal six rats were divided into four groups including a normal control group, untreated diabetic control group, aldose reductase (AR) inhibitor (fidarestat, 16 mg ˙ kg-1 ˙ day-1) treated diabetic group, and angiotensin receptor blocker (losartan, 20 mg ˙ kg-1 ˙ day-1)treated diabetic group. We checked body weights and blood glucose levels monthly and measured urine albumin-creatinine ratio (ACR) at 8 and 32 weeks. We extracted the kidney to examine the renal morphology and VEGF expressions. Results: The ACR decreased in fidarestat and losartan treated diabetic rat groups than in untreated diabetic group (24.79 ± 11.12, 16.11 ± 9.95, and 84.85 ± 91.19, p < 0.05). The renal VEGF messenger RNA (mRNA) and protein expression were significantly decreased in the fidarestat and losartan treated diabetic rat groups than in the diabetic control group. Conclusion: We suggested that aldose reductase inhibitor may have preventive effect on diabetic nephropathy by reducing renal VEGF overexpression.
성중경,김장영,연영진,이준원,안성균,유병수,이승환,윤정한,최경훈,윤진하,박종구 한국심초음파학회 2010 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.18 No.4
Background: Albuminuria is a surrogate marker of endothelial dysfunction and a predictor of cardiovascular events. Data are limited with regard to the relationship between albuminuria and subclinical atherosclerosis in a community-based cohort. We determined the association between albuminuria measured by the urine albumin creatinine ratio (UACR) and carotid intima media thickness (CIMT) in a Korean rural population. Methods: We enrolled 1,369 healthy subjects older than 40 years (857 males and 518 females) with normal renal function and measured the CIMT. We excluded subjects with overt proteinuria (> 300 mg/day) or with treatment of diabetes mellitus,hypertension, dyslipidemia, and any cardiovascular disease. The subjects were stratified into the quartile value of the UACR (lowest quartile: UACR < 4.8 and highest quartile: UACR > 17.7). And we evaluate the relationship between UACR and CIMT by linear regression and logistic regression analysis. Results: Increasing quartile of the UACR had a stepwise increase in body mass index, blood pressure, cholesterol profile [low density lipoprotein (LDL)-cholesterol and triglyceride], glucose, homeostratic model assessment of insulin resistance (HOMA-IR), and C-reactive protein (all p values < 0.001). Maximal CIMT from the 1st to the 4th quartile values of the UACR were 0.74 ± 0.17, 0.77 ± 0.18, 0.78 ± 0.18, and 0.82 ± 0.21 mm, respectively (p < 0.001). In a multivariate regression model adjusted for age, sex, systolic blood pressure, triglyceride, LDL-cholesterol, fasting blood sugar, waist circumference,adiponectin, HOMA-IR, high sensitive C-reactive protein, smoking, UACR showed a significant association with maximal CIMT (B = 0.014, R2 = 0.145, p = 0.002). Conclusion: Albuminuria measured by the UACR was significantly associated with both CIMT and traditional risk factors of atherosclerosis except for smoking in healthy Koreans.
A Case of Hypocalcemia-Induced Dilated Cardiomyopathy
성중경,김장영,류동욱,이준원,윤영진,유병수,최경훈 한국심초음파학회 2010 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.18 No.1
Hypocalcemia is a rare cause of dilated cardiomyopathy. Hypocalcemia induced cardiomyopathy is usually reversible when calcium level returns to normal range. We experienced a case of 57-year-old woman who had suffered from hypocalcemia after total thyroidectomy and its consequence of dilated cardiomyopathy. After supplementation of calcium and vitamin D,symptoms of heart failure and LV function were recovered.
Obesity and Preclinical Changes of Cardiac Geometry and Function
성중경,김장영 대한심장학회 2010 Korean Circulation Journal Vol.40 No.2
Overweight and obesity are rapidly increasing in prevalence due to adoption of the westernized life style in Korea. Obesity is strongly associated with the development of cardiovascular risk factors such as diabetes, hypertension,and dyslipidemia. In addition, accumulating evidence suggests that obesity per se has a direct effect on cardiac functional and structural changes that may not be the result of atherosclerosis. In this review, we focus on the view that obesity can influence on the structural and functional changes of the heart, drawing evidence from human and animal studies. We also review influencing factors such as physical, neurohormonal, and metabolic alterations that are associated with changes of the heart in obesity.
IPSS 검사로 진단된 TSH 분비 뇌하수체 미세선종 1예
성중경 ( Joong Kyung Sung ),김은미 ( Eun Mi Kim ),남수민 ( Su Min Nam ),신영구 ( Young Goo Shin ),정춘희 ( Choon Hee Chung ),황금 ( Kum Whang ),고장현 ( Jang Hyun Koh ) 대한내과학회 2009 대한내과학회지 Vol.76 No.6
Thyroid stimulating hormone (TSH)-secreting pituitary adenomas are rare tumors of the pituitary gland and represent 1~2% of all pituitary adenomas. A TSH-secreting pituitary adenoma shows as a normal or elevated thyrotropin level in a hyperthyroid patient. We present a 32-year-old woman who was diagnosed with a TSH-secreting pituitary microadenoma. She had a high free T4, with a normal TSH and α-subunit. Bilateral inferior petrosal sinus sampling (IPSS) was done to confirm the α-subunit secreting adenoma, and the concentration of the α-subunit was high on the tumor side. The pituitary microadenoma was removed, and her TSH and free T4 levels decreased to normal. IPSS may help give an accurate diagnosis in the patient with a normal α-subunit. (Korean J Med 76:752-757, 2009)
李愚升,趙殷衡,成重慶 慶北大學校 1989 論文集 Vol.47 No.-
In order to search for the methods to enhance flowering of onions, mother bulbs were planted at 10days interval from Sep. 26 to Oct. 26. At every planting, two group of mother bulbs, one treated at 8∼10℃ for 70days and the other stored at room temperature, were planted and the results were as follows. Percentage of flower bud differentiation within the year of planting was high in the plots treated at low temperature and planted before Oct. 5, and the flower bud growth was also advanced. Flower bud differentiation was delayed in the plots planted later. Flower bud differentiation in the plots of mother bulbs stored at room temperature was observed in Spring next year. Bolting percentage on April 4 was 28%., 12.2%, and 5.5% in the plots treated at low temperature and planted on Sep. 26, Oct. 5, and Oct. 16, respectively. Bolting was not observed in the plots planted on Oct. 26 and in the plots where mother bulbs were stored at room temperature. On April 27 percentage of bolting was high in all the plots treated at low temperature and the percentage was decreased with delayed planting in the plots where mother bulbs were stored at room temperature. Percentage of flowering on May 25 was decreasing with delayed planting date in the plots of low temperature treatment. Flowering was not observed even on Jun 3 in the plots where bulbs were not treated at low temperture. Thus bolting and flowering of onion were enhanced by treating mother bulbs and planting late in October as compared to planting mother bulbs stored at room temperature at conventional time of planting.
윤영진,윤정한,한상우,이준원,성중경,안성균,김장영,유병수,이승환,최경훈 대한심장학회 2011 Korean Circulation Journal Vol.41 No.3
Background and Objectives: Transradial coronary angiography and intervention are increasing in frequency due to lower major vascular access site complications and the potential for early mobilization. However, the small size of the radial artery (RA) is a major limitation of this technique. A sheathless guiding catheter (GC) has recently been introduced that has a 1-2 French smaller diameter compared with the corresponding introducer sheath. This catheter also has a hydrophilic coating along its entire length. We evaluated the feasibility of using a sheathless GC in patients who have small radial arteries. Subjects and Methods: The procedural results were evaluated in patients with small radial arteries (diameter <2.3 mm) who underwent transradial coronary intervention using a sheathless GC. Results: A total of 25 (male: 9) patients with 29 lesions were enrolled. The mean RA diameter was 1.81±0.26 mm. 44% of the patients had stable angina and 50.0% had acute coronary syndrome. The procedural success rate was 93.1%. Two patients (6.9%) had chronic total occlusive lesions that could not be crossed with a guide-wire despite good guiding support. An intravascular ultrasound could be used for all of the treated lesions. Multi-vessel intervention was performed in 29.2% of the patients. Two bifurcated lesions were treated with a kissing balloon technique, and one with a modified T-stenting technique. No catheter related complications were reported. Conclusion: The use of a sheathless GC is feasible in patients with small radial arteries without catheter related complications.
Clinical Characteristics and Prognostic Factors of Stress-Induced Cardiomyopathy
이준원,김장영,윤영진,성중경,이남석,이경훈,유병수,이승환,윤정한,최경훈 대한심장학회 2010 Korean Circulation Journal Vol.40 No.6
(LV) dysfunction due to emotional and physical stress. There are limited data about the clinical characteristics in Korean patients. We sought to clarify the clinical features and prognosis in patients with SCM. Subjects and Methods:We reviewed 39 cases diagnosed with SCM in a tertiary hospital. The SCM was diagnosed as: 1) no previous history of cardiac disease, 2) acute onset, 3) regional wall motion abnormality, typically in the takotsubo or inverted takotsubo shape by echocardiography, and 4) no significant stenosis in the coronary angiogram. We evaluated clinical characteristics, biomarkers, and prognosis. Results: Mean age was 61.3±16.1 years (female 69%). The triggering factors were physical stress in 32 patients (82%) and emotional stress in 5 patients (13%). The initial symptom was dyspnea (n=18, 46%) rather than chest pain (n=10, 26%). An initial electrocardiogram (EKG)presented T-wave inversion (n=18, 46%), ST-elevation (n=11, 28%), and ST-depression (n=2, 5%). Multivariate logistic regression analysis showed that initial high sensitive C-reactive protein (hs-CRP) {odds ratio (OR) 1.41,95% confidence interval (CI); 1.02-1.97} and initial left ventricular ejection fraction (LVEF) (OR 0.89, 95% CI;0.80-0.98) were significantly associated with death or cardiogenic shock, respectively. Conclusion: The major triggering factor of SCM is physical stress due to illness or surgical procedures, and the first manifestation is dyspnea rather than chest pain. Elevated hs-CRP and decreased LVEF at admission were independent risk factors for death or cardiogenic shock.