풍향계 - 울주군 - 전국 최초 원자력융합 산업단지 조성

신장열,Sin, Jang-Yeol 한국원자력산업회의 2013 원자력산업 Vol.33 No.5

제2형 당뇨병환자에서 혈관 내피세포 기능장애와 만성염증 표지자인 High Sensitivity C-reactive Protein과의 연관성

신장열,이미영,고장현,김장영,신영구,정춘희 대한당뇨병학회 2005 Diabetes and Metabolism Journal Vol.29 No.5

건강한 폐경기 여성에서 호르몬 대체요법이 경동맥 내중막두께에 미치는 영

신장열,차봉수,정춘희,심원흠,이현철 대한내분비학회 2006 Endocrinology and metabolism Vol.21 No.1

Background: Cardiovascular disease is the leading cause of death in postmenopausal women. The use of hormone replacement therapy (HRT) preventing for cardiovascular disease in postmenopausal women remains controversial. We investigated the effect of HRT on carotid intima-media thickness (IMT) according to the HRT duration in healthy postmenopausal women. Methods: One hundred and twenty postmenopausal women (mean age: 55.4 ± 3.3 years) were classified into never users, short-term, and long-term users according to the HRT duration. Carotid IMT was measured, and the clinical and biochemical cardiovascular risk factors were examined.Results: The mean IMT was significantly thinner in the long-term users than that in the never users (0.62 ± 0.11 vs. 0.71 ± 0.14 mm, P < 0.01). Also, the maximal IMT was significantly thinner in the short-term and the long-term users. However, there is no significant difference in the mean and maximal IMTs between the estrogen alone and estrogen plus progestins used group. The period exposed to menopause was significantly shorter in the long-term users than that in the never users (1.8 ± 2.3 vs. 4.3 ± 3.3 years, P < 0.001). Conclusion: Our findings suggest that if HRT is initiated during early postmenopausal period before the onset of atherosclerosis, HRT may have a beneficial effect on the prevention of carotid atherosclerosis (J Kor Soc Endocrinol 21:14~21, 2006). 연구배경: 관상동맥질환은 폐경기 여성의 주된 사망 원인으로 알려져 있다. 현재 폐경기 여성에서 심혈관질환 예방을 위한 호르몬 대체요법의 사용은 논란의 여지가 많다. 이에 저자 등은 건강한 폐경기 여성에서 초음파를 이용하여 경동맥 내중막두께를 측정하여 투여기간에 따라 호르몬 대체요법이 경동맥 죽상경화증에 미치는 영향을 고찰하였다.방법: 심혈관질환의 과거력이 없는 50세에서 60세까지의 폐경기 여성 120명을 호르몬 대체요법 투여기간에 따라 투여 받지 않은 대조군 (52명), 3년 미만 투여군 (40명), 및 3년 이상 투여군 (28명)으로 분류하였다. 심혈관질환의 위험인자로 알려진 임상적 특성과 생화학적 인자를 측정하였으며, 경동맥 죽상경화증의 정도를 평가하기 위해 초음파를 이용하여 경동맥 내중막두께를 측정하였다.결과: 경동맥 내중막두께의 평균값은 대조군에 비해 3년 이상 투여군에서 유의하게 낮았다 (0.62 ± 0.11 vs. 0.71 ± 0.14 mm, P < 0.01). 또한, 경동맥 내중막두께의 최대값도 대조군에 비해 3년 미만 투여군 및 3년 이상 투여군에서 각각 유의하게 낮았다. 그러나 에스트로겐 단독투여군과 프로게스테론 병용투여군 간에 경동맥 내중막두께의 평균값 및 최대값은 유의한 차이를 보이지 않았다. 폐경에 노출된 기간은 3년 이상 투여군에서 대조군에 비해 유의하게 짧았다 (1.8 ± 2.3 vs. 4.3 ± 3.3 years, P < 0.001).

당뇨병성 족부병변에서 임상경과와 동맥경화증 지표

신장열 ( Jang Yel Shin ),정춘희 ( Choon Hee Chung ) 대한내과학회 2006 대한내과학회지 Vol.70 No.4

호산구증다증을 동반한 P-ANCA 양성 괴사성 사구체신염

신장열 ( Jang Yel Shin ),강이화 ( Ea Wha Kang ),류동렬 ( Dong Ryeol Ryu ),송정식 ( Jung Sik Song ),이원기 ( Won Ki Lee ),박용범 ( Yong Beom Park ),김루시아 ( Lucia Kim ),정현주 ( Heun Ju Jung ),이수곤 ( Soo Kon Lee ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.1

Antineutrophil cytoplasmic antibodies (ANCAs) are now regarded as a serologic marker for pauci-immune crescentic necrotizing glomerulonephritis either in renal-limited form or in association with systemic vasculitis, such as Wegener`s granulomatosis, microscopic polyarteritis, and Churg-Strauss syndrome. Two major ANCA antigens have been indentified: proteinase3, which produces a cytoplasmic staining pattern termed C-ANCA, and myeloperoxidase, which produces a perinuclear pattern termed P-ANCA on ethanol-fixed neutrophils by indirect immunofluorescence. In ANCA- associated diseases, eosinphilia in excess of 1.5×10(9)/L has been proposed to be characteristic of Churg-Strauss syndrome and is rare in other forms of ANCA-associated systemic vasculitis and crescentic necrotizing glomerulonephritis. Recently, there were two cases of P-ANCA positive crescentic necrotizing glomerulonephritis with peripheral blood eosinophilia and extrarenal microscopic vasculitis without asthma or granulomas. We experienced a patient with P-ANCA positive pauci-immune necrotizing glomerulonephritis with few eosinophilic infiltration and eosinophilia. He improved with oral prednisolone along with combination of intravenous cyclophosphamide. So we report this case with the review of literature.

일본뇌염병독(日本腦炎病毒) 난내번식(卵內繁殖)에 관한 연구

김경호,신장열 대한미생물학회 1958 大韓微生物學會誌 Vol.1 No.1

광범위한 뇌하수체 석회화 2 예

김도영,신장열,허갑범,이현철,임승길,김경래,송영득,남재현,안철우,박석원,강신명 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.4

Although calcification of such endocrine gland as adrenal or pineal gland is common, extensive calcification of the pituitary gland is unusual. Calcification is a well recognized but uncommon feature of prolactin-secreting, growth hormone-secreting and non-functioning pituitary tumours. The calcification varies in extent, but rarely exceeds a tiny amount histologically or radiologically. Recently, we had the opportunity to investigate two patients with radiologically demonstrated "pituitary stone" (severely calcified pituitary adenoma). The first Patient, a 51 year-old female, initially presented with general weakness, dizziness, visual disturbance, and loss of hair for 2 months. She was suspected to have a pituitary lesion. Decreased secretion of GH, TSH, LH, and FSH was demonstrated by dynamic tests. On CT scan, she was found to have multilobulated calcified sella mass. She was successfully managed by medical treatment. The second patient, a 65 year-old male, presented with general weakness, nausea, vomiting and polyuria for 2 months. Combined pituitary stimulation test showed subnormal response of GH and prolactine. Radiologic studies revealed pituitary stone which was managed with medical treatment of hormone replacement. We suggest that calcific changes in the pituitary adenoma might be common and occur to the extent of pituitary stone formation with the possible alteration of hormonal secretion (J Kor Soc Endocrinol 14:739-744, 1999).

부신에 발생한 내피성 낭종 1예

전태주,신장열,이유미,김세화,안철우,차봉수,김경래,이현철,허갑범,박희백,임승길 대한내과학회 2002 대한내과학회지 Vol.62 No.6

Adrenal cysts are rare lesions usually discovered incidentally during surgery, or at the time of autopsy. Most adrenal cysts are generally asymptomatic and small, less than 10 cm in diameter. When adrenal cysts enlarge sufficiently, they cause pain and gastrointestinal disturbances or become palpable. When cystic lesions in upper abdomen are found, many cystic lesions such as hepatic, splenic, renal and pancreatic cysts should be considered. It's difficult to differentiate between benign and malignant lesions. Usually these cystic lesions have been excised to rule out malignancy. Herein we report a case of adrenal endothelial cyst which was detected in a 63-year-old female patient during a routine health examination by ultrasonography.

당뇨병 환자에서 발생한 Bartter 증후군

김도영,신장열,허갑범,이현철,임승길,김경래,송영득,남재현,안철우,최규헌,조정래,이준규,남수연,한재호,정현주 대한당뇨병학회 2000 Diabetes and Metabolism Journal Vol.24 No.1

Banter's syndrome is characterized by hypokalemia, metabolic alkalosis, hyperreninemia and secondary hyperaldosteronism without hypertension and edema. Histologically, existing hyperplasia of the juxtaglomerular cell occurs mostly in childhood or adolescence, and initial presentation in patients over 40 years old of age is very rare. It has been recorded that Bartter's syndrome is associated with glucose intolerance, but not with overt diabetes mellitus. Whether this association is coincidental or causal is uncertain, although hypokalemia can cause glucose intolerance. We experienced a case of Banter's syndrome in 44 years old non-insulin dependent diabetic woman. She improved with potassium supplements along with combination of prostaglandin synthetase inhibitor and aldosterone antagonist. We report present case with the review of literature.

뇌하수체 우연종을 동반한 부신 우연종 1예

이명규,남수민,고장현,이미영,신장열,박광화,정춘희 대한내분비학회 2006 Endocrinology and metabolism Vol.21 No.6

Incidentaloma is defined as an asymptomatic mass lesion that shows no associated hormonal hyper- or hyposecretion. Adrenal incidentaloma is also a typical mass detection of which is known to have increased with improved imaging techniques such as CT or MRI. We report a case in which a pituitary incidentaloma is accompanied by an adrenal incidentaloma. The 65-year-old patient was admitted due to oropharyngeal pain, and had a medical history that included an operation for rectal cancer. The adrenal tumor had no function, but left adrenalectomy was performed for the evaluation of rectal cancer recurrence, which was diagnosed pathologically as a benign adrenocortical nodule. In our experience we have found that, in the case of multiple incidentalomas, it is important to evaluate the function or malignancy status of each. (J Kor Endocrinol Soc 21:577~582, 2006) 저자 등은 인후통증을 주소로 내원하여 뇌자기공명영상촬영을 시행, 뇌하수체 거대선종을 우연히 발견하였으며 직장암 과거력이 있어 복부 컴퓨터단층촬영을 시행 후 부신 우연종이 발견되어 두 가지 우연종이 동시에 발견된 증례를 경험하였기에 보고하는 바이다. 뇌하수체 우연종은 추적관찰 중이며, 부신 우연종은 전이병변을 배제할 수 없어 수술적 제거를 시행한 상태로 두 가지 우연종이 서로 명확한 상관관계를 보이고 있지 않아 치료방침은 각각의 우연종의 경우와 크게 다르지 않을 것이라 생각된다.