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KSNM60 in Non-thyroidal Radionuclide Therapy: Leaping into the Future
변병현,김명현,한연희,정환정 대한핵의학회 2021 핵의학 분자영상 Vol.55 No.5
This year, the Korean Society of Nuclear Medicine (KSNM) is celebrating its 60th anniversary. Treatment, as well as diagnosis, has played a very important role in the development of nuclear medicine. Since I-131 was used for thyroid therapy in 1959, other radionuclide therapy is still being used, and attempts to use new radionuclide are increasing. In this review, we briefly summarize and introduce the therapies such as radioimmunotherapy, transarterial radioembolization, radionuclide therapy for neuroendocrine tumors, peptide receptor radionuclide therapy, control of metastatic bone pain, radiation synovectomy, radionuclide brachytherapy, alpha particle therapy, and boron neutron capture therapy, which has been being attempted so far in the field of nuclear medicine.
변병현,이재훈,이상무,Byoun, Byung Hyun,Lee, Jae Hun,Lee, Sang Moo 한국초지조사료학회 2016 한국초지조사료학회지 Vol.36 No.1
본 연구는 한우 암소의 임신 단계에 따른 채식 및 반추 행동에 미치는 영향을 규명하기 위하여 실시하였다. 실험에 사용한 공시한우는 미경산 육성우(C), 미경산 임신 3개월령(T1), 미경산 임신 6개월령(T2) 그리고 미경산 임신 9개월령(T3)을 각각 3두씩, 총 12두를 4처리 3반복으로 배치하였다. 그리고 사료급여는 배합사료 체중의 1%, 조사료는 자유 채식시킨 후 육안으로 48시간 행동관찰을 실시하였다. 조사료 섭취량은 T3구(3.68 kg)에서 가장 높았던 반면, C구(1.02 kg)가 가장 낮게 나타났다(p<0.05). 총사료 섭취량은 T3 > T2 > T1 > C구 순으로 높게 나타났다(p<0.05). 또한 체중 대비 건물 채식량 역시 T3 > T2 > T1 > C구 순으로 높게 나타났다(p<0.05). 채식시간, 반추시간 및 저작시간은 유의적으로 T3구에서 높게 나타났으며(p<0.05), 휴식시간은 C구에서 높게 나타났다(p<0.05). 식괴수와 총 저작수는 다른 처리구에 비하여 T3구가 유의적으로 높게 나타났다(p<0.05). 그러나 식괴수 당 반추시간은 처리구들 간에 유의적인 차이를 보이지 않았다. 식괴 당 저작수는 C > T1 > T3 > T2구 순으로 높게 나타났다(p<0.05). 분 당 식괴수는 처리구들 간에 유의적인 차이를 보이지 않았다. 음수 회수 및 배분 회수는 각각 C, T1구에서 유의적으로 높게 나타났다(p<0.05). 그러나 배뇨 회수는 임신기간에 따라 유의적인 차이를 보이지 않았다. 채식율과 저작 효율은 임신기간이 진전됨에 따라 유의적으로 높게(p<0.05) 나타났다. 반추 효율은 T1구가 다른 처리구들에 비하여 높게 나타났다(p<0.05). The objective of this study was to determine the effect of different pregnancy stages on the eating and ruminating behavior of Hanwoo heifers (Bos taurus coreanae). A total of twelve Hanwoo heifers were divided into four groups depending on pregnancy stage: C: before pregnancy, 9 months old, T1: 3 months pregnant, 16 months old, T2: 6 months pregnant, 19 months old, T3: 9 months pregnant, 22 months old (3 replicates per group). Concentrate of 1% of the body weight was fed to them. Roughage was provided at ad libitum to all treatments. Our results revealed that the intake of roughage was the highest in the T3 group (at 3.68 kg) and the lowest in the C group (at 1.02 kg, p<0.05). Total intake in the order from high to low was: T3 > T2 > T1 > C (p<0.05). The rate of dry matter intake compared to body weight (DMI/BW, %) from high to low order was: T3 > T2 > T1 > C (p<0.05). Eating time, ruminating time, and chewing time were the highest in T3 group (p<0.05). Resting time was the highest in C group (p<0.05). The number of bolus and the number of total chews were significantly higher in T3 compared to those in other groups. However, ruminating time per bolus was not significantly difference among groups. The number of chews per bolus from high to low order was: C > T1 > T3 > T2 (p<0.05). The number of bolus per minute was not significantly different among groups. The number of drinking and the number of defecating were significantly higher in C and T1, respectively (p<0.05). However, the number of urinating had no effect according to pregnancy stage. Eating rate and chewing efficiency were significantly higher (p<0.05) in accordance with pregnancy stage (T3 > T2 > T1 > C). Ruminating efficiency was significantly (p<0.05) higher T1 than that in other groups.
반복적인 131I rituximab 방사면역치료를 시행 받은 비호지킨 림프종 환자 군에서 종양 부위의 영상기반 방사선 흡수선량 평가와 임상적 의의
변병현 ( Byung Hyun Byun ),김경민 ( Kyeong Min Kim ),우상근 ( Sang Keun Woo ),최태현 ( Tae Hyun Choi ),강혜진 ( Hye Jin Kang ),오동현 ( Dong Hyun Oh ),김병일 ( Byeong Il Kim ),천기정 ( Gi Jeong Cheon ),최창운 ( Chang Woon Choi 대한핵의학회 2009 핵의학 분자영상 Vol.43 No.1
변병현(Byung Hyun Byun),이국행(Guk Haeng Lee),김동호(Dong Ho Kim),임중섭(Jung Sub Lim),임일한(Ilhan Lim),임상무(Sang Moo Lim),이병철(Byeong Cheol Lee),이준아(Jun Ah Lee) 대한두경부종양학회 2020 대한두경부 종양학회지 Vol.36 No.2
Background/Objectives: To analyze the clinical characteristics of differentiated thyroid cancer (DTC) in children and adolescents. Materials & Methods: Medical records of 31 DTC cases that were diagnosed and treated at Korea Cancer Center Hospital between 2002 and 2018 were retrospectively reviewed. Results: Most cases were papillary carcinoma (n=26), with female predominance (n=25). Median age was 16.4 years (range, 11.9-18.6 years). Extrathyroidal extension was present in 24 cases. Twenty cases had tumor involvement at cervical lymph nodes and three had lung metastasis. Twenty-two patients received radioactive iodide treatment with a median cumulative dose of 300 mCi (range, 100-920 mCi). During a median follow-up of 68.2 months (range, 2.3-191.4 months), serum thyroglobulin level was elevated in 15 patients. Among them, two cases had remnant thyroid tissue, 4 had recurrence at cervical lymph nodes, and the remaining 9 did not have any detectable lesion. All were alive, and 5-year event-free survival (EFS) was 45.2±10.1%. Age £15 years, tumor size, lymph node status (N1b), and distant metastasis had negative effects on EFS. On multivariate analysis, age and tumor size had prognostic significance. Conclusion: For DTC of children and adolescents (£18 years old), age ≤15 years and tumor size were prognostic factor. Therefore, patients in this age group need meticulous follow-up. Further studies are necessary to answer the potential influence of age on the incidence and behavior of DTC.
Perirenal 18F-FDG Uptake in a Patient with a Pheochromocytoma
박지현,변병현,정창원,문한솔,장경진,임일한,김병일,최창운,임상무 대한핵의학회 2014 핵의학 분자영상 Vol.48 No.3
Increased 18F-fluorodeoxyglucose (FDG) uptake ofbrown fat on 18F-FDG positron emission tomography (PET)originating from physiological activation is a common incidentalfinding and is usually located in the neck, shoulder, andsupraclavicular areas. We present a case of an incidentalpheochromocytoma showing diffusely increased 18F-FDGuptake in bilateral perirenal fat tissue as well assupraclavicular and paravertebral fat tissue on 18F-FDGPET/CT. The patient had no clinical symptoms except hypertension,and a pheochromocytoma was confirmed in a postsurgicalspecimen. A pheochromocytoma should be considereda cause in cases of increased 18F-FDG uptake of perirenalbrown fat.
Tenosynovial Giant Cell Tumor of Diffuse Type Mimicking Bony Metastasis Detected on F-18 FDG PET/CT
장경진,변병현,문한솔,박지현,고재수,김병일,임상무 대한핵의학회 2014 핵의학 분자영상 Vol.48 No.3
Tenosynovial giant cell tumor of diffuse type(TGCT-D) is a locally aggressive neoplasm that arises in thetendon sheath, bursa, or synovium. It typically involves theappendicular skeleton and rarely involves the axial skeleton. Because there are no specific findings of TGCT-D based onimaging studies or clinical symptoms, TGCT-D can be confusedwith other primary or metastatic bone tumors.We reportfindings of TGCT-D involving the T9 vertebra incidentallydetected on F-18 FDG PET/CT in a patient with papillarythyroid cancer.
강세령,변병현,오종률,김현식,홍선표,권선영,정아리,송호천,김자혜,조상건,박희정,김영철,안성자,민정준,범희승 대한핵의학회 2014 핵의학 분자영상 Vol.48 No.1
Purpose We evaluated the value of variable 18F-FDG PET/CT parameters for the prediction of disease progression afterconcurrent chemoradiotherapy (CCRT) in patients with inoperablestage III non-small-cell lung cancer (NSCLC). Methods One hundred sixteen pretreatment FDG PET/CTscans of inoperable stage III NSCLC were retrospectivelyreviewed (stage IIIA: 51; stage IIIB: 65). The volume ofinterest was automatically drawn for each primary lung tumor,and PET parameters were assessed as follows: maximumstandardized uptake value (SUVmax), metabolic tumor volume(MTV) using the boundaries presenting SUV intensity exceeding3.0, and the area under the curve of the cumulativeSUV-volume histograms (AUC-CSH), which is known toreflect the tumor heterogeneity. Progression-free survival(PFS), locoregional recurrence-free survival (LRFS), and distantmetastasis-free survival (DMFS) were compared witheach PET and clinical parameters by univariate and multivariatesurvival analysis. Results In the ROC analysis, the optimal cutoff values ofSUVmax, MTV (cm3), and AUC-CSH for prediction of PFSwere determined as 21.5, 27.7, and 4,800, respectively. Inunivariate analysis, PFS was statistically significantly reducedin those with AUC-CSH<4,800 (p =0.004). In multivariateanalysis, AUC-CSH and SUVmax were statistically significantindependent prognostic factors (HR 3.35, 95 % CI 1.79–6.28,p <0.001; HR 0.25, 95%CI 0.09–0.70, p =0.008, respectively). Multivariate analysis showed that AUC-CSH was the mostsignificant independent prognostic factor for LRFS and DMFS(HR 3.27, 95 % CI 1.54–6.94, p =0.002; HR 2.79, 95 % CI1.42–5.50, p =0.003). Conclusions Intratumoral metabolic heterogeneity of primarylung tumor in 18F-FDG PET/CT can predict disease progressionafter CCRT in inoperable stage III NSCLC.
이인기,나해리,변병현,임일한,김병일,최창운,고인옥,이교철,김경민,박수연,김유경,이준영,부선희,김정화,길희섭,박찬수,지대윤,하정호,임상무 대한신경과학회 2020 Journal of Clinical Neurology Vol.16 No.1
Background and Purpose The aim of this study was to determine the diagnostic performance and safety of a new 18F-labeled amyloid tracer, 18F-FC119S. Methods This study prospectively recruited 105 participants, comprising 53 with Alzheimer’s disease (AD) patients, 16 patients with dementia other than AD (non-AD), and 36 healthy controls (HCs). In the first screening visit, the Seoul Neuropsychological Screening Battery cognitive function test was given to the dementia group, while HC subjects completed the Korean version of the Mini Mental State Examination. Individuals underwent 18F-FC119S PET, 18F-fluorodeoxyglucose (FDG) PET, and brain MRI. The diagnostic performance of 18F-FC119S PET for AD was compared to a historical control (comprising previously reported and currently used amyloid-beta PET agents), 18F-FDG PET, and MRI. The standardized uptake value (SUV) ratio (ratio of the cerebral cortical SUV to the cerebellar SUV) was measured for each PET data set to provide semiquantitative analysis. All adverse effects during the clinical trial periods were monitored. Results Visual assessments of the 18F-FC119S PET data revealed a sensitivity of 92% and a specificity of 84% in detecting AD. 18F-FC119S PET demonstrated equivalent or better diagnostic performance for AD detection than the historical control, 18F-FDG PET (sensitivity of 80.0% and specificity of 76.0%), and MRI (sensitivity of 98.0% and specificity of 50.0%). The SUV ratios differed significantly between AD patients and the other groups, at 1.44±0.17 (mean±SD) for AD, 1.24±0.09 for non-AD, and 1.21±0.08 for HC. No clinically significant adverse effects occurred during the trial periods. Conclusions 18F-FC119S PET provides high sensitivity and specificity in detecting AD and therefore may be considered a useful diagnostic tool for AD.