Genome-Wide Association Study of Bone Mineral Density in Korean Men

배예슬,임선화,강미소,김진희,이순항,조비룡,박진호,남유선,손호영,양산덕,성주헌,오광호,윤재문,김종일 한국유전체학회 2016 Genomics & informatics Vol.14 No.2

Osteoporosis is a medical condition of global concern, with increasing incidence in both sexes. Bone mineral density (BMD), a highly heritable trait, has been proven a useful diagnostic factor in predicting fracture. Because medical information is lacking about male osteoporotic genetics, we conducted a genome-wide association study of BMD in Korean men. With 1,176 participants, we analyzed 4,414,664 single nucleotide polymorphisms (SNPs) after genomic imputation, and identified five SNPs and three loci correlated with bone density and strength. Multivariate linear regression models were applied to adjust for age and body mass index interference. Rs17124500 (p = 6.42 × 10−7), rs34594869 (p = 6.53 × 10−7) and rs17124504 (p = 6.53 × 10−7) in 14q31.3 and rs140155614 (p = 8.64 × 10−7) in 15q25.1 were significantly associated with lumbar spine BMD (LS-BMD), while rs111822233 (p = 6.35 × 10−7) was linked with the femur total BMD (FT-BMD). Additionally, we analyzed the relationship between BMD and five genes previously identified in Korean men. Rs61382873 (p = 0.0009) in LRP5, rs9567003 (p = 0.0033) in TNFSF11 and rs9935828 (p = 0.0248) in FOXL1 were observed for LS-BMD. Furthermore, rs33997547 (p = 0.0057) in ZBTB and rs1664496 (p = 0.0012) in MEF2C were found to influence FT-BMD and rs61769193 (p = 0.0114) in ZBTB to influence femur neck BMD. We identified five SNPs and three genomic regions, associated with BMD. The significance of our results lies in the discovery of new loci, while also affirming a previously significant locus, as potential osteoporotic factors in the Korean male population.

디지털치료제로서 인지/의사소통 훈련 애플리케이션 ‘토키랜드’의 활용 가능성: 어휘와 조음 능력 향상에 미치는 영향

김나연,유재형,윤상열,박기수,민유선,윤장혁,배예슬,양유미,정수진,하지완 한국언어청각임상학회 2023 Communication Sciences and Disorders Vol.28 No.2

Objectives: This study was designed to find out whether the cognitive-communication training application ‘Talky Land’ can be used as digital therapeutics for children with communication disorders. Methods: Children with language and speech sound disorders were divided into three groups: One group using the Talky Land app (10 children in Talky Land group), the second group using the MITA app (7 children in MITA group), and the third group that only received traditional language therapy (10 children in control group). Changes in vocabulary and articulation before and after intervention among three groups were compared, and changes during the intervention period were observed through additional probe measurements for the Talky Land group. This study also examined changes in the perception of caregivers for applications before and after intervention. Results: All three groups showed significant improvement in vocabulary and articulation post-intervention compared to pre-intervention; with the Talky Land group showing strength in receptive vocabulary compared to the other two groups. In the Talky land group, the children’s progress varied somewhat depending on their baseline levels. And caregivers had a more positive perception of the value of the application as an education or treatment tool after intervention than before intervention. Conclusion: The results of this study will be used to further enhance Talky Land and contribute to its completion as digital therapeutics.

Osteoarthritis Affects Health-Related Quality of Life in Korean Adults with Chronic Diseases: The Korea National Health and Nutritional Examination Surveys 2009–2013

양지혜,이기헌,정세영,배우경,주혜진,조인영,송재경,박화연,한종수,이가혜,배예슬 대한가정의학회 2017 Korean Journal of Family Medicine Vol.38 No.6

Background: Osteoarthritis (OA) is a chronic disease that commonly afflicts the elderly. This disease reduces thehealth-related quality of life (HRQoL) and causes a significant social burden. Whether the effect of coexistingchronic conditions on HRQoL varies according to the presence of OA remains unclear. Therefore, this study aimedto investigate this notion. Methods: A total of 13,395 participants were identified from the 2009–2013 Korean National Health and NutritionExamination Survey for analysis. HRQoL was assessed using the European quality of life-5 dimensions (EQ-5D) index. Patients with OA were defined as those diagnosed by a physician or those who displayed both, symptoms andradiological findings consistent with OA at the time of the survey. Associations between OA and 8 chronic conditionswere tested using regression analysis. Results: The EQ-5D index was lower in patients with OA than in those without (mean difference, -0.145; 95% confidenceinterval [CI], -0.138 to -0.151; P<0.001). Most patients with OA and chronic conditions showed a lower scorethan those without. EQ-5D was particularly lower in OA patients with hypertension, dyslipidemia, stroke, and renalfailure. The estimated β coefficient for the interaction term was significant in renal failure (-0.034; 95% CI, -0.055 to-0.012), after adjusting for demographic and socio-economic variables. Conclusion: OA significantly affects HRQoL of Korean elderly individuals alone or when combined with other conditions. OA combined with renal failure is particularly detrimental. These results indicate the importance of managingOA, which is an underestimated disease in public health surveys.

Is Vitamin D an Independent Risk Factor of Nonalcoholic Fatty Liver Disease?: a Cross-Sectional Study of the Healthy Population

박단비,권혁태,오승원,조희경,황승식,박진호,윤재문,이혜진,정고은,Sangjoon Ze,박재홍,배예슬,이아랑 대한의학회 2017 Journal of Korean medical science Vol.32 No.1

The association between vitamin D levels and nonalcoholic fatty liver disease (NAFLD) has been recognized. However, few studies showed independent associations between vitamin D deficiency and NAFLD after a sex-related adjustment for metabolic factors. We aimed to study whether vitamin D deficiency is an independent risk factor of NAFLD even after controlling for metabolic syndrome and visceral fat in both sexes. In this cross-sectional study, 7,514 Korean adults (5,278 men, 2,236 women) participated in a health check-up program. They underwent blood tests, abdominal computed tomography (CT) of the visceral fat area, and ultrasonography for NAFLD screening. Multiple logistic regression analysis was used to investigate the association of vitamin D deficiency with NAFLD according to the sex differences. Vitamin D deficiency is associated with NAFLD. The adjusted odds ratio (aOR) for NAFLD increased sequentially with decreasing vitamin D level, even after adjusting for metabolic syndrome and visceral fat. The subjects in the vitamin D sufficiency group (20–30 ng/mL) had an aOR for NAFLD of 1.18 (95% CI, 1.00–1.39), whereas the deficiency group (< 20 ng/mL) had an aOR of 1.29 (95% CI, 1.10–1.52). However, we have detected a significant sex-related interaction when analyzing the results. A significant relationship between vitamin D deficiency and NAFLD was found in men (aOR, 1.33; 95% CI, 1.11–1.60) but not in women.

비대면치료를 통한 조음중재가 말소리장애 아동의 /ㅅ/음소 산출에 미치는 효과

박수나(Su Na Park),하지완(Ji-Wan Ha),배예슬(Ye-Seul Bae),박기수(Ki-Su Park),이길준(GilJoon Lee) 한국언어치료학회 2021 言語治療硏究 Vol.30 No.1

Perception of Korean Speech-Language Pathologists on Telepractice Service

김나연(Na Yeon Kim),하지완(Ji-Wan Ha),박기수(Ki-Su Park),이길준(GilJoon Lee),박수나(Su Na Park),배예슬(Ye-Seul Bae) 한국언어청각임상학회 2020 Communication Sciences and Disorders Vol.25 No.4

배경 및 목적: 비대면 원격 언어재활서비스는 통신 기술과 의사소통 기술을 접목시킨 건강 및 의료 서비스이다. 본 연구는 설문조사를 통해 비대면 원격 언어재활서비스에 대한 언어재활사의 인식에 대해 알아보고자 하였다. 방법: 321명의 언어재활사가 연구에 참여하였다. 설문 문항으로는 응답자의 기본 정보, 비대면 원격 언어재활서비스 경험, 인식, 방향, 교육과 지원 요구에 대한 내용으로 구성하였다. 온라인으로 설문조사를 하였고, 분석은 기술통계와 카이제곱 검정을 이용하여 분석하였다. 결과: 비대면 원격 언어재활서비스 경험이 있는 치료사는 5.9%로 매우 소수였다. 언어치료 경력이 많은 응답자는 적은 응답자보다 비대면 원격치료가 대면치료와 동등한 서비스라는 의견에는 유의하게 부정적이었고, 비대면 원격치료 사용여부가 치료 대상자의 특성에 따라 결정된다는 의견에는 유의하게 긍정적이었다. 비대면 원격치료에 가장 적절한 대상으로 읽기장애와 유창성장애가, 가장 적절하지 않은 대상으로 삼킴장애와 청각장애가 거론되었다. 비대면 원격치료를 위해 가장 고려해야 할 사항으로 대상자의 인지 및 행동 특성을 꼽았다. 비대면 원격 언어재활서비스에 대한 교육참가 의지는 연령, 학력, 경력에 상관없이 높은 것으로 나타났다. 논의 및 결론: 본 연구는 비대면 원격 언어재활서비스에 대한 언어재활사의 인식을 개선시키고, 새로운 시스템 구축에 필요한 실질적인 정보와 방향성을 제공할 수 있을 것이다. Objectives: Telepractice is the application of telecommunication technologies in health and medical services. This survey study focused on Korean Speech-Language Pathologists’ (K-SLPs) perception of telepractice service. Methods: 321 K-SLPs participated in this survey. The survey consisted of the respondents’ basic information, and their experiences, perception, future direction and needs regarding telepractice, the survey data were analyzed using descriptives statistics and chi-squared tests. Results: Only 19 of the respondents used telepractice. Most of them were willing to participate education programs. Respondents with more clinical experience were more likely to think that telepractice is not equivalent to traditional therapy. And they also tended to think that the use of telepractice depends on the characteristics of clients. Respondents felt that reading and fluency disorders were the most appropriate subjects, and swallowing disorder and hearing impairment were the least appropriate for telepractice. The subject’s cognitive and behavioral characteristics were selected as the most important consideration for telepractice. Conclusion: This study will improve the perception of K-SLPs regrading telepractice, and provide practical information and directions necessary for building a new system.