열성 경련 재발의 위험인자와 그들의 조합에 따른 재발률 조사

문수정,선규근,김은영,나경희,박선영,김경심,김용욱,Moon, Su Jung,Sun, Gu Ken,Kim, Eun Young,Na, Kyong Hee,Park, Sun Young,Kim, Kyoung Sim,Kim, Yong Wook 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.11

목 적: 열성 경련은 6개월에서 5세사이 소아의 2-5%가 경험하게 되는 소아과 영역에서 가장 흔한 신경계 질환으로, 열성 경련 환아 중 30-50%가 재발을 경험한다. 열성 경련의 재발을 증가시키는 위험인자들에 대한 연구들은 많이 되어 있으나, 여러 위험인자들이 재발에 관계되어 일관된 결과를 나타내지 않기 때문에 개개 위험인자에 따른 분석보다는 여러 인자들을 조합해 재발률이 높은 환자군을 가려내어 이들에게 예방적 항경련제를 투여하는 것이 효과적이라 하겠다. 따라서 저자들은 열성 경련 재발의 위험인자들을 알아 보고, 나아가 의의있는 인자들을 조합하여 재발률이 높은 군을 가려냄으로써 열성 경련의 재발을 예방하기 위한 항경련제 투여를 결정하는 데 도움이 되고자 하였다. 방 법: 1997년 3월부터 1999년 7월까지 2년 5개월동안 본원에 열성 경련으로 입원한 환자 중 최소 2년이상 외래에서 추적 관찰이 가능했던 204명을 대상으로 하여 성별, 첫 열성 경련의 발생 연령, 열성 경련과 간질의 가족력 유무, 첫 경련의 형태, 신경학적 이상 유무, 뇌파의 이상 유무 등에 따라 재발률을 조사, 비교하였다. 그리고 통계적으로 유의하였던 재발의 위험인자들을 조합하여 재발률을 조사하였다. 결 과 : 1. 위험인자별 재발률 첫 열성 경련의 발생 연령이 12개월 이전이었던 68명 중 48명(70.5%)에서 재발하여, 12개월 이후에 첫 경련이 있었던 군(66/136명, 48.5%)에 비해 재발이 유의하게 많았다(P=0.0027). 사촌이내에 열성 경련의 가족력이 있는 52명 중 39명(75.0%)이 재발하여, 가족력이 없는 군(75명/152명, 47.5%)에 비해 재발이 유의하게 많았다(P=0.0006). 성별, 간질의 가족력, 첫 열성 경련의 형태, 첫 경련전 신경계 발달 이상, 뇌파의 이상 등은 열성 경련의 재발을 증가시키지 못했다. 2. 유의한 재발인자들의 조합에 따른 재발률 열성 경련의 가족력과 첫 열성 경련의 발생 연령이 재발의 위험인자로 유의하였으므로 이들 인자들을 조합하여 재발률을 조사하였다. 1) 첫 재발률 열성 경련의 가족력이 없고 첫 경련시기가 12개월 이후였던 경우(위험인자가 없는 경우)는 43.8%에서 재발이 일어났다. 열성 경련의 가족력이 없고 첫 경련의 시기가 12개월 이전이었던 경우(위험인자가 하나)는 61.7%에서 재발이 일어났다. 열성 경련의 가족력이 있으면서 첫 경련의 발생이 12개월 이후였던 경우(위험인자가 하나)는 64.5%에서 재발이 일어났다. 열성 경련의 가족력이 있으면서 12개월 이전에 첫 경련이 있었던 경우(두가지 위험인자를 모두 가진 경우)는 90.4%에서 재발이 일어났다. 2) 두 번째 재발률 위험인자가 없는 경우는 18.1%, 하나인 경우는 44.7%, 54.9%였고, 두가지 위험인자를 모두 가진 경우는 81.0%의 높은 재발률을 보였다. 결 론 : 열성 경련의 가족력과 첫 열성 경련의 발생연령(12개월 미만)이 열성 경련 재발의 의미있는 위험인자이었고, 인자 조합시 유의한 재발인자의 수가 많아지면 재발률도 증가하였다. 열성 경련의 가족력이 있으면서 12개월 이전에 첫 열성 경련이 있었던 환아들은 재발률이 90%나 되는 고위험군에 속하였다. Purpose : In previous studies, various risk factors for recurrent febrile seizures have been identified. But none of these risk factors alone could sufficiently discriminate children at high or low risk for recurrent seizures. Therefore, we tried to identify patients at high risk of recurrent febrile seizures by combining risk factors. Methods : Two hundred and four children who had been admitted to our hospital from March, 1997 to July, 1999 with their first febrile seizures were enrolled in our study, and followed up over 2 years. We investigated the recurrence rate according to variables such as sex, age at first febrile seizure, family history of febrile seizures or epilepsy, type of the first seizure, neurologic abnormality and EEG abnormality. Results : Family history of febrile seizures and age at first febrile seizure(<12 months) were significant independent risk factors for recurrent febrile seizures. With these two combined factors, four groups were allocated and the recurrence rate by each group was designated as follows: group with no family history of febrile seizures and age at first febrile seizure ${\geq}12$ months (no risk factor), 43.8%; the group with no family history and age <12 months(one risk factor), 61.7%; group with family history and age ${\geq}12$ months(one risk factor), 64.5%; group with family history and age <12 months(two risk factors), 90.4%. Conclusion : A correlation between numbers of risk factors and recurrence rate was present and the children with a family history of febrile seizures and a young age at onset(<12 months) were regarded as a high risk group of recurrence.

골다공증을 동반한 골반 골절환자의 보존적 치료에 대한 증례

문수정,이유진,고연석,송용선,이정한,Moon, Su-Jeong,Lee, Eu-Gene,Ko, Youn-Seok,Song, Yong-Sun,Lee, Jeong-Han 척추신경추나의학회 2010 척추신경추나의학회지 Vol.5 No.1

본 증례는 골절 치유 과정에서 치유기간의 연장을 가져올 수 있는 심한 골다공증에 이환된 환자에게 약한 충격으로 야기된 골반골절 환자에 대하여 침상 안정과 함께 침구 및 부항치료, 약침치료, 한약물치료를 실시하여, 환자가 느끼는 통증 정도를 측정하는 VAS 및 일상 생활 장애의 정도를 반영하는 ODI의 감소, 3차원 전산화단층촬영 상 골절 치유라는 결과를 얻었기에 이를 보고하는 바이다. Objectives: The objective of this study is to report the effectiveness of conservative treatment on pelvic fracture accompanied with osteoporosis. Methods: A female patient, 68 years old, who were diagnosed as right iliac wing fracture with osteoporosis by X-ray, bone scan and bone densitometry, were treated with conservative treatment. We evaluated the effectiveness by checking Visual Analog Scale(VAS), Oswestry Disability Index(ODI) and 3D computed tomography. Results: The symptoms of the patient got improved and the 3D computed tomography image showed the fracture were healing. Conclusions: Conservative oriental treatment can be effectively used for a patient with iliac wing fracture and osteoporosis.

지역사회 기반 당뇨병 환자의 보완대체요법 이용 실태조사

문수정,백승민,박정환,이상훈,서현주,김슬기,이민희,정지훈,최선미,Moon, Su-Jeong,Baek, Seung-Min,Park, Jeong-Hwan,Lee, Sang-Hun,Seo, Hyun-Ju,Kim, Sul-Gi,Lee, Min-Hee,Jeong, Ji-Hoon,Choi, Sun-Mi 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.3

Objectives : To investigate the prevalence and utilization pattern of complementary and alternative medicine (CAM) in individuals with type 2 diabetes. Methods : We conducted a nationwide survey and a total of 535 individuals with type 2 diabetes were asked about their demographic, diabetes-related characteristics and CAM use. We used multiple logistic regression modeling to determine independent predictors of CAM use. Results : Of the 535 subjects, 417 (77.9%) used CAM in last 12 months. The most commonly used modality was red ginseng (17.9%). CAM use was independently associated with being married, northern area residence, higher education and diabetes duration of 3-5 years. More than half(58.3%) of the CAM users used it expecting a better outcome in addition to conventional therapy. Information sources about CAM were mostly friends (36.0%) and family (31.9%), only 28.1% of diabetic patients seek counsel from medical doctors or oriental medical doctors about CAM. Many people perceived CAM as effective (62.7%) and reported side effects only rarely (1.2%). Conclusions : Many diabetic patients used CAM and found it effective, which urges clinicians to pay attention to CAM use of their diabetic patients. Also, further studies are required regarding efficacy and safety about CAM.

가와사끼병 환아에서 발생한 거대관상동맥류 내 혈전의 성공적 용해요법과 장기 치료 및 경과 1례

문수정,이수야,나경희,박선영,김은영,김경심,김용욱,Moon, Su Jung,Lee, Su Ya,Na, Kyong Hee,Park, Sun Young,Kim, Eun Young,Kim, Kyoung Sim,Kim, Yong Wook 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.3

환아는 3개월된 영아로 발병 10일째에 본원에 내원하여 초기에 적절한 진단과 치료를 받지 못했으며 발병 2주에 시행한 심초음파상 거대 관상동맥류를 보였다. 이에 정맥용 면역글로불린 투여와 aspirin과 dipyridamole로 치료 중 발병 24일째 혈전증이 동반되어 urokinase와 heparin의 IV 투여를 통한 혈전용해 치료로 혈전을 완전히 제거할 수 있었다. 이후 5년간 aspirin, dipyridamole, coumadin을 투여하면서 심전도와 심초음파검사를 반복하며 외래 추적 관찰 중 점차 좌측관상동맥내 혈전이 증가하고 내경이 점차 좁아지는 소견과 함께 협착이 의심되었다. 발병 5년 후 시행한 관상동맥 혈관조영술상 관상동맥 좌측 전하지가 완전 폐색되고 우측관상동맥으로부터 발달한 측부순환에서 혈류를 공급받고 있었고, 핵의학 검사상 좌심실의 전벽과 중격, 일부 외벽에 완전 가역적 관류 결손을 보였던 가와사끼병 환아 1례를 경험하여 보고한다. The long-term clinical issues in Kawasaki disease are concerned with the coronary artery lesions that result in aneurysmal formation, thrombotic occlusion, progression to ischemic heart disease, and premature atherosclerosis. We here report a 3 month old infant with Kawasaki disease complicated by giant coronary aneurysm with thrombosis. After urokinase(10,000 IU/kg) and heparin(400 IU/kg) were injected for two days as thrombolytic agents, thrombi were successfully dissolved. Even though long-term oral anticoagulation with low-dose aspirin, dipyridamole and coumadin were administered, thrombosis of the left main coronary artery was slowly increased. five years later, coronary angiography showed nearly total occlusion of the left anterior descending artery and collaterals from the right posterior branch and radionuclide scan demonstrated complete reversible perfusion defect of several portions of the left ventricle.

디지털 진단방사선촬영에서 부가여과판 사용에 따른 피폭선량 감소와 화질 개선

문수정,김영근,이성길,Moon, Su-Jeong,Kim, Young-Keun,Lee, Seong-Kil 대한디지털의료영상학회 2010 대한디지털의료영상학회논문지 Vol.12 No.1

This study is mainly for the reduction of exposure dose by using a heavy elements filter(Gd) in the digital radiology. They contained heavy elements filter of Gd and X-ray beam hardening filters such as Al and Cu. According to the results of experimental evaluation, X-ray property was not changed with variety of kVp in the case of the Gd filter. The surface dose and absorption dose were increased in order of Cu and Al. The contrast of image showed the higher value in order of Cu, Al and Gd. While the use of Gd has increased the numerical value of the CR image, and grayscale has decreased noise value of the DR image.

비만의 한방 치료에 대한 국내 임상 논문 고찰

문수정(Sujeong Moon),공재철(Jaecheol Kong),권영달(Youngdal Kwon),송용선(Yongsun Song),한아름(A-Lum Han),권영미(Youngmi Kwon),이수경(Sukyung Lee) 한국한의학연구원 2010 한국한의학연구원논문집 Vol.16 No.3

The aim of this review is to investigate clinical studies on oriental medicine treatment for obesity in Korean literature and to propose for the better method of clinical studies in order to seek more effective treatment. Electric searches were performed with NDSL, National assembly library, RISS4U, DBPIA, KISS, KMBASE, KoreaMed, Korean traditional knowledge portal and Oasis. Also, 21 major journals associated with oriental medicine in Korea were searched manually. Eighty three studies were included and analyzed in terms of study design, subjects, interventions, results and evaluation of safety. The numbers of controlled, non-controlled and case studies are respectively 26(31%), 43(52%) and 14(17%). Studies using sample size less than 30 accounts for 49% and studies using subjects diagnosed as obese or overweight by specific criteria were 35(42%). Studies which used more than 2 interventions or co-interventions were 76%. Clinical studies which used single herbal medicine were few and clinically studied single herbal medicine were limited to ephedra. More than half of 83 studies were studied for 8 weeks and less. 12% of 69 studies(except case studies) were not statistically analyzed and studies which evaluated safety of intervention were 22(27%) and reported adverse events were 9(11%). To improve the quality of clinical studies on oriental medicine treatment for obesity, studies need to use restricted number of interventions and subjects need to specifically diagnosed as overweight or obese. In addition, various kinds of single herbs need to be clinically studied based on experimental studies and herbalogy.

생체 역학적 분석에 의한 Compression Hip Screw의 디자인 요소에 대한 평가

문수정(S. J. Moon),이희성(H. S. Lee),권순영(S. Y. Kwon),이성재(S. J. Lee),안세영(S. Y. Ahn),이훈(H Lee) 한국정밀공학회 2004 한국정밀공학회 학술발표대회 논문집 Vol.2004 No.10월

At present, CHS(Compression Hip Screw) is one of the best prosthesis for the intertrochanteric fracture. There is nothing to evaluate the CHS itself with the finite element analysis and mechanical tests. They have same ways of the experimental test of the ASTM standards. The purpose of this study is to evaluate the existing CHS and the new CHS which have transformational design factors with finite element analysis and mechanical tests. The mechanical tests are divided into compression tests and fatigue test for evaluating the failure load, strength and fatigue life. This finite element method is same as the experimental test of the ASTM standards. Under 300N of compression load at the lag screw head. There are less differences between Group (5H, basic type) and GroupⅡ which has 8 screw holes. However, there are lots of big differences between GroupⅠ and GroupⅢ which is reinforced about thickness of the neck range. Moreover, the comparison of GroupⅢ and GroupⅣ shows similar tendency of the comparison of Group and GroupⅡ. The GroupⅣ is reinforced the neck range from GroupⅡ. After the experimental tests and the finite element analysis, the most effective design factor of the compression hip screws is the reinforcement of the thickness, even though, there are lots of design factors. Moreover, to unite the lag screw with the plate and to analyze by static analysis, the result of this method can be used with experimental test or instead of it.

화침에 대한 국내외 연구 경향 고찰

문수정 ( Su Jeong Moon ),공재철 ( Jae Cheol Kong ),조동찬 ( Dong Chan Jo ),김에스더 ( Esther Kim ),송용선 ( Young Sun Song ),이정한 ( Jung Han Lee ) 한방재활의학과학회 2011 한방재활의학과학회지 Vol.21 No.4

Objectives: The aim of this review was to investigate studies on fire needle and to propose for the better method of studies in the future. Methods: Studies related to fire needle were searched with electric database for this study, and 10 domestic and overseas databases were included. Results: 19 clinical studies were analyzed in terms of condition, time of heating, number and frequency of treatment, number of heating, safety procedure or device and reports of adverse events. Also 3 review studies were summarized. The number of studies was increasing and the kind of diseases to treat with fire needle were various. Especially musculoskeletal diseases like ligament lesion and lumbago were noticeable. Heating-after-insertion method was recently proposed but the use of term was confusing. The report of adverse events or safety procedure was rare. Also there was an effort to develop more convenient and safer device. Conclusions: High quality clinical trial on fire needle is needed especially to compare 2 methods, heating-after-insertion and heating-before-insertion. And studies need to report safety procedures and adverse events to evaluate the safety of fire needle therapy.

다차원 실시간 지도서비스 구축을 위한 요소 분석

문수정(Moon, Su Jung),편무욱(Pyeon, Mu Wook),김창재(Kim, Chang Jae),이승우(Lee, Seung Woo),강남기(Kang, Nam Gi) 한국측량학회 2012 한국측량학회 학술대회자료집 Vol.2012 No.4

다차원 공간정보 서비스 개발을 위한 관련 표준 분석

문수정(Sujung Moon),편무욱(Moo-wook Pyeon),배상원(SangWon Bae),장일웅(Illwoong Jang) 대한공간정보학회 2013 한국공간정보학회 학술대회 Vol.2013 No.5