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유당분해효소 결핍증의 진단을 위한 십이지장 점막의 자당분해효소 대 유당분해효소 활성도 비
김병관(Byeong Gwan Kim),김선미(Sun Mi Kim),김유선(You Sun Kim),문선희(Sun Hi Moon),이국래(Kook Lae Lee),정현채(Hyun Chae Jung),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.2
N/A Background/Aims: Jejunal biopsy with direct quantitative analysis of mucosal enzyme activities is the standard diagnostic method of lactase deficiency. But this test is seldom used in the clinical setting, because it is incovenient and cumbersome. On the contrary, sucrase to lactase activities ratio in duodenal mucosa is easy to measure and comp]iant with patients. We performed this study to investigate the value of sucrase to lactase activities ratio in duodenal mucosa as a diagnostic method of lactase deficiency. Methods: The 36 cases(22 men, 14 women) of this study were selected from healtby adults free from gastrointestinal symptom. We performed H breath test and syptom analysis after lactose load. And then, we obtained the duodenal mucosa by endoscopic biopsy and measured enzyme activities of the duodenal mucosa. Results: In 36 subjects, there were 21 subjects(58%) who had the intolerant symptoms and had more than a 20ppni increase in breath hydrogen. Sucrase to lactase activities ratio of the 21 subjects was more than 8. By the definition of sucrase to lactase activities ratio, the prevalence of lactase deficiency was 86 percent. This result was sirnilar to the previous prevalence(84%) defined by jejunal mucosa enzyme assay in Korean adults. Conclusion: Sucrase to lactase activities ratio of duodenal mucosa is a useful diagnostic tool for lactase deficiency. (Korean J Gastroenterol 1997;29:175 -181)
장기간 스테로이드 및 Sulfasalazine 투여를 받아 온 아메바성 대장염 의 임상경과
이준규(Jun Kyu Lee),석웅(Woong Seok),천재희(Jae Hee Chun),김유선(You Sun Kim),최일주(Il Ju Choi),김주성(Joo Sung Kim),정현채(Hyun Chae Jung),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한소화기학회 2000 대한소화기학회지 Vol.36 No.3
Many of water-borne infectious diseases are under control nowadays because of the improvement of hygiene and sewage system, but some of them (e.g. amebic colitis) are still endemic in developing countries. Since there is no definite method of diagnosis, amebic colitis is often diagnosed too late or misdiagnosed as idiopathic inflammatory bowel disease. There have been some reports that treatment with glucocorticoids or immuno-suppressive agents may lead to catastrophic result in amebic colitis. We experienced a 65-year-old man who showed somewhat different clinical consequences. He had longstanding hematochezia with lower abdominal pain, and was misdiagnosed as ulcerative colitis. Because his symptom continued over a year despite treatment with glucocorticoids and sulfasalazine, total colectomy was considered. However, the diagnosis of amebic colitis was made with repeated stool parasite examinations, colonoscopic biopsy and serologic tests. He showed dramatic improvement after the antiamebic therapy with metronidazole. (Kor J Gastroenterol 2000;35:398 - 403)
원발성 점막연관림프조직형 위림프종 환자에서 Helicobacter pylori 제균 후 장기간 추적관찰
김태호,이동호,김유선,이창희,송인성,정현채,김철우,김정룡,이국래,김주성,최일주 대한소화기학회 2000 대한소화기학회지 Vol.35 No.5
Background/Aims : We performed this prospective study to evaluate the long-term outcome of patients with low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma after H. pylori eradication. We also investigated the relationship between p16 hypermethylation and the remission of MALT lymphoma in the patients. Methods : We prospectively enrolled 21 patients with H. pylori-positive low-grade gastric MALT lymphoma (stage ⅠE1). The patients received the eradication therapy of H. pylori and then, follow-up endoscopic and histologic examinations were performed at regular intervals. Methylation-specific polymerase chain reaction (MSP) method was used for the serial detection of p16 hypermethylation. Results : Nineteen patients (90.5%) achieved complete remission and their median duration of remission was 15.7 months. One patient had a relapse of MALT lymphoma for two times. Seven patients (58%) revealed p16 hypermethylation initially and in 3 patients who were followed-up for median 28 months, p16 hypermehylation was disappeared. Conclusions : Complete remission of low-grade gastric MALT lymphoma after H. pylori eradication could be maintained in long-term period. Further studies are needed to investigate a role of p16 hypermethylation in the pathogenesis of gastric MALT lymphoma.
소화성 궤양 환자에서 Helicobacter pylori 박멸 전후의 전정부 위염 양상의 변화
김태호,이동호,김유선,이창희,송인성,정현채,김우호,김정룡,이국래,김주성,최일주 대한소화기학회 1999 대한소화기학회지 Vol.34 No.5
Background/Aims : Helicobacter pylori (H. pylori) infection and gastric adenocarcinoma are highly prevalent in Korea. Thus, it is suspected that H. pylori infection is associated with the development of gastric cancer through the process of glandular atrophy and intestinal metaplasia. We have investigated the effects of H. pylori eradication on gastric histology using updated Sydney system of gastritis. Methods: One hundred thirty-three patients with peptic ulcer associated with H. pylori infection had received H. pylori eradication therapy for 1 week (PPI based triple therapy). Then, the patients were investigated by endoscopy with gastric antral biopsy at 3 month (n=133) and 9 month (n=81) after completing eradication therapy. Results: The eradication rate was 84.9% (113/133). In H. pylori eradicated patients, the neutrophilic activity and chronic inflammation were markedly improved at 3 month (p$lt;0.05). However, the glandular atrophy and intestinal metaplasia remained unchanged until 9 months. Reinfection rate with H. pylori at 9 month was 13.6% (11/81), and most of these were suspected as recrudescent. Thus, real natural reinfection rate was thought to be much lower. Conclusions : H. pylori eradication showed no effect on the glandular atrophy and intestinal metaplasia during follow-up of 9 months.
장중첩증과 심한 빈혈을 일으킨 Brunner 선 과오종 1예
김유선,송인성,김용태,정현채,최규완,김정룡,우광훈,김진,김선희,문선희,황진혁,정준오 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.5
Brunner's gland hamartomas are rare duodenal tumors with characteristic pathologic featmes. The usual clinical presentation is nonspecific symptoms, obstructive symptoms, or intestinal bleeding. The majority of these tumors are less than 3 cm in diameter. In cases of larger size, the manifestations are usually intestinal obstruction or intestinal bleeding. The cases with massive gastrointestinal bleeding and severe anemia, requiring transfusion are rare. The diagnosis is made by radiologic studies and gastroduodenoscopy. The treatment of Brunner's gland hamartomas should be conservative, since they are not premalignant, However, the lesions originate in the submucosa, so the confimative diagnosis usually cannot be made by endoscopie biopey. For definitive diagnosis and relief of symptoms, the lesions must be removed surgically or endoscopically. Endoscopic excision is indicated if the tumar is pedunculated. We recently experienced a case of Brunner's gland hamartoma of about 5.5 cm in diameter with intestinal bleeding, requiring transfusion and intussusception. Preoperative diagnosis was submucosal tumor, such as lymphoma, with duodeno-duodenal intussusception. After surgical removal, the resected specimen showed the histologic features of Bruaner's gland hamartoma.
대량 출혈로 발현한 원발성 위장관 말초 T세포 림프종 1예
김유선,송인성,정현채,김상균,김우호,김정룡,김주성,천재희,서승오,박규주 대한소화기학회 2000 대한소화기학회지 Vol.36 No.2
Most primary gastrointestinal lymphomas are B-cell origin. T-cell lymphomas of the intestine comprise the small portion of gastrointestinal lymphomas. Peripheral T-cell lymphomas (PTCL) rarely affect the gastrointestinal tracts at their initial presentation and the majority of primary gastrointestinal PTCL involve the small intestine. There has been few reports about the diffuse and extensive involvement of gastrointestinal tracts by PTCL. In Korea, there has been no report of a primary gastrointestinal PTCL so far. The common manifestations of PTCL involving the gastrointestinal tracts are abdominal pain, gastrointestinal bleeding, perforation, and diarrhea. However, these are not sufficient for the correct diagnosis. Several other gastrointestinal diseases may mimic PTCL. Its low incidence and clinical similarity to other gastrointestinal diseases make a correct diagnosis difficult. We report a case of primary gastrointestinal PTCL involving the whole gastrointestinal tracts, which rarely casuses massive bleeding, with a review of literatures.
소화성 궤양 출혈에 대한 내시경적 순수에탄올 국소주사요법의 치료 효과 및 예후
김태호,이동호,김유선,정현채,송인성,김용태,이경미,박민정,김정룡,김주성,윤용범,이진혁,이국래,최일주 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.3
Background/Aims: Endoscopic injection therapy improves the outcome in bleeding peptic ulcer, but the optimum regimen is unknown. Although endoscopic injection therapy is effective in controlling initial hemorrhage from a peptic ulcer, between 10% to 30% of patients suffer rebleeding. The aim of this study was to evaluate the initial and ultimate success rate of hemostasis, the rebleeding rate, hospital stay (days), and the emergency operation rate in patients who had undergone endoscopic ethanol injection for bleeding peptic ulcer. Methods: Thirty nine patients presented with active bleeding (spurting), visible vessels, or blood clots on endoscopic findings were given an endoscopic ethanol injection with a total of 1.0∼3.0 ml of ethanol. The initial and ultimate success rate of hemostasis, rebleeding rate, and emergency operation rate after the endoscopic injection was evaluated. Results: 1) The initial success of hemostasis was 38/39 (97.4%). 2) The rebleeding rate after ethanol injection was 8/39 (20.5%). ) The success rate of the second trial of ethanol injection was 3/8 (37.8%). 4) Emergency operations were conducted in5/39 (12.8%). 5) The ultimate success rate of hemostasis was 34/39 (87.2%). 6) There were no mortalities [0/39 (0%)] related to the ethanol injections and bleeding peptic ulcers. 7) There were no complications [0/39 (0%)] related to the ethanol injections. 8) The mean duration of hospitalization was 9.5 4.5 days. Conclusions: Endoscopic ethanol injection in the treatment of bleeding peptic ulcers was as effective and safe as any other injection or mechanical hemostatic method. Further prospective studies or endoscopic trials for hemostasis are needed to reduce the rebleeding rate and emergency operation rate of bleeding peptic ulcer.
흰쥐에서 비스테로이드성 항염증제 유발성 소장병증의 병태생리
김유선,송인성,정현채,김정룡,김주성,이나래 대한소화기학회 2000 대한소화기학회지 Vol.36 No.1
Background/Aims : The pathophysiology of nonsteroidal anti-inflammatory drug (NSAID) induced enteropathy is still uncertain. It is proposed that an increase in intestinal permeability due to NSAID plays an important role in it. We have investigated the change of gastrointestinal permeability after administration of NSAID to rats. Prostagrandin E2 (PGE2) level and gene expression of COX enzyme were also investigated. Methods : After administration of indomethacin 15 mg/kg, gastrointestinal permeability was measured at the 1st day, 3rd day, 7th day, and 14th day using mixture of sucrose, lactulose and mannitol. We evaluated PEG2 level by RIA method and gene expression of COX enzyme by reverse transcription-polymerase chain reaction. Results : The gastric permeability was increased as 7 times as baseline (p$lt;0.01) at 1st day and then normalized at 7th day. On the other hand, the small intestinal permeability was peaked at 3rd day and normalized at 14th day. PGE2 level was increased at 1st day in both gastropathy and enteropathy lesions and the new gene expression of COX-2 enzyme was confirmed. Conclusions : The increased small intestinal permeability by NSAID and aggravation through consequent enterohepatic recirculation of NSAID may act as an important mechanism in NSAID-induced enteropathy. The PGE2 produced by COX-2 may play an important role in the healing process of NSAID-induced gastroenteropathy.