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권보성,전훈재,엄순호,최정우,류호상,김창덕,박재연,주문경,장진수,김진남,김승영,금보라,서연석,김용식,진윤태 대한소화기내시경학회 2006 Clinical Endoscopy Vol.33 No.5
Follicular lymphoma (FL) is one of the most common non-Hodgkin's lymphomas in the United States, but it is relatively rare in Asia. FL typically arises in lymph nodes together with spleen, liver, and bone marrow involvement. So, primary extra-nodal FL without peripheral nodal involvement is rare. Histologically, it shows nodular aggregates of lymphoma cells and positivity for CD 10, CD 20 and bcl-2. Not only the stage, but also the grade is associated with the survival rate. Grade 3 FL presents a worse prognosis than does grade 1 and 2 FL and this should be treated with an anthracycline based CHOP regimen. We report here on a case of primary follicular lymphoma arising in the rectum; this was observed in a 58-year-old woman who complained of anorexia, dyspepsia and diarrhea. (Korean J Gastrointest Endosc 2006; 33:285-288) 소포 림프종(follicular lymphoma)은 미국에서는 가장 흔한 비호지킨 림프종 중 하나이지만 동양에서는 드물다. 대부분의 경우 림프절에서 발생하며 림프절 침범 없이 원발성 위장관 림프종으로 진단되는 경우는 매우 드물다. 조직학적으로는 결절을 형성하는 림프종 세포들이 보이며, 면역 조직 화학 검사에서 bcl-2에 양성을 보인다. 소포 림프종에서는 병기뿐만 아니라 조직학적 등급도 예후에 영향을 미친다. 3등급인 경우 예후가 불량하여 고위도 림프종(high grade lymphoma)과 마찬가지로 anthracycline을 기본으로 한 CHOP 항암 요법이 필요하다. 저자들은 식욕부진, 소화불량, 설사로 내원한 58세 여자 환자에서 직장에 발생한 원발성 소포 림프종 1예를 경험하였기에 문헌 고찰과 함께 보고한다.
Inhibitory Effect of Mitoxantrone on Collagen Synthesis in Dermal Fibroblasts
김경일,권창일,이증훈,김창덕,윤태진 대한피부과학회 2022 Annals of Dermatology Vol.34 No.3
Background: Fibroblasts produce collagen molecules that support the structure of the skin. The decrease and hypersynthesis of collagen causes skin problems such as skin atrophy, wrinkles and scars. Objective: The purpose of this study is to investigate the mechanism of mitoxantrone on collagen synthesis in fibroblasts. Methods: Cultured fibroblasts were treated with mitoxantrone, and then collagen synthe- sis was confirmed by reverse transcription-polymerase chain reaction and Western blot. Results: Mitoxantrone inhibited the expression of type I collagen in fibroblasts at both the mRNA and protein levels. In the collagen gel contraction assay, mitoxantrone significantly inhibited gel contraction compared to the control group. Mitoxantrone inhibited trans- forming growth factor (TGF)-β-induced phosphorylation of SMAD3. Finally, mitoxan- trone inhibited the expression of LARP6, an RNA-binding protein that regulates collagen mRNA stability. Conclusion: These results suggest that mitoxantrone reduces collagen synthesis by inhibit- ing TGF-β/SMAD signaling and LARP6 expression in fibroblasts, which can be developed as a therapeutic agent for diseases caused by collagen hypersynthesis.
특징점과 장단기 메모리를 활용한 순환 신경망 기반 사고 감지 시스템
최원홍,권창덕,유병수,김민형,민준기 한국정보과학회 2023 정보과학회 컴퓨팅의 실제 논문지 Vol.29 No.7
사고 상황에서의 빠른 조치는 인적, 물적 손실을 최소화하는 가장 효과적인 방법이다. 그러나 관리 감독이 부족한 작업환경에서는 빠르게 사고를 감지하고 조치하기 어렵다. 이러한 문제를 해결하기 위해 인공지능을 활용한 낙상 감지 시스템이 개발되었다. 그러나 작업 현장의 특성상 낙상 감지만으로는 모든 사고를 감지하기에 부족하다. 따라서, 본 논문에서는 낙상뿐만 아니라 기절 등 분류 기준을 추가한 사고 감지 시스템을 제안한다. 본 연구에서는, 사고 발생 여부를 탐지할 수 있는 시스템을 구현하였다. 구현된 시스템은 우선 Mediapipe를 이용하여 영상에서 특징점을 추출하고, 장단기 메모리(Long Short Term Memory: LSTM)을 기반한 순환 신경망(Recurrent Neural Network: RNN)을 이용하여 사고를 식별하였다. 자체 실험 결과, 구현 시스템이 낙상 상태뿐만이 아닌 기절 상태 또한 사고로 감지하면서도 우수한 정확도를 보였다.
Clinical Relevance for Serum Cold-Inducible RNA-Binding Protein Level in Alopecia Areata
신정민,고정우,권인선,최종원,홍동균,이진협,서영준,김창덕,이증훈,이영,박경덕 대한피부과학회 2019 Annals of Dermatology Vol.31 No.4
Background: Alopecia areata (AA), a chronic, relapsing hairloss disorder, is considered to be a T-cell-mediated autoimmune disease. Cold-inducible RNA-binding protein (CIRP) belongs to a family of cold-shock proteins that respond to cold stress, and has been identified as a damage-associated molecular pattern (DAMP) molecule that triggers the inflammatory response. Recent studies have shown that highmobility group box 1, another DAMP molecule, is elevated in serum and scalp tissue of AA patients, suggesting a relationship between DAMP molecules and the pathogenesis of AA. Objective: To investigate the clinical significance of serum CIRP levels in AA. Methods: The serum levels of CIRP were compared between 68 patients with AA and 20 healthy controls. Additionally, the correlation between CIRP level and various clinical parameters was evaluated. Results: The serum CIRP levels were significantly higher in AA patients compared to healthy subjects. Moreover, there was an association between the serum CIRP level and clinical characteristics, such as disease duration and disease activity. However, there was no significant difference in the serum CIRP level among the clinical types of AA (AA multiplex, alopecia totalis, and alopecia universalis). Conclusion: These results suggest that CIRP may play a significant role in the pathogenesis of AA and could be a potential biologic marker for monitoring the disease activity of AA.
한국인 말단흑색종에서 Yes-Associated Protein의 면역조직화학적 발현 양상
김승미,김도연,권인선,신정민,홍동균,정경은,김창덕,이영,서영준,박상현 대한피부과학회 2022 대한피부과학회지 Vol.60 No.10
Background: Acral melanoma is the most common subtype of melanoma among Koreans, and regional or distantmetastasis is an indicator of poor prognosis. Yes-associated protein (YAP), a key effector of the Hippo pathway, isknown to induce tumor progression and metastasis in various cancers. Objective: We aimed to analyze the clinical and histopathological characteristics of acral melanoma among Koreansand to evaluate their association with YAP expression. Methods: This retrospective review included 27 patients with acral melanoma. Clinical features including age, sex, lesionsite, and stage were obtained from the medical records and images. Biopsy slides of patients with acral melanoma werereviewed, and immunohistochemical staining for YAP was performed. Results: The rate of YAP expression was significantly higher in patients having acral melanoma with regional ordistant lymph node (LN) metastasis than in those without metastasis (n=4/5, 80.0% vs. n=2/22, 9.1%; p=0.004). Histopathologically,the rate of YAP expression was higher in patients having acral melanoma with lymphovascularinvasion than in those without lymphovascular invasion (n=4/8, 50.0% vs. n=2/19, 10.5%; p=0.044). Among the 27lesions, 14 (51.9%) were on stress-bearing sites such as the forefoot and heel. However, the rate of YAP expressiondid not differ significantly between weight-bearing and non-weight-bearing locations (p=0.834). Conclusion: YAP expression is significantly associated with metastasis, especially LN metastasis, in patients with acralmelanoma. Therefore, YAP expression may be used as a prognostic factor for LN metastasis and a target for noveltreatments in patients with melanoma.
한국인 50세 이상 여성의 안면 피부 노화와 생활습관 간의 상관관계
김승미,이영윤,황초롱,신정민,권인선,박상현,정경은,김창덕,서영준,홍동균,이영 대한피부과학회 2022 대한피부과학회지 Vol.60 No.4
Background: Skin aging can be divided into intrinsic and extrinsic processes, and occur due to several factors. Although the interest in skin youthfulness is increasing globally, research on facial skin youthfulness and lifestyle is limited. Objective: This study aimed to evaluate the association between facial skin youthfulness and biophysical facial skin parameters in Korean women over 50 years of age. We further investigated lifestyle factors that make people appear younger than their chronological age. Methods: We surveyed the essential information and lifestyle of subjects by questionnaires, and measured the biophysical parameters of the facial skin. We then performed clinical facial assessments, and the values were compared with the chronologic age. The associations between age differences, biophysical parameters, and living habits were evaluated. Results: We identified a positive correlation between age and melanin index (r=0.245, p<0.001) and erythema index (r=0.119, p=0.002). The melanin index was statistically significantly lower in the group without regular outdoor activities (144.66±43.24 vs. 137.00±55.48, p=0.043). The melanin index and erythema index were the significant differences that defined younger perceived age than chronological age. The perceived age was younger in the group who wore a hat when performing outdoor activities than the group who did not (3.70±1.84 vs. 3.40±1.94, p=0.034). Conclusion: To retain youthful skin, it is essential to reduce sun exposure, as this factor can affect the melanin and erythema indices by inducing photoaging. Therefore, avoiding the sun bia proper methods, such as wearing a hat and sunscreen during outdoor activities, is recommended to maintain skin youthfulness. (Korean J Dermatol 2022;60(4): 201∼208)